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公开(公告)号：US5478557A
公开(公告)日：1995-12-26
申请号：US166779
申请日：1993-12-13
IPC分类号： A61K39/02 , A61K35/74 , A61K35/744 , A61K35/745 , A61K35/747 , A61K39/05 , A61K39/108 , A61K39/114 , A61P31/04 , C12N1/20 , C12Q1/10
CPC分类号： C12Q1/10 , A23K10/18 , A23K50/75 , A61K35/74 , A61K35/744 , A61K35/745 , A61K35/747 , C12N1/20 , G01N2333/255
摘要： A defined probiotic or composition of anaerobic bacteria effective for controlling or inhibiting Salmonella colonization of fowl. The probiotic includes populations or cultures of 29 substantially biologically pure bacteria. In use, the probiotic is administered to the subject fowl in an amount effective for increasing resistance to Salmonella colonization thereof.The invention also relates to a novel method for isolating probiotics which are effective for controlling or inhibiting Salmonella colonization of domestic animals, from fecal droppings, cecal contents or large intestines of the adult animals. The droppings, cecal contents or large intestine are combined with a culture medium and incubated without dilution (i.e. batch culture) under anaerobic conditions. Following this preliminary incubation, the resultant culture is subjected to continuous flow conditions until a steady state is achieved, after which time the steady state culture may be recovered for use as a probiotic.
摘要翻译： 定义的有益于控制或抑制家禽沙门氏菌定居的厌氧细菌的益生菌或组合物。 益生菌包括29种基本上生物纯的细菌的种群或培养物。 在使用中，将益生菌以有效增加对沙门氏杆菌定植的抗性的量施用于家禽。 本发明还涉及一种用于分离有益于控制或抑制家畜的沙门氏菌定殖的益生菌的新方法，来自成年动物的粪便粪便，盲肠内容物或大肠。 将粪便，盲肠内容物或大肠与培养基组合，并在无氧条件下进行稀释（即分批培养）孵育。 在该初步温育之后，将所得培养物进行连续流动条件直到达到稳定状态，此后可以恢复稳态培养物以用作益生菌。
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公开(公告)号：US5340577A
公开(公告)日：1994-08-23
申请号：US921173
申请日：1992-07-29
IPC分类号： A61K35/74 , A61K35/741 , A61K35/744 , A61K35/745 , A61K35/747 , C12N1/20 , C12Q1/10
CPC分类号： C12Q1/10 , A61K35/741 , A61K35/744 , A61K35/745 , A61K35/747 , C12N1/20 , G01N2333/255
摘要： A defined probiotic or composition of anaerobic bacteria effective for controlling or inhibiting Salmonella colonization of fowl. The probiotic includes populations or cultures of substantially biologically pure bacteria, which bacteria include:(a) at least one Lactobacillus species;(b) one or both of:Lactococcus lactis, andCitrobacter freundii; and(c) at least one of:one or more Enterococcus species,one or more Bifidobacterium species,one or more Propionibacterium species, andone or more Escherichia species.In use, the probiotic is administered to the subject fowl in an amount effective for inhibiting Salmonella colonization thereof.The invention also relates to a novel method for isolating probiotics which are effective for controlling or inhibiting Salmonella colonization of fowl, from fecal droppings or cecal contents of adult fowl. The droppings or cecal contents are combined with a culture medium and incubated without dilution (i.e. batch culture) under anaerobic conditions. Following this preliminary incubation, the resultant culture is subjected to continuous flow conditions until a steady state is achieved, after which time the steady state culture may be recovered for use as a probiotic.
摘要翻译： 定义的有益于控制或抑制家禽沙门氏菌定居的厌氧细菌的益生菌或组合物。 益生菌包括基本上生物纯的细菌的群体或培养物，该细菌包括：（a）至少一种乳杆菌属物种; （b）以下之一或两者：乳酸乳球菌和弗氏氟柠檬酸杆菌; 和（c）至少一种：一种或多种肠球菌属物种，一种或多种双歧杆菌属物种，一种或多种丙酸杆菌属物种和一种或多种埃希氏杆菌属物种。 在使用中，将益生菌以有效抑制其沙门氏菌定植的量给予受试禽。 本发明还涉及一种用于分离有益于控制或抑制家禽的沙门氏菌定殖的益生菌的新方法，来自粪便粪便或成年禽类的盲肠内容物。 将粪便或盲肠内容物与培养基组合，并在无氧条件下进行稀释（即分批培养）孵育。 在该初步温育之后，将所得培养物进行连续流动条件直到达到稳定状态，此后可以恢复稳态培养物以用作益生菌。
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3.发明授权Probiotic for control of Salmonella in fowl produced by continuous culture of fecal/cecal material 失效用于控制通过连续培养粪便/盲肠材料产生的家禽中的沙门氏菌的益生菌
公开(公告)号：US5604127A
公开(公告)日：1997-02-18
申请号：US345010
申请日：1994-11-23
IPC分类号： A61K35/74 , A61K35/741 , A61K35/744 , A61K35/745 , A61K35/747 , C12N1/20 , C12Q1/10 , A01N63/00
CPC分类号： C12Q1/10 , A61K35/741 , A61K35/744 , A61K35/745 , A61K35/747 , C12N1/20 , G01N2333/255
摘要： A defined probiotic or composition of anaerobic bacteria effective for controlling or inhibiting Salmonella colonization of fowl. The probiotic includes populations or cultures of substantially biologically pure bacteria, which bacteria include:(a) at least one Lactobacillus species;(b) one or both of:Lactococcus lactis, andCitrobacter freundii; and(c) at least one of:one or more Enterococcus species,one or more Bifidobacterium species,one or more Propionibacterium species, andone or more Escherichia species.In use, the probiotic is administered to the subject fowl in an amount effective for inhibiting Salmonella colonization thereof. The invention also relates to a novel method for isolating probiotics which are effective for controlling or inhibiting Salmonella colonization of fowl, from fecal droppings or cecal contents of adult fowl. The droppings or cecal contents are combined with a culture medium and incubated without dilution (i.e. batch culture) under anaerobic conditions. Following this preliminary incubation, the resultant culture is subjected to continuous flow conditions until a steady state is achieved, after which time the steady state culture may be recovered for use as a probiotic.
摘要翻译： 定义的有益于控制或抑制家禽沙门氏菌定居的厌氧细菌的益生菌或组合物。 益生菌包括基本上生物纯的细菌的群体或培养物，该细菌包括：（a）至少一种乳杆菌属物种; （b）以下之一或两者：乳酸乳球菌和弗氏氟柠檬酸杆菌; 和（c）至少一种：一种或多种肠球菌属物种，一种或多种双歧杆菌属物种，一种或多种丙酸杆菌属物种和一种或多种埃希氏杆菌属物种。 在使用中，将益生菌以有效抑制其沙门氏菌定植的量给予受试禽。 本发明还涉及一种用于分离有益于控制或抑制家禽的沙门氏菌定殖的益生菌的新方法，来自粪便粪便或成年禽类的盲肠内容物。 将粪便或盲肠内容物与培养基组合，并在无氧条件下进行稀释（即分批培养）孵育。 在该初步温育之后，将所得培养物进行连续流动条件直到达到稳定状态，此后可以恢复稳态培养物以用作益生菌。
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公开(公告)号：US5308615A
公开(公告)日：1994-05-03
申请号：US822505
申请日：1992-01-17
IPC分类号： A23K1/16 , A01N63/00 , A61K35/74 , A61K35/741 , A61K35/744 , A61K35/747 , C12N1/20
CPC分类号： C12R1/01 , A61K35/741 , A61K35/744 , A61K35/747
摘要： Salmonella colonization of fowl may be effectively controlled or inhibited using a defined composition of anaerobic bacteria (i.e., probiotic). the probiotic includes a first culture of substantially pure anaerobic bacteria effective for fermenting lactic acid to produce volatile organic acids including acetic, propionic and/or butyric acids. A second culture of at least one anaerobic bacteria effective for fermenting carbonhydrates to produce lactic acid is also employed in combination with the above-mentioned first cuture. Suitable organisms for use in this first culture include bacteria of the genera Veillonella, Megasphaera, and mixtures thereof. These first and second cultures are administered to the subject fowl in amounts effective for inhibiting Salmonella colonization thereof. In one embodiment, the above-mentioned probiotic may be combined with a conventional feed, providing a novel feed product which may be orally ingested by the fowl.
摘要翻译： 可以使用规定的厌氧细菌组合物（即益生菌）有效地控制或抑制家禽的沙门氏菌定植。 益生菌包括有效用于发酵乳酸以产生包括乙酸，丙酸和/或丁酸的挥发性有机酸的基本纯净的厌氧细菌的第一培养物。 至少一种有效用于发酵碳水化合物以产生乳酸的至少一种厌氧细菌的第二种培养物也与上述第一种切割剂组合使用。 用于该第一培养物中的合适的生物体包括韦勒氏菌属，大戟科及其混合物的细菌。 将这些第一和第二培养物以有效抑制其沙门氏菌定植的量给予受试禽。 在一个实施方案中，上述益生菌可以与常规饲料组合，提供可以由家禽口服摄取的新型饲料产品。
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公开(公告)号：US5951977A
公开(公告)日：1999-09-14
申请号：US949348
申请日：1997-10-14
IPC分类号： A61K35/74 , A61K35/742 , A61K35/744 , C12N1/20
CPC分类号： C12R1/46 , A23K10/18 , A23K50/30 , A61K35/74 , A61K35/742 , A61K35/744 , C12N1/20
摘要： A defined probiotic or composition of anaerobic bacteria effective for controlling or inhibiting Salmonella colonization of swine is disclosed. The probiotic includes populations or cultures of substantially biologically pure bacteria which include:Enterococcus faecalis,Streptococcus bovis,Clostridium clostridiforme,Clostridium symbiosum,Clostridium ramosum,Bacteroides fragilis,Bacteroides distasonis,Bacteroides vulgatus,Bacteroides thetaiotamicron, andBacteroides caccae.In use, the probiotic is administered to the subject swine in an amount effective for increasing resistance to Salmonella colonization thereof.
摘要翻译： 公开了一种定义好的有益于控制或抑制猪沙门氏菌定殖的厌氧细菌的益生菌或组合物。 益生菌包括基本上生物纯的细菌的群体或培养物，其包括：粪肠球菌，牛链球菌，梭菌，梭菌，梭菌，脆弱拟杆菌，特异拟杆菌，拟杆菌和拟杆菌。 在使用中，将益生菌以有效增加对其沙门氏菌定植的抗性的量施用于受试者的猪。
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公开(公告)号：US06555106B2
公开(公告)日：2003-04-29
申请号：US09779179
申请日：2001-02-08
IPC分类号： A01N6300
摘要： The invention provides a method and compositions for controlling food borne enteric bacterial pathogens in poultry populations. The incidence of the colonization of poultry by enteropathogenic bacteria, and/or the populations of enteropathogenic bacteria within colonized poultry, may by substantially reduced by providing particles of an expanded matrix material to the locus or vicinity of the animals, particularly during the period of feed removal prior to slaughter. The method and compositions are particularly useful for the control of Salmonella species, enteropathogenic Escherichia coli, and Campylobacter species.
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7.发明授权公开(公告)号：US06228355B1
公开(公告)日：2001-05-08
申请号：US09592777
申请日：2000-06-13
IPC分类号： C12N120
摘要： The invention provides a method and compositions for controlling food borne enteric bacterial pathogens in poultry populations. The incidence of the colonization of poultry by enteropathogenic bacteria, and/or the populations of enteropathogenic bacteria within colonized poultry, may by substantially reduced by providing particles of an expanded matrix material to the locus or vicinity of the animals, particularly during the period of feed removal prior to slaughter. The method and compositions are particularly useful for the control of Salmonella species, enteropathogenic Escherichia coli, and Campylobacter species.
摘要翻译： 本发明提供了一种用于控制家禽种群中食物肠道细菌病原体的方法和组合物。 肠道致病细菌和/或肠道致病细菌种群在定殖家禽中的殖民发生率可以通过将动物的场所或附近的特别是饲料期间的扩展基质材料的颗粒提供给基本上减少， 屠宰之前移走。 该方法和组合物特别适用于沙门氏菌属，肠致病性大肠杆菌和弯曲杆菌属物种的控制。
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