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公开(公告)号：US09441266B2
公开(公告)日：2016-09-13
申请号：US13773868
申请日：2013-02-22
CPC分类号： C12Q1/6816 , C12Q1/6827 , C12Q1/686 , C12Q1/6883 , C12Q1/6886 , C12Q2600/172 , C12Q2563/159 , C12Q2565/629 , C12Q2537/143 , C12Q2531/113 , C12Q2535/131
摘要： The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
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公开(公告)号：US09074242B2
公开(公告)日：2015-07-07
申请号：US13026120
申请日：2011-02-11
CPC分类号： C12Q1/6816 , C12Q1/6827 , C12Q1/686 , C12Q1/6883 , C12Q1/6886 , C12Q2600/172 , C12Q2563/159 , C12Q2565/629 , C12Q2537/143 , C12Q2531/113 , C12Q2535/131
摘要： The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
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公开(公告)号：US08658430B2
公开(公告)日：2014-02-25
申请号：US13554655
申请日：2012-07-20
申请人： Benjamin J. Miller , Qun Zhong , Darren Roy Link
发明人： Benjamin J. Miller , Qun Zhong , Darren Roy Link
IPC分类号： G01N1/10
CPC分类号： C12Q1/6806 , B01F3/0807 , B01F13/0062 , B01F15/00357 , B01L3/502761 , B01L7/525 , B01L2200/025 , B01L2200/0647 , B01L2200/141 , B01L2200/143 , B01L2200/148 , B01L2300/0867 , B01L2300/14 , B01L2400/0487 , B05B1/02 , B05B1/08 , B05B1/26 , B05B7/0012 , Y10T436/2575
摘要： The invention generally relates to methods and systems for manipulating droplet size. In certain aspects, the invention provides methods for manipulating droplet size that include forming droplets of aqueous fluid surrounded by an immiscible carrier fluid, and manipulating droplet size during the forming step by adjusting pressure exerted on the aqueous fluid or the carrier fluid.
摘要翻译： 本发明一般涉及用于操纵液滴尺寸的方法和系统。 在某些方面，本发明提供了用于操纵液滴尺寸的方法，其包括形成由不混溶的载体流体包围的水性流体的液滴，并且在成形步骤期间通过调节施加在含水流体或载体流体上的压力来操纵液滴尺寸。
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公开(公告)号：US20130196324A1
公开(公告)日：2013-08-01
申请号：US13773868
申请日：2013-02-22
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q1/6827 , C12Q1/686 , C12Q1/6883 , C12Q1/6886 , C12Q2600/172 , C12Q2563/159 , C12Q2565/629 , C12Q2537/143 , C12Q2531/113 , C12Q2535/131
摘要： The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
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公开(公告)号：US20130295567A1
公开(公告)日：2013-11-07
申请号：US13866126
申请日：2013-04-19
申请人： Darren Roy Link , Qun Zhong , Andrew Watson
发明人： Darren Roy Link , Qun Zhong , Andrew Watson
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , C12Q1/686 , C12Q2563/159 , C12Q2565/629
摘要： The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
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公开(公告)号：US20130099018A1
公开(公告)日：2013-04-25
申请号：US13554655
申请日：2012-07-20
申请人： Benjamin J. Miller , Qun Zhong , Darren Roy Link
发明人： Benjamin J. Miller , Qun Zhong , Darren Roy Link
IPC分类号： B05B1/08
CPC分类号： C12Q1/6806 , B01F3/0807 , B01F13/0062 , B01F15/00357 , B01L3/502761 , B01L7/525 , B01L2200/025 , B01L2200/0647 , B01L2200/141 , B01L2200/143 , B01L2200/148 , B01L2300/0867 , B01L2300/14 , B01L2400/0487 , B05B1/02 , B05B1/08 , B05B1/26 , B05B7/0012 , Y10T436/2575
摘要： The invention generally relates to methods and systems for manipulating droplet size. In certain aspects, the invention provides methods for manipulating droplet size that include forming droplets of aqueous fluid surrounded by an immiscible carrier fluid, and manipulating droplet size during the forming step by adjusting pressure exerted on the aqueous fluid or the carrier fluid.
摘要翻译： 本发明一般涉及用于操纵液滴尺寸的方法和系统。 在某些方面，本发明提供了用于操纵液滴尺寸的方法，其包括形成由不混溶的载体流体包围的水性流体的液滴，并且在成形步骤期间通过调节施加在含水流体或载体流体上的压力来操纵液滴尺寸。
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公开(公告)号：US20110150244A1
公开(公告)日：2011-06-23
申请号：US12279313
申请日：2008-04-18
CPC分类号： H03G1/0082
摘要： A configurable amplifier circuit for a karaoke player is described. In one embodiment, a karaoke player includes: a DVD/CD reader port for coupling to a DVD/CD reader, a microphone input to receive audio signals from an external microphone, an MPEG decoder coupled to the DVD/CD reader port and the microphone input, the MPEG decoder having first and second output terminals, a processor coupled to the MPEG decoder, the processor to control the MPEG decoder, and a configurable amplifier coupled to the first and second output terminals, wherein a first audio signal originating from the first output terminal is selectively amplified by the configurable amplifier circuit in accordance with a second signal originating from the second output terminal.
摘要翻译： 描述了用于卡拉OK播放器的可配置放大器电路。 在一个实施例中，卡拉OK播放器包括：用于耦合到DVD / CD读取器的DVD / CD读取器端口，用于从外部麦克风接收音频信号的麦克风输入端，耦合到DVD / CD读取器端口的MPEG解码器和麦克风 输入，具有第一和第二输出端的MPEG解码器，耦合到MPEG解码器的处理器，用于控制MPEG解码器的处理器以及耦合到第一和第二输出端的可配置放大器，其中源自第一和第二输出端的第一音频信号 输出端子由可配置放大器电路根据源自第二输出端子的第二信号选择放大。
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公开(公告)号：US20100294665A1
公开(公告)日：2010-11-25
申请号：US12668579
申请日：2008-07-11
申请人： Richard Allen , Randall E. Burton , Bryan Crane , Jeffrey R. Krogmeier , Jonathan W. Larson , Vyacheslav Papkov , Nicaulas Sabourin , Qun Zhong , Yi Zhou
发明人： Richard Allen , Randall E. Burton , Bryan Crane , Jeffrey R. Krogmeier , Jonathan W. Larson , Vyacheslav Papkov , Nicaulas Sabourin , Qun Zhong , Yi Zhou
IPC分类号： G01N27/447
CPC分类号： G01N1/40 , B01L3/502753 , B01L3/502761 , B01L2300/0816 , B01L2300/0864 , B01L2400/0415 , G01N2001/4038 , G01N2001/4088
摘要： A system for transferring and/or concentrating a sample is provided. The system includes a chamber with a membrane brave positioned within the chamber. An electrode assembly is configured to create an electric field across the membrane to move a charged sample through the chamber such that the sample collects and may concentrate on the membrane. The system may include a plurality of membranes. The system may also include a plurality of microchannels outwardly extending from the channel, where the membrane extends along the plurality of microchannels. Aspects of the invention are also directed to a pipette which may be used to transfer and concentrate a sample on a membrane. Certain embodiments are directed to methods and systems for concentrating a nucleic acid sample.
摘要翻译： 提供了用于转移和/或浓缩样品的系统。 该系统包括具有位于腔室内的膜勇者的腔室。 电极组件被配置为在膜上产生电场以使带电样品移动通过室，使得样品收集并且可以集中在膜上。 该系统可以包括多个膜。 系统还可以包括从通道向外延伸的多个微通道，其中膜沿着多个微通道延伸。 本发明的方面还涉及可用于将样品转移并浓缩在膜上的移液管。 某些实施方案涉及用于浓缩核酸样品的方法和系统。
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公开(公告)号：US08535889B2
公开(公告)日：2013-09-17
申请号：US13026107
申请日：2011-02-11
CPC分类号： C12Q1/6816 , C12Q1/6827 , C12Q1/686 , C12Q1/6883 , C12Q1/6886 , C12Q2600/172 , C12Q2563/159 , C12Q2565/629 , C12Q2537/143 , C12Q2531/113 , C12Q2535/131
摘要： The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
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公开(公告)号：US08335327B2
公开(公告)日：2012-12-18
申请号：US12279313
申请日：2008-04-18
IPC分类号： H03F99/00
CPC分类号： H03G1/0082
摘要： A configurable amplifier circuit for a karaoke player is described. In one embodiment, a karaoke player includes: a DVD/CD reader port for coupling to a DVD/CD reader, a microphone input to receive audio signals from an external microphone, an MPEG decoder coupled to the DVD/CD reader port and the microphone input, the MPEG decoder having first and second output terminals, a processor coupled to the MPEG decoder, the processor to control the MPEG decoder, and a configurable amplifier coupled to the first and second output terminals, wherein a first audio signal originating from the first output terminal is selectively amplified by the configurable amplifier circuit in accordance with a second signal originating from the second output terminal.
摘要翻译： 描述了用于卡拉OK播放器的可配置放大器电路。 在一个实施例中，卡拉OK播放器包括：用于耦合到DVD / CD读取器的DVD / CD读取器端口，用于从外部麦克风接收音频信号的麦克风输入端，耦合到DVD / CD读取器端口的MPEG解码器和麦克风 输入，具有第一和第二输出端的MPEG解码器，耦合到MPEG解码器的处理器，用于控制MPEG解码器的处理器以及耦合到第一和第二输出端的可配置放大器，其中源自第一和第二输出端的第一音频信号 输出端子由可配置放大器电路根据源自第二输出端子的第二信号选择放大。
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