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    Predictive Method for Controlling a Blood Processing System
    1.
    发明申请
    Predictive Method for Controlling a Blood Processing System 有权
    控制血液处理系统的预测方法

    公开(公告)号：US20100025336A1

    公开(公告)日：2010-02-04

    申请号：US12561419

    申请日：2009-09-17

    申请人： Lee F. CARTER ,  Jeremy P. KOLENBRANDER ,  James R. LADTKOW ,  Joseph A. SCIBONA ,  Jeffrey A. STEWARD ,  Chris FLETCHER

    发明人： Lee F. CARTER ,  Jeremy P. KOLENBRANDER ,  James R. LADTKOW ,  Joseph A. SCIBONA ,  Jeffrey A. STEWARD ,  Chris FLETCHER

    IPC分类号： B04B13/00

    CPC分类号： G01N15/042 ,  A61M1/3693 ,  B04B13/00 ,  B04B2013/006 ,  G01N15/05 ,  G01N2015/047

    摘要： The invention relates generally to methods of monitoring and controlling the processing of blood and blood samples, particularly the separation of blood and blood samples into its components. In one aspect, the invention relates to optical methods for measuring two-dimensional distributions of transmitted light intensities, scattered light intensities or both from a separation chamber of a density centrifuge. The method may include performing first and second measurements of an operating condition; analyzing the first and second measurements using a predictive data analysis algorithm; comparing the predicted operating condition to a desired operating condition; and adjusting at least one setting.

    摘要翻译： 本发明一般涉及监测和控制血液和血液样品的处理，特别是将血液和血液样品分离成其组分的方法。 一方面，本发明涉及用于测量来自密度离心机的分离室的透射光强度，散射光强度或二者的二维分布的光学方法。 该方法可以包括执行操作条件的第一和第二测量; 使用预测数据分析算法分析第一和第二测量; 将预测的操作条件与期望的操作条件进行比较; 并调整至少一个设置。

    Blood processing apparatus with digitally controlled linear voltage regulator for optical pulses
    4.
    发明授权
    Blood processing apparatus with digitally controlled linear voltage regulator for optical pulses 有权
    具有光脉冲数字控制线性电压调节器的血液处理设备

    公开(公告)号：US08241196B2

    公开(公告)日：2012-08-14

    申请号：US12631289

    申请日：2009-12-04

    申请人： Joseph A. Scibona

    发明人： Joseph A. Scibona

    IPC分类号： B04B15/00

    CPC分类号： G01N15/042 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2205/331 ,  B04B13/00 ,  B04B2013/006 ,  G01N15/05 ,  G01N2015/047

    摘要： The invention relates to apparatus for controlling the processing of blood into blood components, particularly components for stroboscopic LED light sources for centrifuges. A digital control circuit controls a high amperage linear voltage regulator. The voltage regulator charges a capacitor bank, which in turn powers LED light sources. The digital control circuit comprises an N-channel switched mode FET. The switched mode FET receives a pulsed digital signal from the microprocessor controlling the blood processing apparatus. A by-pass resistor in parallel with the FET allows most of the current to flow past the FET, thus minimizes heating of the FET. The performance of the FET, therefore, remains stable despite extended use of the apparatus.

    摘要翻译： 本发明涉及用于控制血液加工成血液成分的设备，特别是用于离心机的频闪LED光源的组件。 数字控制电路控制高电流强度的线性稳压器。 电压调节器为电容器组充电，这反过来为LED光源供电。 数字控制电路包括N沟道开关模式FET。 开关模式FET从控制血液处理装置的微处理器接收脉冲数字信号。 与FET并联的旁路电阻允许大部分电流流过FET，从而最小化FET的加热。 因此，即使扩展使用该装置，FET的性能也保持稳定。

    Monitoring and control system for blood processing
    5.
    发明授权
    Monitoring and control system for blood processing 有权
    血液处理监控系统

    公开(公告)号：US07422693B2

    公开(公告)日：2008-09-09

    申请号：US10884877

    申请日：2004-07-01

    申请人： Lee F. Carter ,  Jeremy P. Kolenbrander ,  James R. Ladtkow ,  Joseph A. Scibona ,  Jeffrey A. Steward ,  Chris Fletcher

    发明人： Lee F. Carter ,  Jeremy P. Kolenbrander ,  James R. Ladtkow ,  Joseph A. Scibona ,  Jeffrey A. Steward ,  Chris Fletcher

    IPC分类号： B04B9/10

    CPC分类号： G01N15/042 ,  A61M1/3693 ,  B04B13/00 ,  B04B2013/006 ,  G01N15/05 ,  G01N2015/047

    摘要： The invention relates generally to methods of monitoring and controlling the processing of blood and blood samples, particularly the separation of blood and blood samples into its components. In one aspect, the invention relates to optical methods, devices and device components for measuring two-dimensional distributions of transmitted light intensities, scattered light intensities or both from a separation chamber of a density centrifuge. In embodiment, two-dimensional distributions of transmitted light intensities, scattered light intensities or both measured by the methods of the present invention comprise images of a separation chamber or component thereof, such as an optical cell of a separation chamber. In another aspect, the present invention relates to multifunctional monitoring and control systems for blood processing, particularly blood processing via density centrifugation. Feedback control systems are provided wherein two-dimensional distributions of transmitted light intensities, scattered light intensities or both are measured, processed in real time and are used as the basis of output signals for controlling blood processing. In another aspect, optical cells and methods of using optical cells for monitoring and control blood processing are provided.

    摘要翻译： 本发明一般涉及监测和控制血液和血液样品的处理，特别是将血液和血液样品分离成其组分的方法。 一方面，本发明涉及用于测量来自密度离心机的分离室的透射光强度，散射光强度或二者的二维分布的光学方法，装置和装置部件。 在实施例中，通过本发明的方法测量的透射光强度，散射光强度或二者的二维分布包括分离室或其分量（诸如分离室的光学单元）的图像。 另一方面，本发明涉及用于血液处理的多功能监测和控制系统，特别是通过密度离心进行血液处理。 提供反馈控制系统，其中测量透射光强度，散射光强度或二者的二维分布，实时处理，并用作控制血液处理的输出信号的基础。 在另一方面，提供了光学单元和使用光学单元来监测和控制血液处理的方法。

    Blood processing apparatus with sealed diffuser in optical control apparatus
    6.
    发明授权
    Blood processing apparatus with sealed diffuser in optical control apparatus 有权
    血液处理装置在光学控制装置中具有密封扩散器

    公开(公告)号：US08057376B2

    公开(公告)日：2011-11-15

    申请号：US12241441

    申请日：2008-09-30

    申请人： James R. Ladtkow ,  Joseph A. Scibona ,  Jeremy Kolenbrander

    发明人： James R. Ladtkow ,  Joseph A. Scibona ,  Jeremy Kolenbrander

    IPC分类号： B04B15/00 ,  G02B5/02

    CPC分类号： G01N33/491 ,  G01N15/05 ,  G01N21/51 ,  G02B19/0028 ,  G02B19/0061

    摘要： A centrifugal blood separation apparatus having an optical camera control system with a focused, stationary light source. A diffusion plate mounted on a rotor, rather than on or near the light source, allows an intense light beam to be transmitted from the light source to the rotor and then diffused at the rotor across an observation region. Different characteristics of a diffusion surface allow different lighting regions within the observation region. The diffusion plate has upper and lower plates with a diffusion surface sealed between the plates. This prevents degradation or contamination of the diffusion surface by abrasion, dirt, blood components or other materials that might incidentally contact the diffusion surface.

    摘要翻译： 一种具有光学照相机控制系统的离心式血液分离装置，其具有聚焦的静止光源。 安装在转子上，而不是在光源上或附近的扩散板允许强光束从光源传递到转子，然后在转子处在观察区域上扩散。 扩散表面的不同特性允许观察区域内的不同照明区域。 扩散板具有在板之间密封的扩散表面的上板和下板。 这可防止由于磨损，污垢，血液成分或可能附带地接触扩散表面的其它材料而导致的扩散表面的降解或污染。

    Blood Processing Apparatus With Sealed Diffuser in Optical Control Apparatus
    7.
    发明申请
    Blood Processing Apparatus With Sealed Diffuser in Optical Control Apparatus 有权
    带有密封散射器的血液处理装置在光学控制装置中

    公开(公告)号：US20090156383A1

    公开(公告)日：2009-06-18

    申请号：US12241441

    申请日：2008-09-30

    申请人： James R. LADTKOW ,  Joseph A. SCIBONA ,  Jeremy KOLENBRANDER

    发明人： James R. LADTKOW ,  Joseph A. SCIBONA ,  Jeremy KOLENBRANDER

    IPC分类号： B04B7/00 ,  G02B5/02

    CPC分类号： G01N33/491 ,  G01N15/05 ,  G01N21/51 ,  G02B19/0028 ,  G02B19/0061

    摘要： A centrifugal blood separation apparatus having an optical camera control system with a focused, stationary light source. A diffusion plate mounted on a rotor, rather than on or near the light source, allows an intense light beam to be transmitted from the light source to the rotor and then diffused at the rotor across an observation region. Different characteristics of a diffusion surface allow different lighting regions within the observation region. The diffusion plate has upper and lower plates with a diffusion surface sealed between the plates. This prevents degradation or contamination of the diffusion surface by abrasion, dirt, blood components or other materials that might incidentally contact the diffusion surface.

    摘要翻译： 一种具有光学照相机控制系统的离心式血液分离装置，其具有聚焦的静止光源。 安装在转子上，而不是在光源上或附近的扩散板允许强光束从光源传递到转子，然后在转子处在观察区域上扩散。 扩散表面的不同特性允许观察区域内的不同照明区域。 扩散板具有在板之间密封的扩散表面的上板和下板。 这可防止由于磨损，污垢，血液成分或可能附带地接触扩散表面的其它材料而导致的扩散表面的降解或污染。

    Stroboscopic LED light source for blood processing apparatus
    8.
    发明授权
    Stroboscopic LED light source for blood processing apparatus 有权
    射频LED光源用于血液处理设备

    公开(公告)号：US07355685B2

    公开(公告)日：2008-04-08

    申请号：US11867816

    申请日：2007-10-05

    申请人： Joseph A. Scibona ,  Shannon Durkee

    发明人： Joseph A. Scibona ,  Shannon Durkee

    IPC分类号： G01N33/48

    CPC分类号： A61M1/3693 ,  A61M1/3696 ,  A61M2205/331 ,  B04B13/00 ,  B04B2013/006 ,  G01N15/042 ,  G01N15/05 ,  G01N33/5002 ,  G01N2015/047

    摘要： The invention relates to apparatus for controlling the processing of blood into blood components, particularly components for stroboscopic LED light sources for centrifuges. The stroboscopic apparatus comprises a first light source with reflective surfaces spaced around a central illumination axis, and light-emitting diodes spaced away from the axis radially outward from the reflective surfaces. An additional light source comprises a modified parabolic reflector surrounding a light emitting diode, the parabolic reflector having walls spaced outwardly from an axis of symmetry such that focal points fall radially outwardly from a center of the LED, forming a circular focal area. A controller that energizes the diodes for selected periods of time comprises a pair of switches connected in series, with an LED connected between the switches. One of the switches is connected to ground and is closed at the end of a period of illumination.

    摘要翻译： 本发明涉及用于控制血液加工成血液成分的设备，特别是用于离心机的频闪LED光源的组件。 频闪设备包括具有围绕中心照明轴线间隔开的反射表面的第一光源和从反射表面径向向外离开轴线的发光二极管。 附加的光源包括围绕发光二极管的修改的抛物面反射器，抛物面反射器具有从对称轴向外间隔开的壁，使得焦点从LED的中心径向向外放置，形成圆形焦点区域。 在二选一时间段上激励二极管的控制器包括串联连接的一对开关，LED连接在开关之间。 其中一个开关连接到地面，并在照明周期结束时关闭。

    Stroboscopic LED light source for blood processing apparatus
    9.
    发明授权
    Stroboscopic LED light source for blood processing apparatus 有权

    公开(公告)号：US07327443B2

    公开(公告)日：2008-02-05

    申请号：US10905353

    申请日：2004-12-29

    申请人： Joseph A. Scibona ,  Shannon Durkee

    发明人： Joseph A. Scibona ,  Shannon Durkee

    IPC分类号： G01N33/48

    CPC分类号： A61M1/3693 ,  A61M1/3696 ,  A61M2205/331 ,  B04B13/00 ,  B04B2013/006 ,  G01N15/042 ,  G01N15/05 ,  G01N33/5002 ,  G01N2015/047

    摘要： The invention relates to apparatus for controlling the processing of blood into blood components, particularly components for stroboscopic LED light sources for centrifuges. The stroboscopic apparatus comprises a first light source with reflective surfaces spaced around a central illumination axis, and light-emitting diodes spaced away from the axis radially outward from the reflective surfaces. An additional light source comprises a modified parabolic reflector surrounding a light emitting diode, the parabolic reflector having walls spaced outwardly from an axis of symmetry such that focal points fall radially outwardly from a center of the LED, forming a circular focal area. A controller that energizes the diodes for selected periods of time comprises a pair of switches connected in series, with an LED connected between the switches. One of the switches is connected to ground and is closed at the end of a period of illumination.