公开(公告)号：US20110065138A1

公开(公告)日：2011-03-17

申请号：US10566050

申请日：2004-07-21

申请人： Luis Miguel Botana López ,  Amparo Alfonso Rancaño ,  Maria Jose Pazos Guldris ,  Mercedes Rodrugues Vieytes ,  Maria Isabel Loza Garcia ,  JUan Manuel Vieites Baptista De Sousa

发明人： Luis Miguel Botana López ,  Amparo Alfonso Rancaño ,  Maria Jose Pazos Guldris ,  Mercedes Rodrugues Vieytes ,  Maria Isabel Loza Garcia ,  JUan Manuel Vieites Baptista De Sousa

IPC分类号： C12Q1/42 ,  A61K31/47

CPC分类号： C12Q1/44 ,  A61K31/35

摘要： The present invention relates to a quantitative method for detecting yessotoxins in fishery products based on the activation the toxin produces on cellular phosphodiesterases and the therapeutic use of this activation. The cellular target of yessotoxin (YTX) and its analogs is the activation of phosphodiesterases (PDEs). The PDEs-YTX bond produces a measurable signal. The bond can be quantified by means of an affinity biosensor or by fluorescence. The biosensor detects biomolecular interactions and allows determining the presence of YTX due to its interaction with PDEs. The variations in the degradation rate of the fluorescent derivative anthraniloyl-cAMP are determined by means of plate fluorescence. The rate at which the PDEs degrade this molecule increases in the presence of YTX. YTX inhibits immunological activation of mastocytes in rats and induces a cytotoxic effect in human hepatocarcinoma cells, which implies two therapeutic uses of YTXs as an antiallergic and antitumor compound.

摘要翻译： 本发明涉及一种基于毒素在细胞磷酸二酯酶上产生的活化以及该活化的治疗用途来检测渔业产品中的黄曲霉毒素的定量方法。 yessotoxin（YTX）及其类似物的细胞靶标是磷酸二酯酶（PDE）的活化。 PDE-YTX键产生可测量的信号。 可以通过亲和生物传感器或通过荧光来定量该键。 生物传感器检测生物分子相互作用，并允许确定YTX由于其与PDE的相互作用而存在。 通过平板荧光测定荧光衍生物苯氨喋呤-CAMP的降解速率的变化。 在YTX存在下，PDE降解该分子的速率增加。 YTX抑制大鼠乳腺细胞的免疫激活，诱导人肝癌细胞的细胞毒作用，这意味着YTXs作为抗过敏和抗肿瘤化合物的两种治疗用途。

公开(公告)号：US20070149631A1

公开(公告)日：2007-06-28

申请号：US11315517

申请日：2005-12-22

申请人： Karl Haider ,  Jose Pazos

发明人： Karl Haider ,  Jose Pazos

IPC分类号： C08G18/00 ,  C08F20/00 ,  C07C43/11

CPC分类号： C08G18/4829 ,  C08G65/10 ,  C08G65/2642 ,  C08G2101/0008

摘要： The present invention provides a long-chain polyether polyol having a number average molecular weight of more than about 1,200 g/mole and produced by alkoxylating an initiator with an alkylene oxide in the presence of a basic catalyst having at least one cation thereof chelated with about 0.5 to about 20 wt. % of a polyoxyethylene-containing compound having a molecular weight of less than about 10,000 g/mole, wherein the weight percentage is based on the weight of the long-chain polyether polyol. The long-chain polyether polyols of the present invention may find use in providing flexible polyurethane foams and non-cellular polyurethanes.

摘要翻译： 本发明提供一种数均分子量大于约1200g / mol的长链聚醚多元醇，其通过在具有至少一个阳离子的碱性催化剂存在下，在烯烃氧化物的存在下，与约 0.5至约20wt。 ％的分子量小于约10,000g / mol的含聚氧乙烯的化合物，其中重量百分数是基于长链聚醚多元醇的重量。 本发明的长链聚醚多元醇可用于提供柔性聚氨酯泡沫和非细胞聚氨酯。

公开(公告)号：US20070106097A1

公开(公告)日：2007-05-10

申请号：US11270100

申请日：2005-11-09

申请人： Jose Pazos ,  Kenneth McDaniel ,  Edward Browne ,  George Combs ,  Don Wardius

发明人： Jose Pazos ,  Kenneth McDaniel ,  Edward Browne ,  George Combs ,  Don Wardius

IPC分类号： C07C41/03

CPC分类号： C08G65/2639 ,  C08G18/283 ,  C08G65/2606 ,  C08G65/2663 ,  C10L1/1985

摘要： The present invention provides a process for the double metal cyanide (DMC)-catalyzed production of low unsaturation polyethers from boron-containing starters. The polyethers produced by the inventive process may be reacted with one or more isocyanates to provide polyurethane products including coatings, adhesives, sealants, elastomers, foams and the like. The inventive process may be used to prepare fuel additives from C9-C30 boron-containing polyethers, more particularly from C13 alcohols.

摘要翻译： 本发明提供了一种双金属氰化物（DMC）催化从含硼起始剂生产低不饱和聚醚的方法。 通过本发明方法制备的聚醚可以与一种或多种异氰酸酯反应以提供包括涂料，粘合剂，密封剂，弹性体，泡沫等的聚氨酯产品。 本发明的方法可以用于从C 9 -C 30 - 含硼聚醚，更特别是C 13-30醇制备燃料添加剂。

公开(公告)号：US20060229375A1

公开(公告)日：2006-10-12

申请号：US11100221

申请日：2005-04-06

申请人： Yu-Ling Hsiao ,  Richard Skorpenske ,  Bryan Kaushiva ,  Kenneth McDaniel ,  Jose Pazos ,  Stanley Hager ,  Karl Haider

发明人： Yu-Ling Hsiao ,  Richard Skorpenske ,  Bryan Kaushiva ,  Kenneth McDaniel ,  Jose Pazos ,  Stanley Hager ,  Karl Haider

IPC分类号： C08G18/00

CPC分类号： C08G18/4891 ,  C08G18/4866 ,  C08G2101/0008 ,  C08G2101/005

摘要： The present invention provides polyurethane foams and elastomers made with an alkoxylated vegetable oil hydroxylate replacing at least a portion of the typically used petroleum-based polyol(s). Also provided are processes for making the inventive foams and elastomers and for making alkoxylated vegetable oil hydroxylates. The alkoxylated vegetable oil hydroxylates are environ mentally-friendly, bio-based polyols which advantageously also offer the potential of improved hydrophobicity in polyurethane foams and elastomers. The inventive polyurethane foams and elastomers may find use in a wide variety of products such as automobile interior parts, polyurethane structural foams, floor coatings and athletic running tracks.

摘要翻译： 本发明提供用烷氧基化植物油羟基化物制备的聚氨酯泡沫和弹性体，代替至少一部分通常使用的石油基多元醇。 还提供了制备本发明的泡沫和弹性体以及用于制备烷氧基化植物油羟基化物的方法。 烷氧基化植物油羟基化物是环境友好的基于生物的多元醇，其有利地也提供了在聚氨酯泡沫和弹性体中改进的疏水性的潜力。 本发明的聚氨酯泡沫和弹性体可以用于各种各样的产品，例如汽车内部部件，聚氨酯结构泡沫，地板涂料和运动跑道。

公开(公告)号：US20070149634A1

公开(公告)日：2007-06-28

申请号：US11315667

申请日：2005-12-22

申请人： Karl Haider ,  Jose Pazos ,  Steven Rodberg ,  Daniel Wagner ,  Jack Reese ,  Barbara Buck

发明人： Karl Haider ,  Jose Pazos ,  Steven Rodberg ,  Daniel Wagner ,  Jack Reese ,  Barbara Buck

IPC分类号： C08G18/00 ,  C07C43/11 ,  C08F20/00

CPC分类号： C08G65/105 ,  C08G18/4841 ,  C08G18/4883 ,  C08G65/2642 ,  C08G2101/00

摘要： The present invention provides a long-chain polyether polyol having a number average molecular weight of greater than about 500 g/mole and produced by alkoxylating a polyoxyethylene-containing initiator with an alkylene oxide in the presence of a basic catalyst having at least one cation thereof chelated by the polyoxyethylene-containing initiator. The inventive long-chain polyether polyols may be used to provide flexible polyurethane foams and non-cellular polyurethanes.

摘要翻译： 本发明提供一种数均分子量大于约500g / mol的长链聚醚多元醇，其通过在具有至少一个阳离子的碱性催化剂存在下，使烯化氧烷氧基化， 由含聚氧乙烯的引发剂螯合。 本发明的长链聚醚多元醇可用于提供柔性聚氨酯泡沫和非细胞聚氨酯。

公开(公告)号：US20070149633A1

公开(公告)日：2007-06-28

申请号：US11315639

申请日：2005-12-22

申请人： Karl Haider ,  Jose Pazos ,  Steven Rodberg

发明人： Karl Haider ,  Jose Pazos ,  Steven Rodberg

IPC分类号： C08G18/00 ,  C08F20/00 ,  C07C43/11

CPC分类号： C08G18/485 ,  C08G65/2645 ,  C08G65/269 ,  C08G2101/0008 ,  C08G2101/005

摘要： The present invention provides a long-chain polyether polyol having a number average molecular weight of greater than about 1,200 g/mole and produced by alkoxylating an initiator with an alkylene oxide in the presence of a basic catalyst having at least one cation thereof chelated with a non-linear polyoxyethylene-containing compound having a functionality of at least about three. The long-chain polyether polyols of the present invention may find use in providing flexible polyurethane foams and non-cellular polyurethanes.

摘要翻译： 本发明提供数均分子量大于约1200g / mol的长链聚醚多元醇，其通过在具有至少一个阳离子的碱性催化剂存在下，使烯化氧烷氧基化而制备，所述碱性催化剂与 具有至少约三个官能度的非线性聚氧乙烯化合物。 本发明的长链聚醚多元醇可用于提供柔性聚氨酯泡沫和非细胞聚氨酯。

公开(公告)号：US20050192369A1

公开(公告)日：2005-09-01

申请号：US10788066

申请日：2004-02-26

申请人： Jose Pazos ,  John Hayes

发明人： Jose Pazos ,  John Hayes

IPC分类号： C08F2/44 ,  C08F283/06 ,  C08G18/42 ,  C08G18/48 ,  C08G18/63 ,  C08G65/26 ,  C08J9/00

CPC分类号： C08G65/002 ,  C08G18/4866 ,  C08G18/632 ,  C08G65/26 ,  C08G65/2663 ,  C08G2101/00

摘要： The present invention provides a process for preparing a polymer polyol (PMPO) by alkoxylating a starter compound(s) having active hydrogen atoms in the presence of a double metal cyanide (DMC) catalyst, radical initiator(s) and optionally PMPO stabilizers and simultaneously polymerizing unsaturated monomer(s) with radical initiator(s). The polymer polyols (PMPOs) made by the inventive process may find use in the preparation of polyurethane foams and elastomers.

摘要翻译： 本发明提供一种通过在双金属氰化物（DMC）催化剂，自由基引发剂和任选的PMPO稳定剂的存在下烷氧基化具有活性氢原子的起始化合物来制备聚合物多元醇（PMPO）的方法，同时 用自由基引发剂聚合不饱和单体。 通过本发明方法制备的聚合物多元醇（PMPO）可用于制备聚氨酯泡沫和弹性体。