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1.Prime ring substituted thyroid receptor antagonists for the treatment of cardiac and metabolic disorders 失效
标题翻译: 主环取代甲状腺受体拮抗剂治疗心脏和代谢紊乱公开(公告)号:US20050107347A1
公开(公告)日:2005-05-19
申请号:US10485849
申请日:2002-08-13
申请人: Johan Malm , Peter Brandt , Karin Edvinsson , Konrad Koehler , Andrei Sanin , Sandra Gordon
发明人: Johan Malm , Peter Brandt , Karin Edvinsson , Konrad Koehler , Andrei Sanin , Sandra Gordon
IPC分类号: C07D277/24 , A61K31/192 , A61K31/195 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/496 , A61K31/603 , A61P1/16 , A61P3/00 , A61P5/14 , A61P9/00 , A61P9/06 , A61P17/00 , A61P17/06 , A61P37/08 , A61P43/00 , C07C59/68 , C07C65/24 , C07C65/26 , C07D213/30 , C07D241/12 , C07F9/28 , A61K31/198 , A61K31/66
CPC分类号: C07D213/30 , A61K31/192 , A61K31/425 , A61K31/44 , A61K31/603 , C07C59/68 , C07C65/26 , C07D241/12
摘要: This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac and metabolic disorders, such as cardiac arrhythmias, thyrotoxicosis, subclinical hyperthyrodism and liver diseases.
摘要翻译: 本发明涉及作为甲状腺受体配体,优选拮抗剂的新化合物,以及使用这些化合物治疗心脏和代谢紊乱如心律失常,甲状腺毒症,亚临床甲状腺功能亢进和肝脏疾病的方法。
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2.Prime ring substituted thyroid receptor antagonists for the treatment of cardiac and metabolic disorders 失效
标题翻译: 主环取代甲状腺受体拮抗剂治疗心脏和代谢紊乱公开(公告)号:US07279593B2
公开(公告)日:2007-10-09
申请号:US10485849
申请日:2002-08-13
申请人: Johan Malm , Peter Brandt , Karin Edvinsson , Konrad Koehler , Andrei Sanin , Sandra Gordon
发明人: Johan Malm , Peter Brandt , Karin Edvinsson , Konrad Koehler , Andrei Sanin , Sandra Gordon
IPC分类号: C07C69/76 , A61K31/085
CPC分类号: C07D213/30 , A61K31/192 , A61K31/425 , A61K31/44 , A61K31/603 , C07C59/68 , C07C65/26 , C07D241/12
摘要: This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac and metabolic disorders, such as cardiac arrhythmias, thyrotoxicosis, subclinical hyperthyrodism and liver diseases.
摘要翻译: 本发明涉及作为甲状腺受体配体,优选拮抗剂的新化合物,以及使用这些化合物治疗心脏和代谢紊乱如心律失常,甲状腺毒症,亚临床甲状腺功能亢进和肝脏疾病的方法。
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3.Thyroid hormone receptor antagonists for cardiac and metabolic disorders II 失效
标题翻译: 甲状腺激素受体拮抗剂用于心脏和代谢紊乱II公开(公告)号:US07319096B2
公开(公告)日:2008-01-15
申请号:US10477676
申请日:2002-04-15
申请人: Johan Malm , Peter Brandt , Karin Edvinsson , Thomas Ericsson , Sandra Gordon
发明人: Johan Malm , Peter Brandt , Karin Edvinsson , Thomas Ericsson , Sandra Gordon
IPC分类号: A61K31/426 , A61K31/42 , A61K64/192 , A61K31/165 , C07D277/22 , C07D263/32 , C07C309/19 , C07C259/06
CPC分类号: C07D213/30 , C07C59/68 , C07C229/36 , C07D261/08 , C07D277/24
摘要: This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac and metabolic disorders, such as cardiac arrhythmias, thyrotoxicosis, subclinical hyperthyrodism and liver diseases.
摘要翻译: 本发明涉及作为甲状腺受体配体,优选拮抗剂的新化合物,以及使用这些化合物治疗心脏和代谢紊乱如心律失常,甲状腺毒症,亚临床甲状腺功能亢进和肝脏疾病的方法。
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4.Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders 失效
标题翻译: 甲状腺受体拮抗剂用于治疗心脏和代谢紊乱公开(公告)号:US07005538B1
公开(公告)日:2006-02-28
申请号:US10130434
申请日:2000-11-16
申请人: Johan Malm , Chris Litten , Theresa Apelqvist , Asa Hedfors , Peter Brandt , Karin Edvinsson , Sandra Gordon
发明人: Johan Malm , Chris Litten , Theresa Apelqvist , Asa Hedfors , Peter Brandt , Karin Edvinsson , Sandra Gordon
IPC分类号: C07C61/00
CPC分类号: C07D213/30 , A61K31/192 , A61K31/42 , A61K31/4402 , A61K31/47 , A61K31/59 , C07C59/64 , C07C59/72 , C07C59/90 , C07C205/37 , C07C217/76 , C07C233/56 , C07C255/54 , C07C311/51 , C07C2601/02 , C07D215/14 , C07D261/08 , C07D277/24 , C07D309/06 , C07D333/56 , A61K31/44 , A61K31/19 , A61K2300/00
摘要: This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac arrhythmias, thyrotoxicosis and subclinical hyperthyrodism.
摘要翻译: 本发明涉及作为甲状腺受体配体,优选拮抗剂的新化合物,以及使用这些化合物治疗心律失常,甲状腺毒症和亚临床甲状腺功能亢进的方法。
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5.Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders 失效
标题翻译: 甲状腺受体拮抗剂用于治疗心脏和代谢紊乱公开(公告)号:US07319163B2
公开(公告)日:2008-01-15
申请号:US11166821
申请日:2005-06-24
申请人: Johan Malm , Chris Litten , Theresa Apelqvist , Asa Hedfors , Peter Brandt , Karin Edvinsson , Sandra Gordon
发明人: Johan Malm , Chris Litten , Theresa Apelqvist , Asa Hedfors , Peter Brandt , Karin Edvinsson , Sandra Gordon
IPC分类号: C07C9/22 , C07C9/28 , C07C309/00 , C07C259/00
CPC分类号: C07D213/30 , A61K31/192 , A61K31/42 , A61K31/4402 , A61K31/47 , A61K31/59 , C07C59/64 , C07C59/72 , C07C59/90 , C07C205/37 , C07C217/76 , C07C233/56 , C07C255/54 , C07C311/51 , C07C2601/02 , C07D215/14 , C07D261/08 , C07D277/24 , C07D309/06 , C07D333/56 , A61K31/44 , A61K31/19 , A61K2300/00
摘要: This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac arrhythmias, thyrotoxicosis and subclinical hyperthyrodism.
摘要翻译: 本发明涉及作为甲状腺受体配体,优选拮抗剂的新化合物以及用于治疗心律失常,甲状腺毒症和亚临床甲状腺功能亢进的方法。
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6.Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders 失效
标题翻译: 甲状腺受体拮抗剂用于治疗心脏和代谢紊乱公开(公告)号:US20050267206A1
公开(公告)日:2005-12-01
申请号:US11166821
申请日:2005-06-24
申请人: Johan Malm , Chris Litten , Theresa Apelqvist , Asa Hedfors , Peter Brandt , Karin Edvinsson , Sandra Gordon
发明人: Johan Malm , Chris Litten , Theresa Apelqvist , Asa Hedfors , Peter Brandt , Karin Edvinsson , Sandra Gordon
IPC分类号: A61K31/192 , A61K31/42 , A61K31/4402 , A61K31/47 , A61K31/59 , A61P5/14 , A61P9/06 , C07C59/64 , C07C59/72 , C07C59/90 , C07C205/37 , C07C217/76 , C07C233/56 , C07C255/54 , C07C311/51 , C07D213/30 , C07D215/14 , C07D261/08 , C07D277/24 , C07D309/06 , C07D333/56 , A61K31/277
CPC分类号: C07D213/30 , A61K31/192 , A61K31/42 , A61K31/4402 , A61K31/47 , A61K31/59 , C07C59/64 , C07C59/72 , C07C59/90 , C07C205/37 , C07C217/76 , C07C233/56 , C07C255/54 , C07C311/51 , C07C2601/02 , C07D215/14 , C07D261/08 , C07D277/24 , C07D309/06 , C07D333/56 , A61K31/44 , A61K31/19 , A61K2300/00
摘要: This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac arrhythmias, thyrotoxicosis and subclinical hyperthyrodism.
摘要翻译: 本发明涉及作为甲状腺受体配体,优选拮抗剂的新化合物以及用于治疗心律失常,甲状腺毒症和亚临床甲状腺功能亢进的方法。
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