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公开(公告)号：US20230314433A1
公开(公告)日：2023-10-05
申请号：US18023065
申请日：2021-08-24
Applicant: KURUME UNIVERSITY
Inventor： Tomoaki HOSHINO
IPC: G01N33/569
CPC classification number: G01N33/56983 , C12Y306/04013 , G01N2333/914 , G01N2470/04
Abstract: The disclosure provides a method of determining whether a subject is infected with a virus, comprising (1) testing whether a protein comprising an amino acid sequence of at least a part of the helicase domain of MDA5 protein and having a molecular weight of about 60 kDa is detected in a sample obtained from the subject; and (2) determining the subject is infected with the virus when the protein was detected. The disclosure also provides a monoclonal antibody capable of binding to the protein.
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公开(公告)号：US11000258B2
公开(公告)日：2021-05-11
申请号：US15757617
申请日：2016-09-07
Applicant: Kurume University
Inventor： Hiroshi Tomoeda
Abstract: The present invention provides an arteriovenous pressure measurement device which allows noninvasive and accurate measurement of arteriovenous pressure, and also provides an arteriovenous pressure measurement method using the measurement device. The noninvasive arteriovenous pressure measurement device comprises a probe (20) for radiating ultrasound toward a blood vessel in the skin, a pressing part (10) for pressing the skin in a state of being placed between the skin and the probe (20), and a pressure sensor (33) for detecting a pressing force applied to the skin at the pressing part (10), the pressing part (10) having water (36) permeable to the ultrasound and a balloon (31) accommodating the water (36), the flexible container (31) being made of a flexible material permeable to the ultrasound, and an outer surface of the balloon (31) presses the skin.
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公开(公告)号：US20130230861A1
公开(公告)日：2013-09-05
申请号：US13779470
申请日：2013-02-27
Applicant: SAGA UNIVERSITY , KURUME UNIVERSITY
Inventor： Kenji IZUHARA , Shoichiro Ohta , Hiroshi Shiraishi , Hisamichi Aizawa , Tomoaki Hoshino , Masaki Okamoto
CPC classification number: G01N33/6884 , C07K16/28 , C12Q1/6883 , C12Q2600/136 , G01N2333/51 , G01N2500/00 , G01N2500/10 , G01N2800/12 , G01N2800/26
Abstract: The present invention provides a method for detecting idiopathic interstitial pneumonia, which comprises measuring the expression level of a periostin gene or the amount of a periostin protein in a biological sample. Thereby, a method for detecting idiopathic interstitial pneumonia using a marker is provided.
Abstract translation: 本发明提供一种检测特发性间质性肺炎的方法，其包括测量生物样品中骨膜素基因的表达水平或骨膜素蛋白的量。 因此，提供了使用标记物检测特发性间质性肺炎的方法。
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公开(公告)号：US12108746B2
公开(公告)日：2024-10-08
申请号：US17255688
申请日：2019-06-28
Applicant: KURUME UNIVERSITY
Inventor： Takahiro Sato , Masayasu Kojima , Kanae Oishi
IPC: A01K67/0275 , C12N9/10 , C12Q1/6883
CPC classification number: A01K67/0275 , C12N9/1029 , C12Q1/6883 , A01K2217/05 , A01K2227/105 , A01K2267/0306 , C12Q2600/156
Abstract: The disclosure provides a non-human transgenic animal having at least one CREBBP gene locus into which a mutation has been introduced, wherein the mutated CREBBP gene encodes a mutant CREBBP consisting of an amino acid sequence having at least 90% identity with the amino acid sequence of SEQ ID NO: 5. The disclosure also provides a method of producing the transgenic animal comprising introducing a mutation into at least one CREBBP gene locus of a non-human animal. The disclosure further provides use of the transgenic animal as a model of Rubinstein-Taybi syndrome or advanced sleep phase syndrome.
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公开(公告)号：US20240082559A1
公开(公告)日：2024-03-14
申请号：US18263645
申请日：2022-01-07
Applicant: JMS Co., Ltd. , KURUME UNIVERSITY , MDI CO., LTD.
Inventor： Takehiko YUKI , Masaya MUTSUKADO , Ken KANDA , Koichiro TOYOTA , Masahiro KINOSHITA , Osuke IWATA , Manabu MOCHIZUKI , Yasuo IMAMURA
CPC classification number: A61M39/10 , A61J15/0003 , A61J15/0026 , A61B1/00126
Abstract: A connector (50) includes a tubular member (52) and a base tube (58). A light-guiding tube (60) is drawn out from the base tube (58) toward the opposite side to the tubular member (52). An adapter (1) includes: a first connecting portion (10) that can be connected to and disconnected from a light source device (70); a second connecting portion (20) that can be connected to and disconnected from the connector (50); and a light-guiding member (30) that guides light emitted from the light source device (70) to a proximal end surface (61) of the tube (60).
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Patent Agency Ranking
公开(公告)号：US10590388B2
公开(公告)日：2020-03-17
申请号：US15546047
申请日：2016-01-26
Applicant: UBE INDUSTRIES, LTD. , KURUME UNIVERSITY
Inventor： Keisuke Ohta , Shingo Hirashima , Masahiko Hagihara , Motohisa Shimizu
Abstract: The present invention relates to a method for culturing bone marrow cells, in which bone marrow cells are applied to a porous polyimide film and cultured. Moreover, the present invention relates to a porous polyimide film for healing a bone injury site.
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7.发明申请公开(公告)号：US20190307851A1
公开(公告)日：2019-10-10
申请号：US16437486
申请日：2019-06-11
Applicant: KURUME UNIVERSITY
Inventor： Toyojiro MATSUISHI , Masayasu KOJIMA , Kotaro YUGE , Munetsugu HARA , Yushiro YAMASHITA
Abstract: A prophylactic and therapeutic agent for Rett Syndrome (RTT) is provided, a pharmaceutical composition comprising ghrelin and a pharmaceutically acceptable carrier and a prophylactic and therapeutic agent for RTT comprising a therapeutically effective amount of ghrelin. The side chain of serine at the 3rd position of ghrelin is modified with octanoic acid.
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公开(公告)号：US20180242945A1
公开(公告)日：2018-08-30
申请号：US15757617
申请日：2016-09-07
Applicant: Kurume University
Inventor： Hiroshi Tomoeda
CPC classification number: A61B8/04 , A61B5/022 , A61B5/023 , A61B8/4455 , G01L11/06 , G01L17/00 , G01S15/8906
Abstract: The present invention provides an arteriovenous pressure measurement device which allows noninvasive and accurate measurement of arteriovenous pressure, and also provides an arteriovenous pressure measurement method using the measurement device. The noninvasive arteriovenous pressure measurement device comprises a probe (20) for radiating ultrasound toward a blood vessel in the skin, a pressing part (10) for pressing the skin in a state of being placed between the skin and the probe (20), and a pressure sensor (33) for detecting a pressing force applied to the skin at the pressing part (10), the pressing part (10) having water (36) permeable to the ultrasound and a balloon (31) accommodating the water (36), the flexible container (31) being made of a flexible material permeable to the ultrasound, and an outer surface of the balloon (31) presses the skin.
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9.发明申请公开(公告)号：US20180148693A1
公开(公告)日：2018-05-31
申请号：US15546047
申请日：2016-01-26
Applicant: UBE INDUSTRIES, LTD. , KURUME UNIVERSITY
Inventor： Keisuke OHTA , Shingo HIRASHIMA , Masahiko HAGIHARA , Motohisa SHIMIZU
IPC: C12N5/077 , A61L27/36 , A61L27/18 , C12N5/0789 , A61L27/56
Abstract: The present invention relates to a method for culturing bone marrow cells, in which bone marrow cells are applied to a porous polyimide film and cultured. Moreover, the present invention relates to a porous polyimide film for healing a bone injury site.
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公开(公告)号：US20210327294A1
公开(公告)日：2021-10-21
申请号：US17273156
申请日：2019-08-23
Applicant: Kurume University
Inventor： Reiji KATAYAMA
IPC: G09B9/00 , G09B23/36 , G06F3/0481 , B29C64/393 , B33Y50/02
Abstract: A simulated experience system that includes a video display device that is an HMD; a controller that has a body part that is a full-scale simulation of a human liver and a signal oscillator; a computer connected to the video display device and the controller, and having a signal receiver, an arithmetic unit, a video generator, a synchronization processing unit, a video output unit, a storage unit, an additional video generator, and a video synthesizer; and an infrared radiation device configured such that each of a pair of infrared radiation units can output infrared rays that three-dimensionally scan an installation space.
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