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    Agent for slowing hair loss and/or stimulating hair growth
    5.
    发明授权
    Agent for slowing hair loss and/or stimulating hair growth 有权
    减轻脱发和/或刺激头发生长的代理

    公开(公告)号：US08080524B2

    公开(公告)日：2011-12-20

    申请号：US11884543

    申请日：2006-02-16

    申请人： Joanna Elzbieta Bakala ,  Jérôme Bignon ,  Jean-Yves Lallemand

    发明人： Joanna Elzbieta Bakala ,  Jérôme Bignon ,  Jean-Yves Lallemand

    IPC分类号： A61K38/07 ,  A61P17/14

    CPC分类号： A61K8/64 ,  A61Q7/00

    摘要： The cosmetic use of at least one compound of formula (I) wherein: A1 is the radical corresponding to D- or L-Ser; A2 is the radical corresponding to D- or L-Asp or Glu; A3 is the radical corresponding to D- or L-Lys, Arg or Orn; A4 is the radical corresponding to D- or L-Pro; R1, R2, R3 are such as defined in the claims, as agent for controlling hair loss.

    摘要翻译： 至少一种式（I）化合物的化妆品用途，其中：A1是对应于D-或L-Ser的基团; A2是对应于D-或L-Asp或Glu的基团; A3是对应于D-或L-Lys，Arg或Orn的基团; A4是对应于D-或L-Pro的基团; R 1，R 2，R 3如权利要求中所定义，作为用于控制脱发的试剂。

    Angiogenic agents and their uses
    6.
    发明授权
    Angiogenic agents and their uses 有权
    血管生成剂及其用途

    公开(公告)号：US07235532B2

    公开(公告)日：2007-06-26

    申请号：US10380983

    申请日：2001-09-20

    申请人： Joanna Bakala ,  Jean-Paul Pierre Potier ,  Françoise Lawrence ,  Nathalie Cheviron ,  Jérôme Bignon ,  Yves Fromes

    发明人： Joanna Bakala ,  Jean-Paul Pierre Potier ,  Françoise Lawrence ,  Nathalie Cheviron ,  Jérôme Bignon ,  Yves Fromes

    IPC分类号： A61K38/06 ,  A61K38/07

    CPC分类号： A61K38/07 ,  A61K38/06

    摘要： The present invention relates to the use of a compound of formula I: in which, A1 is the radical corresponding to D- or L-Ser, A2 is the radical corresponding to D- or L-Asp or Glu, A3 is the radical corresponding to D- or L-Lys, Arg or Gm, A4 is the radical corresponding to D- or L-Pro, R1 and R2 are chosen, independently, from H, C1–C12-alkyl which may or may not be substituted, C7–C20-arylalkyl which may or may not be substituted, R4CO or R4COO, R4 being C1–C12-alkyl which may or may not be substituted, or C7–C20-arylalkyl which may or may not be substituted; among the substitutions, mention should be made of OH, NH2 or COOH, X1 and X2 are peptide or pseudopeptide bonds, X3 is CO or CH2 and R3 is OH, NH2, C1–C1-alkoxy or NH-X4-CH2-Z, X4 is a normal or branched C1–C12 hydrocarbon, and Z is H, OH, CO2H or CONH2, or the corresponding tripeptides comprising the radicals A1, A2, A3, and also the pharmacautically acceptable salts, for the preparation of a medicament for treating pathologies which may benefit from stimulation of angiogenesis.

    摘要翻译： 本发明涉及式I化合物的用途：其中A 1是对应于D-或L-Ser的基团，A 2是基团 对应于D-或L-Asp或Glu，A 3是与D-或L-Lys，Arg或Gm相应的基团，A 4是与 D或L-Pro，R 1和R 2独立地选自H，C 1 -C 12， 可以被取代的或可以不被取代的C 1 -C 6烷基，可以被取代的也可以不被取代的C 7 -C 20 - 芳烷基，R 4 CO或R 4 COO，R 4为C 1 -C 12 - 烷基，其可以或不可以 或可以被取代的C 7 -C 20 - 芳基烷基; 在这些取代中，应该提及OH，NH 2或COOH，X 1和X 2是肽或假肽键，X < SO 3是CO或CH 2，R 3是OH，NH 2，C 1 H 2 -C 1 - 烷氧基或NH-X 4 -CH 2 - Z，X 4是正常的 或支链C 1 -C 12烃，Z是H，OH，CO 2 H或CONH 2 CO 2， ，或包含基团A 1，A 2，A 3 N的相应的三肽以及药学上可接受的盐，用于制备 用于治疗可能受益于血管生成刺激的病症的药物。