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公开(公告)号：US06555813B1
公开(公告)日：2003-04-29
申请号：US09561604
申请日：2000-04-27
IPC分类号： G01N2175
CPC分类号： H01J49/0418 , B01L3/5085 , Y10S977/881 , Y10S977/891 , Y10S977/892 , Y10T436/255
摘要： This invention provides a mass spectrometry probe including a substrate having a surface and a film that coats the surface. The film includes openings that define features for the presentation of an analyte. The film also has a lower surface tension that the surface tension of the substrate surface, and has a water contact angle between 120° and 180°.
摘要翻译： 本发明提供了一种质谱探针，其包括具有表面的基材和涂覆该表面的膜。 该膜包括限定用于呈现分析物的特征的开口。 该膜还具有较低的表面张力，即基材表面的表面张力，并具有120°和180°之间的水接触角。
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公开(公告)号：US07479631B2
公开(公告)日：2009-01-20
申请号：US11681377
申请日：2007-03-02
申请人： William E. Rich , Pil-Je Um , Kamen Voivodov , Tai-Tung Yip , Jody Beecher
发明人： William E. Rich , Pil-Je Um , Kamen Voivodov , Tai-Tung Yip , Jody Beecher
CPC分类号： H01J49/0418 , H01J49/12 , Y10T428/261 , Y10T428/31504 , Y10T436/24
摘要： The invention provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a hydrogel material on the surface, the hydrogel material comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. The invention also provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a plurality of particles that are uniform in diameter on the surface, the particles comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. Further, the invention provides a system comprising the probe of the present invention and a gas phase ion spectrometer comprising an energy source that directs light to the probe surface to desorb an analyte and a detector in communication with the probe surface that detects the desorbed analyte. The invention also provides a method for desorbing an analyte from a probe surface, the method comprising exposing the binding functionalities to a sample containing an analyte under conditions to allow binding between the analyte and the binding functionalities, and desorbing the analyte from the probe by gas phase ion spectrometry.
摘要翻译： 本发明提供一种探针和一种使探针可移除地插入到气相离子光谱仪中的探针，该探针包括在表面上具有表面和水凝胶材料的基底，该水凝胶材料包含用于与分析物结合的结合官能团 可由气相离子光谱仪检测。 本发明还提供了一种探针和一种使探针可移除地插入到气相离子分光计中的方法，该探针包括具有表面和表面上直径均匀的多个颗粒的基底，该颗粒包含结合 用于与气相离子光谱仪可检测的分析物结合的功能。 此外，本发明提供了一种包括本发明的探针和气相离子光谱仪的系统，该气相离子光谱仪包括将光引导到探针表面以解吸分析物的能量源和与检测解吸附的分析物的探针表面连通的检测器。 本发明还提供了一种用于从探针表面解吸分析物的方法，该方法包括在允许分析物和结合官能团之间结合的条件下将结合功能暴露于含有分析物的样品，并通过气体从探针解吸分析物 相离子光谱法。
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公开(公告)号：US06897072B1
公开(公告)日：2005-05-24
申请号：US09560715
申请日：2000-04-27
申请人： William E. Rich , Pil-Je Um , Kamen Voivodov , Tai-Tung Yip , Jody Beecher
发明人： William E. Rich , Pil-Je Um , Kamen Voivodov , Tai-Tung Yip , Jody Beecher
IPC分类号： H01J49/16 , C08F20/10 , C08F20/56 , G01N1/28 , G01N27/62 , G01N27/64 , H01J49/04 , H01J49/12 , G01N24/00
CPC分类号： H01J49/0418 , H01J49/12 , Y10T428/261 , Y10T428/31504 , Y10T436/24
摘要： The invention provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a hydrogel material on the surface, the hydrogel material comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. The invention also provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a plurality of particles that are uniform in diameter on the surface, the particles comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. Further, the invention provides a system comprising the probe of the present invention and a gas phase ion spectrometer comprising an energy source that directs light to the probe surface to desorb an analyte and a detector in communication with the probe surface that detects the desorbed analyte. The invention also provides a method for desorbing an analyte from a probe surface, the method comprising exposing the binding functionalities to a sample containing an analyte under conditions to allow binding between the analyte and the binding functionalities, and desorbing the analyte from the probe by gas phase ion spectrometry.
摘要翻译： 本发明提供一种探针和一种使探针可移除地插入到气相离子光谱仪中的探针，该探针包括在表面上具有表面和水凝胶材料的基底，该水凝胶材料包含用于与分析物结合的结合官能团 可由气相离子光谱仪检测。 本发明还提供了一种探针和一种使探针可移除地插入到气相离子分光计中的方法，该探针包括具有表面和表面上直径均匀的多个颗粒的基底，该颗粒包含结合 用于与气相离子光谱仪可检测的分析物结合的功能。 此外，本发明提供了一种包括本发明的探针和气相离子光谱仪的系统，该气相离子光谱仪包括将光引导到探针表面以解吸分析物的能量源和与检测解吸附的分析物的探针表面连通的检测器。 本发明还提供了一种用于从探针表面解吸分析物的方法，该方法包括在允许分析物和结合官能团之间结合的条件下将包含分析物的样品的结合官能团暴露，并通过气体从探针解吸分析物 相离子光谱法。
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公开(公告)号：US07205156B2
公开(公告)日：2007-04-17
申请号：US10960222
申请日：2004-10-06
申请人： William E. Rich , Pil-Je Um , Kamen Voivodov , Tai-Tung Yip , Jody Beecher
发明人： William E. Rich , Pil-Je Um , Kamen Voivodov , Tai-Tung Yip , Jody Beecher
IPC分类号： G01N24/00
CPC分类号： H01J49/0418 , H01J49/12 , Y10T428/261 , Y10T428/31504 , Y10T436/24
摘要： The invention provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a hydrogel material on the surface, the hydrogel material comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. The invention also provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a plurality of particles that are uniform in diameter on the surface, the particles comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. Further, the invention provides a system comprising the probe of the present invention and a gas phase ion spectrometer comprising an energy source that directs light to the probe surface to desorb an analyte and a detector in communication with the probe surface that detects the desorbed analyte. The invention also provides a method for desorbing an analyte from a probe surface, the method comprising exposing the binding functionalities to a sample containing an analyte under conditions to allow binding between the analyte and the binding functionalities, and desorbing the analyte from the probe by gas phase ion spectrometry.
摘要翻译： 本发明提供一种探针和一种使探针可移除地插入到气相离子光谱仪中的探针，该探针包括在表面上具有表面和水凝胶材料的基底，该水凝胶材料包含用于与分析物结合的结合官能团 可由气相离子光谱仪检测。 本发明还提供了一种探针和一种使探针可移除地插入到气相离子分光计中的方法，该探针包括具有表面和表面上直径均匀的多个颗粒的基底，该颗粒包含结合 用于与气相离子光谱仪可检测的分析物结合的功能。 此外，本发明提供了一种包括本发明的探针和气相离子光谱仪的系统，该气相离子光谱仪包括将光引导到探针表面以解吸分析物的能量源和与检测解吸附的分析物的探针表面连通的检测器。 本发明还提供了一种用于从探针表面解吸分析物的方法，该方法包括在允许分析物和结合官能团之间结合的条件下将包含分析物的样品的结合官能团暴露，并通过气体从探针解吸分析物 相离子光谱法。
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公开(公告)号：US20050090016A1
公开(公告)日：2005-04-28
申请号：US10960222
申请日：2004-10-06
申请人： William Rich , Pil-Je Um , Kamen Voivodov , Tai-Tung Yip , Jody Beecher
发明人： William Rich , Pil-Je Um , Kamen Voivodov , Tai-Tung Yip , Jody Beecher
IPC分类号： H01J49/16 , C08F20/10 , C08F20/56 , G01N1/28 , G01N27/62 , G01N27/64 , H01J49/04 , H01J49/12 , G01N1/00
CPC分类号： H01J49/0418 , H01J49/12 , Y10T428/261 , Y10T428/31504 , Y10T436/24
摘要： The invention provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a hydrogel material on the surface, the hydrogel material comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. The invention also provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a plurality of particles that are uniform in diameter on the surface, the particles comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. Further, the invention provides a system comprising the probe of the present invention and a gas phase ion spectrometer comprising an energy source that directs light to the probe surface to desorb an analyte and a detector in communication with the probe surface that detects the desorbed analyte. The invention also provides a method for desorbing an analyte from a probe surface, the method comprising exposing the binding functionalities to a sample containing an analyte under conditions to allow binding between the analyte and the binding functionalities, and desorbing the analyte from the probe by gas phase ion spectrometry.
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公开(公告)号：US20070158547A1
公开(公告)日：2007-07-12
申请号：US11681377
申请日：2007-03-02
申请人： William Rich , Pil-Je Um , Kamen Voivodov , Tai-Tung Yip , Jody Beecher
发明人： William Rich , Pil-Je Um , Kamen Voivodov , Tai-Tung Yip , Jody Beecher
IPC分类号： B01D59/44
CPC分类号： H01J49/0418 , H01J49/12 , Y10T428/261 , Y10T428/31504 , Y10T436/24
摘要： The invention provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a hydrogel material on the surface, the hydrogel material comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. The invention also provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a plurality of particles that are uniform in diameter on the surface, the particles comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. Further, the invention provides a system comprising the probe of the present invention and a gas phase ion spectrometer comprising an energy source that directs light to the probe surface to desorb an analyte and a detector in communication with the probe surface that detects the desorbed analyte. The invention also provides a method for desorbing an analyte from a probe surface, the method comprising exposing the binding functionalities to a sample containing an analyte under conditions to allow binding between the analyte and the binding functionalities, and desorbing the analyte from the probe by gas phase ion spectrometry.
摘要翻译： 本发明提供一种探针和一种使探针可移除地插入到气相离子光谱仪中的探针，该探针包括在表面上具有表面和水凝胶材料的底物，该水凝胶材料包含用于与分析物结合的结合官能团 可由气相离子光谱仪检测。 本发明还提供了一种探针和一种使探针可移除地插入到气相离子分光计中的方法，该探针包括具有表面和表面上直径均匀的多个颗粒的基底，该颗粒包含结合 用于与气相离子光谱仪可检测的分析物结合的功能。 此外，本发明提供了一种包括本发明的探针和气相离子光谱仪的系统，该气相离子光谱仪包括将光引导到探针表面以解吸分析物的能量源和与检测解吸附的分析物的探针表面连通的检测器。 本发明还提供了一种用于从探针表面解吸分析物的方法，该方法包括在允许分析物和结合官能团之间结合的条件下将结合功能暴露于含有分析物的样品，并通过气体从探针解吸分析物 相离子光谱法。
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公开(公告)号：US20060183863A1
公开(公告)日：2006-08-17
申请号：US11058330
申请日：2005-02-14
申请人： Wenxi Huang , Sarah Ngola , Kamen Voivodov
发明人： Wenxi Huang , Sarah Ngola , Kamen Voivodov
IPC分类号： C08L9/02
CPC分类号： C08F220/38 , B01D15/364 , B01J20/264 , B01J20/3276 , B01J2220/54 , C08F220/36
摘要： Zwitterionic polymers bearing positive and negative charges are readily prepared from easily accessible precursors. The polymers show enhanced binding affinities for analytes under high salt conditions, compared to similar polymers bearing a charge of a single polarity. The polymers can also include an energy absorbing moiety for use in matrix assisted laser desorption/ionization mass spectrometry. The polymer can also include a photo-curable group, which can be used to form cross-links within the bulk polymer or between the polymer and a surface functionalized with a polymerizable moiety. The polymers are incorporated into devices of use for the analysis, capture, separation, or purification of an analyte. In an exemplary embodiment, the invention provides a substrate coated with a polymer of the invention, the substrate being adapted for use as a probe for a mass spectrometer.
摘要翻译： 带有正电荷和负电荷的两性离子聚合物易于从容易获得的前体制备。 与具有单一极性电荷的类似聚合物相比，聚合物在高盐条件下显示出增强的分析物的结合亲和力。 聚合物还可以包括用于基质辅助激光解吸/电离质谱的能量吸收部分。 聚合物还可以包括可光固化基团，其可以用于在本体聚合物内形成交联，或者在聚合物与用可聚合部分官能化的表面之间形成交联。 将聚合物并入用于分析，捕获，分离或纯化分析物的装置中。 在一个示例性实施方案中，本发明提供涂覆有本发明的聚合物的基材，所述基材适于用作质谱仪的探针。
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公开(公告)号：US20060183242A1
公开(公告)日：2006-08-17
申请号：US11057880
申请日：2005-02-14
申请人： Wenxi Huang , Aaron Chen , Sarah Ngola , Kamen Voivodov
发明人： Wenxi Huang , Aaron Chen , Sarah Ngola , Kamen Voivodov
IPC分类号： G01N31/22
CPC分类号： B01J20/26 , B01J20/265 , B01J20/285 , B01J20/3265 , B01J2220/54 , C07K1/22
摘要： Polymers bearing metal chelating groups are readily prepared from easily accessible precursors. The polymers are readily converted to the corresponding metal chelates. The polymers can also include an energy absorbing moiety for use in matrix assisted laser desorption/ionization mass spectrometry. The polymer can also include a photo-curable group, which can be used to form cross-links within the bulk polymer or between the polymer and a surface functionalized with a polymerizable moiety. The polymers are incorporated into devices of use for the analysis, capture, separation, or purification of an analyte. In an exemplary embodiment, the invention provides a substrate coated with a polymer of the invention, the substrate being adapted for use as a probe for a mass spectrometer.
摘要翻译： 具有金属螯合基团的聚合物可以容易地从容易获得的前体制备。 聚合物容易转化为相应的金属螯合物。 聚合物还可以包括用于基质辅助激光解吸/电离质谱法中的能量吸收部分。 聚合物还可以包括可光固化基团，其可以用于在本体聚合物内形成交联，或者在聚合物与用可聚合部分官能化的表面之间形成交联。 将聚合物并入用于分析，捕获，分离或纯化分析物的装置中。 在一个示例性实施方案中，本发明提供涂覆有本发明的聚合物的基材，所述基材适于用作质谱仪的探针。
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