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公开(公告)号：US20080317738A1
公开(公告)日：2008-12-25
申请号：US10556637
申请日：2004-06-18
申请人： Gregory D. Plowman , Felix D. Karim , Candace Swimmer , Hinrich Alexander Habeck , Thomas I. Koblizek , Stefan Schulte-Merker , Ulrike Eisenmann , Gordon Mark Stott , Torsten Trowe , Andreas Michael Vogel , Joerg Heinrich Odenthal , Jochen Konrad Scheel , Torsten Tilmann Will , Yinsheng Jin , Lynn Margaret Bjerke , Timothy S. Heuer
发明人： Gregory D. Plowman , Felix D. Karim , Candace Swimmer , Hinrich Alexander Habeck , Thomas I. Koblizek , Stefan Schulte-Merker , Ulrike Eisenmann , Gordon Mark Stott , Torsten Trowe , Andreas Michael Vogel , Joerg Heinrich Odenthal , Jochen Konrad Scheel , Torsten Tilmann Will , Yinsheng Jin , Lynn Margaret Bjerke , Timothy S. Heuer
IPC分类号： A61K39/395 , G01N33/00 , C12Q1/48 , G01N33/566 , C12Q1/68 , C12Q1/02 , A01K67/027 , C12N5/06
CPC分类号： G01N33/5091 , C07K14/47 , G01N33/5008 , G01N33/5011 , G01N33/5026 , Y10T436/143333
摘要： Human MYLK genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MYLK are provided.
摘要翻译： 人MYLK基因被鉴定为分支形态发生的调节剂，因此是与缺陷支配形态发生功能相关的病症的治疗靶点。 提供了用于鉴定分支形态发生调节剂的方法，包括筛选调节MYLK活性的试剂。
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公开(公告)号：US08105785B2
公开(公告)日：2012-01-31
申请号：US10556637
申请日：2004-06-18
申请人： Gregory D. Plowman , Felix D. Karim , Candace Swimmer , Hinrich Alexander Habeck , Thomas I. Koblizek , Stefan Schulte-Merker , Ulrike Eisenmann , Gordon Mark Stott , Torsten Trowe , Andreas Michael Vogel , Joerg Heinrich Odenthal , Jochen Konrad Scheel , Torsten Tilmann Will , Yinsheng Jin , Lynn Margaret Bjerke , Timothy S. Heuer
发明人： Gregory D. Plowman , Felix D. Karim , Candace Swimmer , Hinrich Alexander Habeck , Thomas I. Koblizek , Stefan Schulte-Merker , Ulrike Eisenmann , Gordon Mark Stott , Torsten Trowe , Andreas Michael Vogel , Joerg Heinrich Odenthal , Jochen Konrad Scheel , Torsten Tilmann Will , Yinsheng Jin , Lynn Margaret Bjerke , Timothy S. Heuer
CPC分类号： G01N33/5091 , C07K14/47 , G01N33/5008 , G01N33/5011 , G01N33/5026 , Y10T436/143333
摘要： Human MYLK genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MYLK are provided.
摘要翻译： 人MYLK基因被鉴定为分支形态发生的调节剂，因此是与缺陷支配形态发生功能相关的病症的治疗靶点。 提供了用于鉴定分支形态发生调节剂的方法，包括筛选调节MYLK活性的试剂。
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公开(公告)号：US20080213247A1
公开(公告)日：2008-09-04
申请号：US10532547
申请日：2003-10-22
申请人： Gregory D. Plowman , Felix D. Karim , Candace Swimmer , Hinrich Alexander Habeck , Thomas I. Koblizek , Stefan Schulte-Merker , Ulrike Langheinrich , Gordon Mark Stott , Torsten Trowe , Andreas Michael Vogel , Joerg Heinrich Odenthal , Jochen Konrad Scheel , Torsten Tilmann Will , Yisheng Jin , Lynn Margaret Bjerke , Bing Hai , Joanne I. Adamkewicz , Kim Licketeig , R. Glenn R. Hammonds , Craig D. Amundsen , Haiguang Zhang , Monique Nicoll
发明人： Gregory D. Plowman , Felix D. Karim , Candace Swimmer , Hinrich Alexander Habeck , Thomas I. Koblizek , Stefan Schulte-Merker , Ulrike Langheinrich , Gordon Mark Stott , Torsten Trowe , Andreas Michael Vogel , Joerg Heinrich Odenthal , Jochen Konrad Scheel , Torsten Tilmann Will , Yisheng Jin , Lynn Margaret Bjerke , Bing Hai , Joanne I. Adamkewicz , Kim Licketeig , R. Glenn R. Hammonds , Craig D. Amundsen , Haiguang Zhang , Monique Nicoll
CPC分类号： C12N9/1205 , A01K2217/05
摘要： Human MBM genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MBM are provided.
摘要翻译： 人类MBM基因被鉴定为分支形态发生的调节剂，因此是与缺陷支配形态发生功能相关的病症的治疗靶点。 提供了鉴定分支形态发生调节剂的方法，包括筛选调节MBM活性的试剂。
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