公开(公告)号：US20050106366A1

公开(公告)日：2005-05-19

申请号：US10969758

申请日：2004-10-20

申请人： Joseph Schulman ,  Joseph Lucisano ,  Rajiv Shah ,  Charles Byers ,  Shaun Pendo

发明人： Joseph Schulman ,  Joseph Lucisano ,  Rajiv Shah ,  Charles Byers ,  Shaun Pendo

IPC分类号： A61L2/00 ,  A61N1/02 ,  B05D3/00 ,  B32B9/00 ,  C23C14/00 ,  C23C14/04 ,  G03F1/00 ,  G03F7/20 ,  H01L21/308 ,  H01L23/29 ,  H05K3/28 ,  B32B15/04 ,  C23C14/32

CPC分类号： G03F7/70641 ,  A61N1/02 ,  A61N1/375 ,  C23C14/042 ,  H01L21/308 ,  H01L23/291 ,  H01L2924/0002 ,  H05K3/284 ,  Y10T29/49144 ,  Y10T428/24802 ,  Y10T428/24917 ,  Y10T428/24926 ,  Y10T428/265 ,  H01L2924/00

摘要： A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material comprises a thin layer or layers of alumina, zerconia, or other ceramic, less than 25 microns thick, e.g., 5-10 microns thick. The alumina layer(s) may be applied at relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils area while soaking in a saline solution at temperatures up to 80° C. over a three month period.

公开(公告)号：US20050059871A1

公开(公告)日：2005-03-17

申请号：US10698911

申请日：2003-10-31

申请人： David Gough ,  Michael Jablecki ,  Joseph Lucisano ,  Mark Catlin

发明人： David Gough ,  Michael Jablecki ,  Joseph Lucisano ,  Mark Catlin

IPC分类号： A61B5/00 ,  A61B5/05

CPC分类号： A61B5/14865 ,  A61B5/0031 ,  A61B5/14532

摘要： A tissue-implantable sensor for measurement of solutes in fluids and gases, such as oxygen and glucose, is provided. The sensor includes a multiplicity of detectors, constructed and arranged to improve the probability that one or more detectors will have access to a vascular source at points in time sufficient to permit accurate measurements to be taken. Means and methods for calculating solute levels using the sensor device of the invention are also provided.

摘要翻译： 提供了用于测量流体和气体中的溶质（例如氧气和葡萄糖）的组织可植入传感器。 传感器包括多个检测器，其被构造和布置成提高一个或多个检测器在足以允许进行精确测量的时间点处进入血管源的概率。 还提供了使用本发明的传感器装置计算溶质水平的方法和方法。

公开(公告)号：US20080033272A1

公开(公告)日：2008-02-07

申请号：US11823477

申请日：2007-06-26

申请人： David Gough ,  Michael Jablecki ,  Joseph Lucisano ,  Mark Catlin

发明人： David Gough ,  Michael Jablecki ,  Joseph Lucisano ,  Mark Catlin

IPC分类号： A61B5/05

CPC分类号： A61B5/14865 ,  A61B5/0031 ,  A61B5/14532

摘要： A tissue-implantable sensor for measurement of solutes in fluids and gases, such as oxygen and glucose, is provided. The sensor includes a multiplicity of detectors, constructed and arranged to improve the probability that one or more detectors will have access to a vascular source at points in time sufficient to permit accurate measurements to be taken. Means and methods for calculating solute levels using the sensor device of the invention are also provided.

摘要翻译： 提供了用于测量流体和气体中的溶质（例如氧气和葡萄糖）的组织可植入传感器。 传感器包括多个检测器，其被构造和布置成提高一个或多个检测器在足以允许进行精确测量的时间点处进入血管源的概率。 还提供了使用本发明的传感器装置计算溶质水平的方法和方法。

公开(公告)号：US20050233172A1

公开(公告)日：2005-10-20

申请号：US11150547

申请日：2005-06-10

申请人： Joseph Schulman ,  Joseph Lucisano ,  Rajiv Shah ,  Charles Byers ,  Shaun Pendo

发明人： Joseph Schulman ,  Joseph Lucisano ,  Rajiv Shah ,  Charles Byers ,  Shaun Pendo

IPC分类号： A61L2/00 ,  A61N1/02 ,  B05D3/00 ,  B32B9/00 ,  C23C14/00 ,  C23C14/04 ,  G03F1/00 ,  G03F7/20 ,  H01L21/308 ,  H01L23/29 ,  H05K3/28

CPC分类号： G03F7/70641 ,  A61N1/02 ,  A61N1/375 ,  C23C14/042 ,  H01L21/308 ,  H01L23/291 ,  H01L2924/0002 ,  H05K3/284 ,  Y10T29/49144 ,  Y10T428/24802 ,  Y10T428/24917 ,  Y10T428/24926 ,  Y10T428/265 ,  H01L2924/00

摘要： A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material comprises a thin layer or layers of alumina, zerconia, or other ceramic, less than 25 microns thick, e.g., 5-10 microns thick. The alumina layer(s) may be applied at relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils area while soaking in a saline solution at temperatures up to 80° C. over a three month period.

摘要翻译： 保护性的，生物相容的涂层或包封材料保护和绝缘想要植入生物体组织的组件或装置。 涂层或包封材料包括薄层或多层氧化铝，稀土或其它小于25微米厚，例如5-10微米厚的陶瓷。 氧化铝层可以在相对较低的温度下施加。 一旦施加，该层提供优异的气密性，并防止漏电。 即使非常薄，氧化铝层保持优异的绝缘特性。 在一个实施方案中，小于约6微米厚的氧化铝层提供了一种绝缘涂层，其在75密耳25密耳面积的面积上表现出低于10pA的漏电流，同时在高达80℃的温度下浸入盐水溶液中 一个三个月的时间。