-
1.发明申请公开(公告)号：US20110027295A1
公开(公告)日：2011-02-03
申请号：US12676741
申请日：2008-09-08
CPC分类号： A61K31/53 , A61K38/177 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/40 , A61K2300/00
摘要： Described are uses of A2a adenosine receptor antagonists and agonists to provide long term modulation of immune responses. A2a receptor antagonists in particular are provided to enhance immune responses by reducing T-cell mediated tolerance to antigenic stimuli and agonists are provided to enhance effectiveness of immunosuppressive agents. The application provides methods of treatment and prevention based on the long term effects of the compounds on T cell responses.
摘要翻译： 描述了A2a腺苷受体拮抗剂和激动剂用于提供免疫应答的长期调节的用途。 提供A2a受体拮抗剂以通过降低T细胞介导的对抗原刺激的耐受性来增强免疫应答，并提供激动剂以增强免疫抑制剂的有效性。 该应用基于化合物对T细胞应答的长期作用提供了治疗和预防的方法。
-
2.发明授权公开(公告)号：US09585957B2
公开(公告)日：2017-03-07
申请号：US12676741
申请日：2008-09-08
IPC分类号： A61K39/00 , A61P37/00 , A61P35/00 , A61K45/06 , A61K39/395
CPC分类号： A61K31/53 , A61K38/177 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/40 , A61K2300/00
摘要： Described are uses of A2a adenosine receptor antagonists and agonists to provide long term modulation of immune responses. A2a receptor antagonists in particular are provided to enhance immune responses by reducing T-cell mediated tolerance to antigenic stimuli and agonists are provided to enhance effectiveness of immunosuppressive agents. The application provides methods of treatment and prevention based on the long term effects of the compounds on T cell responses.
摘要翻译： 描述了A2a腺苷受体拮抗剂和激动剂用于提供免疫应答的长期调节的用途。 提供A2a受体拮抗剂以通过降低T细胞介导的对抗原刺激的耐受性来增强免疫应答，并提供激动剂以增强免疫抑制剂的有效性。 该应用基于化合物对T细胞应答的长期作用提供了治疗和预防的方法。
-
3.发明申请Manipulation of Regulatory T Cell and Dc Function By Targeting Neuritin Gene Using Antibodies, Agonists and Antagonists 审中-公开通过使用抗体，激动剂和拮抗剂靶向神经元基因来操纵调节性T细胞和Dc功能公开(公告)号：US20100040636A1
公开(公告)日：2010-02-18
申请号：US11991693
申请日：2006-09-11
申请人： Hong Yu , Drew Pardoll , Xiaoya Pan , Charles George Drake , Jonathan D. Powell , Ching-Tai Huang
发明人： Hong Yu , Drew Pardoll , Xiaoya Pan , Charles George Drake , Jonathan D. Powell , Ching-Tai Huang
IPC分类号： A61K39/395 , A61K35/12 , A61K38/16 , C07K16/00 , A61P31/00 , C07H21/00 , A61P35/00 , C12N15/63 , A61P37/06 , A01K67/027 , C12Q1/02
CPC分类号： C07K14/475 , A01K67/0275 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/0325 , A61K38/00 , A61K48/00 , C07K16/22 , C07K2319/30 , C12N15/8509 , C12N2510/00 , C12N2830/008 , G01N33/505
摘要： We demonstrate herein that neuritin controls the homeostasis of regulatory T cells in an antigen dependent manner. Based on this discovery, we describe herein the application of neuritin as a therapeutic agent to manipulate antigen specific regulatory T cells in various disease settings is described. Thus manipulation of Treg cells and DCs through neuritin can be used to enhance immunotherapy of autoimmune diseases, cancer and infectious diseases, as well as enhance lymphocyte engraftment in settings of donor lymphocyte infusion, bone marrow transplant, as well as other types of transplants, and adoptive transfer.
摘要翻译： 我们在这里证明神经细胞以抗原依赖的方式控制调节性T细胞的体内平衡。 基于这一发现，我们在这里描述了神经元作为治疗剂在各种疾病设置中操作抗原特异性调节性T细胞的应用。 因此，通过神经氨酸处理Treg细胞和DC可用于增强自身免疫性疾病，癌症和感染性疾病的免疫治疗，以及在供体淋巴细胞输注，骨髓移植以及其他类型的移植环境中增强淋巴细胞移植，以及 收养转让。
-
公开(公告)号：US20110229498A1
公开(公告)日：2011-09-22
申请号：US12991654
申请日：2009-05-08
申请人： Charles George Drake , Drew M. Pardoll , Jonathan Davie Powell , Derese Getnet , Edward Luther Hipkiss , Joseph Frank Grosso
发明人： Charles George Drake , Drew M. Pardoll , Jonathan Davie Powell , Derese Getnet , Edward Luther Hipkiss , Joseph Frank Grosso
CPC分类号： C12Q1/6881 , A61K39/0011 , A61K39/39 , A61K2039/55561 , A61K2039/572 , C07K14/4702 , C12N15/113 , C12N15/117 , C12N2310/14 , C12N2310/17 , C12N2320/31 , C12Q2600/136 , G01N33/5011
摘要： The invention generally features compositions and methods for modulating an immune response. In particular embodiments, such compositions and methods modulate regulatory T cell suppressive activity.
摘要翻译： 本发明通常具有用于调节免疫应答的组合物和方法。 在具体实施方案中，这样的组合物和方法调节调节性T细胞抑制活性。
-
5.发明授权公开(公告)号：US09132281B2
公开(公告)日：2015-09-15
申请号：US14127597
申请日：2012-06-19
申请人： Jing Zeng , Charles George Drake , Drew M. Pardoll , Michael Lim
发明人： Jing Zeng , Charles George Drake , Drew M. Pardoll , Michael Lim
IPC分类号： G21K5/04 , A61N5/10 , A61K41/00 , C07K16/24 , C07K16/28 , A61K45/06 , A61K39/395 , A61K39/00
CPC分类号： A61N5/1001 , A61K39/39558 , A61K41/00 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2300/00 , A61N5/1042 , C07K16/24 , C07K16/2818 , C07K16/2878
摘要： An approach combining immune-based therapies with focused radiation, including stereotactic radiation, to treat cancers is disclosed. The use of focused radiation primes the immune system in a similar manner to vaccines to augment immune-based therapies and can counteract the suppressive effects of a tumor. The combination of focused radiation and immune-based therapies, including administration of at least one immunotherapeutic agent, improves survival compared to each therapy alone and can, in some cases, lead to a durable cure. Accordingly, focused radiation can be an adjuvant for immune-based therapies for treating cancers.
摘要翻译： 公开了一种将基于免疫的疗法与聚焦辐射（包括立体定向辐射）结合治疗癌症的方法。 使用聚焦辐射以与疫苗相似的方式对免疫系统进行补充，以增强基于免疫的疗法，并且可以抵消肿瘤的抑制作用。 聚焦辐射和基于免疫的疗法的组合，包括施用至少一种免疫治疗剂，与单独的每种治疗相比，改善了存活，并且在一些情况下可以导致持久的治愈。 因此，聚焦辐射可以是用于治疗癌症的基于免疫的疗法的佐剂。
-
6.发明申请公开(公告)号：US20140155678A1
公开(公告)日：2014-06-05
申请号：US14127597
申请日：2012-06-19
申请人： Jing Zeng , Charles George Drake , Drew M. Pardoll , Michael Lim
发明人： Jing Zeng , Charles George Drake , Drew M. Pardoll , Michael Lim
IPC分类号： A61N5/10 , A61K45/06 , A61K39/395
CPC分类号： A61N5/1001 , A61K39/39558 , A61K41/00 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2300/00 , A61N5/1042 , C07K16/24 , C07K16/2818 , C07K16/2878
摘要： An approach combining immune-based therapies with focused radiation, including stereotactic radiation, to treat cancers is disclosed. The use of focused radiation primes the immune system in a similar manner to vaccines to augment immune-based therapies and can counteract the suppressive effects of a tumor. The combination of focused radiation and immune-based therapies, including administration of at least one immunotherapeutic agent, improves survival compared to each therapy alone and can, in some cases, lead to a durable cure. Accordingly, focused radiation can be an adjuvant for immune-based therapies for treating cancers.
摘要翻译： 公开了一种将基于免疫的疗法与聚焦辐射（包括立体定向辐射）结合治疗癌症的方法。 使用聚焦辐射以与疫苗相似的方式对免疫系统进行补充，以增强基于免疫的疗法，并且可以抵消肿瘤的抑制作用。 聚焦辐射和基于免疫的疗法的组合，包括施用至少一种免疫治疗剂，与单独的每种治疗相比，改善了存活，并且在一些情况下可以导致持久的治愈。 因此，聚焦辐射可以是用于治疗癌症的基于免疫的疗法的佐剂。
-
公开(公告)号：US09248170B2
公开(公告)日：2016-02-02
申请号：US13663045
申请日：2012-10-29
申请人： Young Jun Kim , Drew M. Pardoll , Charles George Drake , Meghan Davis , Juan Fu
发明人： Young Jun Kim , Drew M. Pardoll , Charles George Drake , Meghan Davis , Juan Fu
IPC分类号： A61K38/18 , C12N15/27 , A61K35/12 , A61K39/00 , A61K45/06 , A61K38/19 , A61K31/7024 , A61K31/739 , A61K35/36 , A61K35/38 , A61K35/39 , A61K35/55 , A61K38/12
CPC分类号： A61K39/0011 , A61K31/7024 , A61K31/739 , A61K35/12 , A61K35/36 , A61K35/38 , A61K35/39 , A61K35/55 , A61K38/193 , A61K39/0005 , A61K45/06 , A61K2039/5152 , A61K2039/5156 , A61K2039/55511 , A61K2039/55522 , A61K2039/55572 , A61K2300/00
摘要： The invention provides provides immunogenic compositions comprising neoplastic cells expressing a cytokine (GM-CSF) formulated with at least one TLR agonist and methods of using the composition to induce or enhance an immune response.
摘要翻译： 本发明提供了包含表达与至少一种TLR激动剂配制的细胞因子（GM-CSF）的肿瘤细胞的免疫原性组合物以及使用该组合物诱导或增强免疫应答的方法。
-
公开(公告)号：US20130177625A1
公开(公告)日：2013-07-11
申请号：US13663045
申请日：2012-10-29
申请人： Young Jun Kim , Drew M. Pardoll , Charles George Drake , Meghan Davis , Juan Fu
发明人： Young Jun Kim , Drew M. Pardoll , Charles George Drake , Meghan Davis , Juan Fu
CPC分类号： A61K39/0011 , A61K31/7024 , A61K31/739 , A61K35/12 , A61K35/36 , A61K35/38 , A61K35/39 , A61K35/55 , A61K38/193 , A61K39/0005 , A61K45/06 , A61K2039/5152 , A61K2039/5156 , A61K2039/55511 , A61K2039/55522 , A61K2039/55572 , A61K2300/00
摘要： The invention provides provides immunogenic compositions comprising neoplastic cells expressing a cytokine (GM-CSF) formulated with at least one TLR agonist and methods of using the composition to induce or enhance an immune response.
摘要翻译： 本发明提供了包含表达与至少一种TLR激动剂配制的细胞因子（GM-CSF）的肿瘤细胞的免疫原性组合物以及使用该组合物诱导或增强免疫应答的方法。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.025 秒)
