公开(公告)号：US07918350B2

公开(公告)日：2011-04-05

申请号：US12399545

申请日：2009-03-06

申请人： Kyungyoon Min ,  Richard I. Brown ,  Alp Akonur ,  Julie Moriarty

发明人： Kyungyoon Min ,  Richard I. Brown ,  Alp Akonur ,  Julie Moriarty

IPC分类号： B04B3/00 ,  B04B1/06 ,  B04B1/12 ,  B04B7/10 ,  B01D21/26 ,  B01D45/12

CPC分类号： A61M1/3693 ,  A61M1/3696 ,  A61M1/38 ,  A61M2205/128 ,  B04B5/0442 ,  B04B2005/045

摘要： A separation apparatus and method are employed using a separation channel for rotation about an axis. Such channel includes radially spaced apart inner and outer side wall portions and an end wall portion. An inlet conveys fluid into the channel. A barrier is located in the channel intermediate of the inner and outer side wall portions. A first flow path communicates between upstream and downstream sides of the barrier. A collection region may be located downstream of the barrier for communication with the first flow path. An outer side wall section of the channel may be positioned radially outward of an upstream section thereof. The barrier may join the outer side wall portion along a substantial portion of an axial length of the channel. First and second exit flow paths may allow communication with the channel either upstream or downstream of the barrier or both.

摘要翻译： 使用分离装置和方法来使用用于围绕轴线旋转的分离通道。 这种通道包括径向间隔开的内侧壁部分和外侧壁部分以及端壁部分。 入口将流体输送到通道中。 屏障位于内外侧壁部分的通道中间。 第一流动路径在屏障的上游侧和下游侧之间连通。 收集区域可以位于屏障的下游，用于与第一流动路径通信。 通道的外侧壁部分可以位于其上游部分的径向外侧。 屏障可以沿着通道的轴向长度的大部分连接外侧壁部分。 第一和第二出口流动路径可以允许在障碍物的上游或下游与两者的通道进行通信。

公开(公告)号：US06849039B2

公开(公告)日：2005-02-01

申请号：US10279765

申请日：2002-10-24

申请人： Kyungyoon Min ,  Richard I. Brown ,  Julie Moriarty

发明人： Kyungyoon Min ,  Richard I. Brown ,  Julie Moriarty

IPC分类号： A61M1/36 ,  A61M1/38 ,  B04B5/04 ,  B01D21/26 ,  B04B11/00

CPC分类号： A61M1/3693 ,  A61M1/3633 ,  A61M1/3696 ,  A61M1/38 ,  A61M2202/0429 ,  A61M2205/128 ,  B04B5/0442 ,  B04B2005/045

摘要： Blood separation systems and methods introduce blood into an annular separation channel between a low-G wall and a high-G wall while rotating the separation channel about an axis, for separation of the blood into blood components. The annular separation channel has an annular boundary wall. The systems and methods direct a first blood component into a constricted channel along the low-G wall. The systems and methods remove the first blood component through a first path that communicates with the separation channel through an opening that adjoins the constricted channel adjacent the low-G wall. The systems and methods direct a second blood component along a surface that extends generally in an axial direction along the high-G wall toward the annular boundary wall. The systems and methods collect the second blood component through a second path that communicates with the separation channel through an opening that adjoins the surface adjacent the high-G wall axially spaced from the annular boundary wall.

摘要翻译： 血液分离系统和方法将血液引入低G壁和高G壁之间的环形分离通道，同时围绕轴线旋转分离通道，以将血液分离成血液成分。 环形分隔通道具有环形边界壁。 系统和方法将第一血液成分引导到沿着低G壁的收缩通道。 系统和方法通过与分离通道连通的第一路径去除第一血液成分，所述第一路径通过邻近靠近低G壁的收缩通道的开口。 系统和方法沿着沿着高G壁的轴向方向朝着环形边界壁延伸的表面引导第二血液成分。 所述系统和方法通过第二路径收集第二血液成分，所述第二路径通过与所述环形边界壁轴向间隔开的邻近所述高G壁的表面邻接的开口与所述分离通道连通。

公开(公告)号：US20090218277A1

公开(公告)日：2009-09-03

申请号：US12399545

申请日：2009-03-06

申请人： Kyungyoon Min ,  Richard I. Brown ,  Alp Akonur ,  Julie Moriarty

发明人： Kyungyoon Min ,  Richard I. Brown ,  Alp Akonur ,  Julie Moriarty

IPC分类号： B01D17/038

CPC分类号： A61M1/3693 ,  A61M1/3696 ,  A61M1/38 ,  A61M2205/128 ,  B04B5/0442 ,  B04B2005/045

摘要： A separation apparatus and method are employed using a separation channel for rotation about an axis. Such channel includes radially spaced apart inner and outer side wall portions and an end wall portion. An inlet conveys fluid into the channel. A barrier is located in the channel intermediate of the inner and outer side wall portions. A first flow path communicates between upstream and downstream sides of the barrier. A collection region may be located downstream of the barrier for communication with the first flow path. An outer side wall section of the channel may be positioned radially outward of an upstream section thereof. The barrier may join the outer side wall portion along a substantial portion of an axial length of the channel. First and second exit flow paths may allow communication with the channel either upstream or downstream of the barrier or both.

摘要翻译： 使用分离装置和方法来使用用于围绕轴线旋转的分离通道。 这种通道包括径向间隔开的内侧壁部分和外侧壁部分以及端壁部分。 入口将流体输送到通道中。 屏障位于内外侧壁部分的通道中间。 第一流动路径在屏障的上游侧和下游侧之间连通。 收集区域可以位于屏障的下游，用于与第一流动路径通信。 通道的外侧壁部分可以位于其上游部分的径向外侧。 屏障可以沿着通道的轴向长度的大部分连接外侧壁部分。 第一和第二出口流动路径可以允许在障碍物的上游或下游与两者的通道进行通信。

公开(公告)号：US09533089B2

公开(公告)日：2017-01-03

申请号：US14008651

申请日：2012-03-28

申请人： Kyungyoon Min ,  Richard I. Brown ,  John T. Foley ,  Brian C. Case

发明人： Kyungyoon Min ,  Richard I. Brown ,  John T. Foley ,  Brian C. Case

IPC分类号： A61M1/36 ,  B04B5/04

CPC分类号： A61M1/3693 ,  A61M1/3696 ,  A61M2205/128 ,  A61M2205/3331 ,  A61M2205/3337 ,  B04B5/0442 ,  B04B2005/045 ,  C12N5/0634 ,  C12N5/0641 ,  C12N5/0644

摘要： Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port.

摘要翻译： 提供离心系统和方法用于将血液分离成其组成部分。 离心机的内壁和外壁各自包括朝向另一壁延伸的突起。 分离室被容纳在离心机之间的壁之间，其中腔室包括用于使血液进入腔室的入口端口，用于使等离子体流出腔室的等离子体出口和用于使红细胞流出的红细胞出口 的房间。 随着室中的离心机容纳在壁之间，第一突出部延伸到分离的血液成分流向等离子体出口端口的路径中，并防止细胞血液成分流入等离子体出口。 第二突出部延伸到朝向红细胞出口流动的分离的血液成分的路径中，并防止血浆流入红细胞出口。

公开(公告)号：US20140045671A1

公开(公告)日：2014-02-13

申请号：US14008651

申请日：2012-03-28

申请人： Kyungyoon Min ,  Richard I. Brown ,  John T. Foley ,  Brian C. Case

发明人： Kyungyoon Min ,  Richard I. Brown ,  John T. Foley ,  Brian C. Case

IPC分类号： A61M1/36

CPC分类号： A61M1/3693 ,  A61M1/3696 ,  A61M2205/128 ,  A61M2205/3331 ,  A61M2205/3337 ,  B04B5/0442 ,  B04B2005/045 ,  C12N5/0634 ,  C12N5/0641 ,  C12N5/0644

摘要： Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port.

摘要翻译： 提供离心系统和方法用于将血液分离成其组成部分。 离心机的内壁和外壁各自包括朝向另一壁延伸的突起。 分离室被容纳在离心机之间的壁之间，其中腔室包括用于使血液进入腔室的入口端口，用于使等离子体流出腔室的等离子体出口和用于使红细胞流出的红细胞出口 的房间。 随着室中的离心机容纳在壁之间，第一突出部延伸到分离的血液成分流向等离子体出口端口的路径中，并防止细胞血液成分流入等离子体出口。 第二突出部延伸到朝向红细胞出口流动的分离的血液成分的路径中，并防止血浆流入红细胞出口。

公开(公告)号：US08075468B2

公开(公告)日：2011-12-13

申请号：US12394375

申请日：2009-02-27

申请人： Kyungyoon Min ,  Richard I. Brown

发明人： Kyungyoon Min ,  Richard I. Brown

IPC分类号： B01D21/26 ,  B04B3/00

CPC分类号： A61M1/3693 ,  A61M1/0209 ,  A61M1/3696 ,  A61M2205/3306 ,  B01D21/262 ,  B01D21/302 ,  B01D21/34 ,  B01D2221/08 ,  B01D2221/10

摘要： Blood separation methods are provided for mid-processing calculation of blood composition. Blood is conveyed into a device having an outlet line and the device is spun to separate platelets from the blood. A flow of platelets is conveyed from the device by the outlet line and the platelets in the outlet line are optically measured. With said optical measurement, a current platelet yield, a platelet pre-count, the volume of blood to process to collect a target amount of platelets, and/or the processing time required to collect a target amount of platelets is calculated. The optical measurement can also be used to calculate an amount of storage fluid to convey into a collection container with the platelets.

摘要翻译： 提供血液分离方法用于血液成分的中间处理计算。 将血液输送到具有出口管线的装置中，并且将该装置旋转以将血小板与血液分开。 通过出口管线从装置输送血小板流，并且光学测量出口管线中的血小板。 通过所述光学测量，计算目前的血小板产量，血小板预计数，用于收集目标量的血小板的血液的体积和/或收集目标量的血小板所需的处理时间。 光学测量还可用于计算与血小板一起输送到收集容器中的储存液体的量。

公开(公告)号：US20090215602A1

公开(公告)日：2009-08-27

申请号：US12394375

申请日：2009-02-27

申请人： Kyungyoon Min ,  Richard I. Brown

发明人： Kyungyoon Min ,  Richard I. Brown

IPC分类号： A61M1/36 ,  B01D17/038 ,  B01D21/26 ,  B04B1/00 ,  B04B1/18

CPC分类号： A61M1/3693 ,  A61M1/0209 ,  A61M1/3696 ,  A61M2205/3306 ,  B01D21/262 ,  B01D21/302 ,  B01D21/34 ,  B01D2221/08 ,  B01D2221/10

摘要： Blood separation methods and systems are provided for mid-processing calculation of blood composition. Blood is conveyed into a device having an outlet line and the device is spun to separate a blood component from the blood. A flow of blood component is conveyed from the device by the outlet line and the blood component in the outlet line is optically measured. With said optical measurement, a current blood component yield, a blood component pre-count, the volume of blood to process to collect a target amount of said blood component, and/or the processing time required to collect a target amount of said blood component is calculated. The optical measurement can also be used to calculate an amount of storage fluid to convey into a collection container with the blood component.

摘要翻译： 提供血液分离方法和系统用于血液成分的中间处理计算。 将血液输送到具有出口管线的装置中，并且将该装置旋转以将血液成分与血液分离。 通过出口管路从装置输送血液成分流，并且光学测量出口管线中的血液成分。 通过所述光学测量，当前的血液成分收率，血液成分预计数，用于收集目标量的所述血液成分的血液的体积和/或收集目标量的所述血液成分所需的处理时间 被计算。 光学测量还可以用于计算要输送到具有血液成分的收集容器中的存储流体的量。

公开(公告)号：US5750039A

公开(公告)日：1998-05-12

申请号：US745779

申请日：1996-11-08

申请人： Richard I. Brown ,  Kyungyoon Min

发明人： Richard I. Brown ,  Kyungyoon Min

IPC分类号： A61K35/14 ,  A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  B01D17/02 ,  B01D21/24 ,  B01D21/26 ,  B04B5/04 ,  B04B7/08 ,  B04B13/00

CPC分类号： A61M1/0209 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3603 ,  A61M1/3624 ,  A61M1/3693 ,  A61M1/3696 ,  B01D17/0217 ,  B01D21/003 ,  B01D21/0087 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/262 ,  B01D21/32 ,  B01D21/34 ,  B04B13/00 ,  B04B5/0442 ,  B04B7/08 ,  A61M1/025 ,  A61M1/30 ,  A61M2202/0427 ,  A61M2205/331 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3393 ,  B01D2221/10 ,  B04B2005/045

摘要： Systems and methods centrifugally separate mono nuclear cells from whole blood in a separation chamber. The systems and methods control the exit hematocrit value of red blood cells separated in the chamber by recirculating a portion of the red blood cells removed from the chamber for mixing whole blood entering the separation chamber. The systems and methods also control the entry hematocrit value of whole blood entering the separation chamber by recirculating a portion of the plasma constituent removed from the separation chamber for mixing whole blood entering the separation chamber.

摘要翻译： 系统和方法在分离室中离心分离单核细胞与全血。 系统和方法通过再循环从腔室中取出的一部分红细胞来控制在腔室中分离的红细胞的出血血细胞比值，用于混合进入分离室的全血。 系统和方法还通过再循环从分离室除去的等离子体成分的一部分来混合进入分离室的全血，从而控制进入分离室的全血进入血细胞比容值。

公开(公告)号：US20090211962A1

公开(公告)日：2009-08-27

申请号：US12392952

申请日：2009-02-25

申请人： Kyungyoon Min ,  Richard I. Brown

发明人： Kyungyoon Min ,  Richard I. Brown

IPC分类号： B01D33/74

CPC分类号： A61M1/3693 ,  A61M1/0218 ,  A61M1/0231 ,  A61M1/3652 ,  A61M1/3696 ,  A61M1/38 ,  A61M2205/128

摘要： Processing chamber for use with apheresis devices are described herein. An example centrifugal processing chamber includes first and second lateral walls spaced at a distance from one another. Additionally, the example centrifugal processing chamber includes a channel at least partially defined by the first and second lateral walls. Further, the centrifugal processing chamber includes an inlet fluidly coupled to the channel to convey blood to the channel. Further still, the centrifugal processing chamber includes a first outlet fluidly coupled to the channel having a first opening adjacent the first lateral wall. The first outlet is to convey separated plasma from the channel. Additionally, the centrifugal processing chamber includes a second fluid outlet fluidly coupled to the channel having a second opening adjacent the second lateral wall. The second outlet is to convey separated red blood cells from the channel. Additionally, the processing chamber includes a barrier formed along the second lateral wall to intercept platelets. The first and second lateral walls are spaced such that the distance between the first and second lateral walls enables at least one therapeutic unit of single dose platelets to pool adjacent the barrier without spilling into the first outlet or the second outlet.

摘要翻译： 本文描述了与分离装置一起使用的处理室。 一个示例性离心处理室包括彼此间隔一定距离的第一和第二侧壁。 另外，示例性离心处理室包括至少部分地由第一和第二侧壁限定的通道。 此外，离心处理室包括流体耦合到通道以将血液输送到通道的入口。 此外，离心处理室包括流体耦合到通道的第一出口，其具有与第一侧壁相邻的第一开口。 第一个出口是从通道传送分离的等离子体。 此外，离心处理室包括流体地联接到通道的第二流体出口，其具有邻近第二侧壁的第二开口。 第二个出口是从通道传送分离的红细胞。 另外，处理室包括沿着第二侧壁形成的屏障，以拦截血小板。 第一和第二侧壁间隔开，使得第一和第二侧壁之间的距离使得单剂量血小板的至少一个治疗单元能够在不渗入第一出口或第二出口的情况下相邻隔离池。

公开(公告)号：US06706008B2

公开(公告)日：2004-03-16

申请号：US09800133

申请日：2001-03-06

申请人： Rohit Vishnoi ,  Richard I. Brown ,  Kyungyoon Min ,  Tom Westberg

发明人： Rohit Vishnoi ,  Richard I. Brown ,  Kyungyoon Min ,  Tom Westberg

IPC分类号： A61M3700

CPC分类号： A61M1/3693 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/342 ,  A61M1/3441 ,  A61M1/3672 ,  A61M1/3675 ,  A61M1/3679 ,  A61M1/3687 ,  A61M1/3692 ,  A61M1/3696 ,  A61M2205/12

摘要： Automated systems and methods for withdrawing a selected compound from blood are disclosed. The systems and methods utilize a disposable fluid circuit mounted on a re-usable hardware component or module. The system withdraws blood from a donor or patient, separates the blood into two or more components and further combines the separated component with a solvent so as to remove a compound from the blood component.

摘要翻译： 公开了用于从血液中取出选定化合物的自动化系统和方法。 系统和方法利用安装在可重复使用的硬件部件或模块上的一次性流体回路。 系统从供体或患者抽出血液，将血液分离成两个或更多个组分，并进一步将分离的组分与溶剂组合，以从血液组分中除去化合物。