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公开(公告)号：US07471765B2
公开(公告)日：2008-12-30
申请号：US11023037
申请日：2004-12-27
IPC分类号： A61N5/10
CPC分类号： A61B6/032 , A61B6/027 , A61B6/06 , A61B6/4085 , A61B6/4405 , A61B6/4458 , A61B6/466 , A61B6/482 , A61B6/508 , A61B6/583 , A61N5/1038 , A61N5/1049 , A61N5/1065 , A61N5/1069 , A61N2005/1061
摘要： A radiation therapy system that includes a radiation source that moves about a path and directs a beam of radiation towards an object and a cone-beam computer tomography system. The cone-beam computer tomography system includes an x-ray source that emits an x-ray beam in a cone-beam form towards an object to be imaged and an amorphous silicon flat-panel imager receiving x-rays after they pass through the object, the imager providing an image of the object. A computer is connected to the radiation source and the cone beam computerized tomography system, wherein the computer receives the image of the object and based on the image sends a signal to the radiation source that controls the path of the radiation source.
摘要翻译： 一种放射治疗系统，其包括围绕路径移动并将辐射束引向物体的辐射源和锥束计算机断层摄影系统。 锥束计算机断层摄影系统包括：x射线源，其以锥形束朝向待成像的物体发射X射线束;以及非晶硅平板成像器，在它们通过物体之后接收x射线 ，成像器提供对象的图像。 计算机连接到辐射源和锥束计算机断层摄影系统，其中计算机接收对象的图像并且基于图像将信号发送到控制辐射源的路径的辐射源。
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2.发明授权Processes and intermediates useful in preparing β3-adrenergic receptor agonists 失效可用于制备β3肾上腺素能受体激动剂的方法和中间体公开(公告)号：US06919460B2
公开(公告)日：2005-07-19
申请号：US10682762
申请日：2003-10-09
申请人： Robert J. Chambers , Robert W. Dugger , Ming Kang , Yong Tao , John W. Wong
发明人： Robert J. Chambers , Robert W. Dugger , Ming Kang , Yong Tao , John W. Wong
IPC分类号： C12P17/12 , A61K31/4439 , A61P3/04 , A61P3/10 , C07D213/30 , C07D413/12 , C07D213/26 , A61K31/4406 , C07D213/46
CPC分类号： C07D213/30 , C07D413/12
摘要： The present invention provides processes useful in the preparation of certain β3-adrenergic receptor agonists of the structural formula the pharmaceutically acceptable salts thereof, and the hydrates of said pharmaceutically acceptable salts, wherein HET is as described herein. The invention further provides intermediates useful in the preparation of such agonists, and processes useful in the production of such intermediates.
摘要翻译： 本发明提供了可用于制备结构式的其药学上可接受的盐的某些β3 - 肾上腺素能受体激动剂和所述药学上可接受的盐的水合物的方法，其中HET如本文所述。 本发明还提供了可用于制备这种激动剂的中间体，以及可用于生产这种中间体的方法。
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3.发明授权Microbial process for preparation of optically active 3-hydroxypyrrolidine derivatives 失效用于制备光学活性3-羟基吡咯烷衍生物的微生物方法公开(公告)号：US06613550B2
公开(公告)日：2003-09-02
申请号：US09796278
申请日：2001-02-28
申请人： John W. Wong
发明人： John W. Wong
IPC分类号： C12P1710
CPC分类号： C12P41/002 , C12P17/10 , C12P41/00
摘要： The present invention is directed to a process for the production of compounds of the formula: from a compound of the formula comprising hydroxylating a compound of the formula I in the presence of an enzyme produced by a microorganism of the genera Cunninghamella species or Aspergillus. Preferred microorganisms are Cunninghamella echinulata var. elegans and Aspergillus flavipes. Mixtures of compounds of formulae II and III may also be highly enriched in their composition of compound II by using the enzyme from Cunninghamella echinulata ATC 8688b.
摘要翻译： 本发明涉及一种制备下式化合物的方法：由在本发明的化合物中制备式I化合物的化合物在由坎宁坎属或曲霉属的微生物产生的酶的存在下进行羟化。优选的微生物 是Cunninghamella echinulata var。 线虫和曲霉菌。通过使用Cunninghamella echinulata ATC 8688b的酶，式II和III化合物的混合物也可以高度富集其化合物II的组成。
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4.发明授权X-ray transparent hospital bed compatible with open geometry portable CT scanners 有权X射线透明医院床兼容开放式几何便携式CT扫描仪公开(公告)号：US06526609B2
公开(公告)日：2003-03-04
申请号：US09821004
申请日：2001-03-29
申请人： John W. Wong
发明人： John W. Wong
IPC分类号： A47B700
CPC分类号： A61B6/0442 , A61G7/012 , A61G7/0513 , A61G7/1017 , A61G7/103 , A61G7/1034 , A61G7/1046 , A61G7/1057 , A61G7/1067 , A61G2210/50 , Y10S5/942
摘要： A hospital bed adapted for use with an open geometry imaging system, such as a C-arm imager. The hospital bed includes a mobile base, a frame, a bed top, and a patient support. At least one portion of the bed top and patient support are substantially radiotransparent. The radiotransparent portions are capable of axial displacement along the lengthwise axis of the bed, thereby allowing the use of an imager on a patient in the bed without interference from the base. The axial displacement is preferably indexed to at least one predetermined stop position. One or more independent lateral sections can be selectively moved away from the radiotransparent portion, allowing for a reduction in the overall width of the bed. A patient transport system, in which the bed top and attached patient support can be used as a portable support, such as a stretcher, and may be secured to the base for subsequent transport and/or imaging when appropriate.
摘要翻译： 适用于开放几何成像系统的医院床，如C形臂成像仪。 医院病床包括移动基座，框架，床顶和患者支架。 床顶部和患者支架的至少一部分基本上是无线电透射的。 无线电透射部分能够沿着床的纵向轴向轴向移动，从而允许在床上的患者上使用成像器而不受到基部的干扰。 轴向位移优选地被索引到至少一个预定的停止位置。 一个或多个独立的横向部分可以选择性地远离无线电透射部分移动，从而允许床的整体宽度的减小。 患者运输系统，其中床顶和附接的患者支撑件可以用作便携式支撑件，例如担架，并且可以固定到基座，以便在适当时进行后续运输和/或成像。
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公开(公告)号：US20110228906A1
公开(公告)日：2011-09-22
申请号：US12917079
申请日：2010-11-01
CPC分类号： A61B6/032 , A61B6/027 , A61B6/06 , A61B6/4085 , A61B6/4405 , A61B6/4458 , A61B6/466 , A61B6/482 , A61B6/508 , A61B6/583 , A61N5/1038 , A61N5/1049 , A61N5/1065 , A61N5/1069 , A61N2005/1061
摘要： A radiation therapy system that includes a radiation source that moves about a path and directs a beam of radiation towards an object and a cone-beam computer tomography system. The cone-beam computer tomography system includes an x-ray source that emits an x-ray beam in a cone-beam form towards an object to be imaged and an amorphous silicon flat-panel imager receiving x-rays after they pass through the object, the imager providing an image of the object. A computer is connected to the radiation source and the cone beam computerized tomography system, wherein the computer receives the image of the object and based on the image sends a signal to the radiation source that controls the path of the radiation source.
摘要翻译： 一种放射治疗系统，其包括围绕路径移动并将辐射束引向物体的辐射源和锥束计算机断层摄影系统。 锥束计算机断层摄影系统包括：x射线源，其以锥形束朝向待成像的物体发射X射线束;以及非晶硅平板成像器，在它们通过物体之后接收x射线 ，成像器提供对象的图像。 计算机连接到辐射源和锥束计算机断层摄影系统，其中计算机接收对象的图像并且基于图像将信号发送到控制辐射源的路径的辐射源。
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公开(公告)号：US07826592B2
公开(公告)日：2010-11-02
申请号：US12313646
申请日：2008-11-21
CPC分类号： A61B6/032 , A61B6/027 , A61B6/06 , A61B6/4085 , A61B6/4405 , A61B6/4458 , A61B6/466 , A61B6/482 , A61B6/508 , A61B6/583 , A61N5/1038 , A61N5/1049 , A61N5/1065 , A61N5/1069 , A61N2005/1061
摘要： A radiation therapy system that includes a radiation source that moves about a path and directs a beam of radiation towards an object and a cone-beam computer tomography system. The cone-beam computer tomography system includes an x-ray source that emits an x-ray beam in a cone-beam form towards an object to be imaged and an amorphous silicon flat-panel imager receiving x-rays after they pass through the object, the imager providing an image of the object. A computer is connected to the radiation source and the cone beam computerized tomography system, wherein the computer receives the image of the object and based on the image sends a signal to the radiation source that controls the path of the radiation source.
摘要翻译： 一种放射治疗系统，其包括围绕路径移动并将辐射束引向物体的辐射源和锥束计算机断层摄影系统。 锥束计算机断层摄影系统包括：x射线源，其以锥形束朝向待成像的物体发射X射线束;以及非晶硅平板成像器，在它们通过物体之后接收x射线 ，成像器提供对象的图像。 计算机连接到辐射源和锥束计算机断层摄影系统，其中计算机接收对象的图像并且基于图像将信号发送到控制辐射源的路径的辐射源。
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公开(公告)号：US06842502B2
公开(公告)日：2005-01-11
申请号：US09788335
申请日：2001-02-16
IPC分类号： G21K5/00 , A61B6/00 , A61B6/03 , A61B6/06 , A61N5/10 , G01T1/20 , G01T1/24 , G21K5/02 , H05G1/60
CPC分类号： A61B6/032 , A61B6/027 , A61B6/06 , A61B6/4085 , A61B6/4405 , A61B6/4458 , A61B6/466 , A61B6/482 , A61B6/508 , A61B6/583 , A61N5/1038 , A61N5/1049 , A61N5/1065 , A61N5/1069 , A61N2005/1061
摘要： A radiation therapy system that includes a radiation source that moves about a path and directs a beam of radiation towards an object and a cone-beam computer tomography system. The cone-beam computer tomography system includes an x-ray source that emits an x-ray beam in a cone-beam form towards an object to be imaged and an amorphous silicon flat-panel imager receiving x-rays after they pass through the object, the imager providing an image of the object. A computer is connected to the radiation source and the cone beam computerized tomography system, wherein the computer receives the image of the object and based on the image sends a signal to the radiation source that controls the path of the radiation source.
摘要翻译： 一种放射治疗系统，其包括围绕路径移动并将辐射束引向物体的辐射源和锥束计算机断层摄影系统。 锥束计算机断层摄影系统包括：x射线源，其以锥形束朝向待成像的物体发射X射线束;以及非晶硅平板成像器，在它们通过物体之后接收x射线 ，成像器提供对象的图像。 计算机连接到辐射源和锥束计算机断层摄影系统，其中计算机接收对象的图像并且基于图像将信号发送到控制辐射源的路径的辐射源。
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公开(公告)号：US08135111B2
公开(公告)日：2012-03-13
申请号：US12917079
申请日：2010-11-01
CPC分类号： A61B6/032 , A61B6/027 , A61B6/06 , A61B6/4085 , A61B6/4405 , A61B6/4458 , A61B6/466 , A61B6/482 , A61B6/508 , A61B6/583 , A61N5/1038 , A61N5/1049 , A61N5/1065 , A61N5/1069 , A61N2005/1061
摘要： A radiation therapy system that includes a radiation source that moves about a path and directs a beam of radiation towards an object and a cone-beam computer tomography system. The cone-beam computer tomography system includes an x-ray source that emits an x-ray beam in a cone-beam form towards an object to be imaged and an amorphous silicon flat-panel imager receiving x-rays after they pass through the object, the imager providing an image of the object. A computer is connected to the radiation source and the cone beam computerized tomography system, wherein the computer receives the image of the object and based on the image sends a signal to the radiation source that controls the path of the radiation source.
摘要翻译： 一种放射治疗系统，其包括围绕路径移动并将辐射束引向物体的辐射源和锥束计算机断层摄影系统。 锥束计算机断层摄影系统包括：x射线源，其以锥形束朝向待成像的物体发射X射线束;以及非晶硅平板成像器，在它们通过物体之后接收x射线 ，成像器提供对象的图像。 计算机连接到辐射源和锥束计算机断层摄影系统，其中计算机接收对象的图像并且基于图像将信号发送到控制辐射源的路径的辐射源。
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9.发明授权Method and apparatus for delivering radiation therapy during suspended ventilation 失效在悬吊通气期间传送放射治疗的方法和装置公开(公告)号：US07393329B1
公开(公告)日：2008-07-01
申请号：US09424431
申请日：1998-05-22
IPC分类号： A61B5/08
CPC分类号： A61N5/1048 , A61M16/024 , A61M16/106 , A61M16/22 , A61M2016/0036 , A61N5/1064 , Y10S128/916
摘要： Methods and apparatus for delivering radiation therapy to patients during suspended ventilation are provided. The apparatus includes a ventilator assembly having first and second selectively operable valves that independently control inhalation and exhalation of the patient. Both valves are shut to suspend patient ventilation for a period of time. In the methods of the present invention, radiation therapy is administered during this period of suspended patient ventilation.
摘要翻译： 提供了在悬浮通气期间向患者输送辐射治疗的方法和装置。 该装置包括具有独立地控制患者的吸入和呼气的第一和第二可选择性操作的阀的通气机组件。 关闭两个阀门以暂停患者通气一段时间。 在本发明的方法中，在暂停患者通气期间施用放射治疗。
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公开(公告)号：US06746856B2
公开(公告)日：2004-06-08
申请号：US09924292
申请日：2001-08-08
申请人： James J. Cawley , John W. Wong
发明人： James J. Cawley , John W. Wong
IPC分类号： C12P1700
摘要： The present invention relates to processes for the microbial oxidation of bicyclic heteroaromatic compounds which comprise contacting these compounds with a microorganism, or a suitable mutant thereof, and incubating the resulting mixture under conditions sufficient to yield an amount of their respective carboxylic acids. The present processes optionally further comprise the isolation and purification of the product carboxylic acids.
摘要翻译： 本发明涉及双环杂芳族化合物的微生物氧化方法，其包括使这些化合物与微生物或其合适的突变体接触，并将所得混合物在足以产生其各自羧酸的量的条件下孵育。 本方法任选进一步包括产物羧酸的分离和纯化。
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