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    Use of antimicrobial peptides in regeneration of skin cells
    2.
    发明授权
    Use of antimicrobial peptides in regeneration of skin cells 有权
    抗菌肽在皮肤细胞再生中的应用

    公开(公告)号：US08871716B2

    公开(公告)日：2014-10-28

    申请号：US13095763

    申请日：2011-04-27

    申请人： Sun-Chang Kim ,  Da-Jung Kim ,  Su-A Jang ,  Bong Hyun Sung ,  Ki-Jung Lim ,  Ju-Ri Shin ,  Young Woong Lee

    发明人： Sun-Chang Kim ,  Da-Jung Kim ,  Su-A Jang ,  Bong Hyun Sung ,  Ki-Jung Lim ,  Ju-Ri Shin ,  Young Woong Lee

    IPC分类号： A61K8/64 ,  A61K38/00 ,  A61K38/10

    CPC分类号： A61K38/10

    摘要： Disclosed are novel antimicrobial peptides which can promote the regeneration of skin cells, thus healing wounds. Pharmaceutical compositions comprising the peptides as active ingredients are also provided for wound healing and skin rejuvenation. The antimicrobial peptides exhibit inhibitory activity against antibiotic-resistant strains, and their antimicrobial activity is maintained without loss of structural stability even under a high salt condition. Also, being proven to promote the migration and regeneration of skin cells in mice as well as in vitro, the antimicrobial peptides may be widely used as an agent for regenerating skin cells. Further, they can find applications in various fields including the medical industry and the cosmetic industry. Hence, the novel antimicrobial peptides are anticipated to have considerable repercussions in the market for antibiotics, wound healing agents and cosmetics.

    摘要翻译： 公开了可以促进皮肤细胞再生的新型抗微生物肽，从而伤口愈合。 包含肽作为活性成分的药物组合物也用于伤口愈合和皮肤年轻化。 抗菌肽对抗生素抗性菌株表现出抑制活性，即使在高盐条件下，其抗微生物活性仍保持不失结构稳定性。 此外，被证明可促进小鼠和体外皮肤细胞的迁移和再生，抗微生物肽可以广泛用作再生皮肤细胞的药剂。 此外，他们可以在包括医疗行业和化妆品行业在内的各个领域找到应用。 因此，预期新型抗菌肽在市场上对抗生素，伤口愈合剂和化妆品具有相当大的影响。

    NOVEL USE OF ANTIMICROBIAL PEPTIDES IN REGENERATION OF SKIN CELLS
    5.
    发明申请
    NOVEL USE OF ANTIMICROBIAL PEPTIDES IN REGENERATION OF SKIN CELLS 有权
    在皮肤细胞再生中使用抗微生物肽

    公开(公告)号：US20120088733A1

    公开(公告)日：2012-04-12

    申请号：US13095763

    申请日：2011-04-27

    申请人： Sun-Chang Kim ,  Da-Jung Kim ,  Su-A Jang ,  Bong Hyun Sung ,  Ki-Jung Lim ,  Ju-Ri Shin ,  Young Woong Lee

    发明人： Sun-Chang Kim ,  Da-Jung Kim ,  Su-A Jang ,  Bong Hyun Sung ,  Ki-Jung Lim ,  Ju-Ri Shin ,  Young Woong Lee

    IPC分类号： A61K38/10 ,  A61P17/02 ,  A61P17/00

    CPC分类号： A61K38/10

    摘要： Disclosed are novel antimicrobial peptides which can promote the regeneration of skin cells, thus healing wounds. Pharmaceutical compositions comprising the peptides as active ingredients are also provided for wound healing and skin rejuvenation.The antimicrobial peptides exhibit inhibitory activity against antibiotic-resistant strains, and their antimicrobial activity is maintained without loss of structural stability even under a high salt condition. Also, being proven to promote the migration and regeneration of skin cells in mice as well as in vitro, the antimicrobial peptides may be widely used as an agent for regenerating skin cells. Further, they can find applications in various fields including the medical industry and the cosmetic industry. Hence, the novel antimicrobial peptides are anticipated to have considerable repercussions in the market for antibiotics, wound healing agents and cosmetics.

    摘要翻译： 公开了可以促进皮肤细胞再生的新型抗微生物肽，从而伤口愈合。 包含肽作为活性成分的药物组合物也用于伤口愈合和皮肤年轻化。 抗菌肽对抗生素抗性菌株表现出抑制活性，即使在高盐条件下，其抗微生物活性仍保持不失结构稳定性。 此外，被证明可促进小鼠和体外皮肤细胞的迁移和再生，抗微生物肽可以广泛用作再生皮肤细胞的药剂。 此外，他们可以在包括医疗行业和化妆品行业在内的各个领域找到应用。 因此，预期新型抗菌肽在市场上对抗生素，伤口愈合剂和化妆品具有相当大的影响。

    Method for the mass expression of an antimicrobial peptide by using a translational coupling system
    6.
    发明申请
    Method for the mass expression of an antimicrobial peptide by using a translational coupling system 有权
    通过使用平移耦合系统大量表达抗微生物肽的方法

    公开(公告)号：US20100184949A1

    公开(公告)日：2010-07-22

    申请号：US12313513

    申请日：2008-11-19

    申请人： Sun Chang Kim ,  Su A. Jang ,  Bong Hyun Sung ,  Jung Min Kim ,  Ki Jung Lim ,  Ju Ri Shin ,  Ju Young Lee

    发明人： Sun Chang Kim ,  Su A. Jang ,  Bong Hyun Sung ,  Jung Min Kim ,  Ki Jung Lim ,  Ju Ri Shin ,  Ju Young Lee

    IPC分类号： C07K14/00 ,  C12P21/00 ,  C07H21/04

    CPC分类号： C12N15/67 ,  C07K14/4702

    摘要： The present invention relates to a gene construct which is capable of achieving efficient production of an antimicrobial peptide in a microorganism, and a method for efficient mass production and separation of an antimicrobial peptide using the same. The gene construct of the present invention has a translationally coupled configuration of two independent and separate cistrons which encode an acidic peptide and a basic antimicrobial peptide, each having an opposite charge, under the control of a single promoter. The translationally coupled acidic peptide and basic antimicrobial peptide undergo charge-charge interaction simultaneously with expression thereof to neutralize the potential cytotoxicity of the antimicrobial peptide, resulting in prevention of antimicrobial peptide-mediated killing of host microorganisms. In addition, a conjugate of the acidic peptide and the antimicrobial peptide can be separated without chemical or enzymatic treatment. Therefore, it is possible to achieve easy mass production of antimicrobial peptides from recombinant microorganisms.

    摘要翻译： 本发明涉及能够实现微生物中抗微生物肽的高效生产的基因构建体，以及使用该抗体肽高效批量生产和分离的方法。 本发明的基因构建体具有两个独立和分离的顺反子的翻译偶联构型，其在单个启动子的控制下编码各自具有相反电荷的酸性肽和碱性抗微生物肽。 翻译偶联的酸性肽和碱性抗微生物肽与其表达同时进行电荷 - 电荷相互作用以中和抗微生物肽的潜在细胞毒性，从而防止抗微生物肽介导的宿主微生物的杀伤。 此外，酸性肽和抗微生物肽的缀合物可以在没有化学或酶处理的情况下分离。 因此，可以从重组微生物容易地大量生产抗微生物肽。

    Method for the mass expression of an antimicrobial peptide by co-expression of a basic antimicrobial peptide and an acidic peptide using a translational coupling system
    7.
    发明授权
    Method for the mass expression of an antimicrobial peptide by co-expression of a basic antimicrobial peptide and an acidic peptide using a translational coupling system 有权
    通过使用平移耦合系统共同表达碱性抗微生物肽和酸性肽来大量表达抗微生物肽的方法

    公开(公告)号：US08003348B2

    公开(公告)日：2011-08-23

    申请号：US12313513

    申请日：2008-11-19

    申请人： Sun Chang Kim ,  Su A Jang ,  Bong Hyun Sung ,  Jung Min Kim ,  Ki Jung Lim ,  Ju Ri Shin ,  Ju Young Lee

    发明人： Sun Chang Kim ,  Su A Jang ,  Bong Hyun Sung ,  Jung Min Kim ,  Ki Jung Lim ,  Ju Ri Shin ,  Ju Young Lee

    IPC分类号： C12P21/06 ,  C12P21/04

    CPC分类号： C12N15/67 ,  C07K14/4702

    摘要： The present invention relates to a gene construct which is capable of achieving efficient production of an antimicrobial peptide in a microorganism, and a method for efficient mass production and separation of an antimicrobial peptide using the same. The gene construct of the present invention has a translationally coupled configuration of two independent and separate cistrons which encode an acidic peptide and a basic antimicrobial peptide, each having an opposite charge, under the control of a single promoter. The translationally coupled acidic peptide and basic antimicrobial peptide undergo charge-charge interaction simultaneously with expression thereof to neutralize the potential cytotoxicity of the antimicrobial peptide, resulting in prevention of antimicrobial peptide-mediated killing of host microorganisms. In addition, a conjugate of the acidic peptide and the antimicrobial peptide can be separated without chemical or enzymatic treatment. Therefore, it is possible to achieve easy mass production of antimicrobial peptides from recombinant microorganisms.

    摘要翻译： 本发明涉及能够实现微生物中抗微生物肽的高效生产的基因构建体，以及使用该抗体肽高效批量生产和分离的方法。 本发明的基因构建体具有两个独立和分离的顺反子的翻译偶联构型，其在单个启动子的控制下编码各自具有相反电荷的酸性肽和碱性抗微生物肽。 翻译偶联的酸性肽和碱性抗微生物肽与其表达同时进行电荷 - 电荷相互作用以中和抗微生物肽的潜在细胞毒性，从而防止抗微生物肽介导的宿主微生物的杀伤。 此外，酸性肽和抗微生物肽的缀合物可以在没有化学或酶处理的情况下分离。 因此，可以从重组微生物容易地大量生产抗微生物肽。