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1.发明授权Biological adhesive composition and method of promoting adhesion between tissue surfaces 失效生物粘合剂组合物和促进组织表面之间粘附的方法
公开(公告)号：US5549904A
公开(公告)日：1996-08-27
申请号：US071528
申请日：1993-06-03
CPC分类号： C12N9/1044 , A61K38/45 , A61L24/0015 , A61L24/10 , A61L24/106 , A61L2300/102 , A61L2300/254 , A61L2300/414 , Y10S514/953 , Y10S514/955 , Y10S514/965 , Y10S530/835 , Y10S530/84 , Y10S530/841 , Y10S530/842 , Y10S530/846 , Y10S530/85
摘要： A formulated biological adhesive composition utilizes tissue transglutaminase in a pharmaceutically acceptable aqueous carrier. The tissue transglutaminase is used in an effective catalytic amount to promote adhesion between tissue surfaces upon treatment thereof by catalyzing the reaction between glutaminyl residues and amine donors of the tissue and/or the enzyme. The carrier contains a divalent metal ion such as calcium to promote said reaction.
摘要翻译： 配制的生物粘合剂组合物在药学上可接受的水性载体中使用组织转谷氨酰胺酶。 组织转谷氨酰胺酶以有效的催化量使用，以通过催化组织和/或酶的谷氨酰胺残基和胺供体之间的反应来促进组织表面之间的粘附。 载体包含二价金属离子如钙，以促进所述反应。
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公开(公告)号：US5736132A
公开(公告)日：1998-04-07
申请号：US592921
申请日：1996-01-29
CPC分类号： C12N9/1044 , A61K38/45 , A61L24/0015 , A61L24/10 , A61L24/106 , A61L2300/102 , A61L2300/254 , A61L2300/414 , Y10S514/953 , Y10S514/955 , Y10S514/965 , Y10S530/835 , Y10S530/84 , Y10S530/841 , Y10S530/842 , Y10S530/846 , Y10S530/85
摘要： A formulated biological adhesive composition utilizes tissue transglutaminase in a pharmaceutically acceptable aqueous carrier. The tissue transglutaminase is used in an effective catalytic amount to promote adhesion between tissue surfaces upon treatment thereof by catalyzing the reaction between glutaminyl residues and amine donors of the tissue and/or the enzyme. The carrier contains a divalent metal ion such as calcium to promote said reaction.
摘要翻译： 配制的生物粘合剂组合物在药学上可接受的水性载体中使用组织转谷氨酰胺酶。 组织转谷氨酰胺酶以有效的催化量使用，以通过催化组织和/或酶的谷氨酰胺残基和胺供体之间的反应来促进组织表面之间的粘附。 载体包含二价金属离子如钙，以促进所述反应。
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