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    Peptide modulators of the δPKC interaction with the d subunit of F1Fo ATP synthase/ATPase and uses thereof
    1.
    发明授权
    Peptide modulators of the δPKC interaction with the d subunit of F1Fo ATP synthase/ATPase and uses thereof 有权
    与F1Fo ATP合成酶/ ATP酶的d亚基的δPKC相互作用的肽调节剂及其用途

    公开(公告)号：US08754051B2

    公开(公告)日：2014-06-17

    申请号：US13401035

    申请日：2012-02-21

    申请人： John A. Johnson ,  Tiffany Tuyen M. Nguyen ,  Mourad Ogbi

    发明人： John A. Johnson ,  Tiffany Tuyen M. Nguyen ,  Mourad Ogbi

    IPC分类号： A61K38/16 ,  C07K14/00

    CPC分类号： A61K38/16 ,  A61K38/00 ,  C07K14/00 ,  C07K2319/00 ,  C12N9/14

    摘要： The present invention provides isolated or synthetic peptides derived from the d subunit of mammalian F1Fo ATP synthase (dF1Fo) protein for the purposes of tissue protection and improved energy production following acute injury from ischemia/reperfusion or other toxic insults, or in chronic diseases such as diabetes and cancer. The major focus of the patent protection will be 2 peptides comprising an amino acid sequence having at least 75% sequence identity to SEQ ID NO: 1 or SEQ ID NO: 2 and pharmaceutical compositions thereof. However, additional peptide sequences within the dF1Fo protein may also have efficacies in these disease states and therefore all peptides shown in the Figures of this application (combined with the human immunodeficiency virus (HIV)-Tat protein transduction, cytochrome oxidase subunit IV (COIV) mitochondrial targeting and Flag domains) are included for their efficacies in these conditions.

    摘要翻译： 本发明提供衍生自哺乳动物F1Fo ATP合成酶（dF1Fo）蛋白质的d亚基的分离或合成的肽，用于组织保护和由缺血/再灌注或其它毒性侮辱或慢性疾病例如 糖尿病和癌症。 专利保护的主要焦点将是2个肽，其包含与SEQ ID NO：1或SEQ ID NO：2具有至少75％序列同一性的氨基酸序列及其药物组合物。 然而，dF1Fo蛋白内的其他肽序列也可能具有这些疾病状态的功效，因此本申请图中所示的所有肽（与人免疫缺陷病毒（HIV）-Tat蛋白转导，细胞色素氧化酶亚基IV（COIV） 线粒体靶向和标记域）包括在这些条件下的功效。

    Peptide Modulators of the deltaPKC Interaction with the d Subunit of F1F0 ATP Synthase/ATPase and Uses Thereof
    2.
    发明申请
    Peptide Modulators of the deltaPKC Interaction with the d Subunit of F1F0 ATP Synthase/ATPase and Uses Thereof 有权
    δPKC与F1F0 ATP合成酶/ ATP酶的d亚基相互作用的肽调节剂及其用途

    公开(公告)号：US20120283182A1

    公开(公告)日：2012-11-08

    申请号：US13401035

    申请日：2012-02-21

    申请人： John A. Johnson ,  Tiffany Tuyen M. Nguyen ,  Mourad Ogbi

    发明人： John A. Johnson ,  Tiffany Tuyen M. Nguyen ,  Mourad Ogbi

    IPC分类号： C07K7/08 ,  A61K38/10 ,  A61P29/00 ,  A61P35/00 ,  A61P9/10 ,  A61P9/12 ,  C07H21/04 ,  A61P3/10

    CPC分类号： A61K38/16 ,  A61K38/00 ,  C07K14/00 ,  C07K2319/00 ,  C12N9/14

    摘要： The present invention provides isolated or synthetic peptides derived from the d subunit of mammalian F1Fo ATP synthase (dF1Fo) protein for the purposes of tissue protection and improved energy production following acute injury from ischemia/reperfusion or other toxic insults, or in chronic diseases such as diabetes and cancer. The major focus of the patent protection will be 2 peptides comprising an amino acid sequence having at least 75% sequence identity to SEQ ID NO: 1 or SEQ ID NO: 2 and pharmaceutical compositions thereof. However, additional peptide sequences within the dF1Fo protein may also have efficacies in these disease states and therefore all peptides shown in the Figures of this application (combined with the HIV-Tat protein transduction, COIV mitochondrial targeting and Flag domains) are included for their efficacies in these conditions.

    摘要翻译： 本发明提供衍生自哺乳动物F1Fo ATP合成酶（dF1Fo）蛋白质的d亚基的分离或合成的肽，用于组织保护和由缺血/再灌注或其它毒性侮辱或慢性疾病例如 糖尿病和癌症。 专利保护的主要焦点将是2个肽，其包含与SEQ ID NO：1或SEQ ID NO：2具有至少75％序列同一性的氨基酸序列及其药物组合物。 然而，dF1Fo蛋白内的另外的肽序列也可以在这些疾病状态中具有功效，因此包括本申请图中显示的所有肽（结合HIV-Tat蛋白转导，COIV线粒体靶向和Flag结构域），用于其功效 在这些条件下。

    Molded decorative fence panel
    4.
    发明授权
    Molded decorative fence panel 有权
    模制装饰栅栏面板

    公开(公告)号：US07478797B2

    公开(公告)日：2009-01-20

    申请号：US11256216

    申请日：2005-10-21

    申请人： David J. Laws ,  R. Dru Laws ,  Gregory Wilson ,  Phillip Swindler ,  Robert Magdars ,  John A. Johnson

    发明人： David J. Laws ,  R. Dru Laws ,  Gregory Wilson ,  Phillip Swindler ,  Robert Magdars ,  John A. Johnson

    IPC分类号： E04H17/14

    CPC分类号： E04H17/168

    摘要： The opposite plastic walls 20a and 20b can be made from a polymeric resin material such as thermoplastic or thermoset resin, and/or can be made from olefins, styrenes, nylons, or mixtures of these polymeric families. In one aspect, the opposite plastic walls can be formed from an olefin, such as polyethylene or polypropylene, or the like. In another aspect, the opposite plastic walls can be formed from a styrene, such as acrylonitrile or butadiene styrene, or the like. In still another aspect, the opposite plastic walls can be formed from a mixture of olefins and styrenes. The polymeric resin material can also be made from recycled olefin, styrene, or nylon products. It will also be appreciated that the material of the walls can include additives, such as glass, fiber, talc, UV resistive or protective materials, etc. In one aspect, plastic granules of different colors can be combined to obtain a wall color that is a composite color to more readily simulate another material.

    摘要翻译： 相对的塑料壁20a和20b可以由诸如热塑性树脂或热固性树脂的聚合树脂材料制成，和/或可以由烯烃，苯乙烯，尼龙或这些聚合物族的混合物制成。 在一个方面，相对的塑料壁可由烯烃如聚乙烯或聚丙烯等形成。 另一方面，相对的塑料壁可以由苯乙烯形成，例如丙烯腈或丁二烯苯乙烯等。 在另一方面，相对的塑料壁可以由烯烃和苯乙烯的混合物形成。 聚合树脂材料也可以由循环烯烃，苯乙烯或尼龙制品制成。 还应当理解，壁的材料可以包括添加剂，例如玻璃，纤维，滑石，UV电阻或保护材料等。在一个方面，可以组合不同颜色的塑料颗粒以获得壁颜色 复合颜色更容易模拟另一种材料。

    Container coupler
    9.
    发明授权
    Container coupler 失效
    集装箱连接器

    公开(公告)号：US4856150A

    公开(公告)日：1989-08-15

    申请号：US198177

    申请日：1988-05-24

    申请人： John A. Johnson

    发明人： John A. Johnson

    IPC分类号： B65D90/00

    CPC分类号： B65D90/0013 ,  Y10T24/28 ,  Y10T24/3449

    摘要： A portable coupler which can detachably fit into opposing corner fittings of adjacent freight containers for joining the containers into an integral unit is disclosed. The coupler includes a unitary tension spindle member shaped at each end to fit into and latch onto a standard container corner fitting. In use, one end of the spindle is fitted into an end opening of the corner fitting of a first container and the spindle is then moved longitudinally to engage and hook into the opening of an opposed end corner fitting of an adjacent container. A pair of bearing rings are fitted about the spindle, each formed with a bearing face to bear against the external face of an opposed container corner fitting. Both bearing rings are engaged to a common outer collar ring that may be manually rotated to separate the bearing rings and simultaneously provide a compression force between the corner fittings of the joined containers and a tension force in the spindle member hooked into both containers. Latch members are slidably mounted on the spindle member with each linked to an opposed bearing ring. Each latch member is engaged into a container corner fitting opening, preventing detachment of the spindle member for the corner fitting in the extended mode.

    摘要翻译： 公开了一种便携式联接器，其可拆卸地装配到相邻货柜的相对的角配件中，用于将容器连接成一体的单元。 联接器包括在每个端部成形的单一张力主轴构件，以适合并闩锁在标准容器角配件上。 在使用中，主轴的一端装配到第一容器的角配件的端部开口中，然后主轴被纵向移动以接合并钩入相邻容器的相对的端部角配件的开口中。 一对轴承环安装在主轴上，每个轴承环都形成有一个支承面，以抵靠对置的集装箱角配件的外表面。 两个轴承环都接合到公共的外圈环上，该外圈环可以手动旋转以分离轴承环，并且同时在连接的容器的角配件之间提供压缩力，并且在主轴构件中钩住两个容器中的张力。 闩锁构件可滑动地安装在心轴构件上，每个构件连接到相对的轴承环。 每个闩锁构件接合到容器角配件开口中，防止用于角配件的心轴构件在伸出模式中脱离。

    Knock-down merchandise display fixture
    10.
    发明授权
    Knock-down merchandise display fixture 失效
    敲门商品展示夹具

    公开(公告)号：US4655353A

    公开(公告)日：1987-04-07

    申请号：US678289

    申请日：1984-12-05

    申请人： John A. Johnson ,  Edward O. Gandolf ,  Ronald M. Preksta

    发明人： John A. Johnson ,  Edward O. Gandolf ,  Ronald M. Preksta

    IPC分类号： A47F5/10 ,  A47B47/00

    CPC分类号： A47F5/103

    摘要： A fabricated knock-down merchandise display fixture which includes telescopic, extendible and retractable standard sections for increasing and decreasing the height of the fixture, and including a two piece gravity actuated latch unit mounted on the standards for holding the extendible standard section in selected position. The latch unit is automatically deactivated to permit ready extension of the extendible standard section by merely lifting up on the extendible section to increase the height of the fixture standard and upon release of the extendible section from upward movement, the latch unit is automatically reactivated to hold the extendible section of the standard in its newly extended position. Abutment structure is provided on the standards for limiting the telescopic movement thereof and for guiding the lengthwise movement of the extendible section. The novel features of the fixture are adapted for use with a considerable variety of different fixture arrangements for use in displaying products, with the display fixtures being readily assembled and disassembled using unskilled labor and a minimum of tools, time and effort.

    摘要翻译： 一种制造的压倒式商品展示夹具，其包括用于增加和降低夹具高度的伸缩式伸缩标准部分，并且包括安装在用于将可延伸标准部分保持在选定位置的标准上的两件式重力驱动的闩锁单元。 闩锁单元自动停用，以允许通过仅在可延伸部分上提升可扩展标准部分来提高夹具标准的高度，并且在可伸缩部分从向上移动释放时，锁闩单元被自动重新启动以保持 标准的可扩展部分在其新的扩展位置。 提供了用于限制其伸缩运动并用于引导可延伸部分的纵向移动的标准的基台结构。 夹具的新颖特征适用于用于显示产品的各种各样的不同的夹具装置，其中显示装置可以使用非熟练劳动和最少的工具，时间和精力容易地组装和拆卸。