公开(公告)号：US20150050371A1

公开(公告)日：2015-02-19

申请号：US14382237

申请日：2012-03-09

申请人： Matthias Gehling ,  Bärbel Köpcke ,  Thomas Küper ,  Kathrin Reinhardt ,  Peter Reinemer ,  Annie George ,  Sasikala Chinnappan ,  Mazria Haslina Md Akir

发明人： Matthias Gehling ,  Bärbel Köpcke ,  Thomas Küper ,  Kathrin Reinhardt ,  Peter Reinemer ,  Annie George ,  Sasikala Chinnappan ,  Mazria Haslina Md Akir

IPC分类号： A61K36/61 ,  A23L1/30 ,  A61K45/06

CPC分类号： A61K36/61 ,  A23L33/105 ,  A23V2002/00 ,  A61K45/06 ,  A61K2236/33

摘要： The present invention primarily relates to the use of certain extract formulations of Rhodamnia cinerea as defined herein as alpha-amylase inhibitors and as actives for the therapeutic (including prophylactic) treatment of a carbohydrate metabolic disorder or of a disease attendant on hyperglycemia, preferably selected from the group consisting of prediabetes, obesity, hyperlipemia, arteriosclerosis, arteriolosclerosis, atherosclerosis, diabetes, postprandial hyperglycemia, and metabolic syndrome. The present invention also relates to corresponding methods. The invention further relates to specific extract formulations obtainable from Rhodamnia cinerea and to compositions, in particular orally consumable compositions, comprising an effective amount of such an extract formulation.

摘要翻译： 本发明主要涉及本文定义的灰葡萄糖苷的某些提取物制剂在α-淀粉酶抑制剂中的用途，以及用于治疗（包括预防）治疗碳水化合物代谢紊乱或伴随高血糖症的疾病的活性物质，优选选自 由糖尿病前期，肥胖，高脂血症，动脉硬化，动脉硬化，动脉粥样硬化，糖尿病，餐后高血糖症和代谢综合征组成的组。 本发明还涉及相应的方法。 本发明还涉及可从灰葡萄球菌获得的特定提取物制剂以及包含有效量的这种提取物制剂的组合物，特别是口服消耗品组合物。

公开(公告)号：US20140178444A1

公开(公告)日：2014-06-26

申请号：US14124429

申请日：2012-06-06

申请人： Marc Stadler ,  Jens Bitzer ,  Bärbel Köpcke ,  Kathrin Reinhardt ,  Jana Moldenhauer

发明人： Marc Stadler ,  Jens Bitzer ,  Bärbel Köpcke ,  Kathrin Reinhardt ,  Jana Moldenhauer

IPC分类号： A01N43/16 ,  A61Q5/02 ,  A23L2/44 ,  C07H15/04 ,  A61K8/33

CPC分类号： A01N43/16 ,  A01N63/04 ,  A23B4/20 ,  A23B5/14 ,  A23B7/154 ,  A23B9/26 ,  A23L2/44 ,  A61K8/33 ,  A61K8/365 ,  A61K8/37 ,  A61K8/99 ,  A61Q5/02 ,  A61Q17/005 ,  C07H15/04 ,  C12P19/44

摘要： The invention relates to the use of, and methods of use employing, certain glycolipid compounds as defined in detail below and having preservative or antimicrobial properties, novel compounds of the glycolipid class, and related invention embodiments.The compounds have the formula I wherein m is 3 to 5, n is 2 to 5, o is 0 or 1 and p is 3 to 17, with the proviso that the sum m+n+o+p is not less than 14; and R is a carbohydrate moiety bound via one of its carbon atoms to the binding oxygen, and/or a physiologically, especially pharmaceutically or nutraceutically or cosmetically, acceptable salt thereof, or an ester thereof, as such or in the form of a composition, where the compound may be present in open chain form and/or in the form of a lactone (FIG. 1).

摘要翻译： 本发明涉及使用以下详细定义的具有防腐或抗微生物性质的某些糖脂化合物的使用和使用方法，糖脂类的新型化合物和相关的发明实施方案。 化合物具有式I，其中m为3至5，n为2至5，o为0或1，p为3至17，条件是和m + n + o + p不小于14; 并且R是通过其碳原子之一与结合氧结合的碳水化合物部分，和/或其生理学上，特别是其药学上或药学上可接受的盐或其酯，或者以组合物的形式， 其中化合物可以以开链形式和/或以内酯的形式存在（图1）。

公开(公告)号：US20120245113A1

公开(公告)日：2012-09-27

申请号：US13402675

申请日：2012-02-22

申请人： Matthias GEHLING ,  Torsten GROTHE ,  Ernst ROEMER ,  Peter REINEMER ,  Kathrin REINHARDT ,  Annie GEORGE ,  Nur Hanisah MOHTAR ,  Noorsyarida Mohd Sapiai

发明人： Matthias GEHLING ,  Torsten GROTHE ,  Ernst ROEMER ,  Peter REINEMER ,  Kathrin REINHARDT ,  Annie GEORGE ,  Nur Hanisah MOHTAR ,  Noorsyarida Mohd Sapiai

IPC分类号： A61K31/7048 ,  A61P29/00 ,  A61P37/08 ,  A61P11/00 ,  A61P27/02 ,  A61P17/06 ,  A61P17/00 ,  A61P1/00 ,  A61P19/08 ,  A61P19/02 ,  A61P21/00 ,  A61P13/10 ,  C07D407/08 ,  C07D407/04 ,  A61K31/365 ,  A61K31/366 ,  C07H15/26

CPC分类号： C07D407/08 ,  C07D407/04 ,  C07H17/08

摘要： The use or methods of use of extracts comprising one or more special clerodane compounds against inflammatory (including allergic) diseases or conditions, as well as novel compounds of this type, said clerodane derivatives for use against inflammatory (including allergic) diseases or conditions, pharmaceutical formulations comprising them especially for use against inflammatory disease or conditions, and related embodiments; said extract and/or compound(s) for use in the treatment or in the preparation of a medicament (including a nutraceutical) for the prophylactic and/or therapeutic treatment of said disease or condition, as well as their preparation; pharmaceutical or nutraceutical formulations comprising said extract and/or natural compound(s) which are useful in said prophylactic and/or therapeutic treatment, and related embodiments.

摘要翻译： 使用或使用包含一种或多种抗炎症（特别是过敏性）疾病或病症的特殊克洛膦酸化合物的提取物以及这种新型化合物的用途，所述用于抗炎症（包括过敏性）疾病或病症的氯化丹烷衍生物，药物 包含它们的制剂，特别是用于抗炎性疾病或病症，以及相关实施方案; 所述提取物和/或化合物用于治疗或制备用于预防和/或治疗所述疾病或病症的药物（包括营养药物）及其制备; 包含可用于所述预防和/或治疗性治疗的所述提取物和/或天然化合物的药物或营养制剂以及相关实施方案。

公开(公告)号：US08962575B2

公开(公告)日：2015-02-24

申请号：US13402675

申请日：2012-02-22

申请人： Matthias Gehling ,  Torsten Grothe ,  Ernst Roemer ,  Peter Reinemer ,  Kathrin Reinhardt ,  Annie George ,  Nur Hanisah Mohtar ,  Noorsyarida Mohd Sapiai

发明人： Matthias Gehling ,  Torsten Grothe ,  Ernst Roemer ,  Peter Reinemer ,  Kathrin Reinhardt ,  Annie George ,  Nur Hanisah Mohtar ,  Noorsyarida Mohd Sapiai

IPC分类号： A61K31/70 ,  A61K31/34 ,  C07D407/08 ,  C07D407/04 ,  C07H17/08

CPC分类号： C07D407/08 ,  C07D407/04 ,  C07H17/08

摘要： The use or methods of use of extracts comprising one or more special clerodane compounds against inflammatory (including allergic) diseases or conditions, as well as novel compounds of this type, said clerodane derivatives for use against inflammatory (including allergic) diseases or conditions, pharmaceutical formulations comprising them especially for use against inflammatory disease or conditions, and related embodiments; said extract and/or compound(s) for use in the treatment or in the preparation of a medicament (including a nutraceutical) for the prophylactic and/or therapeutic treatment of said disease or condition, as well as their preparation; pharmaceutical or nutraceutical formulations comprising said extract and/or natural compound(s) which are useful in said prophylactic and/or therapeutic treatment, and related embodiments.

摘要翻译： 使用或使用包含一种或多种抗炎症（特别是过敏性）疾病或病症的特殊克洛膦酸化合物的提取物以及这种新型化合物的用途，所述用于抗炎症（包括过敏性）疾病或病症的氯化丹烷衍生物，药物 包含它们的制剂，特别是用于抗炎性疾病或病症，以及相关实施方案; 所述提取物和/或化合物用于治疗或制备用于预防和/或治疗所述疾病或病症的药物（包括营养药物）及其制备; 包含可用于所述预防和/或治疗性治疗的所述提取物和/或天然化合物的药物或营养制剂以及相关实施方案。