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    SYSTEM AND METHOD FOR FORMING A CURVED TUNNEL IN BONE
    1.
    发明申请
    SYSTEM AND METHOD FOR FORMING A CURVED TUNNEL IN BONE 有权
    用于形成骨折的隧道的系统和方法

    公开(公告)号：US20140171948A1

    公开(公告)日：2014-06-19

    申请号：US14084460

    申请日：2013-11-19

    申请人： JERRY R. GRIFFITHS ,  JOSE FERNANDEZ

    发明人： JERRY R. GRIFFITHS ,  JOSE FERNANDEZ

    IPC分类号： A61B17/16 ,  A61B17/17

    CPC分类号： A61B17/1796 ,  A61B17/00234 ,  A61B17/04 ,  A61B17/1615 ,  A61B17/1631 ,  A61B17/1633 ,  A61B17/1637 ,  A61B17/1642 ,  A61B2017/00309 ,  A61B2017/00323 ,  Y10T29/49826

    摘要： A drill system for forming a curved tunnel in a bone includes a drill bit guidance device. The drill bit guidance device includes an elongated stationary outer tube extending along a first axis and an elongated inner tube. The elongated inner tube is configured to slidably move within the elongated stationary outer tube along the first axis and to exit from a distal end of the elongated outer tube. The elongated inner tube has a partially slotted distal end portion including a plurality of semi-cross-sectional slots extending perpendicular to the first axis. Each slot is configured to collapse inward in the slot direction when exiting the distal end of the elongated outer tube, thereby curving the distal end portion of the elongated inner tube.

    摘要翻译： 用于在骨中形成弯曲隧道的钻机系统包括钻头引导装置。 钻头引导装置包括沿着第一轴线延伸的细长的固定外管和细长的内管。 细长的内管构造成沿着第一轴线在细长的固定外管内滑动地移动并从细长的外管的远端排出。 细长的内管具有部分开槽的远端部分，其包括垂直于第一轴线延伸的多个半横截面槽。 每个槽被配置为当离开细长外管的远端时在槽方向上向内折叠，从而弯曲细长内管的远端部分。

    Reader shield with tilted magnetization
    2.
    发明授权
    Reader shield with tilted magnetization 有权
    读卡器屏蔽具有倾斜磁化

    公开(公告)号：US08422177B2

    公开(公告)日：2013-04-16

    申请号：US12771490

    申请日：2010-04-30

    申请人： Juan Jose Fernandez-de-Castro

    发明人： Juan Jose Fernandez-de-Castro

    IPC分类号： G11B5/33

    CPC分类号： G11B5/3912 ,  G11B5/115

    摘要： An apparatus that includes a first read shield and a second read shield and a reader stack between the first and second read shields. The first and second read shields each include a tilted magnetization layer closest to the reader stack to control magnetic field flux lines in a free layer of the reader stack and thereby improve a selectivity of the reader to independently sense and isolate media transitions.

    摘要翻译： 一种包括第一读取屏蔽和第二读取屏蔽以及在第一和第二读取屏蔽之间的读取器堆叠的装置。 第一和第二读取屏蔽每个包括最靠近读取器堆叠的倾斜磁化层，以控制读取器堆叠的自由层中的磁场通量线，从而提高读取器独立地感测和隔离媒体转变的选择性。

    Multi-transmitter interferometry
    4.
    发明授权
    Multi-transmitter interferometry 失效
    多发射干涉测量

    公开(公告)号：US08159387B1

    公开(公告)日：2012-04-17

    申请号：US12798170

    申请日：2010-03-15

    申请人： Jose Fernandez ,  Richard Rikoski ,  John Stroud

    发明人： Jose Fernandez ,  Richard Rikoski ,  John Stroud

    IPC分类号： G01S13/42 ,  G01S3/80

    CPC分类号： G01S15/46 ,  G01S13/48

    摘要： Systems and methods for obtaining target elevation information are disclosed. The systems and methods use multiple vertical transmitters and one or more receivers to infer changes in the elevation plane and the height of objects. Changes in elevation and heights of objects are inferred from path length differences between the transmitters and a particular backscattering point. Using known geometric information regarding the configuration of the transmitters, propagation time differences can be estimated via time delay estimation methods in either the time or frequency domain. Appropriate modulation schemes are used such that the multiple signals transmitted are separable upon reception.

    摘要翻译： 公开了用于获得目标高程信息的系统和方法。 系统和方法使用多个垂直发射器和一个或多个接收器来推断仰角平面中的变化和物体的高度。 物体高程和高度的变化由发射机与特定的后向散射点之间的路径长度差异推断出来。 使用关于发射机的配置的已知几何信息，可以通过时域或频域中的时间延迟估计方法估计传播时间差。 使用适当的调制方案，使得发送的多个信号在接收时是可分离的。

    Flexible support member with high pushability
    5.
    发明申请
    Flexible support member with high pushability 审中-公开
    灵活的支撑构件具有高推力

    公开(公告)号：US20070173862A1

    公开(公告)日：2007-07-26

    申请号：US11338300

    申请日：2006-01-24

    申请人： Jose Fernandez ,  Heather Harries

    发明人： Jose Fernandez ,  Heather Harries

    IPC分类号： A61F11/00

    CPC分类号： A61F2/95

    摘要： The present invention is directed to the field of medical devices, and in particular, to a medical device for delivering a medical implant to a patient's body, the device having a pushing member that is constructed of tubes arranged coaxially.

    摘要翻译： 本发明涉及医疗装置的领域，特别涉及用于将医疗植入物递送到患者身体的医疗装置，该装置具有由同轴布置的管构成的推动构件。

    Hyaluronic acid nanoparticles
    7.
    发明申请
    Hyaluronic acid nanoparticles 审中-公开
    透明质酸纳米粒子

    公开(公告)号：US20060188578A1

    公开(公告)日：2006-08-24

    申请号：US10561548

    申请日：2004-06-17

    申请人： Maria Jose Fernandez ,  Maria Fuente Freire ,  Maria Seijo Rey

    发明人： Maria Jose Fernandez ,  Maria Fuente Freire ,  Maria Seijo Rey

    IPC分类号： A61K31/728 ,  A61K9/14

    CPC分类号： A61K9/5161 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/5192 ,  A61K47/36 ,  C08J3/14 ,  C08J2305/08 ,  C08L5/08

    摘要： The invention relates to hyaluronic acid nanoparticles for the administration of at least one active ingredient. The inventive nanoparticles comprise hyaluronic acid in salt form a positively-charged polymer, a polyanionic salt and at least one active ingredient. The method of obtaining the aforementioned nanoparticles comprises the following steps consisting in: preparing an aqueous solution of a hyaluronic acid salt, preparing an aqueous solution of a cationic polymer, adding a polyanionic salt to the solution of the hyaluronic acid salt, and stir-mixing said solutions such as to produce the nanoparticles, the active ingredient being dissolved in one of the initial solutions or in the suspension of nanoparticles obtained in order to be absorbed on the nanoparticles. The invention also relates to pharmaceutical and cosmetic compositions comprising the above-mentioned nanoparticles.

    摘要翻译： 本发明涉及用于施用至少一种活性成分的透明质酸纳米颗粒。 本发明的纳米颗粒包含盐形式的透明质酸，带正电荷的聚合物，聚阴离子盐和至少一种活性成分。 获得上述纳米颗粒的方法包括以下步骤：制备透明质酸盐的水溶液，制备阳离子聚合物的水溶液，将聚阴离子盐加入到透明质酸盐的溶液中，并搅拌混合 所述溶液例如产生纳米颗粒，活性成分溶解在初始溶液之一或为了被吸收在纳米颗粒上而获得的纳米颗粒的悬浮液中。 本发明还涉及包含上述纳米颗粒的药物和化妆品组合物。

    Plasma glucosylceramide deficiency as risk factor for thrombosis and modulator of anticoagulant protein C
    8.
    发明授权
    Plasma glucosylceramide deficiency as risk factor for thrombosis and modulator of anticoagulant protein C 失效
    血浆葡萄糖神经酰胺缺乏作为血栓形成的危险因素和抗凝血蛋白C的调节剂

    公开(公告)号：US06756208B2

    公开(公告)日：2004-06-29

    申请号：US10086943

    申请日：2002-02-28

    申请人： John H. Griffin ,  Hiroshi Deguchi ,  Jose Fernandez

    发明人： John H. Griffin ,  Hiroshi Deguchi ,  Jose Fernandez

    IPC分类号： C12Q156

    CPC分类号： C07H15/10 ,  A61K31/739

    摘要： The present invention has determined that exogenously added glycosylceramide (GlcCer) and other neutral glycolipids such as the homologous Glc-containing globotriaosylceramide (Gb3Cer), dose-dependently prolonged clotting times of normal plasma in the presence but not absence of APC:protein S, indicating GlcCer or Gb3Cer can enhance protein C pathway anticoagulant activity. In studies using purified proteins, inactivation of factor Va by APC:protein S was enhanced by GlcCer alone and by GlcCer, globotriaosylceramide, lactosylceramide, and galactosylceramide in multicomponent vesicles containing phosphatidylserine and phosphatidylcholine. Thus, the present invention provides neutral glycolipids such as GlcCer and Gb3Cer, as anticoagulant cofactors that contribute to the antithrombotic activity of the protein C pathway. The present invention has also determined that a deficiency of plasma GlcCer is a risk factor for thrombosis. Methods are provided to determine individuals at risk for thrombosis, methods of treatment as well as methods of screening for antithrombotic factors from neutral glycolipids.

    摘要翻译： 本发明已经确定外源性加入的糖基神经酰胺（GlcCer）和其它中性糖脂如同源的含Glc的球三孢甲酸神经酰胺（Gb3Cer）在APC存在但不存在APC蛋白S的情况下剂量依赖地延长正常血浆的凝血时间，表明 GlcCer或Gb3Cer可增强蛋白C通路的抗凝活性。 在使用纯化的蛋白质的研究中，通过GlcCer单独的GlcCer，GlcCer，globotriaosylceramide，乳糖神经酰胺和半乳糖神经酰胺在含有磷脂酰丝氨酸和磷脂酰胆碱的多组分囊泡中增强了APC因子Va的失活：蛋白S。 因此，本发明提供中性糖脂如GlcCer和Gb3Cer作为有助于蛋白C途径的抗血栓形成活性的抗凝血辅助因子。 本发明还确定血浆GlcCer的不足是血栓形成的危险因素。 提供方法来确定处于血栓形成风险的个体，治疗方法以及从中性糖脂中筛选抗血栓形成因子的方法。

    Machine, program product, and computer-implemented methods for a hybrid command management aggregator
    10.
    发明授权
    Machine, program product, and computer-implemented methods for a hybrid command management aggregator 有权

    公开(公告)号：US09686097B2

    公开(公告)日：2017-06-20

    申请号：US12771358

    申请日：2010-04-30

    申请人： Jesse Johnson ,  Jose Fernandez ,  Stephen Vowell ,  Kevin Mayer

    发明人： Jesse Johnson ,  Jose Fernandez ,  Stephen Vowell ,  Kevin Mayer

    IPC分类号： H04J3/16 ,  H04L12/413 ,  H04W72/08

    CPC分类号： H04L12/6418 ,  H04L5/0044 ,  H04L12/2816 ,  H04L12/413 ,  H04L69/08 ,  H04L2012/6421 ,  H04W72/087

    摘要： A machine, program product, and method for enabling interoperable and low-latency networking among service devices. The machine, program product and methods perform the tasks of automatically matching, upon the receipt of the incoming data transmission, the data transmission to a plurality of analog device protocols to determine the necessary instructions and transmission media to command and control the plurality of analog service devices according to the data transmission or a plurality of digital device protocols to determine the necessary instructions and transmission media to command and control the plurality of digital service devices according to the data transmission, determining an outgoing transmission media for the incoming data transmission, constructing outgoing data transmissions between any of the analog service devices and any of the digital service devices responsive to the matching of the analog and digital device protocols and the identification of the outgoing transmission media, and dynamically allocating frequency spectrum for data transmissions between any of the analog service devices and any of the digital service devices, the dynamic allocation being responsive to any of a service type, service demand, and quality of service threshold for the outgoing transmission media and digital and analog device protocols.