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1.
公开(公告)号:US20080213247A1
公开(公告)日:2008-09-04
申请号:US10532547
申请日:2003-10-22
申请人: Gregory D. Plowman , Felix D. Karim , Candace Swimmer , Hinrich Alexander Habeck , Thomas I. Koblizek , Stefan Schulte-Merker , Ulrike Langheinrich , Gordon Mark Stott , Torsten Trowe , Andreas Michael Vogel , Joerg Heinrich Odenthal , Jochen Konrad Scheel , Torsten Tilmann Will , Yisheng Jin , Lynn Margaret Bjerke , Bing Hai , Joanne I. Adamkewicz , Kim Licketeig , R. Glenn R. Hammonds , Craig D. Amundsen , Haiguang Zhang , Monique Nicoll
发明人: Gregory D. Plowman , Felix D. Karim , Candace Swimmer , Hinrich Alexander Habeck , Thomas I. Koblizek , Stefan Schulte-Merker , Ulrike Langheinrich , Gordon Mark Stott , Torsten Trowe , Andreas Michael Vogel , Joerg Heinrich Odenthal , Jochen Konrad Scheel , Torsten Tilmann Will , Yisheng Jin , Lynn Margaret Bjerke , Bing Hai , Joanne I. Adamkewicz , Kim Licketeig , R. Glenn R. Hammonds , Craig D. Amundsen , Haiguang Zhang , Monique Nicoll
CPC分类号: C12N9/1205 , A01K2217/05
摘要: Human MBM genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MBM are provided.
摘要翻译: 人类MBM基因被鉴定为分支形态发生的调节剂,因此是与缺陷支配形态发生功能相关的病症的治疗靶点。 提供了鉴定分支形态发生调节剂的方法,包括筛选调节MBM活性的试剂。
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2.
公开(公告)号:US20080317738A1
公开(公告)日:2008-12-25
申请号:US10556637
申请日:2004-06-18
申请人: Gregory D. Plowman , Felix D. Karim , Candace Swimmer , Hinrich Alexander Habeck , Thomas I. Koblizek , Stefan Schulte-Merker , Ulrike Eisenmann , Gordon Mark Stott , Torsten Trowe , Andreas Michael Vogel , Joerg Heinrich Odenthal , Jochen Konrad Scheel , Torsten Tilmann Will , Yinsheng Jin , Lynn Margaret Bjerke , Timothy S. Heuer
发明人: Gregory D. Plowman , Felix D. Karim , Candace Swimmer , Hinrich Alexander Habeck , Thomas I. Koblizek , Stefan Schulte-Merker , Ulrike Eisenmann , Gordon Mark Stott , Torsten Trowe , Andreas Michael Vogel , Joerg Heinrich Odenthal , Jochen Konrad Scheel , Torsten Tilmann Will , Yinsheng Jin , Lynn Margaret Bjerke , Timothy S. Heuer
IPC分类号: A61K39/395 , G01N33/00 , C12Q1/48 , G01N33/566 , C12Q1/68 , C12Q1/02 , A01K67/027 , C12N5/06
CPC分类号: G01N33/5091 , C07K14/47 , G01N33/5008 , G01N33/5011 , G01N33/5026 , Y10T436/143333
摘要: Human MYLK genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MYLK are provided.
摘要翻译: 人MYLK基因被鉴定为分支形态发生的调节剂,因此是与缺陷支配形态发生功能相关的病症的治疗靶点。 提供了用于鉴定分支形态发生调节剂的方法,包括筛选调节MYLK活性的试剂。
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3.
公开(公告)号:US08105785B2
公开(公告)日:2012-01-31
申请号:US10556637
申请日:2004-06-18
申请人: Gregory D. Plowman , Felix D. Karim , Candace Swimmer , Hinrich Alexander Habeck , Thomas I. Koblizek , Stefan Schulte-Merker , Ulrike Eisenmann , Gordon Mark Stott , Torsten Trowe , Andreas Michael Vogel , Joerg Heinrich Odenthal , Jochen Konrad Scheel , Torsten Tilmann Will , Yinsheng Jin , Lynn Margaret Bjerke , Timothy S. Heuer
发明人: Gregory D. Plowman , Felix D. Karim , Candace Swimmer , Hinrich Alexander Habeck , Thomas I. Koblizek , Stefan Schulte-Merker , Ulrike Eisenmann , Gordon Mark Stott , Torsten Trowe , Andreas Michael Vogel , Joerg Heinrich Odenthal , Jochen Konrad Scheel , Torsten Tilmann Will , Yinsheng Jin , Lynn Margaret Bjerke , Timothy S. Heuer
CPC分类号: G01N33/5091 , C07K14/47 , G01N33/5008 , G01N33/5011 , G01N33/5026 , Y10T436/143333
摘要: Human MYLK genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MYLK are provided.
摘要翻译: 人MYLK基因被鉴定为分支形态发生的调节剂,因此是与缺陷支配形态发生功能相关的病症的治疗靶点。 提供了用于鉴定分支形态发生调节剂的方法,包括筛选调节MYLK活性的试剂。
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4.
公开(公告)号:US20080163386A1
公开(公告)日:2008-07-03
申请号:US11627977
申请日:2007-01-28
申请人: Felix D. Karim , Linda Nolan Keyes , Gregory D. Plowman , Michael Martin Ollmann , Mark E. Maxwell , Thierry Tidiane Diagana
发明人: Felix D. Karim , Linda Nolan Keyes , Gregory D. Plowman , Michael Martin Ollmann , Mark E. Maxwell , Thierry Tidiane Diagana
IPC分类号: G01N33/483 , G01N33/50 , C12N5/06 , C12Q1/02
CPC分类号: C12Q1/6883 , C07K14/515 , C07K14/705 , C12Q1/6809 , C12Q2600/136 , C12Q2600/158 , G01N33/74 , G01N2333/515 , G01N2500/04 , Y10T436/145555
摘要: Human CRB genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of CRB are provided.
摘要翻译: 人CRB基因被鉴定为分支形态发生的调节剂,因此是与缺陷支配形态发生功能相关的病症的治疗靶点。 提供了鉴定分支形态发生调节剂的方法,包括筛选调节CRB活性的试剂。
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公开(公告)号:US20130095096A1
公开(公告)日:2013-04-18
申请号:US13335632
申请日:2011-12-22
申请人: Wei-Ching Liang , Gregory D. Plowman , Yan Wu , Weilan Ye
发明人: Wei-Ching Liang , Gregory D. Plowman , Yan Wu , Weilan Ye
IPC分类号: C07K16/28
CPC分类号: C07K16/2842 , A61K47/6835 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/92 , Y02A50/386 , Y02A50/41 , Y02A50/412
摘要: The present invention provides new anti-α5β1 antibodies, compositions and kits comprising the antibodies, and methods of making and using the antibodies.
摘要翻译: 本发明提供新的抗α5β1抗体,包含抗体的组合物和试剂盒,以及制备和使用抗体的方法。
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公开(公告)号:US20100275275A1
公开(公告)日:2010-10-28
申请号:US12536466
申请日:2009-08-05
申请人: Lori Friedman , Gregory D. Plowman , Roel P. Funke , Marcia Belvin , Danxi Li , Stephanie A. Robertson
发明人: Lori Friedman , Gregory D. Plowman , Roel P. Funke , Marcia Belvin , Danxi Li , Stephanie A. Robertson
CPC分类号: G01N33/5008 , A01K2227/706 , C12Q1/6886 , C12Q2600/158 , G01N33/5011 , G01N33/5017 , G01N33/502 , G01N33/5091 , G01N33/574 , G01N33/57419 , G01N33/57449 , G01N33/5748 , G01N33/57496 , G01N33/6872 , G01N2333/82 , G01N2333/914 , G01N2500/10
摘要: Human HADH genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of HADH are provided.
摘要翻译: 人HADH基因被鉴定为p21途径的调节剂,因此是与缺陷型p21功能相关的病症的治疗靶点。 提供了鉴定p21调节剂的方法,包括筛选调节HADH活性的药剂。
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公开(公告)号:US20100260782A1
公开(公告)日:2010-10-14
申请号:US12729999
申请日:2010-03-23
申请人: Wei-Ching Liang , Gregory D. Plowman , Yan Wu , Weilan Ye
发明人: Wei-Ching Liang , Gregory D. Plowman , Yan Wu , Weilan Ye
IPC分类号: A61K39/395 , C07K16/28 , C07K16/00 , A61P13/12 , A61P27/00 , A61P1/00 , A61P19/02 , A61P35/00 , A61P17/06
CPC分类号: C07K16/2842 , A61K47/6835 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/92 , Y02A50/386 , Y02A50/41 , Y02A50/412
摘要: The present invention provides new anti-α5β1 antibodies, compositions and kits comprising the antibodies, and methods of making and using the antibodies.
摘要翻译: 本发明提供新的抗α5和bgr1抗体,包含抗体的组合物和试剂盒,以及制备和使用抗体的方法。
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公开(公告)号:US06972179B2
公开(公告)日:2005-12-06
申请号:US10056790
申请日:2002-01-23
IPC分类号: A01K67/027 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/37 , C12Q1/42 , C12Q1/48 , C12Q1/527 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/573 , G01N33/574 , G01N33/68 , A01N61/00 , C12Q1/70 , G01N33/48
CPC分类号: C07K14/705 , A61K38/00 , C07K16/28 , C12Q1/42 , C12Q1/485 , C12Q1/527 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N33/5017 , G01N33/5308 , G01N33/573 , G01N33/574 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N33/5748 , G01N33/57484 , G01N33/57496 , G01N33/6872 , G01N2333/4739 , G01N2333/62 , G01N2333/705 , G01N2333/82 , G01N2333/912 , G01N2333/914 , G01N2333/988 , G01N2500/00 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要: RRP genes are identified as modulators of the p53 or p21 pathway, and thus are therapeutic targets for disorders associated with defective p53 or p21 function. Methods for identifying modulators of p53 or p21, comprising screening for agents that modulate the activity of RRP are provided. Modulating agents identified using the methods of the invention can be used to specifically inhibit growth of tumor cells that overexpress an RRP protein. mRRP1 knockout mice are also provided.
摘要翻译: RRP基因被鉴定为p53或p21途径的调节剂,因此是与缺陷型p53或p21功能相关的病症的治疗靶点。 提供了鉴定p53或p21调节剂的方法,包括筛选调节RRP活性的试剂。 使用本发明方法鉴定的调节剂可用于特异性抑制过表达RRP蛋白的肿瘤细胞的生长。 还提供了mRRP1敲除小鼠。
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公开(公告)号:US06927022B2
公开(公告)日:2005-08-09
申请号:US10192353
申请日:2002-07-10
申请人: Lori Friedman , Gregory D. Plowman , Roel P. Funke , Marcia Belvin , Danxi Li , Stephanie A. Robertson
发明人: Lori Friedman , Gregory D. Plowman , Roel P. Funke , Marcia Belvin , Danxi Li , Stephanie A. Robertson
CPC分类号: G01N33/5008 , A01K2227/706 , C12Q1/6886 , C12Q2600/158 , G01N33/5011 , G01N33/5017 , G01N33/502 , G01N33/5091 , G01N33/574 , G01N33/57419 , G01N33/57449 , G01N33/5748 , G01N33/57496 , G01N33/6872 , G01N2333/82 , G01N2333/914 , G01N2500/10
摘要: Human HADH genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of HADH are provided.
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公开(公告)号:US06844177B2
公开(公告)日:2005-01-18
申请号:US09822295
申请日:2001-04-02
申请人: Bahija Jallal , Gregory D. Plowman
发明人: Bahija Jallal , Gregory D. Plowman
IPC分类号: C07K14/705 , C12N9/12 , C12N9/16 , A61K38/45 , C07K7/04 , C07K14/435
CPC分类号: C12N9/1205 , C07K14/705 , C07K2319/00 , C12N9/16
摘要: The present invention relates to PTP04 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animal containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for PTP04 related diseases or conditions characterized by an abnormal interaction between a PTP04 binding partner.
摘要翻译: 本发明涉及PTP04多肽,编码此类多肽的核酸,含有此类核酸的细胞,组织和动物,对此类多肽的抗体,利用此类多肽的测定法以及与上述所有相关的方法。 提供治疗,诊断和筛选方法,用于PTP04相关疾病或特征为PTP04结合配偶体之间异常相互作用的病症。
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