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公开(公告)号：US5639597A
公开(公告)日：1997-06-17
申请号：US243010
申请日：1994-05-13
IPC分类号： C07K17/00 , C07K1/22 , C07K14/52 , C07K14/53 , C07K14/535 , C07K14/54 , C07K14/705 , C07K14/715 , C07K16/00 , C07K16/18 , C07K19/00 , C12N15/62 , C12P21/08 , C12Q1/28 , G01N33/53 , G01N33/543 , G01N33/566 , G01N33/68 , C12Q1/70 , C12Q1/42 , C12Q1/66
CPC分类号： C07K14/7155 , C07K14/715 , C07K14/7151 , C07K14/7153 , C07K16/18 , C12N15/62 , G01N33/566 , G01N33/68 , G01N33/6857 , G01N33/6869 , G01N33/6872 , C07K2319/00
摘要： The invention relates to cell-free receptor binding assays which permit the binding behavior of receptor proteins in the cell membrane toward natural or artificial ligands to be investigated. This entails the particular receptor being linked to a suitable carrier molecule, preferably the heavy chain of an immunoglobulin, and being bound via the carrier, with retention of its biological property, to a suitable solid phase.
摘要翻译： 本发明涉及无细胞受体结合测定，其允许细胞膜中的受体蛋白与待研究的天然或人造配体的结合行为。 这需要将特定的受体连接到合适的载体分子，优选免疫球蛋白的重链，并通过载体与其保持其生物学性质结合到合适的固相。
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公开(公告)号：US20110300170A1
公开(公告)日：2011-12-08
申请号：US13110468
申请日：2011-05-18
申请人： Michael Buschle , Jürgen Frisch , Christoph Klade , Karen Lingnau , Wolfgang Zauner , Gerd Zettlmeissl
发明人： Michael Buschle , Jürgen Frisch , Christoph Klade , Karen Lingnau , Wolfgang Zauner , Gerd Zettlmeissl
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/55516 , A61K2039/55561 , C12N2770/24222 , C12N2770/24234
摘要： Disclosed are methods and compositions for inducing immune responses against Hepatatis C virus (HCV). The compositions comprise one or more epitope from a hotspot epitope. In certain embodiments, an HCV vaccine comprising at least two epitopes, each from a different hotspot epitope, is provided.
摘要翻译： 公开了用于诱导针对Hepatatis C病毒（HCV）的免疫应答的方法和组合物。 组合物包含来自热点表位的一个或多个表位。 在某些实施方案中，提供了包含至少两个表位的HCV疫苗，每个表位各自为不同的热点表位。
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公开(公告)号：US5700663A
公开(公告)日：1997-12-23
申请号：US452836
申请日：1995-05-30
IPC分类号： C12N9/99 , A61K38/00 , A61K38/55 , A61P7/02 , C07H21/04 , C07K14/81 , C12N1/21 , C12N15/09 , C12N15/15 , C12P21/02 , C12R1/19 , A61K38/17 , C07K14/47
CPC分类号： C07K14/8128 , A61K38/00
摘要： Mutants of AT III which have been advantageously modified at one or more potential glycosylation sites or at the Arg393 position are described. As a rule, combination of the mutations enhances the advantageous modifications.
摘要翻译： 描述了在一个或多个潜在糖基化位点或Arg393位置有利地修饰的AT III突变体。 通常，突变的组合增强了有利的修饰。
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公开(公告)号：US07220556B1
公开(公告)日：2007-05-22
申请号：US08459044
申请日：1995-06-02
申请人： Ulrich Grundmann , Egon Amann , Gerd Zettlmeissl
发明人： Ulrich Grundmann , Egon Amann , Gerd Zettlmeissl
CPC分类号： C12N9/1044 , A61K38/00 , C07K16/40 , C12Q1/6876 , G01N33/86 , G01N2333/9108 , G01N2333/91085
摘要： The cDNA which codes for factor XIIIa has been isolated using a cDNA bank from human placenta and probes constructed on the basis of the amino acid sequence of factor XIIIa peptide fragments. It is possible with this cDNA not only to obtain factor XIIIa by gene manipulation in high purity but also to prepare diagnostic aids which permit the analysis of genetic factor XIIIa defects. Furthermore, it is possible on the basis of the amino acid sequence to prepare antibodies which are suitable for diagnostic aids and antibody columns.
摘要翻译： 使用来自人胎盘的cDNA库和基于因子XIIIa肽片段的氨基酸序列构建的探针分离了编码因子XIIIa的cDNA。 该cDNA不仅可以通过高纯度的基因操作获得因子XIIIa，而且可以制备能够分析遗传因子XIIIa缺陷的诊断辅助物质。 此外，可以基于氨基酸序列制备适用于诊断辅助剂和抗体柱的抗体。
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公开(公告)号：US06869790B1
公开(公告)日：2005-03-22
申请号：US08032171
申请日：1993-03-12
申请人： Ulrich Grundmann , Egon Amann , Gerd Zettlmeissl
发明人： Ulrich Grundmann , Egon Amann , Gerd Zettlmeissl
IPC分类号： A61K38/00 , C07K16/40 , C12N9/10 , C12Q1/68 , G01N33/86 , C12N5/00 , A61K35/14 , C07H21/04 , C12N15/00
CPC分类号： C12N9/1044 , A61K38/00 , C07K16/40 , C12Q1/6876 , G01N33/86 , G01N2333/9108 , G01N2333/91085
摘要： The cDNA which codes for factor XIIIa has been isolated using a cDNA bank from human placenta and probes constructed on the basis of the amino acid sequence of factor XIIIa peptide fragments. It is possible with this cDNA not only to obtain factor XIIIa by gene manipulation in high purity but also to prepare diagnostic aids which permit the analysis of genetic factor XIIIa defects. Furthermore, it is possible on the basis of the amino acid sequence to prepare antibodies which are suitable for diagnostic aids and antibody columns.
摘要翻译： 使用来自人胎盘的cDNA库和基于因子XIIIa肽片段的氨基酸序列构建的探针分离了编码因子XIIIa的cDNA。 该cDNA不仅可以通过高纯度的基因操作获得因子XIIIa，而且可以制备能够分析遗传因子XIIIa缺陷的诊断辅助物质。 此外，可以基于氨基酸序列制备适用于诊断辅助剂和抗体柱的抗体。
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6.发明授权Transgenic coagulation factor XIII defective animal and its use for testing wound healing and bleeding 有权转基因凝血因子XIII缺陷动物及其用于测试伤口愈合和出血的用途公开(公告)号：US06207877B1
公开(公告)日：2001-03-27
申请号：US09404208
申请日：1999-09-23
申请人： Gerhard Dickneite , Hubert Metzner , Gerd Zettlmeissl , Ulrich Grundmann , Richard Lathe , Austin Smith , Meng Li
发明人： Gerhard Dickneite , Hubert Metzner , Gerd Zettlmeissl , Ulrich Grundmann , Richard Lathe , Austin Smith , Meng Li
IPC分类号： A01K67027
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0306 , A61K49/0008 , C12N9/1044
摘要： The invention provides a transgenic mouse which is heterozygous or homozygous for an at least partially defective coagulation factor XIII gene.
摘要翻译： 本发明提供了对于至少部分有缺陷的凝血因子XIII基因是杂合的或纯合的转基因小鼠。
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公开(公告)号：US5618713A
公开(公告)日：1997-04-08
申请号：US993910
申请日：1992-12-18
IPC分类号： C12N9/99 , A61K38/00 , A61K38/55 , A61P7/02 , C07H21/04 , C07K14/81 , C12N1/21 , C12N15/09 , C12N15/15 , C12P21/02 , C12R1/19 , C12N9/64 , A61K38/17
CPC分类号： C07K14/8128 , A61K38/00
摘要： Mutants of AT III which have been advantageously modified at one or more potential glycosylation sites or at the Arg393 position are described. As a rule, combination of the mutations enhances the advantageous modifications.
摘要翻译： 描述了在一个或多个潜在糖基化位点或Arg393位置有利地修饰的AT III突变体。 通常，突变的组合增强了有利的修饰。
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公开(公告)号：US20090155294A1
公开(公告)日：2009-06-18
申请号：US12248587
申请日：2008-10-09
申请人： MICHAEL BUSCHLE , JURGEN FRISCH , CHRISTOPH KLADE , KAREN LINGNAU , WOLFGANG ZAUNER , GERD ZETTLMEISSL
发明人： MICHAEL BUSCHLE , JURGEN FRISCH , CHRISTOPH KLADE , KAREN LINGNAU , WOLFGANG ZAUNER , GERD ZETTLMEISSL
IPC分类号： A61K39/29
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/55516 , A61K2039/55561 , C12N2770/24222 , C12N2770/24234
摘要： Disclosed are methods and compositions for inducing immune responses against Hepatitis C virus (HCV). The compositions comprise one or more epitope from a hotspot epitope. In certain embodiments, an HCV vaccine comprising at least two epitopes, each from a different hotspot epitope, is provided.
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公开(公告)号：US20090130135A1
公开(公告)日：2009-05-21
申请号：US12248744
申请日：2008-10-09
申请人： MICHAEL BUSCHLE , JURGEN FRISCH , CHRISTOPH KLADE , KAREN LINGNAU , WOLFGANG ZAUNER , GERD ZETTLMEISSL
发明人： MICHAEL BUSCHLE , JURGEN FRISCH , CHRISTOPH KLADE , KAREN LINGNAU , WOLFGANG ZAUNER , GERD ZETTLMEISSL
IPC分类号： A61K39/29
CPC分类号： A61K39/29 , A61K39/00 , A61K39/12 , A61K2039/55505 , A61K2039/55516 , A61K2039/55561 , A61K2039/57 , C07K14/005 , C12N2770/24222 , C12N2770/24234
摘要： Disclosed are methods and compositions for inducing immune responses against Hepatitis C virus (HCV). The compositions comprise one or more epitope from a hotspot epitope. In certain embodiments, an HCV vaccine comprising at least two epitopes, each from a different hotspot epitope, is provided.
摘要翻译： 公开了用于诱导针对丙型肝炎病毒（HCV）的免疫应答的方法和组合物。 组合物包含来自热点表位的一个或多个表位。 在某些实施方案中，提供了包含至少两个表位的HCV疫苗，每个表位各自为不同的热点表位。
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公开(公告)号：US07253264B1
公开(公告)日：2007-08-07
申请号：US08293603
申请日：1994-08-22
IPC分类号： C07K19/00
CPC分类号： C07K14/745 , A61K38/00 , C07K14/505 , C07K14/7155 , C07K16/00 , C07K2319/00
摘要： The invention relates to genetically engineered soluble fusion proteins composed of human proteins not belonging to the immunoglobulin family, or of parts thereof, and of various portions of the constant region of immunoglobulin molecules. The functional properties of the two fusion partners are surprisingly retained in the fusion protein.
摘要翻译： 本发明涉及由不属于免疫球蛋白家族的人蛋白质或其部分以及免疫球蛋白分子恒定区的各种部分组成的遗传工程可溶性融合蛋白。 两个融合配偶体的功能特性令人惊奇地保留在融合蛋白中。
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