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公开(公告)号:US20080213247A1
公开(公告)日:2008-09-04
申请号:US10532547
申请日:2003-10-22
申请人: Gregory D. Plowman , Felix D. Karim , Candace Swimmer , Hinrich Alexander Habeck , Thomas I. Koblizek , Stefan Schulte-Merker , Ulrike Langheinrich , Gordon Mark Stott , Torsten Trowe , Andreas Michael Vogel , Joerg Heinrich Odenthal , Jochen Konrad Scheel , Torsten Tilmann Will , Yisheng Jin , Lynn Margaret Bjerke , Bing Hai , Joanne I. Adamkewicz , Kim Licketeig , R. Glenn R. Hammonds , Craig D. Amundsen , Haiguang Zhang , Monique Nicoll
发明人: Gregory D. Plowman , Felix D. Karim , Candace Swimmer , Hinrich Alexander Habeck , Thomas I. Koblizek , Stefan Schulte-Merker , Ulrike Langheinrich , Gordon Mark Stott , Torsten Trowe , Andreas Michael Vogel , Joerg Heinrich Odenthal , Jochen Konrad Scheel , Torsten Tilmann Will , Yisheng Jin , Lynn Margaret Bjerke , Bing Hai , Joanne I. Adamkewicz , Kim Licketeig , R. Glenn R. Hammonds , Craig D. Amundsen , Haiguang Zhang , Monique Nicoll
CPC分类号: C12N9/1205 , A01K2217/05
摘要: Human MBM genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MBM are provided.
摘要翻译: 人类MBM基因被鉴定为分支形态发生的调节剂,因此是与缺陷支配形态发生功能相关的病症的治疗靶点。 提供了鉴定分支形态发生调节剂的方法,包括筛选调节MBM活性的试剂。
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公开(公告)号:US20120107827A1
公开(公告)日:2012-05-03
申请号:US13271614
申请日:2011-10-12
申请人: ALBERT K. TAI , CHUNYAN SONG , MICHAEL MARTIN OLLMANN , LUCILE A. GILLETT , JOANNE I. ADAMKEWICZ , KIM LICKTEIG
发明人: ALBERT K. TAI , CHUNYAN SONG , MICHAEL MARTIN OLLMANN , LUCILE A. GILLETT , JOANNE I. ADAMKEWICZ , KIM LICKTEIG
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6883 , C12Q2600/158 , G01N33/57496 , G01N2333/4736
摘要: Human PSMC genes are identified as modulators of the RB pathway, and thus are therapeutic targets for disorders associated with defective RB function. Methods for identifying modulators of RB, comprising screening for agents that modulate the activity of PSMC are provided.
摘要翻译: 人类PSMC基因被鉴定为RB途径的调节剂,因此是与缺陷型RB功能相关的疾病的治疗靶点。 提供了用于鉴定RB调节剂的方法,包括筛选调节PSMC活性的试剂。
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公开(公告)号:US20090013420A1
公开(公告)日:2009-01-08
申请号:US10523706
申请日:2003-08-06
申请人: Albert K. Tai , Chunyan Song , Michael Martin Ollmann , Lucile A. Gillett , Joanne I. Adamkewicz , Kim Lickteig
发明人: Albert K. Tai , Chunyan Song , Michael Martin Ollmann , Lucile A. Gillett , Joanne I. Adamkewicz , Kim Lickteig
CPC分类号: C12Q1/6883 , C12Q2600/158 , G01N33/57496 , G01N2333/4736
摘要: Human PSMC genes are identified as modulators of the RB pathway, and thus are therapeutic targets for disorders associated with defective RB function. Methods for identifying modulators of RB, comprising screening for agents that modulate the activity of PSMC are provided.
摘要翻译: 人类PSMC基因被鉴定为RB途径的调节剂,因此是与缺陷型RB功能相关的疾病的治疗靶点。 提供了用于鉴定RB调节剂的方法,包括筛选调节PSMC活性的试剂。
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公开(公告)号:US20140206017A1
公开(公告)日:2014-07-24
申请号:US14122984
申请日:2012-06-01
申请人: Victoria Smith , Joanne I. Adamkewicz , Susan K. Lyman , Jason Chien , Xiaoming Li , Lixin Shao , Jeffrey D. Bornstein
发明人: Victoria Smith , Joanne I. Adamkewicz , Susan K. Lyman , Jason Chien , Xiaoming Li , Lixin Shao , Jeffrey D. Bornstein
IPC分类号: G01N33/573
CPC分类号: G01N33/573 , A61K2039/505 , C07K16/40
摘要: The present disclosure provides an assay to detect and/or quantify circulating lysyl oxidase-like 2 (LOXL2) poly-peptides in an individual. The assay is useful in diagnostic and prognostic applications, which are also provided.
摘要翻译: 本公开提供了检测和/或定量个体中循环赖氨酰氧化酶样2(LOXL2)多肽的测定。 该测定法在诊断和预后应用中也是有用的,也是提供的。
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公开(公告)号:US20120309020A1
公开(公告)日:2012-12-06
申请号:US13487109
申请日:2012-06-01
申请人: Victoria Smith , Joanne I. Adamkewicz , Susan K. Lyman , Jason Chien , Xiaoming Li , Lixin Shao , Jeffrey D. Bornstein
发明人: Victoria Smith , Joanne I. Adamkewicz , Susan K. Lyman , Jason Chien , Xiaoming Li , Lixin Shao , Jeffrey D. Bornstein
IPC分类号: G01N33/573 , G01N33/574
CPC分类号: G01N33/573 , A61K2039/505 , C07K16/40
摘要: The present disclosure provides an assay to detect and/or quantify circulating lysyl oxidase-like 2 (LOXL2) polypeptides in an individual. The assay is useful in diagnostic and prognostic applications, which are also provided.
摘要翻译: 本公开提供了检测和/或定量个体中循环赖氨酰氧化酶样2(LOXL2)多肽的测定。 该测定法在诊断和预后应用中也是有用的,也是提供的。
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