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    Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use
    4.
    发明授权
    Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use 失效
    高度交联，极疏水的一氧化氮释放聚合物及其制造和使用的方法

    公开(公告)号：US06703046B2

    公开(公告)日：2004-03-09

    申请号：US09972219

    申请日：2001-10-04

    申请人： Anthony L. Fitzhugh ,  Robert Cafferata ,  Larry K. Keefer

    发明人： Anthony L. Fitzhugh ,  Robert Cafferata ,  Larry K. Keefer

    IPC分类号： A61K914

    CPC分类号： C08F8/30 ,  A61K31/785 ,  A61K47/59 ,  A61L17/145 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10

    摘要： Extremely hydrophobic nitric oxide (NO) releasing polymers are disclosed. The extremely hydrophobic NO-releasing polymers provided are extensively cross-linked polyamine-derivatized divinylbenzene diazeniumdiolates. These polymers can be loaded with extremely high NO levels and designed to release NO in manners than mimic natural biological systems. The NO-releasing extremely hydrophobic polymers provided can maintain a sustained NO release for periods exceeding nine months. Also provided are related medical devices made using these NO-releasing extremely hydrophobic polymers.

    摘要翻译： 公开了非常疏水​​的一氧化氮（NO）释放聚合物。 所提供的非常疏水的NO释放聚合物是广泛交联的聚胺衍生的二乙烯基苯二氮烯鎓二醇。 这些聚合物可以装载非常高的NO水平，并设计为以比模仿天然生物系统释放NO的方式。 所提供的NO释放的极疏水性聚合物可以在超过9个月的时间内保持持续的NO释放。 还提供了使用这些释放NO的疏水性聚合物制成的相关的医疗装置。

    Helicopter water bucket improvements
    8.
    发明申请
    Helicopter water bucket improvements 失效
    直升机水桶改进

    公开(公告)号：US20080314601A1

    公开(公告)日：2008-12-25

    申请号：US11821490

    申请日：2007-06-22

    申请人： Robert Cafferata

    发明人： Robert Cafferata

    IPC分类号： A62C3/00

    CPC分类号： A62C8/005 ,  A62C3/0235

    摘要： A collapsible wild fire fighting water bucket made from pliable material and suspended from an aircraft to be lowered into an open body of water for filling. A weighted Rim Opening Device holds the bucket top open for filling and facilitates a tipping over action during filling. The buckets open top being free of any centrally located supports. The bucket is equipped with a tubular extension which forms a discharge port for dumping water. The tubular extension being releasably supported under water inside the bucket under tension. Purse lines running through openings in the tubular extension and resilient sealing lips bring sealing lips into abutment sealing the discharge port of the tubular extension.Suspension lines suspend the bucket from the aircraft and a releasable support, releasably supports the free end of the tubular extension within the bucket body extending upwardly from the openings to close the discharge port. The releasable support cooperates with the openings to allow the tubular extension to be rapidly lowered so as to extend downwardly from the bottom to open the discharge port for dumping the water. The purse lines cooperate with the releasable support to lift and lower the tubular extension. The buckets also are equipped with emergency extractor Jump Seats, secured to the inside wall of the bucket to be used for dire straits emergency extraction of wild fire ground crews trapped by fire storm.

    摘要翻译： 一种由柔韧材料制成的可折叠野生消防水桶，从飞机上悬挂下来，进入开放的水体填充。 加重轮胎打开装置将铲斗顶部保持打开以进行填充，并且在填充期间促进倾翻动作。 桶顶部没有任何位于中心的支架。 桶装有一个管状延伸部分，形成一个用于倾倒水的排放口。 管状延伸部在张力下可释放地支撑在铲斗内的水下。 穿过管状延伸部分和弹性密封唇口中的开口的钱包线使密封唇缘邻接地密封管状延伸部的排出口。 悬挂线将铲斗从飞行器上悬挂并且可释放的支撑件可释放地支撑从开口向上延伸以关闭排出口的桶体内的管状延伸部的自由端。 可释放的支撑件与开口配合以允许管状延伸部被快速地降低，从而从底部向下延伸以打开排出口以倾倒水。 钱包线与可释放支撑件配合以提升和降低管状延伸部。 水桶还配备有应急拔罐器跳床，固定在铲斗内壁，用于紧急采伐火灾遇难的野火地勤人员。

    Transthoracic drug delivery device
    9.
    发明授权
    Transthoracic drug delivery device 失效
    胸腔给药装置

    公开(公告)号：US06517527B2

    公开(公告)日：2003-02-11

    申请号：US09888750

    申请日：2001-06-25

    申请人： Richard A. Gambale ,  Stephen J. Forcucci ,  Richard T. Choh ,  Robert Cafferata

    发明人： Richard A. Gambale ,  Stephen J. Forcucci ,  Richard T. Choh ,  Robert Cafferata

    IPC分类号： A61M3100

    CPC分类号： A61M25/0068 ,  A61B2017/00247 ,  A61B2018/00392 ,  A61M25/008 ,  A61M25/0084 ,  A61M25/0133 ,  A61M25/0147 ,  A61M2025/0002 ,  A61M2025/0003 ,  A61M2025/0034 ,  A61M2025/0036 ,  A61M2025/0086 ,  A61M2210/10 ,  A61M2230/005

    摘要： The present invention provides a transthoracic drug delivery device that utilizes pressure to determine the precise location of the distal tip of the delivery tube of the device to insure that therapeutic substances are ejected into the myocardium and not dissipated in unintended tissue locations. In one embodiment the drug delivery device comprises a pressure sensing tube mounted in parallel to a drug delivery tube wherein the tubes are staggered so that the pressure tube extends beyond the delivery tube. When the myocardium is penetrated by the tubes, advancement into the heart and penetration into the left ventricle by the pressures sensing tube results in a pressure increase that indicates to the physician that the drug delivery tube, by its placement relative to the pressure sensing tube is still in the myocardium and, thus, prepared to deliver the drug. In another embodiment, a steerable syringe is provided so that multiple sites in the myocardium can be treated with a therapeutic substance with only one penetration into the heart. Once the delivery tube of the syringe penetrates the left ventricle, its distal tip can be deflected back toward the endocardial surface and the tube withdrawn proximally to cause penetration of the tip into the myocardium. A pressure sensor mounted to the tube indicates, by a measured drop in pressure that the myocardium has been penetrated. The therapeutic substance is ejected into the myocardium and the device is then backed out of the tissue by advancing the syringe in a distal direction. The deflectable tip can be adjusted to a different deflection angle and the delivery tube rotated to make available a circular array of points that may be accessed by the syringe.

    摘要翻译： 本发明提供了经胸廓药物递送装置，其利用压力来确定装置的输送管的远侧末端的精确位置，以确保将治疗物质喷射到心肌中，而不会在非预期的组织位置中消散。 在一个实施方案中，药物递送装置包括平行于药物输送管安装的压力感测管，其中管交错，使得压力管延伸超过输送管。 当心肌被管穿透时，通过压力感测管进入心脏并穿透入左心室，导致压力增加，向医生指示药物输送管通过其相对于压力感测管的位置是 仍然在心肌中，因此准备递送药物。 在另一个实施例中，提供可转向注射器，使得心肌中的多个部位可以用仅具有一次穿透入心脏的治疗物质来治疗。 一旦注射器的输送管穿透左心室，其远侧末端可以偏转回到心内膜表面，并且管向近侧撤回，以引起尖端穿入心肌。 安装在管上的压力传感器指示通过测量的心肌渗透的压力下降。 将治疗物质喷射到心肌中，然后通过沿远端方向前进注射器将装置从组织中退出。 可偏转尖端可以被调节到不同的偏转角，并且输送管旋转以提供可由注射器访问的点的圆形阵列。