公开(公告)号：US4952498A

公开(公告)日：1990-08-28

申请号：US191197

申请日：1988-05-06

申请人： John R. Waters

发明人： John R. Waters

IPC分类号： C12M1/24 ,  C12M1/34 ,  C12Q1/04

CPC分类号： C12M23/08 ,  C12M23/38 ,  C12Q1/04 ,  C12Q2304/40 ,  Y10S435/807

摘要： Gas-generating activity of microorganisms is detected by providing a vessel in which the microorganisms are incubated, the vessel having a cap with a membrane indicator therein. The membrane has a deformed region which is inflated to indicate the existence of an increase in pressure within the vessel as compared with ambient pressure. Visual or automatic monitoring of the inflated portion is disclosed.

公开(公告)号：US4632902A

公开(公告)日：1986-12-30

申请号：US688276

申请日：1985-01-03

申请人： John R. Waters ,  Rodney Broman

发明人： John R. Waters ,  Rodney Broman

IPC分类号： C12Q1/16 ,  C12Q1/02

CPC分类号： C12Q1/16 ,  Y10S435/803

摘要： A method of detections biological activity is disclosed. A nutrient growth medium which isolates antibiotics and other microbial growth inhibitors during culturing of a microorganism. The growth medium includes an aqueous dispersion of nutrient materials and an effective amount of an isolating substance or substances capable of isolating antimicrobial materials during culturing of a microorganism. The isolating substances are selected from ion exchange resins and non-functional adsorbent resins.

摘要翻译： 公开了一种检测生物活性的方法。 营养生长培养基，其在培养微生物期间分离抗生素和其他微生物生长抑制剂。 生长培养基包括营养物质的水性分散体和有效量的在微生物培养过程中能够分离抗菌物质的分离物质或物质。 隔离物质选自离子交换树脂和非功能吸附树脂。

公开(公告)号：US4122626A

公开(公告)日：1978-10-31

申请号：US728934

申请日：1976-10-04

申请人： John R. Waters

发明人： John R. Waters

IPC分类号： A63H27/00 ,  A63H33/00

CPC分类号： A63H27/00

摘要： A pair of arched wings are secured together at their inner ends by a connecting member to form a body portion. A weight is secured to the body portion to provide proper balance in flight. The wings have an upwardly arched configuration which may be accomplished either by molding them in such configuration or by constructing them from a blank which has a curvature therein such as from a cylindrical tubular member. In one embodiment, the wings have a reduced radius toward the front to provide a hang glider type construction which requires no tail.

摘要翻译： 一对拱形翼在其内端由连接构件固定在一起以形成主体部分。 重量被固定到主体部分以在飞行中提供适当的平衡。 翼具有向上拱形的构造，其可以通过在这种构造中模制它们或者通过从其中具有曲率的坯料（例如从圆柱形管状构件）构造而完成。 在一个实施例中，翼部朝向前部具有减小的半径，以提供不需要尾部的悬挂滑翔机类型结构。

公开(公告)号：US3997404A

公开(公告)日：1976-12-14

申请号：US581277

申请日：1975-05-27

申请人： John R. Waters

发明人： John R. Waters

IPC分类号： C12M1/34 ,  C12Q1/16 ,  G01N21/76 ,  C12K1/04

CPC分类号： C12Q1/16 ,  C12M41/34 ,  C12M41/36 ,  G01N21/76 ,  Y10S435/808

摘要： A method for characterization of biological activity comprising providing a plurality of gas-tight cells each having a light-permeable wall section, each cell containing a different .sup.14 C-labeled fermentable substrate, a carbon dioxide absorber and a scintillation compound in intimate proximity to each other remote from said substrate, and an axenic sample of a biologically active material; subjecting said cells to conditions conducive to biological activity and thereafter measuring the light emitted by the scintillation compound as a result of the decay of .sup.14 CO.sub.2 generated by the metabolic action of the biologically active agent in said sample on said substrate and captured by the carbon dioxide absorber. Apparatus is provided comprising a plurality of sterile chambers containing different .sup.14 C-labeled fermentable substrates, means to facilitate introduction of an axenic sample of a biologically active agent into each chamber, means for sealing each chamber to form a gas-tight cell having a light-permeable wall section, and a carbon dioxide absorber and a scintillation compound in intimate proximity to each other in each cell adjacent the light-permeable wall section.

摘要翻译： 一种用于表征生物活性的方法，包括提供多个具有透光壁部分的气密细胞，每个细胞含有不同的14C标记的可发酵底物，二氧化碳吸收剂和闪烁化合物彼此紧邻 远离所述衬底，以及生物活性材料的无色样品; 对所述细胞进行有利于生物活性的条件，然后测量由闪烁化合物发射的光，其是由所述样品中所述生物活性剂在所述底物上的代谢作用产生的14CO 2的衰变并由二氧化碳吸收剂 。 提供了包括多个含有不同14C标记的可发酵底物的无菌室的装置，有助于将生物活性剂的无菌样品引入每个室中的装置，用于密封每个室以形成具有发光基底的气密细胞的装置， 可渗透壁部分，以及邻近透光壁部分的每个细胞中彼此紧密相邻的二氧化碳吸收剂和闪烁体。

公开(公告)号：US5624814A

公开(公告)日：1997-04-29

申请号：US326155

申请日：1994-10-19

申请人： John R. Waters ,  Rodney Broman

发明人： John R. Waters ,  Rodney Broman

IPC分类号： C12Q1/04 ,  C12Q1/02

CPC分类号： C12Q1/045

摘要： A nutrient culture medium which isolates antibiotics and other microbial growth inhibitors during culturing of a microorganism is shown. The culture medium includes an aqueous dispersion of nutrient materials and an effective amount of an isolating substance or substances capable of isolating antimicrobial materials during culturing of a microorganism.The isolating substances are selected from ion exchange resins and non-functional adsorbent resins.

摘要翻译： 显示了在培养微生物期间分离抗生素和其他微生物生长抑制剂的营养培养基。 培养基包括营养物质的水性分散体和有效量的在微生物培养过程中能够分离抗菌物质的分离物质或物质。 隔离物质选自离子交换树脂和非功能吸附树脂。

公开(公告)号：US4730624A

公开(公告)日：1988-03-15

申请号：US525332

申请日：1983-08-22

申请人： John R. Waters

发明人： John R. Waters

IPC分类号： A61B5/15 ,  A61B5/14

CPC分类号： A61B5/153 ,  A61B5/15003 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150389 ,  A61B5/150496 ,  A61B5/150732 ,  A61B5/150351

摘要： A vacuum blood collection system is provided. The blood collection system contains an evacuated sample collection container which is open at both ends. One end of the container is closed by a self-sealing puncturable stopper adapted to be penetrated by one end of a double ended needle. The other end of the collection container is closed by a slidable sealing stopper affixed to a plunger to provide a piston assembly. The blood collection system also includes restraining means to prevent premature movement of the slidable sealing stopper and may contain a temporary seal to prevent movement of the piston assembly prior to the need for removing the blood specimen from the collection container.

摘要翻译： 提供真空采血系统。 采血系统包含一个在两端打开的抽空样本收集容器。 容器的一端由适合于被双头针的一端穿透的自密封穿刺塞子封闭。 收集容器的另一端由固定在柱塞上的可滑动密封止动器封闭以提供活塞组件。 血液收集系统还包括限制装置，以防止可滑动的密封止动器的过早运动，并且可能包含临时密封件，以在需要从收集容器移除血液样本之前防止活塞组件移动。

公开(公告)号：US4624648A

公开(公告)日：1986-11-25

申请号：US748181

申请日：1985-06-24

申请人： John R. Waters

发明人： John R. Waters

IPC分类号： A63H33/40 ,  A63H29/10

CPC分类号： A63H33/40

摘要： A rotary aerial toy comprising a tubular sleeve of flexible material and of circular cross section. In one form of the invention the tubular sleeve tapers from one end toward the other with air entering the larger head end and moving toward the tail end. The head end is adapted for a bridle connection for supporting the sleeve for wind passage therethrough. The sleeve comprises plural strips extending at least generally longitudinally of the sleeve with each strip being of substantially right triangular form, at least at the head end portion thereof. The strips are connected to one another with the hypotenuse leg of one strip being connected to the altitude leg of an adjacent strip and with the base leg being transverse. The strips are arranged at assembly with a step between the head ends of adjacent strips and the seams connecting any selected pair of strips stop short of the head end of the altitude leg of the strip. The head end margins of the strips are secured to a ring to provide airchutes causing the tubular sleeve to rotate. In one form of the invention the strips are spiral along the length of the sleeve, whereas in another form, the strips extend essentially longitudinally of the sleeve. In a further form of the invention, the sleeve can be in the form of a cone. In still another form, the sleeve can be a cylinder. The application also covers the method of producing the above rotary aerial sleeve toys. In a further form, the strips are secured together to form a ringless sleeve. In another form the strips have integral bridle line portions whose free ends are connected by a fastener.

摘要翻译： 一种旋转天线玩具，包括柔性材料的管状套筒和圆形横截面。 在本发明的一种形式中，管状套筒从一端向另一端逐渐变细，空气进入较大的头端并向尾端移动。 头端适于用于支撑套管以用于通过其中的风路的连接件。 套筒包括至少大致纵向延伸的多个条带，每个条带至少在其头端部处具有基本上为三角形的形状。 条带彼此连接，一个条带的斜边腿连接到相邻条带的高度腿，并且基部腿是横向的。 条带以相邻条带的头端之间的台阶组装而布置，并且连接任何选定的一对条的接缝在条带的高度腿的头端短。 条带的头端边缘固定到环上以提供导致管状套筒旋转的气缸。 在本发明的一种形式中，条带沿着套筒的长度是螺旋形的，而在另一种形式中，条带基本上在套筒的纵向延伸。 在本发明的另一形式中，套筒可以是锥体的形式。 在另一种形式中，套筒可以是圆筒。 该应用还涉及生产上述旋转式空中套筒玩具的方法。 在另一种形式中，条被固定在一起以形成无环套筒。 在另一种形式中，条带具有整体的线条部分，其自由端通过紧固件连接。

公开(公告)号：US4073691A

公开(公告)日：1978-02-14

申请号：US717351

申请日：1976-08-24

申请人： Joseph E. Ahnell ,  Rodney L. Broman ,  John R. Waters

发明人： Joseph E. Ahnell ,  Rodney L. Broman ,  John R. Waters

IPC分类号： C12Q1/04 ,  C12K1/04

CPC分类号： C12Q1/04 ,  C12Q2304/46 ,  Y10S435/803 ,  Y10S435/807 ,  Y10S435/874

摘要： A sample of material to be tested for the presence of biologically active agents, such as bacteria, is introduced into a sealable container partially filled with a culture medium; the remainder of the container being filled with a culture gas, the container and its contents are subjected to conditions conducive to biological activity for a predetermined period sufficient for fermentation of the medium to produce at least one gaseous product after which the character of the culture gas in the container is determined and compared to the initial character of the culture gas in order to detect any differences caused by changes in the composition of the culture gas indicating the presence or absence of biologically active agents in the sample.

摘要翻译： 将要测试的生物活性剂如细菌的待测试材料样品引入部分填充有培养基的可密封容器中; 容器的剩余部分填充有培养气体，容器及其内容物经受有利于生物活性的条件达预定时间，足以使培养基发酵以产生至少一种气态产物，之后培养气体的特性 在容器中确定并与培养气体的初始特性进行比较，以便检测由样品中存在或不存在生物活性剂的培养气体组成变化引起的任何差异。

公开(公告)号：US4257187A

公开(公告)日：1981-03-24

申请号：US947723

申请日：1978-10-02

申请人： John R. Waters

发明人： John R. Waters

IPC分类号： A63H27/00 ,  A63H27/16

CPC分类号： A63H27/00

摘要： A pair of arched wings are secured together at their inner ends by a connecting member to form a body portion. A weight is secured to the body portion to provide proper balance in flight. The wings have an upwardly arched configuration which may be accomplished either by molding them in such configuration or by constructing them from a blank which has a curvature therein such as from a cylindrical tubular member. In one embodiment, the wings have a reduced radius toward the front to provide a hang glider type construction which requires no tail.

摘要翻译： 一对拱形翼在其内端由连接构件固定在一起以形成主体部分。 重量被固定到主体部分以在飞行中提供适当的平衡。 翼具有向上拱形的构造，其可以通过在这种构造中模制它们或者通过从其中具有曲率的坯料（例如从圆柱形管状构件）构造而完成。 在一个实施例中，翼部朝向前部具有减小的半径，以提供不需要尾部的悬挂滑翔机类型结构。

公开(公告)号：US4073694A

公开(公告)日：1978-02-14

申请号：US673359

申请日：1976-04-05

申请人： Dennis Buda ,  Rodney L. Broman ,  John R. Waters

发明人： Dennis Buda ,  Rodney L. Broman ,  John R. Waters

IPC分类号： C12Q1/18 ,  C12K1/00

CPC分类号： C12Q1/18 ,  Y10S435/873

摘要： A method of measuring the level of an aminoglycoside antibiotic, such as gentamicin, tobramycin or amikacin, in blood serum or plasma comprising incubating an aliquot of blood serum or plasma from a human patient being treated with an aminoglycoside antibiotic in a urea-containing culture medium with a susceptible strain of an adaptive urease producing microorganism corresponding to Proteus rettgeri JLI 03, ATCC No. 31168.

摘要翻译： 一种测量血清或血浆中氨基糖苷类抗生素（如庆大霉素，妥布霉素或阿米卡星）的含量的方法，包括在含尿素培养基中用氨基糖苷类抗生素处理的人类血清或血浆的等分试样 具有与Proteus rettgeri JLI 03，ATCC No.31168相对应的适应性脲酶产生微生物的敏感菌株。