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1.发明授权Process for producing solid anhydrous composition, and pharmaceutical and cosmetic products comprising same 失效制备固体无水组合物的方法，以及包含其的药物和化妆品
公开(公告)号：US6045823A
公开(公告)日：2000-04-04
申请号：US120269
申请日：1998-07-22
申请人： Jurgen Vollhardt , Robert P. Manzo , Nisha Malkan
发明人： Jurgen Vollhardt , Robert P. Manzo , Nisha Malkan
IPC分类号： A61K8/04 , A61K8/14 , A61K8/34 , A61K8/73 , A61K9/127 , A61K9/133 , A61Q1/06 , A61Q13/00 , A61Q15/00 , A61Q17/00 , A61Q19/00 , A61K91/127 , A61K7/00 , A61K7/027 , A61K7/32
CPC分类号： A61Q17/005 , A61K8/046 , A61K8/14 , A61K8/34 , A61K8/732 , A61K9/127 , A61Q1/06 , A61Q13/00 , A61Q15/00 , A61Q19/00 , Y10S977/907 , Y10S977/926
摘要： Anhydrous cosmetic stick formulations such as lip balms, lipsticks, and underarm deodorant or antiperspirant sticks, comprising an organic matrix having particles homogeneously dispersed therein, which particles are preferably prepared by a process comprising spray-drying a mixture of liposome encapsulated active agent, modified starch, and optionally a hydrocolloid gum such as maltodextrin.
摘要翻译： 无水化妆棒配方如唇膏，唇膏，腋下除臭剂或止汗棒，包含均匀分散有颗粒的有机基质，该颗粒优选通过包括喷雾干燥脂质体包封的活性剂，改性淀粉 ，和任选的水胶体胶如麦芽糖糊精。
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公开(公告)号：US06083529A
公开(公告)日：2000-07-04
申请号：US59320
申请日：1998-04-13
申请人： Robert P. Manzo , Jurgen Vollhardt , Nisha Malkan , Gary Friars
发明人： Robert P. Manzo , Jurgen Vollhardt , Nisha Malkan , Gary Friars
CPC分类号： A61K8/14 , A61K8/732 , A61K9/127 , A61K9/146 , A61Q1/12 , Y10S977/801 , Y10S977/907 , Y10S977/915 , Y10S977/926
摘要： A stable dry powder skin care powder having prolonged and controlled release properties, useful as baby powders, body talcs, deodorizing powders, OTC eczema preparations, foot powders, anti-fungal powders, etc. The dry powder is preferably prepared by a process comprising spray-drying a mixture of liposome encapsulated active agent, starch and maltodextrin. The particle is designed so that activity of, e.g., an anti-inflammatory agent such as Dragosantol.RTM. can be specifically triggered by skin conditions, such as moisture, for optimal timing of delivery.
摘要翻译： 具有延长和控制释放性能的稳定的干粉护肤粉，可用作婴儿粉末，身体滑石，除臭粉末，OTC湿疹制剂，足部粉末，抗真菌粉末等。干燥粉末优选通过包括喷雾 混合脂质体包裹的活性剂，淀粉和麦芽糖糊精。 该颗粒被设计成使得例如Dragosantol TM等抗炎剂的活性可以由皮肤状况例如水分特异性触发，以达到最佳的递送时间。
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公开(公告)号：US20060165637A1
公开(公告)日：2006-07-27
申请号：US10559625
申请日：2004-06-17
申请人： Jurgen Vollhardt , Raphael Beumer
发明人： Jurgen Vollhardt , Raphael Beumer
摘要： The invention relates to agents for topical administration of a compound of formula (I): (CH3)2CH—(CH2)3—CH(CH3)—(CH2)3—CH(CH3)—(CH2)3—C(A)(CH3)—C(B)2—C(O)—R, wherein R represents hydrogen, OR1, N(OH)R1 or NR2R3; R1, R2 and R3 independently represent hydrogen C1-C22-alkyl, C1-C22-alkenyl, C7-C12-arylalkyl (particularly benzyl, phenethyl and phenylpropyl), retinyl, tocopheryl, ascorbyl or a radical stemming from an amino acid or a peptide and A and B represent hydrogen atoms or A and a radical B form a double bond and the other radical B represents a hydrogen atom or radical A represents a hydrogen atom and the radicals B together form an oxygen atom or one of the radicals B represents a hydroxyl group and the other radical B and radical A represent hydrogen atoms. Said agents contain a compound of formula (I) and a pharmaceutically and/or cosmetically acceptable carrier provided that the agent does not contain any retinoids.
摘要翻译： 本发明涉及用于局部施用式（I）化合物的试剂：（CH 3）2 CH-（CH 2） CH 3（CH 3） - （CH 2）3 - （CH 3） （CH 3）3 -C（A）（CH 3） - C（B）2 （O）-R，其中R表示氢，OR 1，N（OH）R 1或NR 2 R SUP> 3 ; R 1，R 2和R 3独立地表示氢C 1 -C 22 烷基，C 1 -C 22 - 烯基，C 7 -C 12 - 芳基烷基（特别是苄基 ，苯乙基和苯基丙基），视黄酯，生育酚，抗坏血酸或源自氨基酸或肽的基团，A和B表示氢原子或A，自由基B形成双键，另一个基团B表示氢原子或基团 A表示氢原子，基团B一起形成氧原子或基团B中的一个表示羟基，另一个基团B和基团A表示氢原子。 所述试剂含有式（I）化合物和药学上和/或化妆品上可接受的载体，条件是该试剂不含任何类维生素A。
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4.发明授权
公开(公告)号：US5981792A
公开(公告)日：1999-11-09
申请号：US31131
申请日：1998-02-26
申请人： Jurgen Vollhardt
发明人： Jurgen Vollhardt
IPC分类号： C07C67/08 , C07C67/293 , C07C69/025 , C07C69/145 , C07C67/00 , C07C67/02 , C07C69/76
CPC分类号： C07C67/08 , C07C67/293
摘要： The process for preparing 1-functional allyl alcohol carboxylic esters comprises reacting a 3-functional allyl alcohol with the anhydride of the carboxylic acid at temperatures above 100.degree. C. in the presence of metal compounds of transition groups V to VII, namely at temperatures of 100-200.degree. C., preferably 130-150.degree. C. As metal compounds, it is possible to use oxidic metal compounds in the highest or at least second highest oxidation state of the transition metals, for example tungstic acid or its salts and/or tungsten(VI) oxide and/or molybdenum(V) oxide and/or molybdenum(VI) oxide and/or rhenium(VII) oxide. The 3-functional allyl alcohol and the carboxylic anhydride are advantageously used in equimolar amounts, if desired with a slight excess of anhydride, and an alkali metal salt of a weak acid, for example sodium carbonate or sodium acetate, can be added to the reaction mixture in an amount sufficient to trap free protons.
摘要翻译： 制备1-官能烯丙醇羧酸酯的方法包括在过渡基团V至VII的金属化合物存在下，在高于100℃的温度下，即3-乙烯基醇与羧酸酐反应，即在 100-200℃，优选130-150℃。作为金属化合物，可以使用过渡金属的最高或至少第二高氧化态的氧化金属化合物，例如钨酸或其盐和/ 或氧化物（V）氧化物和/或氧化钼（V）和/或氧化钼（VI）和/或氧化铼（VII）。 如果需要，3-官能的烯丙醇和羧酸酐有利地以等摩尔量的使用，稍微过量的酸酐，并且可以向反应中加入弱酸的碱金属盐，例如碳酸钠或乙酸钠 混合物的量足以捕获游离质子。
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公开(公告)号：US20090195027A1
公开(公告)日：2009-08-06
申请号：US12362403
申请日：2009-01-29
CPC分类号： B60J1/004 , B62D25/081 , Y10T29/49622
摘要： A windshield support structure for a vehicle is provided, in particular an automobile, which includes, but is not limited to a front bulkhead and a windshield support connected thereto. The windshield support is supported on the front bulkhead by means of at least one support disposed on the windshield support and the front bulkhead. A method is also provided for producing a windshield support structure, and at least one support is disposed on a front bulkhead and on a windshield support.
摘要翻译： 提供了一种用于车辆的挡风玻璃支撑结构，特别是汽车，其包括但不限于与其隔开的前隔板和挡风玻璃支撑件。 挡风玻璃支撑件通过设置在挡风玻璃支撑件和前隔板上的至少一个支撑件支撑在前隔板上。 还提供了一种用于制造挡风玻璃支撑结构的方法，并且至少一个支撑件设置在前隔板和挡风玻璃支撑件上。
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6.发明授权Protein extract from cereal gluten, preparation thereof and use thereof in hair care 失效来自谷物麸质的蛋白质提取物，其制备及其在头发护理中的用途
公开(公告)号：US6063367A
公开(公告)日：2000-05-16
申请号：US36297
申请日：1998-03-06
摘要： The invention describes a protein extract in the form of an alcoholic extraction solution obtained from dried cereal gluten, which solution has been treated with glycerol and/or a short-chain alkanediol and evaporated under reduced pressure until the alcohol content is less than 5% by weight, preferably less than 1% by weight.This extract is outstandingly suitable for use in cosmetic preparations for care of damaged hair.
摘要翻译： 本发明描述了由干燥的谷物麸质获得的醇提取溶液形式的蛋白质提取物，该溶液已用甘油和/或短链烷二醇处理，并在减压下蒸发直到酒精含量小于5％ 重量，优选小于1重量％。 该提取物非常适合用于护理受损头发的化妆品。
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公开(公告)号：US5783211A
公开(公告)日：1998-07-21
申请号：US962906
申请日：1997-11-03
申请人： Robert P. Manzo , Jurgen Vollhardt , Nisha Malkan , Gary Friars
发明人： Robert P. Manzo , Jurgen Vollhardt , Nisha Malkan , Gary Friars
CPC分类号： A61K8/14 , A61K8/732 , A61K9/127 , A61K9/146 , A61Q1/12 , Y10S977/801 , Y10S977/907 , Y10S977/915 , Y10S977/926
摘要： A stable dry powder skin care powder having prolonged and controlled release properties, useful as baby powders, body talcs, deodorizing powders, OTC eczema preparations, foot powders, anti-fungal powders, etc. The dry powder is preferably prepared by a process comprising spray-drying a mixture of liposome encapsulated active agent, starch and maltodextrin. The particle is designed so that activity of, e.g., an anti-inflammatory agent such as Dragosantol.RTM. can be specifically triggered by skin conditions, such as moisture, for optimal timing of delivery.
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