公开(公告)号：US20080074661A1

公开(公告)日：2008-03-27

申请号：US11524489

申请日：2006-09-21

申请人： Jingwu Zhang ,  Sarah Ngola ,  Xing Su

发明人： Jingwu Zhang ,  Sarah Ngola ,  Xing Su

IPC分类号： G01J3/44 ,  G01N21/65

CPC分类号： G01N30/74 ,  B01J2220/54 ,  G01N21/658 ,  G01N27/44721 ,  G01N30/52 ,  G01N30/6082 ,  G01N30/7233 ,  G01N30/78 ,  G01N2030/525 ,  G01N2030/746

摘要： Devices and methods for separating and detecting analytes in a sample. The separation can be accomplished utilizing capillary electrophoresis (CE) or high-performance liquid chromatography (HPLC). The detection can be accomplished by surface enhanced Raman scattering.

摘要翻译： 用于分离和检测样品中分析物的设备和方法。 可以使用毛细管电泳（CE）或高效液相色谱（HPLC）来实现分离。 检测可以通过表面增强拉曼散射来实现。

公开(公告)号：US20050164402A1

公开(公告)日：2005-07-28

申请号：US11036707

申请日：2005-01-13

申请人： Christopher Belisle ,  John Walker ,  Sarah Ngola ,  Douglas Greiner ,  Mark Levy ,  Xiaoxia Zhao ,  Irene Chen ,  Mark Stolowitz ,  Donald Paquin

发明人： Christopher Belisle ,  John Walker ,  Sarah Ngola ,  Douglas Greiner ,  Mark Levy ,  Xiaoxia Zhao ,  Irene Chen ,  Mark Stolowitz ,  Donald Paquin

IPC分类号： B01L3/00 ,  C23C26/00 ,  C23C30/00 ,  G01N1/00

CPC分类号： B01L3/5085 ,  B01L3/502707 ,  B01L3/502792 ,  B01L3/5088 ,  B01L2200/12 ,  B01L2300/087 ,  B01L2300/089 ,  B82Y15/00 ,  B82Y30/00 ,  C23C26/00 ,  C23C30/00 ,  Y10T436/24 ,  Y10T436/25

摘要： The present invention relates to sample presentation devices useful in performing analytical measurements. These devices have been configured to enable various aspects of liquid handling such as: retention, storage, transport, concentration, positioning, and transfer. Additionally, these devices can enhance the detection and characterization of analytes. The sample presentation devices of the present invention are comprised of one or more substrates having a plurality of zones of differing wettability. Methods of analyzing samples using the sample presentation device of the invention, as well as methods of making the sample presentation devices are disclosed.

摘要翻译： 本发明涉及可用于执行分析测量的样本呈现装置。 这些装置已被配置成能够实现液体处理的各个方面，例如：保留，储存，运输，集中，定位和转移。 此外，这些设备可以增强分析物的检测和表征。 本发明的样品展示装置由具有不同润湿性的多个区域的一个或多个基材组成。 公开了使用本发明的样品呈现装置分析样品的方法，以及制备样品显示装置的方法。

公开(公告)号：US20070155021A1

公开(公告)日：2007-07-05

申请号：US11319747

申请日：2005-12-29

申请人： Jingwu Zhang ,  Narayan Sundararajan ,  Sarah Ngola ,  Handong Li

发明人： Jingwu Zhang ,  Narayan Sundararajan ,  Sarah Ngola ,  Handong Li

IPC分类号： G01N33/543 ,  C12M1/34 ,  C12M3/00

CPC分类号： G01N33/54373 ,  B82Y30/00 ,  G01N21/658 ,  G01N33/54346 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2021/656

摘要： A SERS active particle having a metal-containing particle and a cationic coating on the metal-containing particle, wherein the SERS active particle carries a positive charge is disclosed. Also, a SERS active particle having a metal-containing particle and a non-metallic molecule, wherein the metal-containing particle is derivatized with the non-metallic molecule is disclosed. In addition, several methods of modifying the nanoparticles surfaces of a SERS active particle and of improving the interaction between the SERS active particle and an analyte are disclosed.

摘要翻译： 公开了一种SERS活性颗粒，其具有含金属颗粒和阳离子涂层在含金属颗粒上，其中SERS活性颗粒携带正电荷。 另外，公开了含有金属的粒子和非金属分子的SERS活性粒子，其中含金属的粒子被非金属分子衍生化。 另外，公开了改进SERS活性颗粒的纳米颗粒表面和改善SERS活性颗粒与分析物之间的相互作用的几种方法。

公开(公告)号：US20060183863A1

公开(公告)日：2006-08-17

申请号：US11058330

申请日：2005-02-14

申请人： Wenxi Huang ,  Sarah Ngola ,  Kamen Voivodov

发明人： Wenxi Huang ,  Sarah Ngola ,  Kamen Voivodov

IPC分类号： C08L9/02

CPC分类号： C08F220/38 ,  B01D15/364 ,  B01J20/264 ,  B01J20/3276 ,  B01J2220/54 ,  C08F220/36

摘要： Zwitterionic polymers bearing positive and negative charges are readily prepared from easily accessible precursors. The polymers show enhanced binding affinities for analytes under high salt conditions, compared to similar polymers bearing a charge of a single polarity. The polymers can also include an energy absorbing moiety for use in matrix assisted laser desorption/ionization mass spectrometry. The polymer can also include a photo-curable group, which can be used to form cross-links within the bulk polymer or between the polymer and a surface functionalized with a polymerizable moiety. The polymers are incorporated into devices of use for the analysis, capture, separation, or purification of an analyte. In an exemplary embodiment, the invention provides a substrate coated with a polymer of the invention, the substrate being adapted for use as a probe for a mass spectrometer.

摘要翻译： 带有正电荷和负电荷的两性离子聚合物易于从容易获得的前体制备。 与具有单一极性电荷的类似聚合物相比，聚合物在高盐条件下显示出增强的分析物的结合亲和力。 聚合物还可以包括用于基质辅助激光解吸/电离质谱的能量吸收部分。 聚合物还可以包括可光固化基团，其可以用于在本体聚合物内形成交联，或者在聚合物与用可聚合部分官能化的表面之间形成交联。 将聚合物并入用于分析，捕获，分离或纯化分析物的装置中。 在一个示例性实施方案中，本发明提供涂覆有本发明的聚合物的基材，所述基材适于用作质谱仪的探针。

公开(公告)号：US20060183242A1

公开(公告)日：2006-08-17

申请号：US11057880

申请日：2005-02-14

申请人： Wenxi Huang ,  Aaron Chen ,  Sarah Ngola ,  Kamen Voivodov

发明人： Wenxi Huang ,  Aaron Chen ,  Sarah Ngola ,  Kamen Voivodov

IPC分类号： G01N31/22

CPC分类号： B01J20/26 ,  B01J20/265 ,  B01J20/285 ,  B01J20/3265 ,  B01J2220/54 ,  C07K1/22

摘要： Polymers bearing metal chelating groups are readily prepared from easily accessible precursors. The polymers are readily converted to the corresponding metal chelates. The polymers can also include an energy absorbing moiety for use in matrix assisted laser desorption/ionization mass spectrometry. The polymer can also include a photo-curable group, which can be used to form cross-links within the bulk polymer or between the polymer and a surface functionalized with a polymerizable moiety. The polymers are incorporated into devices of use for the analysis, capture, separation, or purification of an analyte. In an exemplary embodiment, the invention provides a substrate coated with a polymer of the invention, the substrate being adapted for use as a probe for a mass spectrometer.

摘要翻译： 具有金属螯合基团的聚合物可以容易地从容易获得的前体制备。 聚合物容易转化为相应的金属螯合物。 聚合物还可以包括用于基质辅助激光解吸/电离质谱法中的能量吸收部分。 聚合物还可以包括可光固化基团，其可以用于在本体聚合物内形成交联，或者在聚合物与用可聚合部分官能化的表面之间形成交联。 将聚合物并入用于分析，捕获，分离或纯化分析物的装置中。 在一个示例性实施方案中，本发明提供涂覆有本发明的聚合物的基材，所述基材适于用作质谱仪的探针。