公开(公告)号：US06211403B1

公开(公告)日：2001-04-03

申请号：US09440609

申请日：1999-11-15

申请人： Thomas L. Siddall ,  Karl L. Krumel ,  Mark V. M. Emonds ,  Jennifer M. Schomaker ,  Mark W. Zettler

发明人： Thomas L. Siddall ,  Karl L. Krumel ,  Mark V. M. Emonds ,  Jennifer M. Schomaker ,  Mark W. Zettler

IPC分类号： C07C31500

CPC分类号： C07D231/20 ,  C07C315/04 ,  C07C317/22 ,  C07C317/44 ,  C07C317/14

摘要： 1-Halo-2-chloro-3-alkoxy-4-alkylsulfonylbenzene and 1-halo-2,3-dichloro-4-alkylsulfonylbenzene compounds were converted to compounds having hydroxycarbonyl or alkoxycarbonyl substituents in place of the 1-halo substituent by reaction with carbon monoxide and water or an alcohol respectively, in the presence of a palladium II salt: trihydrocarbylphosphine complex type catalyst.

摘要翻译： 通过与1-卤代-2-氯-3-烷氧基-4-烷基磺酰基苯和1-卤代-2,3-二氯-4-烷基磺酰基苯化合物的反应转化成具有羟基羰基或烷氧基羰基取代基的化合物代替1-卤素取代基 一氧化碳和水或醇分别在钯II盐：三烃基膦配合物型催化剂存在下进行。

公开(公告)号：US20190233385A1

公开(公告)日：2019-08-01

申请号：US16284258

申请日：2019-02-25

申请人： Jennifer M. Schomaker ,  Eileen G. Burke

发明人： Jennifer M. Schomaker ,  Eileen G. Burke

IPC分类号： C07D291/02

CPC分类号： C07D291/02

摘要： Compounds of Formula I: wherein: R1 and R1′ are independently selected from hydrogen, halogen, C1-to-C12 linear or branched hydroxyalkyl, C1-to-C12 linear or branched halo-alkyl, carboxy, carboxyalkyl, amido, N-alkylamido, N,N-dialkylamido, carbamoyloxy, N-alkylcarbamoyloxy, and N,N-dialkylcarbamoyloxy, provided that that R1 and R1′ are not simultaneously hydrogen; R2 and R2′ hydrogen, halogen, C1-to-C12 linear or branched hydroxyalkyl, C1-to-C12 linear or branched halo-alkyl, carboxy, carboxyalkyl, amido, N-alkylamido, N,N-dialkylamido, carbamoyloxy, N-alkylcarbamoyloxy, and N,N-dialkylcarbamoyloxy, provided that that R2 and R2′ are not simultaneously hydrogen; R3 is selected from hydrogen, C1to C12 linear or branched alkyl, and nitrogen protecting groups; X is oxygen or nitrogen; when X is oxygen, R4 is absent; and when X is nitrogen, R4 is selected from H, C1-to-C12 linear or branched alkyl, and nitrogen protecting groups.

公开(公告)号：US20090012120A1

公开(公告)日：2009-01-08

申请号：US11801395

申请日：2007-05-09

申请人： Babak Borhan ,  Jennifer M. Schomaker ,  Somnath Bhattacharjee ,  Keith Korthals

发明人： Babak Borhan ,  Jennifer M. Schomaker ,  Somnath Bhattacharjee ,  Keith Korthals

IPC分类号： A61K31/4015 ,  C07D207/12 ,  C07D209/32 ,  C07D209/54 ,  C07C211/00 ,  C07D211/00 ,  A61P35/00 ,  A61K31/13 ,  A61K31/403 ,  A61K31/445

CPC分类号： C07D207/12 ,  C07D209/32 ,  C07D209/54

摘要： An ylide-based aza-Payne rearrangement of 2,3-aziridin-1-ols leads to an efficient process for the preparation of pyrrolidines. The aza-Payne rearrangement under the basic reaction conditions favors the formation of epoxy amines. Subsequent nucleophilic attack of the epoxide by the ylide yields a bis-anion, which upon a 5-exo-tet ring closure yields the desired pyrrolidine, thus completing the relay of the 3-membered the 5-membered nitrogen containing ring system. This process takes place with complete transfer of stereochemical fidelity, and can be applied to sterically hindered aziridinols.

摘要翻译： 2,3-氮杂环丁烷-1-基的叶立德碱氮杂 - 佩恩重排导致制备吡咯烷的有效方法。 在碱性反应条件下的氮杂重复排列有利于环氧胺的形成。 随后的内鎓盐对环氧化物的亲核攻击产生双阴离子，其在5-外 - 闭环闭合时产生所需的吡咯烷，从而完成3元5元含氮环系统的中继。 该过程完全转移立体化学保真度，并且可以应用于空间位阻的氮丙啶醇。

公开(公告)号：US06787671B2

公开(公告)日：2004-09-07

申请号：US10341499

申请日：2003-01-13

申请人： Babak Borhan ,  Benjamin R. Travis ,  Jennifer M. Schomaker

发明人： Babak Borhan ,  Benjamin R. Travis ,  Jennifer M. Schomaker

IPC分类号： C07C4500

CPC分类号： C07D315/00 ,  C07B41/06 ,  C07B41/08 ,  C07B41/12 ,  C07C45/28 ,  C07C51/305 ,  C07C51/31 ,  C07C67/293 ,  C07C67/313 ,  C07C67/333 ,  C07C67/39 ,  C07C201/12 ,  C07C253/30 ,  C07C2601/14 ,  C07D307/83 ,  C07D307/88 ,  C07D307/94 ,  C07D311/22 ,  C07D311/56 ,  C07D313/00 ,  C07D313/08 ,  C07D313/10 ,  C07C49/337 ,  C07C49/637 ,  C07C49/577 ,  C07C49/78 ,  C07C47/54 ,  C07C53/126 ,  C07C63/06 ,  C07C63/04 ,  C07C55/14 ,  C07C55/02 ,  C07C59/347 ,  C07C69/003 ,  C07C69/82 ,  C07C69/48 ,  C07C69/24 ,  C07C69/78 ,  C07C69/75 ,  C07C205/57 ,  C07C255/57

摘要： An osmium-assisted process for the oxidative cleavage of oxidizable organic compounds such as unsaturated organic compounds, including alkenes and olefins into aldehydes, carboxylic acids, esters, or ketones. The process uses a metal catalyst comprising osmium and a peroxy compound selected from the group consisting of peroxymonosulfuric acid and salts thereof to oxidatively cleave the oxidizable organic compound. In particular, the process enables aldehydes, carboxylic acids, esters, or ketones to be selectively produced from the corresponding mono-, 1,1-di-, 1,2-di-, tri-, or tetra-substituted olefins in a reaction that produces the result of ozonolysis but with fewer problems. The present invention further provides a process for oxidizing an aldehyde alone or with the osmium in an interactive solvent to produce an ester or carboxylic acid.

摘要翻译： 用于将可氧化有机化合物如不饱和有机化合物（包括烯烃和烯烃）氧化裂解成醛，羧酸，酯或酮的锇辅助方法。 该方法使用包含锇和选自过氧单硫酸及其盐的过氧化合物的金属催化剂来氧化可分解有机化合物。 特别地，该方法使醛，羧酸，酯或酮能够在反应中从相应的单，1,1-二，1,2-二，三或四取代的烯烃选择性地产生 这产生臭氧分解的结果，但是问题较少。 本发明还提供了在交互式溶剂中单独或与锇氧化醛以产生酯或羧酸的方法。

公开(公告)号：US6015911A

公开(公告)日：2000-01-18

申请号：US47173

申请日：1998-03-24

申请人： Thomas L. Siddall ,  Mark V. M. Emonds ,  Karl L. Krumel ,  Jennifer M. Schomaker ,  Mark W. Zettler

发明人： Thomas L. Siddall ,  Mark V. M. Emonds ,  Karl L. Krumel ,  Jennifer M. Schomaker ,  Mark W. Zettler

IPC分类号： C07B61/00 ,  C07C315/04 ,  C07C317/14 ,  C07C317/22 ,  C07C317/44 ,  C07C317/46 ,  C07D231/20 ,  C07C315/00 ,  C07C319/00 ,  C07C323/00 ,  C07D231/08 ,  C07D403/12

CPC分类号： C07C317/44 ,  C07C315/04 ,  C07C317/22 ,  C07D231/20

摘要： Herbicidal 1-alkyl-4-(2-chloro-3-alkoxy-4-alkylsulfonylbenzoyl)-5-hydroxypyrazole compounds, as well as 1-halo-2-chloro-3-alkoxy-4-alkylsulfonylbenzene compounds and 2-chloro-3-alkoxy-4-alkylsulfonylbenzoic acid compounds, were prepared in good yield by the reaction of the corresponding 3-chloro compound with an alkali metal alkoxide compound. 1-Halo-2-chloro-3-alkoxy-4-alkylsulfonylbenzene and 1-halo-2,3-dichloro-4-alkylsulfonylbenzene compounds were converted to compounds having hydroxycarbonyl, alkoxycarbonyl, or 1-alkyl-5-hydroxypyrazole-4-carbonyl substituents in place of the 1-halo substituent by reaction with carbon monoxide and water, an alcohol, or a 1-alkyl-5-hydroxypyrazole compound, respectively, in the presence of a palladium II salt:trihydrocarbylphosphine complex type catalyst.

摘要翻译： 除草1-烷基-4-（2-氯-3-烷氧基-4-烷基磺酰基苯甲酰基）-5-羟基吡唑化合物，以及1-卤代-2-氯-3-烷氧基-4-烷基磺酰基苯化合物和2-氯 - 通过相应的3-氯化合物与碱金属醇盐化合物的反应，以高产率制备3-烷氧基-4-烷基磺酰基苯甲酸化合物。 1-卤代-2-氯-3-烷氧基-4-烷基磺酰基苯和1-卤代-2,3-二氯-4-烷基磺酰基苯化合物转化为具有羟基羰基，烷氧基羰基或1-烷基-5-羟基吡唑-4-基， 在钯II盐：三烃基膦配合物型催化剂存在下分别与一氧化碳和水，醇或1-烷基-5-羟基吡唑化合物反应代替1-卤代基取代的羰基取代基。