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公开(公告)号：US06787671B2
公开(公告)日：2004-09-07
申请号：US10341499
申请日：2003-01-13
IPC分类号： C07C4500
CPC分类号： C07D315/00 , C07B41/06 , C07B41/08 , C07B41/12 , C07C45/28 , C07C51/305 , C07C51/31 , C07C67/293 , C07C67/313 , C07C67/333 , C07C67/39 , C07C201/12 , C07C253/30 , C07C2601/14 , C07D307/83 , C07D307/88 , C07D307/94 , C07D311/22 , C07D311/56 , C07D313/00 , C07D313/08 , C07D313/10 , C07C49/337 , C07C49/637 , C07C49/577 , C07C49/78 , C07C47/54 , C07C53/126 , C07C63/06 , C07C63/04 , C07C55/14 , C07C55/02 , C07C59/347 , C07C69/003 , C07C69/82 , C07C69/48 , C07C69/24 , C07C69/78 , C07C69/75 , C07C205/57 , C07C255/57
摘要： An osmium-assisted process for the oxidative cleavage of oxidizable organic compounds such as unsaturated organic compounds, including alkenes and olefins into aldehydes, carboxylic acids, esters, or ketones. The process uses a metal catalyst comprising osmium and a peroxy compound selected from the group consisting of peroxymonosulfuric acid and salts thereof to oxidatively cleave the oxidizable organic compound. In particular, the process enables aldehydes, carboxylic acids, esters, or ketones to be selectively produced from the corresponding mono-, 1,1-di-, 1,2-di-, tri-, or tetra-substituted olefins in a reaction that produces the result of ozonolysis but with fewer problems. The present invention further provides a process for oxidizing an aldehyde alone or with the osmium in an interactive solvent to produce an ester or carboxylic acid.
摘要翻译： 用于将可氧化有机化合物如不饱和有机化合物（包括烯烃和烯烃）氧化裂解成醛，羧酸，酯或酮的锇辅助方法。 该方法使用包含锇和选自过氧单硫酸及其盐的过氧化合物的金属催化剂来氧化可分解有机化合物。 特别地，该方法使醛，羧酸，酯或酮能够在反应中从相应的单，1,1-二，1,2-二，三或四取代的烯烃选择性地产生 这产生臭氧分解的结果，但是问题较少。 本发明还提供了在交互式溶剂中单独或与锇氧化醛以产生酯或羧酸的方法。
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2.发明授权Maltoside and phosphocholine derivatives, uses thereof and methods of preparing artificial lipid structures thereof 有权麦芽糖苷和磷酸胆碱衍生物，其用途及其制备人造脂质结构的方法公开(公告)号：US08846899B2
公开(公告)日：2014-09-30
申请号：US13272090
申请日：2011-10-12
申请人： Benjamin R. Travis , Ritesh Mittal , Lijun Huang , Liang Tang
发明人： Benjamin R. Travis , Ritesh Mittal , Lijun Huang , Liang Tang
IPC分类号： C07D249/04 , C07H3/04 , C07H5/04 , C07F9/10 , C07H15/26 , C07F9/6518
CPC分类号： C07F9/6518 , C07F9/103 , C07H15/26
摘要： Disclosed are saccharide and phosphocholine derivatives. The derivatives include azide and alkyne derivatives which form one end of a variable length carbon chain. The opposite end of the variable length carbon chain is covalently linked to the saccharide or phosphocholine. The saccharide may be, for instance, a maltoside. The alkyne and azide derivatives of the saccharides and phosphocholine may be reacted together to form amphiphilic molecules useful in cellular membrane studies and applications. By adjusting the length of the carbon chain, the biochemical and biophysical properties of the resultant 1,4-disubstituted 1,2,3-triazole compounds may be custom tailored for the intended application. Resultant molecules may form micelles, bicelle, lipid bilayers and other like structures useful in the isolation and purification of membrane bound or membrane associated proteins and biochemical components. The saccharides and phosphocholine molecules may be alternatively substituted as desired to provide additional flexibility in designing the desired end product.
摘要翻译： 公开了糖和磷酸胆碱衍生物。 衍生物包括形成可变长度碳链的一端的叠氮化物和炔衍生物。 可变长度碳链的相对端与糖或磷酸胆碱共价连接。 糖可以是例如麦芽糖苷。 糖和磷酸胆碱的炔和叠氮衍生物可以一起反应以形成用于细胞膜研究和应用的两亲分子。 通过调整碳链的长度，所得的1,4-二取代的1,2,3-三唑化合物的生物化学和生物物理性质可以根据预期的应用定制。 所产生的分子可以形成胶束，双胞胎，脂质双层和其他类似的结构，可用于分离和纯化膜结合或膜相关蛋白和生化成分。 糖和磷酸胆碱分子可以根据需要被替代地替代，以在设计期望的最终产物时提供额外的灵活性。
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公开(公告)号：US20100016563A1
公开(公告)日：2010-01-21
申请号：US12494159
申请日：2009-06-29
申请人： Lijun Huang , Benjamin R. Travis
发明人： Lijun Huang , Benjamin R. Travis
CPC分类号： C07K1/1136
摘要： Four novel water soluble cholesterol derivative compounds are disclosed. These compounds have various applications in studies of membrane proteins, including drug screening and studies of receptor stability and folding. In one aspect the water soluble cholesterol derivatives disclosed may be used to replace cholesterol in micelle-solubilized membrane protein preparations.
摘要翻译： 公开了四种新的水溶性胆固醇衍生物化合物。 这些化合物在膜蛋白的研究中有各种应用，包括药物筛选和受体稳定性和折叠性研究。 一方面，所公开的水溶性胆固醇衍生物可用于替代胶束溶解的膜蛋白制剂中的胆固醇。
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公开(公告)号：US08609602B2
公开(公告)日：2013-12-17
申请号：US13183282
申请日：2011-07-14
申请人： Benjamin R. Travis , Ritesh Mittal , Seth M. Huff , Lijun M. Huang , Liang Tang
发明人： Benjamin R. Travis , Ritesh Mittal , Seth M. Huff , Lijun M. Huang , Liang Tang
CPC分类号： C11D1/75 , C11D3/04 , C11D3/044 , C11D3/2003 , C11D3/2006 , C11D3/43
摘要： Disclosed are cleaning solutions. More particularly, non-toxic solutions of base, water, alcohol and detergent, that effectively and surprisingly eliminate contaminating aliphatic acids in aqueous solutions. When present as a foam or even a contaminating film remaining on various parts and surfaces, aliphatic acid contaminants can be present a large and costly problem in manufacturing operations, cleaning tasks, personal hygiene. The need to remove such contaminants arises in a myriad environments and situations, such as during the manufacture of detergents, pharmaceuticals, consumer products, coring and core analysis, manipulation of oils, fuels, fermentation applications, manufacture of emollients, moisturizers, liquors, foods such as seafood, milk, butter and other dairy products, water processing, paper products, tissue culture, reusable clinical equipment, and the like. Presented are cleaning compositions and methods that effectively eliminate and prevent build up of such dangerous and costly contaminants in aqueous solutions.
摘要翻译： 披露的是清洁解决方案。 更具体地，碱，水，醇和洗涤剂的无毒溶液有效且令人惊奇的消除了水溶液中的污染性脂肪酸。 当作为泡沫或甚至残留在各种部件和表面上的污染膜存在时，脂肪族酸污染物在制造操作，清洁任务，个人卫生中可能存在大而昂贵的问题。 在无数的环境和情况下，例如在制造洗涤剂，药物，消费品，取芯和核心分析，操作油，燃料，发酵应用，润肤剂，保湿剂，液体，食品的制造 如海鲜，牛奶，黄油等乳制品，水处理，纸制品，组织培养，可重复利用的临床设备等。 提出了清洁组合物和方法，其有效地消除并防止在水溶液中积累这种危险且昂贵的污染物。
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公开(公告)号：US20120041182A1
公开(公告)日：2012-02-16
申请号：US13280127
申请日：2011-10-24
申请人： Lijun M. Huang , Benjamin R. Travis
发明人： Lijun M. Huang , Benjamin R. Travis
CPC分类号： C07K1/1136
摘要： Four novel water soluble cholesterol derivative compounds are disclosed. These compounds have various applications in studies of membrane proteins, including drug screening and studies of receptor stability and folding. In one aspect the water soluble cholesterol derivatives disclosed may be used to replace cholesterol in micelle-solubilized membrane protein preparations.
摘要翻译： 公开了四种新的水溶性胆固醇衍生物化合物。 这些化合物在膜蛋白的研究中有各种应用，包括药物筛选和受体稳定性和折叠性研究。 一方面，所公开的水溶性胆固醇衍生物可用于替代胶束溶解的膜蛋白制剂中的胆固醇。
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公开(公告)号：US20140200171A1
公开(公告)日：2014-07-17
申请号：US14080570
申请日：2013-11-14
申请人： Benjamin R. Travis , Ritesh Mittal , Seth M. Huff , Lijun Huang , Liang Tang
发明人： Benjamin R. Travis , Ritesh Mittal , Seth M. Huff , Lijun Huang , Liang Tang
CPC分类号： C11D1/75 , C11D3/04 , C11D3/044 , C11D3/2003 , C11D3/2006 , C11D3/43
摘要： Disclosed are cleaning solutions. More particularly, non-toxic solutions of base, water, alcohol and detergent, that effectively and surprisingly eliminate contaminating aliphatic acids in aqueous solutions. When present as a foam or even a contaminating film remaining on various parts and surfaces, aliphatic acid contaminants can be present a large and costly problem in manufacturing operations, cleaning tasks, personal hygiene. The need to remove such contaminants arises in a myriad environments and situations, such as during the manufacture of detergents, pharmaceuticals, consumer products, coring and core analysis, manipulation of oils, fuels, fermentation applications, manufacture of emollients, moisturizers, liquors, foods such as seafood, milk, butter and other dairy products, water processing, paper products, tissue culture, reusable clinical equipment, and the like. Presented are cleaning compositions and methods that effectively eliminate and prevent build up of such dangerous and costly contaminants in aqueous solutions.
摘要翻译： 披露的是清洁解决方案。 更具体地，碱，水，醇和洗涤剂的无毒溶液有效且令人惊奇的消除了水溶液中的污染性脂肪酸。 当作为泡沫或甚至残留在各种部件和表面上的污染膜存在时，脂肪族酸污染物在制造操作，清洁任务，个人卫生中可能存在大而昂贵的问题。 在无数的环境和情况下，例如在制造洗涤剂，药物，消费品，取芯和核心分析，操作油，燃料，发酵应用，润肤剂，保湿剂，液体，食品的制造 如海鲜，牛奶，黄油等乳制品，水处理，纸制品，组织培养，可重复利用的临床设备等。 提出了清洁组合物和方法，其有效地消除并防止在水溶液中积累这种危险且昂贵的污染物。
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7.发明申请Maltoside and Phosphocholine Derivatives, Uses thereof and Methods of Preparing Artificial Lipid Structures Thereof 有权麦芽糖苷和磷酸胆碱衍生物，其用途及其制备人造脂质结构的方法公开(公告)号：US20130096295A1
公开(公告)日：2013-04-18
申请号：US13272090
申请日：2011-10-12
申请人： Benjamin R. Travis , Ritesh Mittal , Lijun Huang , Liang Tang
发明人： Benjamin R. Travis , Ritesh Mittal , Lijun Huang , Liang Tang
IPC分类号： C07D249/04 , C07H3/04 , C07F9/10 , C07H5/04
CPC分类号： C07F9/6518 , C07F9/103 , C07H15/26
摘要： Disclosed are saccharide and phosphocholine derivatives. The derivatives include azide and alkyne derivatives which form one end of a variable length carbon chain. The opposite end of the variable length carbon chain is covalently linked to the saccharide or phosphocholine. The saccharide may be, for instance, a maltoside. The alkyne and azide derivatives of the saccharides and phosphocholine may be reacted together to form amphiphilic molecules useful in cellular membrane studies and applications. By adjusting the length of the carbon chain, the biochemical and biophysical properties of the resultant 1,4-disubstituted 1,2,3-triazole compounds may be custom tailored for the intended application. Resultant molecules may form micelles, bicelle, lipid bilayers and other like structures useful in the isolation and purification of membrane bound or membrane associated proteins and biochemical components. The saccharides and phosphocholine molecules may be alternatively substituted as desired to provide additional flexibility in designing the desired end product.
摘要翻译： 公开了糖和磷酸胆碱衍生物。 衍生物包括形成可变长度碳链的一端的叠氮化物和炔衍生物。 可变长度碳链的相对端与糖或磷酸胆碱共价连接。 糖可以是例如麦芽糖苷。 糖和磷酸胆碱的炔和叠氮衍生物可以一起反应以形成用于细胞膜研究和应用的两亲分子。 通过调整碳链的长度，所得的1,4-二取代的1,2,3-三唑化合物的生物化学和生物物理性质可以根据预期的应用定制。 所产生的分子可以形成胶束，双胞胎，脂质双层和其他类似的结构，可用于分离和纯化膜结合或膜相关蛋白和生物化学成分。 糖和磷酸胆碱分子可以根据需要被替代地替代，以在设计期望的最终产物时提供额外的灵活性。
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公开(公告)号：US20120015862A1
公开(公告)日：2012-01-19
申请号：US13183282
申请日：2011-07-14
申请人： Benjamin R. Travis , Ritesh Mittal , Seth M. Huff , Lijun M. Huang , Liang Tang
发明人： Benjamin R. Travis , Ritesh Mittal , Seth M. Huff , Lijun M. Huang , Liang Tang
CPC分类号： C11D1/75 , C11D3/04 , C11D3/044 , C11D3/2003 , C11D3/2006 , C11D3/43
摘要： Disclosed are cleaning solutions. More particularly, non-toxic solutions of base, water, alcohol and detergent, that effectively and surprisingly eliminate contaminating aliphatic acids in aqueous solutions. When present as a foam or even a contaminating film remaining on various parts and surfaces, aliphatic acid contaminants can be present a large and costly problem in manufacturing operations, cleaning tasks, personal hygiene. The need to remove such contaminants arises in a myriad environments and situations, such as during the manufacture of detergents, pharmaceuticals, consumer products, coring and core analysis, manipulation of oils, fuels, fermentation applications, manufacture of emollients, moisturizers, liquors, foods such as seafood, milk, butter and other dairy products, water processing, paper products, tissue culture, reusable clinical equipment, and the like. Presented are cleaning compositions and methods that effectively eliminate and prevent build up of such dangerous and costly contaminants in aqueous solutions.
摘要翻译： 披露的是清洁解决方案。 更具体地，碱，水，醇和洗涤剂的无毒溶液有效且令人惊奇的消除了水溶液中的污染性脂肪酸。 当作为泡沫或甚至残留在各种部件和表面上的污染膜存在时，脂肪族酸污染物在制造操作，清洁任务，个人卫生中可能存在大而昂贵的问题。 在无数的环境和情况下，例如在制造洗涤剂，药物，消费品，取芯和核心分析，操作油，燃料，发酵应用，润肤剂，保湿剂，液体，食品的制造 如海鲜，牛奶，黄油等乳制品，水处理，纸制品，组织培养，可重复利用的临床设备等。 提出了清洁组合物和方法，其有效地消除并防止在水溶液中积累这种危险且昂贵的污染物。
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公开(公告)号：US08071759B2
公开(公告)日：2011-12-06
申请号：US12494159
申请日：2009-06-29
申请人： Lijun Huang , Benjamin R. Travis
发明人： Lijun Huang , Benjamin R. Travis
IPC分类号： C07H1/00
CPC分类号： C07K1/1136
摘要： Four novel water soluble cholesterol derivative compounds are disclosed. These compounds have various applications in studies of membrane proteins, including drug screening and studies of receptor stability and folding. In one aspect the water soluble cholesterol derivatives disclosed may be used to replace cholesterol in micelle-solubilized membrane protein preparations.
摘要翻译： 公开了四种新的水溶性胆固醇衍生物化合物。 这些化合物在膜蛋白的研究中有各种应用，包括药物筛选和受体稳定性和折叠性研究。 一方面，所公开的水溶性胆固醇衍生物可用于替代胶束溶解的膜蛋白制剂中的胆固醇。
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