公开(公告)号：US20110265192A1

公开(公告)日：2011-10-27

申请号：US13062028

申请日：2009-09-03

申请人： Lars Axel Bolund ,  Karsten Kristiansen ,  Jacob Giehm Mikkelsen ,  Nicklas Heine Staunstrup

发明人： Lars Axel Bolund ,  Karsten Kristiansen ,  Jacob Giehm Mikkelsen ,  Nicklas Heine Staunstrup

IPC分类号： G01N33/00 ,  C12N15/873 ,  A01K67/00 ,  A01K67/027 ,  C12N5/10 ,  C12Q1/68

CPC分类号： C12N15/8509 ,  A01K2217/052 ,  A01K2217/15 ,  A01K2217/206 ,  A01K2227/108 ,  A01K2267/03 ,  A01K2267/0393 ,  C07K14/721

摘要： A sensor system for detecting the activation of specific nuclear receptors in a tissue of an animal is provided. The nuclear receptor sensor system comprises a sensor component comprising a nuclear receptor or part thereof coupled to a DNA-binding domain, and a reporter component comprising a reporter gene. Transgenic animals, such as a transgenic pig is provided, which comprises the components of the nuclear receptor sensor system in its genome. Also methods of producing the transgenic animal is provided as well as use of the transgenic animal for evaluating the activity of a nuclear receptor in vivo.

摘要翻译： 提供了用于检测动物组织中的特定核受体活化的传感器系统。 核受体传感器系统包括包含核受体或其部分耦合至DNA结合结构域的传感器组分和包含报告基因的报道分子。 提供转基因动物，例如转基因猪，其包含其基因组中核受体传感器系统的组分。 还提供了产生转基因动物的方法以及转基因动物用于评价体内核受体活性的用途。

公开(公告)号：US20100122356A1

公开(公告)日：2010-05-13

申请号：US12529812

申请日：2008-03-07

申请人： Peter Michael Kragh ,  Lars Axel Bolund ,  Karsten Kristiansen ,  Charlotte Brandt Sørensen ,  Jacob Giehm Mikkelsen ,  Nicklas Heine Staunstrup ,  Thomas Kongstad Petersen ,  Lars Svensson

发明人： Peter Michael Kragh ,  Lars Axel Bolund ,  Karsten Kristiansen ,  Charlotte Brandt Sørensen ,  Jacob Giehm Mikkelsen ,  Nicklas Heine Staunstrup ,  Thomas Kongstad Petersen ,  Lars Svensson

IPC分类号： A61K49/00 ,  A01K67/027 ,  C12N5/10 ,  C12N15/63 ,  A61P17/06

CPC分类号： A01K67/0273 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2227/108 ,  A01K2267/0325 ,  C12N15/8778 ,  C12N2517/04 ,  C12N2800/30 ,  C12N2800/90 ,  G01N2500/00

摘要： The present invention relates to a genetically modified pig as a model for studying psoriasis. The modified pig model displays one or more phenotypes associated with psoriasis. Disclosed is also a modified pig comprising a mutation in the endogenous ILK-I Ra, JunB/cJun, CD18, IKK2, and/or LIG1 gene, and/or a human, porcine and/or murine PPARs, PPAR-δ, lκB-α, STAT3c, Integrin beta 1, Integrin alpha 2, MEK1, Amphiregulin, BMP-6, VEGF, JunBΔec-JunΔep, IL-I a, TGF.beta 1, CD18 hypo, Cre/lkk2FL/FL, Dsg1, SCCE, TGF-a, TNF-a, IL-20, IFN-g, LIG1 KO, KGF, IL-6, PAFR1 Cre/lkk2FL/FL, IL1 R, Dsg3, IFN-gamma, p40, ILI Ra, IKK2, JunB/c-Jun, and/or LIG1 gene, transcriptional and/or translational product or part thereof. The invention further relates to methods for producing the modified pig; and methods for evaluating the effect of a therapeutical treatment of psoriasis, for screening the efficacy of a pharmaceutical composition, and a method for treatment of human being suffering from psoriasis are disclosed.

摘要翻译： 本发明涉及一种转基因猪作为研究牛皮癣的模型。 修改后的猪模型显示与牛皮癣相关的一种或多种表型。 还公开了包含内源性ILK-IRa，JunB / cJun，CD18，IKK2和/或LIG1基因和/或人，猪和/或鼠PPARs，PPAR-δ， B-α，STAT3c，整合素β1，整合素α2，MEK1，Amphiregulin，BMP-6，VEGF，JunB＆Dgr; ec-Jun＆Dgr; ep，IL-1α，TGFβ1，CD18 hypo，Cre / lkk2FL / FL ，Dsg1，SCCE，TGF-α，TNF-α，IL-20，IFN-g，LIG1KO，KGF，IL-6，PAFR1 Cre / Ikk2FL / FL，IL1R，Dsg3，IFN-γ，p40， ，IKK2，JunB / c-Jun和/或LIG1基因，转录和/或翻译产物或其一部分。 本发明还涉及生产改性猪的方法; 公开了用于评价银屑病治疗效果，用于筛选药物组合物的功效以及治疗患有牛皮癣的方法的方法。

公开(公告)号：US07230029B2

公开(公告)日：2007-06-12

申请号：US10363963

申请日：2001-09-27

申请人： Rolf Berge ,  Karsten Kristiansen

发明人： Rolf Berge ,  Karsten Kristiansen

IPC分类号： A61K31/20 ,  A61K31/201 ,  A61K31/22 ,  A61K31/231

CPC分类号： A61K31/20

摘要： The present invention relates to fatty acid analogues of the general formula (I): R1-[xi-CH2]n—COOR2 wherein R1 is; a C1–C24 alkene with one or more double bonds and/or with one or more triple bonds, and/or a C1–C24 alkyne, and/or a C1–C24 alkyl, or a C1–C24 alkyl substituted in one or several positions with one or more compounds selected from the group comprising fluoride, chloride, hydroxy, C1–C4 alkoxy, C2–C4 alkylthio, C1–C5 acyloxy or C1–C4 alkyl, and wherein R2 represents hydrogen or C1–C4 alkyl, and wherein n is an integer from 1 to 12, and wherein i is an odd number and indicates the position relative to COOR2, and wherein Xi independent of each other are selected from the group comprising O, S, SO, SO2, Se and CH2, and with the proviso that at least one of the Xi is not CH2, and with the proviso that if R1 is an alkyne or alkene, then the carbon-carbon triple bond or double bond is positioned between the (ω-1) carbon and the (ω-2) carbon, or between the (ω-2) carbon and the (ω-3) carbon, or between the (ω-3) carbon and the (ω-4) carbon, which can be used for the treatment and/or prevention of proliferative skin disorders. More specifically the invention relates to the inhibition of proliferation and/or differentiation of keratinocytes.

公开(公告)号：US20110178112A1

公开(公告)日：2011-07-21

申请号：US12161317

申请日：2007-01-18

申请人： Karsten Kristiansen ,  Prathama S. Mainkar ,  Jean-Philippe Meyer ,  Alexandra Santana Sorensen

发明人： Karsten Kristiansen ,  Prathama S. Mainkar ,  Jean-Philippe Meyer ,  Alexandra Santana Sorensen

IPC分类号： A61K31/438 ,  A61K31/357 ,  C07D309/06 ,  A61K31/4433 ,  C07D405/04 ,  C07D491/113 ,  C07D407/04 ,  A61P3/10 ,  A61P1/00 ,  A61P19/02 ,  A61P11/06 ,  A61P27/02 ,  A61P17/06 ,  A61P3/06 ,  A61P35/00

CPC分类号： C07D319/06 ,  A61K31/357 ,  C07D319/08 ,  C07D405/04 ,  C07D407/04 ,  C07D491/113

摘要： 1,3-dioxane derivatives are described and their use in the treatment of a disease or condition dependent on PPAR modulation, such as diabetes, cancer, inflammation, neurodegenerative disorders and infections.

摘要翻译： 描述了1,3-二恶烷衍生物及其用于治疗依赖于PPAR调节的疾病或病症，例如糖尿病，癌症，炎症，神经变性疾病和感染。