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    HETEROGENEOUS FILAMENTS,METHODS OF PRODUCING THE SAME, SCAFFOLDS, METHODS OF PRODUCING THE SAME, DROPLETS, AND METHODS OF PRODUCING THE SAME
    2.
    发明申请
    HETEROGENEOUS FILAMENTS,METHODS OF PRODUCING THE SAME, SCAFFOLDS, METHODS OF PRODUCING THE SAME, DROPLETS, AND METHODS OF PRODUCING THE SAME 审中-公开

    公开(公告)号：US20180209069A1

    公开(公告)日：2018-07-26

    申请号：US15745299

    申请日：2016-07-13

    申请人： Wei Sun ,  Qudus Hamid ,  Jessica Snyder

    发明人： Wei Sun ,  Qudus Hamid ,  Jessica Snyder

    IPC分类号： D01D5/30 ,  D04H1/541 ,  D04H3/147

    CPC分类号： D01D5/30 ,  D01D5/38 ,  D04H1/541 ,  D04H3/147

    摘要： One aspect of the invention provides a method of producing a heterogeneous filament. The method includes applying pressure to a plurality of filament components to move the filament components into a common outlet channel. Another aspect of the invention provides a method of fabricating a scaffold. The method includes producing a plurality of filaments according to the methods described herein. Another aspect of the invention provides a scaffold produced according to the methods described herein. Another aspect of the invention provides a heterogeneous filament including a plurality of adjacent filament components. Another aspect of the invention provides a method of producing a droplet. The method includes: positioning a printing tip in proximity to a cross-linking liquid; applying pressure to one or more liquids to produce a droplet extending beyond outside of the printing tip; and contacting the droplet with the cross-linking liquid, thereby producing a droplet.

    Methods for identifying tolerance modulatory compounds and uses therefor
    3.
    发明申请
    Methods for identifying tolerance modulatory compounds and uses therefor 审中-公开
    识别耐受性调节化合物及其用途的方法

    公开(公告)号：US20050048587A1

    公开(公告)日：2005-03-03

    申请号：US10895225

    申请日：2004-07-19

    申请人： Patricia Rao ,  Jessica Snyder ,  Andria Bagley

    发明人： Patricia Rao ,  Jessica Snyder ,  Andria Bagley

    IPC分类号： C12Q1/68 ,  G01N33/50 ,  G01N33/567 ,  G01N33/68

    CPC分类号： G01N33/505 ,  G01N2333/54 ,  G01N2800/52

    摘要： The invention provides methods (also referred to herein as a “screening assays”) for identifying modulators, i.e., candidate or test compounds or agents (e.g., peptides, peptidomimetics, small molecules or other drugs) capable of modulating tolerance. In one embodiment, the invention provides methods for identifying a tolerance modulatory compound, comprising, e.g., contacting a T cell with a stimulating agent and a test compound and assaying for expression or activity of at least one T regulatory (Treg) marker and at least one T effector (Teff) marker.

    摘要翻译： 本发明提供了用于鉴定能够调节耐受性的调节剂，即候选或测试化合物或试剂（例如肽，肽模拟物，小分子或其它药物）的方法（本文也称为“筛选试验”）。 在一个实施方案中，本发明提供了用于鉴定耐受调节化合物的方法，其包括例如使T细胞与刺激剂和测试化合物接触并测定至少一种T调节（Treg）标记的表达或活性，并且至少 一个T效应（Teff）标记。