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公开(公告)号：US09945841B2
公开(公告)日：2018-04-17
申请号：US13982286
申请日：2012-01-25
Applicant: Jeong-Woo Choi , Tae-Hyung Kim , Kafi Md Abdul
Inventor： Jeong-Woo Choi , Tae-Hyung Kim , Kafi Md Abdul
IPC: G01N33/50 , G01N33/569
CPC classification number: G01N33/5008 , G01N33/5011 , G01N33/56966
Abstract: A method for measuring cell cycles includes immobilizing a capture specifically binding to a cell membrane protein to a substrate, wherein the cell membrane protein is a counterpartner binding to the capture, binding a cell having the cell membrane protein as the counterpartner to the capture, and measuring a redox potential of the cell. A method for screening a substance affecting cell cycles includes immobilizing a capture specifically binding to a cell membrane protein to a substrate; wherein the cell membrane protein is a counterpartner binding to the capture, binding a cell having the cell membrane protein as the counterpartner to the capture, treating a test substance of interest for analysis to a cell, and measuring a redox potential of the cell.
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公开(公告)号：US20130029396A1
公开(公告)日：2013-01-31
申请号：US13404696
申请日：2012-02-24
Applicant: Jeong Woo Choi , Taek Lee , Jun Hong Min
Inventor： Jeong Woo Choi , Taek Lee , Jun Hong Min
IPC: C12N11/16 , C07K14/825 , C07K14/00
CPC classification number: C07K14/00 , C12N9/0004 , C12N11/00 , C12N11/14 , C12Y120/09001
Abstract: The present disclosure relates to a multifunctional biomemory device in which a protein having a redox potential substituted with a metal ion is directly immobilized on a substrate. The present disclosure provides an operating method in which the redox state of the protein is controlled by applying three different potentials. The present disclosure provides a biomemory device in which the metal ion of a metalloprotein is substituted to allow for artificial control of the redox potential. The present disclosure provides a new-concept biomemory device as an information storage device based on the principle of electron transfer of a naturally occurring biomolecule.
Abstract translation: 本公开内容涉及一种多功能生物记录装置，其中具有被金属离子取代的氧化还原电位的蛋白质直接固定在基底上。 本公开提供了通过应用三种不同电位来控制蛋白质的氧化还原状态的操作方法。 本公开提供了其中金属蛋白的金属离子被替代以允许人为控制氧化还原电位的生物记忆装置。 本公开提供了一种基于天然存在的生物分子的电子转移原理的作为信息存储装置的新概念生物记忆装置。
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公开(公告)号：US20100270543A1
公开(公告)日：2010-10-28
申请号：US12809646
申请日：2008-04-17
Applicant: Jeong-Woo Choi , Jun-Hong Min , Byung-Keun Oh , Hyun-Hee Kim , Young-Jun Kim
Inventor： Jeong-Woo Choi , Jun-Hong Min , Byung-Keun Oh , Hyun-Hee Kim , Young-Jun Kim
IPC: H01L51/30
CPC classification number: G11C13/0014 , B82Y10/00 , G11C13/0009 , G11C13/0019 , H01L51/0093 , H01L51/0591
Abstract: The present invention relates to a biomolecule-based electronic device in which the biomolecule with redox potential is directly immobilized on the substrate. The present invention enables to excellently exhibit the capability of a protein-based bio-memory device in which it is preferable to use the substrate on which cysteine-introduced recombinant proteins are effectively immobilized and a self-assembled layer (SAM) is fabricated. It becomes realized that a redox potential is regulated using intrinsic redox potential of the protein dependent on applied voltage. The present invention provides a novel operating method in which three potentials are applied throughout four steps. The present invention has some advantages of fabricating a protein layer in a convenient manner and inducing electron transfer by fundamental electrochemical or electronic operation. The method of this invention is considered as a new concept in the senses that intrinsic electron transfer mechanisms induced by natural-occurring biomolecules are used to develop an information storage device.
Abstract translation: 本发明涉及一种基于生物分子的电子器件，其中具有氧化还原电位的生物分子直接固定在基底上。 本发明能够优异地表现出蛋白质生物记忆装置的能力，其中优选使用其上有效固定半胱氨酸导入的重组蛋白质的底物和制造自组装层（SAM）。 实现使用依赖于施加电压的蛋白质的固有氧化还原电位来调节氧化还原电位。 本发明提供一种新的操作方法，其中三个电位通过四个步骤施加。 本发明具有以方便的方式制造蛋白质层并通过基本电化学或电子操作诱导电子转移的一些优点。 本发明的方法被认为是用天然存在的生物分子诱导的固有电子传递机制来开发信息存储装置的感觉的新概念。
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4.发明申请SENSOR FOR DETECTING STEM CELL DIFFERENTIATION BASED ON ELECTROCHEMICAL METHODS 审中-公开用于基于电化学方法检测干细胞分化的传感器公开(公告)号：US20100243479A1
公开(公告)日：2010-09-30
申请号：US12579084
申请日：2009-10-14
Applicant: Jeong-Woo Choi , Cheol-Heon Yea
Inventor： Jeong-Woo Choi , Cheol-Heon Yea
CPC classification number: C12Q1/42 , C12N5/0606 , C12Q1/005
Abstract: This invention relates to a sensor for detecting a stem cell differentiation, including (a) an electrode; and (b) a substrate of an alkaline phosphatase. The phosphorylation or dephosphorylation of the substrate for an alkaline phosphatase as a stem cell undifferentiation marker which dephosphorylates its substrate may be measured using an electrical signal in the present sensor. Therefore, the sensor of the present invention enables to electrically detect a stem cell status in a high-throughput manner and to determine the stem cell differentiation.
Abstract translation: 本发明涉及一种用于检测干细胞分化的传感器，包括（a）电极; 和（b）碱性磷酸酶的底物。 可以使用本传感器中的电信号来测量碱性磷酸酶底物的磷酸化或去磷酸化作为其去磷酸化其底物的干细胞未分化标记物。 因此，本发明的传感器能够以高通量的方式电监测干细胞状态并确定干细胞分化。
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公开(公告)号：US08692233B2
公开(公告)日：2014-04-08
申请号：US12809646
申请日：2008-04-17
Applicant: Jeong-Woo Choi , Jun-Hong Min , Byung-Keun Oh , Hyun-Hee Kim , Young-Jun Kim
Inventor： Jeong-Woo Choi , Jun-Hong Min , Byung-Keun Oh , Hyun-Hee Kim , Young-Jun Kim
CPC classification number: G11C13/0014 , B82Y10/00 , G11C13/0009 , G11C13/0019 , H01L51/0093 , H01L51/0591
Abstract: The present invention relates to a biomolecule-based electronic device in which the biomolecule with redox potential is directly immobilized on the substrate. The present invention enables to excellently exhibit the capability of a protein-based bio-memory device in which it is preferable to use the substrate on which cysteine-introduced recombinant proteins are effectively immobilized and a self-assembled layer (SAM) is fabricated. It becomes realized that a redox potential is regulated using intrinsic redox potential of the protein dependent on applied voltage. The present invention provides a novel operating method in which three potentials are applied throughout four steps. The present invention has some advantages of fabricating a protein layer in a convenient manner and inducing electron transfer by fundamental electrochemical or electronic operation. The method of this invention is considered as a new concept in the senses that intrinsic electron transfer mechanisms induced by natural-occurring biomolecules are used to develop an information storage device.
Abstract translation: 本发明涉及一种基于生物分子的电子器件，其中具有氧化还原电位的生物分子直接固定在基底上。 本发明能够优异地表现出蛋白质生物记忆装置的能力，其中优选使用其上有效固定半胱氨酸导入的重组蛋白质的底物和制造自组装层（SAM）。 实现使用依赖于施加电压的蛋白质的固有氧化还原电位来调节氧化还原电位。 本发明提供一种新的操作方法，其中三个电位通过四个步骤施加。 本发明具有以方便的方式制造蛋白质层并通过基本电化学或电子操作诱导电子转移的一些优点。 本发明的方法被认为是用天然存在的生物分子诱导的固有电子传递机制来开发信息存储装置的感觉的新概念。
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Patent Agency Ranking
6.发明申请BIOMEMORY DEVICE COMPRISING HETEROLAYER OF RECOMBINANT PROTEIN AND INORGANIC PARTICLE 有权包含重组蛋白和无机颗粒的杂环化合物的生物装置公开(公告)号：US20130157335A1
公开(公告)日：2013-06-20
申请号：US13564136
申请日：2012-08-01
Applicant: Jeong Woo Choi , Taek Lee , Jun Hong Min
Inventor： Jeong Woo Choi , Taek Lee , Jun Hong Min
Abstract: The present invention relates to a biomemory device, comprising (a) a substrate; and (b) a heterolayer comprising a protein having a redox potential and an inorganic particle; wherein the heterolayer is immobilized on the substrate. By applying inorganic particles, the present invention provides a biomemory device capable of enhancing low current signals detected electron transfer between biomolecules and substrates up to at least five (5) times greater signals. The present invention is capable of controlling the redox states with help of redox potentials of proteins depending on applied potential. The present invention provides a new-concept biomemory device as an information storage device based on the principle of electron transfer of a naturally occurring biomolecule.
Abstract translation: 本发明涉及一种生物记忆装置，包括（a）基底; 和（b）包含具有氧化还原电位的蛋白质和无机颗粒的分层; 其中所述异层固定在所述基底上。 通过施加无机颗粒，本发明提供了一种生物记录装置，其能够增强在至少五（5）倍的信号下检测到生物分子和基板之间的电子转移的低电流信号。 本发明能够根据应用的潜力帮助蛋白质的氧化还原电位来控制氧化还原状态。 本发明提供了一种基于天然存在的生物分子的电子转移原理的作为信息存储装置的新概念的生物记忆装置。
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公开(公告)号：US09796789B2
公开(公告)日：2017-10-24
申请号：US13564136
申请日：2012-08-01
Applicant: Jeong Woo Choi , Taek Lee , Jun Hong Min
Inventor： Jeong Woo Choi , Taek Lee , Jun Hong Min
Abstract: The present invention relates to a biomemory device, comprising (a) a substrate; and (b) a heterolayer comprising a protein having a redox potential and an inorganic particle; wherein the heterolayer is immobilized on the substrate. By applying inorganic particles, the present invention provides a biomemory device capable of enhancing low current signals detected electron transfer between biomolecules and substrates up to at least five (5) times greater signals. The present invention is capable of controlling the redox states with help of redox potentials of proteins depending on applied potential. The present invention provides a new-concept biomemory device as an information storage device based on the principle of electron transfer of a naturally occurring biomolecule.
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8.发明申请SOLID SUPPORT WITH ENHANCED DENSITY OF SIGNAL MATERIAL, KIT CONTAINING THE SAME AND METHOD OF DETECTING TARGET MATERIAL USING THE SAME 审中-公开具有增强的信号密度的固体支持，包含该材料的试剂盒及使用其检测目标材料的方法公开(公告)号：US20100092985A1
公开(公告)日：2010-04-15
申请号：US12578628
申请日：2009-10-14
Applicant: Beom Seok LEE , Jeong Gun LEE , Jeong Woo CHOI , Byung Keun OH
Inventor： Beom Seok LEE , Jeong Gun LEE , Jeong Woo CHOI , Byung Keun OH
IPC: C12Q1/68 , G01N33/544 , G01N33/553 , G01N33/545
CPC classification number: G01N33/54306 , B82Y15/00
Abstract: A solid support on which a labeled nucleic acid including a high density of signal materials, a kit containing the same, and a method of detecting a target material are provided.
Abstract translation: 提供了包含高密度信号材料的标记核酸的固体支持物，含有其的试剂盒和检测靶材料的方法。
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9.发明授权Device for detecting and separating target molecules and method for detecting and separating target molecules by using the same 有权用于检测和分离靶分子的装置和通过使用它们来检测和分离靶分子的方法公开(公告)号：US08753870B2
公开(公告)日：2014-06-17
申请号：US13605787
申请日：2012-09-06
Applicant: Hun-joo Lee , Jeong-gun Lee , Jeong-woo Choi , Yeon-jeong Kim , Jong-myeon Park , Mi-jeong Song , Jin-mi Oh
Inventor： Hun-joo Lee , Jeong-gun Lee , Jeong-woo Choi , Yeon-jeong Kim , Jong-myeon Park , Mi-jeong Song , Jin-mi Oh
CPC classification number: G01N33/54306 , G01N33/54366
Abstract: A device, system, and method for detecting or separating target molecules allowing efficient detection even when only a small amount of target molecules or target cells are included in a sample involving the use of a target molecule linkage portion, a signal production portion, and first and second separation portions.
Abstract translation: 用于检测或分离目标分子的装置，系统和方法，即使当仅使用少量靶分子或靶细胞包括使用靶分子连接部分，信号产生部分和第一 和第二分离部。
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公开(公告)号：US20140024044A1
公开(公告)日：2014-01-23
申请号：US13982286
申请日：2012-01-25
Applicant: Jeong-Woo Choi , Tae-Hyung Kim , Kafi Md Abdul
Inventor： Jeong-Woo Choi , Tae-Hyung Kim , Kafi Md Abdul
IPC: G01N33/50
CPC classification number: G01N33/5008 , G01N33/5011 , G01N33/56966
Abstract: A method for measuring cell cycles includes immobilizing a capture specifically binding to a cell membrane protein to a substrate, wherein the cell membrane protein is a counterpartner binding to the capture, binding a cell having the cell membrane protein as the counterpartner to the capture, and measuring a redox potential of the cell. A method for screening a substance affecting cell cycles includes immobilizing a capture specifically binding to a cell membrane protein to a substrate; wherein the cell membrane protein is a counterpartner binding to the capture, binding a cell having the cell membrane protein as the counterpartner to the capture, treating a test substance of interest for analysis to a cell, and measuring a redox potential of the cell.
Abstract translation: 用于测量细胞周期的方法包括将与细胞膜蛋白特异性结合的捕获物固定到底物，其中细胞膜蛋白是与捕获结合的对应物质，将具有细胞膜蛋白的细胞作为捕获的对应物结合，以及 测量细胞的氧化还原电位。 筛选影响细胞周期的物质的方法包括将与细胞膜蛋白特异性结合的捕获物固定在底物上; 其中所述细胞膜蛋白是与所述捕获结合的对应物质，将具有所述细胞膜蛋白的细胞作为所述对应物进行捕获，将感兴趣的检测物质与细胞进行分析，以及测量细胞的氧化还原电位。
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