公开(公告)号：US20060014756A1

公开(公告)日：2006-01-19

申请号：US11029064

申请日：2005-01-04

Applicant: Michael Edwards ,  Paul Cox ,  Shelley Amendola ,  Stephanie Deprets ,  Timothy Gillespy ,  Christopher Edlin ,  Andrew Morley ,  Charles Gardner ,  Brian Pedgrift ,  Herve Bouchard ,  Didier Babin ,  Laurence Gauzy ,  Alain Le-Brun ,  Tahir Majid ,  John Reader ,  Lloyd Payne ,  Nawaz Khan ,  Michael Cherry

Inventor： Michael Edwards ,  Paul Cox ,  Shelley Amendola ,  Stephanie Deprets ,  Timothy Gillespy ,  Christopher Edlin ,  Andrew Morley ,  Charles Gardner ,  Brian Pedgrift ,  Herve Bouchard ,  Didier Babin ,  Laurence Gauzy ,  Alain Le-Brun ,  Tahir Majid ,  John Reader ,  Lloyd Payne ,  Nawaz Khan ,  Michael Cherry

IPC: A61K31/496 ,  A61K31/4184 ,  C07D43/02

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04

Abstract: The invention is directed to physiologically active compounds of the general formula (Ix) and compositions containing such compounds, and their prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their prodrugs, as well as to novel compounds within the scope of formula (Ix), and to processes for their preparation. Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit kinases.

Abstract translation: 本发明涉及通式（Ix）的生理活性化合物和含有这些化合物及其前药以及这些化合物及其前药的药学上可接受的盐和溶剂合物的组合物，以及式（Ix）范围内的新化合物 Ix），以及它们的制备过程。 这些化合物和组合物具有有价值的药物特性，特别是抑制激酶的能力。

公开(公告)号：US20050018746A1

公开(公告)日：2005-01-27

申请号：US10626696

申请日：2003-07-25

Applicant: John Reader ,  Amichai Shdaimah ,  Fred Ferguson

Inventor： John Reader ,  Amichai Shdaimah ,  Fred Ferguson

IPC: G01N25/20 ,  B65D17/30 ,  G01N5/04 ,  G01N35/02 ,  G01N35/04 ,  B25J15/00 ,  G01N35/10 ,  G05B19/04

CPC classification number: G01N35/04 ,  G01N2035/0403 ,  G01N2035/0465

Abstract: The present invention relates to apparatus, systems, and methods for opening an autosampler sealed sample pan prior to TGA testing. The sealed sample pan comprises a pan, cover, and bail. A notch is formed in the seal sample pan cover. The cover can be opened by applying a concentrated force to the inside of the notch with a punch element integrated into the autosampler. This causes the center disk portion of the cover to be partially sheared and the sealed sample pan to be opened. It also prevents the punch element from touching the sample. A force sensor is used to determine if the cover has been opened. If the cover has been opened, then the sample pan is loaded to the TGA balance. If the cover has not been opened, the autosampler will not load the pan and will automatically move to the next sealed sample pan.

Abstract translation: 本发明涉及在TGA测试之前打开自动进样器密封样品盘的装置，系统和方法。 密封的样品盘包括锅，盖和保释。 在密封样品盘盖中形成切口。 通过将集中的力通过集成到自动进样器中的冲头元件向凹口的内部施加集中力来打开盖。 这使得盖的中心盘部分被部分地剪切并且密封的样品盘被打开。 也可以防止冲头元件接触样品。 力传感器用于确定盖子是否打开。 如果盖已经打开，则样品盘将被加载到TGA天平。 如果盖子尚未打开，则自动进样器将不会装入纸盘，并自动移动到下一个密封的样品盘中。

公开(公告)号：US07386524B2

公开(公告)日：2008-06-10

申请号：US09887824

申请日：2001-06-22

Applicant: John Reader Hubbell ,  Martha Torrey O'Connor ,  Mark Stewart Nichols ,  Alexander Han Leung Poon ,  Eren Tolga Rosenfeld ,  Beth Elyse Zadik ,  Alexander Zorba

Inventor： John Reader Hubbell ,  Martha Torrey O'Connor ,  Mark Stewart Nichols ,  Alexander Han Leung Poon ,  Eren Tolga Rosenfeld ,  Beth Elyse Zadik ,  Alexander Zorba

IPC: G06N5/00

CPC classification number: G09B7/02 ,  G09B5/06 ,  G09B19/18

Abstract: A system is disclosed that provides a goal based learning system utilizing a rule based expert training system to provide a cognitive educational experience. The system provides the user with a simulated environment that presents a business opportunity to understand and solve optimally. Mistakes are noted and remedial educational material presented dynamically to build the necessary skills that a user requires for success in the business endeavor. The system utilizes an artificial intelligence engine driving individualized and dynamic feedback with synchronized video and graphics used to simulate real-world environment and interactions. Multiple “correct” answers are integrated into the learning system to allow individualized learning experiences in which navigation through the system is at a pace controlled by the learner. A robust business model provides support for realistic activities and allows a user to experience real world consequences for their actions and decisions and entails realtime decision-making and synthesis of the educational material. A dynamic feedback system is utilized that narrowly tailors feedback and focuses it based on the performance and characteristics of the student to assist the student in reaching a predefined goal.

Abstract translation: 公开了一种系统，其提供基于目标的学习系统，其利用基于规则的专家训练系统来提供认知教育经验。 该系统为用户提供了一个模拟环境，为您提供了理解和最佳解决方案的商机。 注意到错误，并动态呈现补救性教材，以建立用户在业务活动中获得成功所需的必要技能。 该系统利用人造智能引擎，驱动具有同步视频和图形的个性化和动态反馈，用于模拟现实环境和交互。 将多个“正确”答案整合到学习系统中，以允许个人化的学习体验，其中通过系统的导航处于学习者控制的步伐。 强大的商业模式提供对现实活动的支持，并允许用户体验现实世界对他们的行动和决策的后果，并需要实时决策和综合教材。 利用动态反馈系统，根据学生的表现和特点，对反馈进行狭义定制并对其进行重点调整，以帮助学生达到预定义的目标。

公开(公告)号：US20060040968A1

公开(公告)日：2006-02-23

申请号：US11032299

申请日：2005-01-10

Applicant: Paul Fleming ,  Zhan Shi ,  Brendan Chen ,  Jane Schmidt ,  John Reader ,  Neal Hone ,  Jeffrey Ciavarri

Inventor： Paul Fleming ,  Zhan Shi ,  Brendan Chen ,  Jane Schmidt ,  John Reader ,  Neal Hone ,  Jeffrey Ciavarri

IPC: A61K31/506 ,  C07D403/02

CPC classification number: C07D239/42 ,  C07D401/10 ,  C07D403/10

Abstract: A heterocyclic inhibitor having the formula I, with the variables defined herein, which is useful for treating inflammatory and other physiological disorders in which PKC-theta isoform plays a role:

Abstract translation: 具有式I的杂环抑制剂，其具有本文定义的变量，其可用于治疗其中PKC-θ同种型起作用的炎性和其他生理障碍：

公开(公告)号：US6125358A

公开(公告)日：2000-09-26

申请号：US221608

申请日：1998-12-22

Applicant: John Reader Hubbell ,  Mark Stewart Nichols

Inventor： John Reader Hubbell ,  Mark Stewart Nichols

IPC: G09B7/04 ,  G06F17/20

CPC classification number: G09B7/04 ,  Y10S706/925

Abstract: A system is disclosed that provides a goal based learning system utilizing a rule based expert training system to provide a cognitive educational experience. The system provides the user with a simulated environment that presents a business opportunity to understand and solve optimally. Mistakes are noted and remedial educational material presented dynamically to build the necessary skills that a user requires for success in the business endeavor. The system utilizes an artificial intelligence engine driving individualized and dynamic feedback with synchronized video and graphics used to simulate real-world environment and interactions. Multiple "correct" answers are integrated into the learning system to allow individualized learning experiences in which navigation through the system is at a pace controlled by the learner. A robust business model provides support for realistic activities and allows one or more users to experience real world consequences for their actions in one or more simulated environments and make decisions that entail realtime decision-making and synthesis of the educational material.

Abstract translation: 公开了一种系统，其提供基于目标的学习系统，其利用基于规则的专家训练系统来提供认知教育经验。 该系统为用户提供了一个模拟环境，为您提供了理解和最佳解决方案的商机。 注意到错误，并动态呈现补救性教材，以建立用户在业务活动中获得成功所需的必要技能。 该系统利用人造智能引擎，驱动具有同步视频和图形的个性化和动态反馈，用于模拟现实环境和交互。 将多个“正确”答案整合到学习系统中，以允许个人化的学习体验，其中通过系统的导航处于学习者控制的步伐。 强大的商业模式提供对现实活动的支持，并允许一个或多个用户体验其在一个或多个模拟环境中的行为的真实世界后果，并做出需要实时决策和综合教育材料的决策。

公开(公告)号：US20060208098A1

公开(公告)日：2006-09-21

申请号：US11349338

申请日：2006-02-08

Applicant: Amichai Shdaimah ,  John Reader ,  Eric Pilacik

Inventor： Amichai Shdaimah ,  John Reader ,  Eric Pilacik

IPC: G01N25/00 ,  F24F3/14 ,  G05D22/02

CPC classification number: G01N5/04 ,  G01N5/025 ,  G01N5/045 ,  G05D22/02 ,  G05D27/02

Abstract: Embodiments of the present invention relate to apparatus, systems and methods for adding a humidity-controlled system to a thermogravimetric instrument. A humidity-controlled controlled chamber incorporates a housing, a humidifier, a sample chamber, a reference chamber, Peltier devices, humidity and temperature sensors, and gas transmission lines into a single unit. This single unit along with an electronic control unit and mass flow controllers provide a humidity-controlled system designed to control the atmosphere of TGA sample and reference chambers simultaneously. A system comprising an arm, motorized linear actuator an electric control unit, allows a humidity-controlled chamber to be automatically opened and closed, in turn, allowing reference and sample chambers to automatically be accessed.

公开(公告)号：US20060027670A1

公开(公告)日：2006-02-09

申请号：US10910575

申请日：2004-08-04

Applicant: Amichai Shdaimah ,  John Reader ,  Eric Pilacik

Inventor： Amichai Shdaimah ,  John Reader ,  Eric Pilacik

IPC: G01N25/00 ,  F24F3/14 ,  G05D22/02 ,  F24F11/00

CPC classification number: G01N5/045 ,  G01N5/025 ,  G05D22/02

Abstract: Embodiments of the present invention relate to apparatus, systems and methods for adding a humidity-controlled system to a thermogravimetric instrument. A humidity-controlled chamber incorporates a housing, a humidifier, a sample chamber, a reference chamber, Peltier devices, humidity and temperature sensors, and gas transmission lines into a single unit. This single unit along with an electronic control unit and mass flow controllers provide a humidity-controlled system designed to control the atmosphere of TGA sample and reference chambers simultaneously. A system comprising an arm, motorized linear actuator and electronic control unit, allows a humidity-controlled chamber to be automatically opened and closed, in turn, allowing reference and sample chambers to automatically be accessed.