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    O2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates
    2.
    发明申请
    O2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates 失效
    O-取代的1 - [（2-羧基）吡咯烷-1-基]二氮-1- ium -1,2-二醇酯

    公开(公告)号：US20050214249A1

    公开(公告)日：2005-09-29

    申请号：US11104232

    申请日：2005-04-12

    申请人： Joseph Saavedra ,  Larry Keefer

    发明人： Joseph Saavedra ,  Larry Keefer

    IPC分类号： A61K31/655 ,  A61K31/726 ,  A61K31/785 ,  A61P35/00 ,  C07C291/08 ,  C07D207/16 ,  C07D213/64 ,  C07D239/34 ,  C07D295/28 ,  C07H19/06 ,  C07H19/16

    CPC分类号： C07D213/64 ,  C07C291/08 ,  C07D207/16 ,  C07D239/34 ,  C07D295/30 ,  C07H19/06 ,  C07H19/16

    摘要： Diazeniumdiolates, wherein the N1 position is substituted by an inorganic or organic moiety and the O2-oxygen is bound to a substituted or unsubstituted aromatic group, are provided. Also provided are O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates (O2-glycosylated diazeniumdiolates) and O2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates (1-[(2-carboxylato)pyrrolidin-1-yl]diazeniumdiolates). The O2-aryl diazeniumdiolates are stable with respect to the hydrolytic generation of nitric oxide in neutral to acidic solutions and generate nitric oxide in basic or nucleophilic environments or microenvironments. Also provided are compositions, including pharmaceutical compositions, comprising such compounds and methods of using such compounds.

    摘要翻译： 其中N 1位置被无机或有机部分取代，并且O 2 - 氧原子与取代或未取代的芳族基团结合。 还提供了O 2 - 二糖化的1-取代的二氮杂-1-鎓-1,2-二醇酯（O 2 O 2 - 糖基化的二氮烯鎓二硫化物）和O 2 1 - [（2-羧基）吡咯烷-1-基]二氮-1- ium -1,2-二醇酯（1 - [（2-羧基）吡咯烷-1-基]二氮烯鎓二醇）。 相对于在中性至酸性溶液中的一氧化氮的水解产生，在碱性或亲核环境或微环境中产生一氧化氮，二硫代二芳基二氮烯鎓二醇是稳定的。 还提供了包含这些化合物的药物组合物和使用这些化合物的方法的组合物。

    Methods for separation and detection of ketosteroids and other carbonyl-containing compounds
    5.
    发明申请
    Methods for separation and detection of ketosteroids and other carbonyl-containing compounds 有权
    分离和检测酮类和其他含羰基化合物的方法

    公开(公告)号：US20050181514A1

    公开(公告)日：2005-08-18

    申请号：US10511409

    申请日：2003-04-15

    申请人： Xia Xu ,  Regina Ziegler ,  David Waterhouse ,  Joseph Saavedra ,  Larry Keefer

    发明人： Xia Xu ,  Regina Ziegler ,  David Waterhouse ,  Joseph Saavedra ,  Larry Keefer

    IPC分类号： G01N30/02 ,  G01N30/72 ,  G01N33/00 ,  G01N33/74

    CPC分类号： G01N33/743 ,  G01N30/02 ,  G01N30/7233 ,  G01N30/7266 ,  Y10S436/817 ,  Y10T436/24 ,  B01D15/325

    摘要： Methods for enhancing detection by mass spectroscopy (MS) and/or chromatographic separability of carbonyl-containing compounds such as steroids are disclosed. Reaction of a carbonyl compound with a sulfonhydrazide compound provides a sulfonhydrazone with enhanced ionization efficiency during the electrospray ionization process. In a particularly disclosed embodiment, derivatization of catechol estrogens with p-toluenesulfonhydrazide enhances both detection by atmospheric pressure ionization-MS (API-MS), such as electron spray ionization-MS (ESI-MS) and separation by liquid chromatography (such as HPLC) under reverse phase conditions. In yet other embodiments, the sulfonhydrazone is further reacted with a sulfonyl halide under alkaline conditions to derivatize hydroxyl groups in the compound. Prior formation of the sulfonhydrazide derivative protects the carbonyl bond of the compound during subsequent alkaline reaction with the sulfonyl halide.

    摘要翻译： 公开了通过质谱（MS）检测和/或含羰基化合物如类固醇的色谱分离性的方法。 羰基化合物与磺酰肼化合物的反应提供了在电喷雾电离过程期间具有增强的电离效率的磺酰腙。 在特别公开的实施方案中，儿茶酚雌激素与对甲苯磺酰肼的衍生增强了通过大气压电离-MS（API-MS）的检测，例如电子喷雾离子化-MS（ESI-MS）和通过液相色谱法分离（例如HPLC ）在反相条件下。 在其它实施方案中，磺酰腙在碱性条件下进一步与磺酰卤反应以衍生化合物中的羟基。 磺酰肼衍生物的先前形成在与磺酰卤的随后碱性反应期间保护化合物的羰基键。