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公开(公告)号:US20070176026A1
公开(公告)日:2007-08-02
申请号:US11699220
申请日:2007-01-29
申请人: Jurgen Frisch , Ullrich Munstermann
发明人: Jurgen Frisch , Ullrich Munstermann
IPC分类号: B05B1/14
CPC分类号: B25B27/0092 , D04H18/04
摘要: A nozzle beam formed with an annular groove is fitted with a seal ring by an apparatus having an elongated support bar, a pair of holders fixed on the bar spaced apart sufficiently that the seal ring can be stretched between them, and a release element for pushing the seal ring off one of the holders.
摘要翻译: 形成有环形槽的喷嘴梁通过具有细长支撑杆的装置装配有密封环,固定在杆上的一对保持架足够间隔开,密封环可以在它们之间被拉伸,以及用于推动的释放元件 密封圈关闭其中一个支架。
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公开(公告)号:US20050187184A1
公开(公告)日:2005-08-25
申请号:US11110050
申请日:2005-04-20
申请人: James Gibbons , Gary Dukart , Jurgen Frisch
发明人: James Gibbons , Gary Dukart , Jurgen Frisch
IPC分类号: A61K31/436 , A61K31/4965 , A61K31/513 , A61K31/519 , A61K31/7068 , A61K45/06 , A61P35/00 , A61K31/7072 , A61K31/4745
CPC分类号: A61K31/436 , A61K31/4965 , A61K31/519 , A61K31/7068 , A61K45/06 , A61K2300/00
摘要: This invention provides the use of a combination of CCI-779 and an antimetabolite antineoplastic agent in the treatment of neoplasms.
摘要翻译: 本发明提供了CCI-779和抗代谢抗肿瘤剂的组合在肿瘤治疗中的应用。
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公开(公告)号:US20090155294A1
公开(公告)日:2009-06-18
申请号:US12248587
申请日:2008-10-09
申请人: MICHAEL BUSCHLE , JURGEN FRISCH , CHRISTOPH KLADE , KAREN LINGNAU , WOLFGANG ZAUNER , GERD ZETTLMEISSL
发明人: MICHAEL BUSCHLE , JURGEN FRISCH , CHRISTOPH KLADE , KAREN LINGNAU , WOLFGANG ZAUNER , GERD ZETTLMEISSL
IPC分类号: A61K39/29
CPC分类号: C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/55516 , A61K2039/55561 , C12N2770/24222 , C12N2770/24234
摘要: Disclosed are methods and compositions for inducing immune responses against Hepatitis C virus (HCV). The compositions comprise one or more epitope from a hotspot epitope. In certain embodiments, an HCV vaccine comprising at least two epitopes, each from a different hotspot epitope, is provided.
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公开(公告)号:US20090130135A1
公开(公告)日:2009-05-21
申请号:US12248744
申请日:2008-10-09
申请人: MICHAEL BUSCHLE , JURGEN FRISCH , CHRISTOPH KLADE , KAREN LINGNAU , WOLFGANG ZAUNER , GERD ZETTLMEISSL
发明人: MICHAEL BUSCHLE , JURGEN FRISCH , CHRISTOPH KLADE , KAREN LINGNAU , WOLFGANG ZAUNER , GERD ZETTLMEISSL
IPC分类号: A61K39/29
CPC分类号: A61K39/29 , A61K39/00 , A61K39/12 , A61K2039/55505 , A61K2039/55516 , A61K2039/55561 , A61K2039/57 , C07K14/005 , C12N2770/24222 , C12N2770/24234
摘要: Disclosed are methods and compositions for inducing immune responses against Hepatitis C virus (HCV). The compositions comprise one or more epitope from a hotspot epitope. In certain embodiments, an HCV vaccine comprising at least two epitopes, each from a different hotspot epitope, is provided.
摘要翻译: 公开了用于诱导针对丙型肝炎病毒(HCV)的免疫应答的方法和组合物。 组合物包含来自热点表位的一个或多个表位。 在某些实施方案中,提供了包含至少两个表位的HCV疫苗,每个表位各自为不同的热点表位。
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公开(公告)号:US20070031446A1
公开(公告)日:2007-02-08
申请号:US10564429
申请日:2004-07-09
申请人: Michael Buschle , Jurgen Frisch , Christoph Klade , Karen Lingnau , Wolfgang Zauner , Gerd Zettlmeissl
发明人: Michael Buschle , Jurgen Frisch , Christoph Klade , Karen Lingnau , Wolfgang Zauner , Gerd Zettlmeissl
CPC分类号: C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/55516 , A61K2039/55561 , C12N2770/24222 , C12N2770/24234
摘要: Disclosed is a Hepatitis C virus (HCV) vaccine comprising at least two epitopes, each from a different hotspot epitope, wherein a hotspot epitope is defined as an epitope containing peptide selected from the group consisting of KFPGGGQIVGGVYLLPRRGPRLGVRATRK, GYKVLVLNPSVAAT, AYAAQGYKVLVLNPSVAAT, DLMGYIP(A/L)VGAPL, GEVQVVSTATQSFLATCINGVCWTV, HMWNFISGIQYLAGLSTLPGNPA, VDYPYRLWHYPCT(V/I)N(F/Y)TIFK(V/I)RMYVGGVEHRL, AAWYELTPAETTVRLR, GQGWRLLAPITAYSQQTRGLLGCIV, IGLGKVLVDILAGYGAGVAGALVAFK, FTDNSSPPAVPQTFQV, LEDRDRSELSPLLLSTTEW, YLVAYQATVCARAQAPPPSWD, MSTNPKPQRKTKRNTNR, LINTNGSWHINRTALNCNDSL, TTILGIGTVLDQAET, FDS(S/V)VLCECYDAG(A/C)AWYE, ARLIVFPDLGVRVCEKMALY, AFCSAMYVGDLCGSV, GVLFGLAYFSMVGNW, VVCCSMSYTWTGALITPC, TRVPYFVRAQGLIRA and TTLLFNILGGWVAAQ.
摘要翻译: 公开了一种丙型肝炎病毒(HCV)疫苗,其包含至少两个表位,每个表位各自为不同的热点表位,其中热点表位定义为选自KFPGGGQIVGGVYLLPRRGPRLGVRATRK,GYKVLVLNPSVAAT,AYAAQGYKVLVLNPSVAAT,DLMGYIP(A / L)VGAPL,GEVQVVSTATQSFLATCINGVCWTV,HMWNFISGIQYLAGLSTLPGNPA,VDYPYRLWHYPCT(V / I)N(F / Y)TIFK(V / I)RMYVGGVEHRL,AAWYELTPAETTVRLR,GQGWRLLAPITAYSQQTRGLLGCIV,IGLGKVLVDILAGYGAGVAGALVAFK,FTDNSSPPAVPQTFQV,LEDRDRSELSPLLLSTTEW,YLVAYQATVCARAQAPPPSWD,MSTNPKPQRKTKRNTNR,LINTNGSWHINRTALNCNDSL,TTILGIGTVLDQAET,FDS(S / VLCECYDAG(A / C)AWYE,ARLIVFPDLGVRVCEKMALY,AFCSAMYVGDLCGSV,GVLFGLAYFSMVGNW,VVCCSMSYTWTGALITPC,TRVPYFVRAQGLIRA和TTLLFNILGGWVAAQ。
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公开(公告)号:US20090060875A1
公开(公告)日:2009-03-05
申请号:US11577798
申请日:2005-09-23
申请人: Jurgen Frisch , Erich Tauber , Vera Burger , Christoph Klade , Michael Buschle , Katherine Cohen
发明人: Jurgen Frisch , Erich Tauber , Vera Burger , Christoph Klade , Michael Buschle , Katherine Cohen
CPC分类号: C07K14/005 , A61K39/39 , A61K2039/55 , A61K2039/55511 , A61K2039/55516 , A61K2039/57 , C12N2770/24222
摘要: The invention discloses the use of polycationic compounds for the preparation and manufacturing of medicaments, pharmaceutical compositions, especially vaccines for the treatment of patients with HCV chronic infections.
摘要翻译: 本发明公开了用于制备和制备药物,药物组合物,特别是用于治疗HCV慢性感染患者的疫苗的聚阳离子化合物的用途。
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公开(公告)号:US07441314B2
公开(公告)日:2008-10-28
申请号:US11699220
申请日:2007-01-29
申请人: Jurgen Frisch , Ullrich Munstermann
发明人: Jurgen Frisch , Ullrich Munstermann
CPC分类号: B25B27/0092 , D04H18/04
摘要: A nozzle beam formed with an annular groove is fitted with a seal ring by an apparatus having an elongated support bar, a pair of holders fixed on the bar spaced apart sufficiently that the seal ring can be stretched between them, and a release element for pushing the seal ring off one of the holders.
摘要翻译: 形成有环形槽的喷嘴梁通过具有细长支撑杆的装置装配有密封环,固定在杆上的一对保持架足够间隔开,密封环可以在它们之间被拉伸,以及用于推动的释放元件 密封圈关闭其中一个支架。
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公开(公告)号:US20060035904A1
公开(公告)日:2006-02-16
申请号:US11238739
申请日:2005-09-29
申请人: Jurgen Frisch , James Gibbons , Gary Dukart
发明人: Jurgen Frisch , James Gibbons , Gary Dukart
IPC分类号: A61K31/525 , A61K31/4745
CPC分类号: A61K31/436 , A61K31/4965 , A61K31/519 , A61K31/7068 , A61K45/06 , A61K2300/00
摘要: This invention provides the use of a combination of an mTOR inhibitor and an antimetabolite antineoplastic agent in the treatment of neoplasms.
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