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1.发明申请DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION 审中-公开DIHYDRO-ISO-CA-4和模拟物：细胞毒素，管状体聚合酶抑制剂公开(公告)号：US20110160228A1
公开(公告)日：2011-06-30
申请号：US12996488
申请日：2009-06-04
申请人： Mouâd Alami , Samir Messaoudi , Abdallah Hamze , Olivier Provot , Jean-Daniel Brion , Jian-Miao Liu , Jérôme Bignon , Joanna Bakala
发明人： Mouâd Alami , Samir Messaoudi , Abdallah Hamze , Olivier Provot , Jean-Daniel Brion , Jian-Miao Liu , Jérôme Bignon , Joanna Bakala
IPC分类号： A61K31/52 , C07C43/23 , A61K31/09 , A61P35/00 , A61P17/06 , A61K31/36 , C07D317/54 , C07C69/035 , A61K31/222 , A61K31/136 , C07C217/84 , C07C271/22 , A61K31/27 , C07D209/12 , A61K31/404 , A61K31/26 , C07C255/37 , C07D473/34
CPC分类号： C07D215/14 , C07C41/16 , C07C41/18 , C07C41/20 , C07C41/30 , C07C43/2055 , C07C43/225 , C07C43/23 , C07C69/013 , C07C217/80 , C07C217/84 , C07C217/90 , C07C217/92 , C07C229/12 , C07C233/25 , C07C255/37 , C07C271/22 , C07C271/44 , C07C2603/18 , C07D209/12 , C07D213/64 , C07D213/74 , C07D215/38 , C07D307/80 , C07D311/12 , C07D317/54 , C07D473/34 , C07F9/12 , C07C43/215
摘要： The present invention relates to compounds of formula (I) below in which: —R1 and R3 represent, independently of one another, a methoxy group optionally substituted by one or more fluorine atoms, —R2 and R4 represent, independently of one another, a hydrogen atom or a methoxy group optionally substituted by one or more fluorine atoms, —A represents a ring chosen from the group comprising aryl and heteroaryl groups, said ring possibly being substituted by or fused to a heterocycle, —X represents a nitrogen atom or a CH group, and —Z1 represents a hydrogen atom or a halogen atom, preferably fluorine, and —Z2 represents a hydrogen atom, a halogen atom, preferably fluorine, a C1 to C4 alkyl group, an aryl group or a —CN, —SO2NR12R13, —SO2R9, —COOR15 or —COR15 group, and also to the pharmaceutically acceptable salts thereof, the isomers thereof and the prodrugs thereof.
摘要翻译： 本发明涉及以下式（I）化合物：其中：-R 1和R 3彼此独立地表示任选被一个或多个氟原子取代的甲氧基，-R 2和R 4彼此独立地表示： 氢原子或任选被一个或多个氟原子取代的甲氧基，-A表示选自芳基和杂芳基的环，所述环可以被杂环取代或稠合，-X表示氮原子或 CH基，-Z1表示氢原子或卤素原子，优选氟，-Z2表示氢原子，卤素原子，优选氟，C1〜C4烷基，芳基或-CN，-SO2NR12R13 ，-SO 2 R 9，-COOR 15或-COR 15基团，以及其药学上可接受的盐，其异构体及其前药。
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2.发明申请ISO CA-4 AND ANALOGUES THEREOF AS POTENT CYTOTOXIC AGENTS INHIBITING TUBULINE POLYMERIZATION 有权ISO CA-4及其类似物作为细胞毒素代谢抑制管道聚合公开(公告)号：US20100129471A1
公开(公告)日：2010-05-27
申请号：US12594495
申请日：2008-04-04
申请人： Mouâd Alami , Jean-Daniel Brion , Olivier Provot , Jean-François Peyrat , Samir Messaoudi , Abdallah Hamze , Anne Giraud , Jérôme Bignon , Joanna Bakala , Jian-Miao Liu
发明人： Mouâd Alami , Jean-Daniel Brion , Olivier Provot , Jean-François Peyrat , Samir Messaoudi , Abdallah Hamze , Anne Giraud , Jérôme Bignon , Joanna Bakala , Jian-Miao Liu
IPC分类号： A61K31/09 , C07C43/23 , C07C43/215 , C07D215/00 , C07C69/00 , C07C205/06 , C07F9/02 , C07C217/80 , C07H15/207 , C07D213/79 , A61K31/36 , A61K31/505 , A61K31/216 , A61K31/352 , A61K31/136 , A61K31/7034 , A61K31/66 , A61K31/44 , A61K31/52 , A61K31/7068 , A61K31/519 , A61K31/4545 , A61K31/7048 , A61K33/24 , A61K38/12
CPC分类号： C07H15/203 , C07C43/215 , C07C43/225 , C07C43/23 , C07C69/017 , C07C69/24 , C07C205/37 , C07C217/84 , C07C219/32 , C07C229/12 , C07C229/42 , C07C271/22 , C07C271/44 , C07C305/24 , C07C309/65 , C07C2603/18 , C07D215/14 , C07D317/54 , C07F9/12
摘要： The invention relates to a compound of the formula (I) in which: R1, R2 and R3 are independently a methoxy group optionally substituted by one or more fluorine atoms; R4 is a hydrogen atom; R5 and R6 are identical and each represent a hydrogen or fluorine atom; A is a cycle selected from the group including aryl and heteroaryl groups, wherein said groups can be substituted.
摘要翻译： 本发明涉及式（I）化合物，其中：R 1，R 2和R 3独立地为任选被一个或多个氟原子取代的甲氧基; R4是氢原子; R5和R6相同，各自表示氢或氟原子; A是选自包括芳基和杂芳基的基团，其中所述基团可被取代。
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3.发明授权Cosmetic use of at least the natural tetrapeptide Ac-Ser-Asp-Lys-Pro or one of its analogs as a skin restructuring agent 有权化妆品使用至少天然四肽Ac-Ser-Asp-Lys-Pro或其类似物之一作为皮肤重组剂公开(公告)号：US08697652B2
公开(公告)日：2014-04-15
申请号：US11630264
申请日：2005-06-22
摘要： This invention relates to the cosmetic use of at least one compound of formula (I) wherein A1 is the radical corresponding to D- or L-Ser A2 is the radical corresponding to D- or L-Asp or Glu, A3 is the radical corresponding to D- or L-Lys, Arg or Orn, A4 is the radical corresponding to D- or L-pro, R1, R2 and R3 are as defined in the claims as anti-aging and restructuring agents.
摘要翻译： 本发明涉及至少一种式（I）化合物的化妆品用途，其中A1是对应于D-或L-Ser A2的基团是对应于D-或L-Asp或Glu的基团，A3是相应的基团 对于D-或L-Lys，Arg或Orn，A4是对应于D-或L-pro的基团，R 1，R 2和R 3如权利要求中所定义，作为抗老化和重组剂。
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4.发明申请Cosmetic Use of at Least Natural Tetrapeptide Ac-Ser-Asp-Lys-Pro or One of Its Analogs as a Skin Anti-Aging and Restructuring Agent 有权至少天然四肽Ac-Ser-Asp-Lys-Pro或其类似物之一的化妆品使用作为皮肤抗衰老和重组剂公开(公告)号：US20070259819A1
公开(公告)日：2007-11-08
申请号：US11630264
申请日：2005-06-22
摘要： This invention relates to the cosmetic use of at least one compound of formula (I) wherein A1 is the radical corresponding to D- or L-Ser A2 is the radical corresponding to D- or L-Asp or Glu, A3 is the radical corresponding to D- or L-Lys, Arg or Orn, A4 is the radical corresponding to D- or L-pro, R1, R2 and R3 are as defined in the claims as anti-aging and restructuring agents.
摘要翻译： 本发明涉及至少一种式（I）化合物的化妆品用途，其中A 1是对应于D-或L-Ser A 2 N 2的基团是自由基 对应于D-或L-Asp或Glu，A 3是与D-或L-Lys，Arg或Orn相应的基团，A 4是对应于 D-或L-丙基，R 1，R 2和R 3如权利要求中所定义，作为抗老化和重组剂。
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5.发明授权Iso CA-4 and analogues thereof as potent cytotoxic agents inhibiting tubuline polymerization 有权Iso CA-4及其类似物作为抑制微管蛋白聚合的有效细胞毒性剂公开(公告)号：US08273768B2
公开(公告)日：2012-09-25
申请号：US12594495
申请日：2008-04-04
申请人： Mouâd Alami , Jean-Daniel Brion , Olivier Provot , Jean-François Peyrat , Samir Messaoudi , Abdallah Hamze , Anne Giraud , Jérôme Bignon , Joanna Bakala , Jian-Miao Liu
发明人： Mouâd Alami , Jean-Daniel Brion , Olivier Provot , Jean-François Peyrat , Samir Messaoudi , Abdallah Hamze , Anne Giraud , Jérôme Bignon , Joanna Bakala , Jian-Miao Liu
IPC分类号： A61K31/47 , C07D215/14
CPC分类号： C07H15/203 , C07C43/215 , C07C43/225 , C07C43/23 , C07C69/017 , C07C69/24 , C07C205/37 , C07C217/84 , C07C219/32 , C07C229/12 , C07C229/42 , C07C271/22 , C07C271/44 , C07C305/24 , C07C309/65 , C07C2603/18 , C07D215/14 , C07D317/54 , C07F9/12
摘要： The invention relates to a compound of the formula (I) in which: R1, R2 and R3 are independently a methoxy group optionally substituted by one or more fluorine atoms; R4 is a hydrogen atom; R5 and R6 are identical and each represent a hydrogen or fluorine atom; A is a cycle selected from the group including aryl and heteroaryl groups, wherein said groups can be substituted.
摘要翻译： 本发明涉及式（I）化合物，其中：R 1，R 2和R 3独立地为任选被一个或多个氟原子取代的甲氧基; R4是氢原子; R5和R6相同，各自表示氢或氟原子; A是选自包括芳基和杂芳基的基团，其中所述基团可被取代。
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