公开(公告)号：US08986358B2

公开(公告)日：2015-03-24

申请号：US12377595

申请日：2007-08-15

Applicant: Sune Svanberg ,  Johan Axelsson ,  Johannes Swartling ,  Ann Johansson ,  Stefan Andersson-Engels

Inventor： Sune Svanberg ,  Johan Axelsson ,  Johannes Swartling ,  Ann Johansson ,  Stefan Andersson-Engels

IPC: A61N5/06 ,  A61B17/00 ,  A61B18/00 ,  A61B19/00

CPC classification number: A61N5/062 ,  A61B2017/00022 ,  A61B2018/00642 ,  A61B2034/105 ,  A61N5/0601 ,  A61N2005/0612 ,  A61N2005/063

Abstract: A method and system for controlling and adjusting light in interstitial photodynamic light therapy (IPDT) in a subject is disclosed. More particularly, a method for controlling the light in interstitial tumor photodynamic light therapy is described using a calculation method for determination of status of tissue during the PDT treatment. The status is used in a feedback loop to control the continued PDT treatment. Methods are disclosed that constitute pre-treatment and realtime dosimetry modules for IPDT on the whole prostate glandular tissue. The method includes reconstruction of the target geometry, optimization of source fiber positions within this geometry, monitoring of the light attenuation during the treatment procedure and updating individual fiber irradiation times to take into account any variation in tissue light transmission. A control device that is arranged to restrict delivery of therapeutic light treatment at least temporary in dependence of at least one attribute of one of photodynamic treatment parameters. In comparison to no treatment feedback, a significant undertreatment of the patient as well as damage to healthy organs at risk are avoided.

Abstract translation: 公开了一种用于控制和调节受试者中的间质性光动力光疗法（IPDT）中的光的方法和系统。 更具体地，使用用于在PDT处理期间确定组织状态的计算方法来描述用于控制间质肿瘤光动力光疗法中的光的方法。 该状态用于反馈回路以控制持续的PDT治疗。 公开了构成用于IPDT在整个前列腺腺组织上的预处理和实时剂量测定模块的方法。 该方法包括重建目标几何形状，优化该几何形状内的源光纤位置，监测处理过程中的光衰减和更新单个光纤照射时间以考虑组织光透射中的任何变化。 一种控制装置，其被配置为根据光动力学治疗参数之一的至少一个属性至少临时地限制治疗性光处理的递送。 与没有治疗反馈相比，避免对患者的重大治疗以及处于危险中的健康器官的损害。

公开(公告)号：US08582841B2

公开(公告)日：2013-11-12

申请号：US12836497

申请日：2010-07-14

Applicant: Johannes Swartling ,  Sune Svanberg ,  Johan Axelsson ,  Stefan Andersson-Engels ,  Jarl Ebbe Johansson

Inventor： Johannes Swartling ,  Sune Svanberg ,  Johan Axelsson ,  Stefan Andersson-Engels ,  Ann Johansson

IPC: G06K9/00

CPC classification number: A61N5/0601 ,  A61B6/5247 ,  A61N5/062 ,  A61N2005/0612 ,  G06K2209/057

Abstract: A system for providing interstitial photodynamic and/or photothermal therapy on a region of tissue in a body, comprising at least one light source adapted to deliver a therapeutic light to the region of tissue, such that the light source is interstitially inserted into the tissue for interaction with a photosensitizer agent and/or for providing a controlled thermal environment of the tissue; and a unit for determining an optimized number of the light sources and individual position of each of the light sources in the region of tissue as well as individual control parameters for each of the light sources.

Abstract translation: 一种用于在体内的组织区域上提供间质性光动力学和/或光热疗法的系统，其包括至少一种适于将治疗光输送到组织区域的光源，使得光源被间隙插入组织中 与光敏剂的相互作用和/或用于提供组织的受控热环境; 以及用于确定组织区域中的光源的优化数量和每个光源的单独位置的单元以及用于每个光源的单独控制参数的单元。

公开(公告)号：US09012869B2

公开(公告)日：2015-04-21

申请号：US13318403

申请日：2010-05-05

Applicant: Stefan Andersson-Engels ,  Can Xu ,  Haichun Liu ,  Johan Axelsson ,  Niclas Svensson ,  Pontus Svenmarker

Inventor： Stefan Andersson-Engels ,  Can Xu ,  Haichun Liu ,  Johan Axelsson ,  Niclas Svensson ,  Pontus Svenmarker

IPC: G01N21/64 ,  A61B5/00 ,  G01N21/47

CPC classification number: A61B5/0059 ,  A61B5/0068 ,  A61B5/0073 ,  G01N21/4795 ,  G01N21/6428 ,  G01N21/6456

Abstract: A method and system for luminescence molecular imaging or tomography of a region of interest in a scattering medium is disclosed. The system comprises a non-linear luminescent marker material arranged in the scattering medium. Contrast and resolution of the imaging or tomography is thus improved. The non-linear marker is for instance configured to upconvert incoming light of an illumination wavelength. The non-linear power dependence of the marker enables further improvement of the imaging by using images taken with two or more excitation beams simultaneously.

Abstract translation: 公开了一种用于散射介质中感兴趣区域的发光分子成像或层析成像的方法和系统。 该系统包括布置在散射介质中的非线性发光标记材料。 因此，成像或层析成像的对比度和分辨率得到改善。 例如，非线性标记被配置为上变频照明波长的入射光。 标记的非线性功率依赖性通过使用同时具有两个或更多个激发束拍摄的图像来进一步改善成像。

公开(公告)号：US20110034971A1

公开(公告)日：2011-02-10

申请号：US12377595

申请日：2007-08-15

Applicant: Sune Svanberg ,  Johan Axelsson ,  Johannes Swartling ,  Ann Johansson ,  Stefan Andersson-Engels

Inventor： Sune Svanberg ,  Johan Axelsson ,  Johannes Swartling ,  Ann Johansson ,  Stefan Andersson-Engels

IPC: A61N5/06

CPC classification number: A61N5/062 ,  A61B2017/00022 ,  A61B2018/00642 ,  A61B2034/105 ,  A61N5/0601 ,  A61N2005/0612 ,  A61N2005/063

Abstract: A method and system for controlling and adjusting light in interstitial photodynamic light therapy (IPDT) in a subject is disclosed. More particularly, a method for controlling the light in interstitial tumor photodynamic light therapy is described using calculation method for determination of status of tissue during the PDT treatment. The status is used in a feedback loop to control the continued PDT treatment. Methods are disclosed that constitute pre-treatment and realtime dosimetry modules for IPDT on the whole prostate glandular tissue. The method includes reconstruction of the target geometry, optimization of source fiber positions within this geometry, monitoring of the light attenuation during the treatment procedure and updating individual fiber irradiation times to take into account any variation in tissue light transmission. A control device that is arranged to restrict delivery of therapeutic light treatment at least temporary in dependence of at least one attribute of one of photodynamic treatment parameters. In comparison to no treatment feedback, a significant undertreatment of the patient as well as damage to healthy organs at risk are avoided.

Abstract translation: 公开了一种用于控制和调节受试者中的间质性光动力光疗法（IPDT）中的光的方法和系统。 更具体地，使用用于在PDT处理期间用于确定组织状态的计算方法来描述用于控制间质肿瘤光动力光疗法中的光的方法。 该状态用于反馈回路以控制持续的PDT治疗。 公开了构成用于IPDT在整个前列腺腺组织上的预处理和实时剂量测定模块的方法。 该方法包括目标几何的重建，该几何中的源光纤位置的优化，处理过程中的光衰减的监测以及更新各个光纤照射时间以考虑到组织光透射中的任何变化。 一种控制装置，其被配置为根据光动力学治疗参数之一的至少一个属性至少临时地限制治疗性光处理的递送。 与没有治疗反馈相比，避免对患者的重大治疗以及处于危险中的健康器官的损害。

公开(公告)号：US20080004377A1

公开(公告)日：2008-01-03

申请号：US11820188

申请日：2007-06-19

Applicant: Johan Axelsson ,  Fredrik Lilieblad ,  Anders Wretling ,  Carl Bieneck

Inventor： Johan Axelsson ,  Fredrik Lilieblad ,  Anders Wretling ,  Carl Bieneck

IPC: C08L1/10 ,  C08L5/00 ,  C08L5/02

CPC classification number: F42B6/00 ,  C08L5/00 ,  F41B9/0087 ,  F42B12/40

Abstract: The present invention relates to a product comprising a preparation for mixture with a solvent to form a squirtable polymer solution for use in squirt devices. The preparation comprises a polymer thickening agent in combination with a mixing material. The thickening agent and mixing material are selected and formulated so that said product retains its homogeneity during storage of at least 1 week and that the mixing material is selected and formulated so that the preparation does not form lumps dissolved in a solvent. The invention further comprises methods to obtain suitable such preparation and a method of loading a squirt device with the product.

Abstract translation: 本发明涉及包含与溶剂混合形成用于喷射装置的可喷射聚合物溶液的制剂的产品。 该制剂包含与混合材料组合的聚合物增稠剂。 选择和配制增稠剂和混合材料，使得所述产品在至少1周的储存期间保持其均匀性，并且选择和配制混合材料，使得制剂不会形成溶解在溶剂中的块状物。 本发明还包括获得合适的这种制剂的方法以及用该产品装载喷射装置的方法。