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公开(公告)号:US07098024B2
公开(公告)日:2006-08-29
申请号:US10684656
申请日:2003-10-15
申请人: Koji Nagai , Nakako Arao , Kinya Souda , Kazuma Kamigiri , Masamichi Mori , Nobuaki Shindo , Haruo Seto , Kazuo Shin-Ya
发明人: Koji Nagai , Nakako Arao , Kinya Souda , Kazuma Kamigiri , Masamichi Mori , Nobuaki Shindo , Haruo Seto , Kazuo Shin-Ya
CPC分类号: C07K5/0205 , A61K35/00 , A61K38/00
摘要: This invention relates to a novel compound which has a cytotoxic activity and TGF-β like activity for human cancer cells and is useful as an antitumor agent and to a pharmaceutical composition which contains the same.
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公开(公告)号:US20050063927A1
公开(公告)日:2005-03-24
申请号:US10502949
申请日:2003-01-29
申请人: Akira Nakagawa , Senji Takahashi , Toshitsugu Miyazaki , Yuuko Osanai , Kunio Kosaka , Koji Nagai , Nakako Arao , Kouichi Tanaka
发明人: Akira Nakagawa , Senji Takahashi , Toshitsugu Miyazaki , Yuuko Osanai , Kunio Kosaka , Koji Nagai , Nakako Arao , Kouichi Tanaka
IPC分类号: A61K8/60 , A61K8/99 , A61Q19/02 , C12P19/02 , C12P19/46 , C12R1/01 , A61K7/135 , C07H5/06 , C12N1/20
摘要: There are provided a novel microorganism Enterobacter sp. B20 strain which produces (E)-4-(2-isocyanovinyl)phenyl α-rhamnopyranoside having a favorable effect of inhibiting melanogenesis and α-L-rhamnopyranoside produced thereby. This novel microorganism is a gram-negative bacillus isolated from soil and shows motility owing to polar flagellum. The α-L-rhamnopyranoside, which is produced by culturing the microorganism under aerobic conditions at a culture temperature of 10 to 37° C. and at a medium pH of about 5 to 9 usually for about 1 to 7 days, is useful as a highly safe and stable whitening agent.
摘要翻译: 提供了一种新型微生物肠杆菌属 B20菌株,其产生具有抑制黑素生成的有利效果的由(E)-4-(2-异氰酸基乙烯基)苯基α-鼠李糖吡喃糖苷生成的α-L-鼠李糖吡喃糖苷。 这种新型微生物是从土壤中分离的革兰氏阴性芽孢杆菌,由极鞭毛引起的运动性。 通过在需氧条件下在10〜37℃的培养温度和约5〜9的中等pH下培养约1〜7天来制备的α-L-鼠李糖苷可用作 高度安全稳定的美白剂。
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公开(公告)号:US07115721B2
公开(公告)日:2006-10-03
申请号:US10502949
申请日:2003-01-29
申请人: Akira Nakagawa , Senji Takahashi , Toshitsugu Miyazaki , Yuuko Osanai , Kunio Kosaka , Koji Nagai , Nakako Arao , Kouichi Tanaka
发明人: Akira Nakagawa , Senji Takahashi , Toshitsugu Miyazaki , Yuuko Osanai , Kunio Kosaka , Koji Nagai , Nakako Arao , Kouichi Tanaka
摘要: There are provided a novel microorganism Enterobacter sp. B20 strain which produces (E)-4-(2-isocyanovinyl)phenyl α-rhamnopyranoside having a favorable effect of inhibiting melanogenesis and α-L-rhamnopyranoside produced thereby. This novel microorganism is a gram-negative bacillus isolated from soil and shows motility owing to polar flagellum. The α-L-rhamnopyranoside, which is produced by culturing the microorganism under aerobic conditions at a culture temperature of 10 to 37° C. and at a medium pH of about 5 to 9 usually for about 1 to 7 days, is useful as a highly safe and stable whitening agent.
摘要翻译: 提供了一种新型微生物肠杆菌属 B20菌株,其产生具有抑制黑素生成的有利效果的由(E)-4-(2-异氰酸基乙烯基)苯基α-鼠李糖吡喃糖苷生成的α-L-鼠李糖吡喃糖苷。 这种新型微生物是从土壤中分离的革兰氏阴性芽孢杆菌,由极鞭毛引起的运动性。 通过在需氧条件下在10〜37℃的培养温度和约5〜9的中等pH下培养约1〜7天来制备的α-L-鼠李糖苷可用作 高度安全稳定的美白剂。
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公开(公告)号:US07030085B2
公开(公告)日:2006-04-18
申请号:US10471873
申请日:2002-03-12
申请人: Kazuma Kamigiri , Masato Watanabe , Koji Nagai , Nakako Arao , Kenichi Suzumura , Ken-ichi Suzuki , Ryuichiro Kurane , Masakazu Yamaoka , Yasuhiro Kawano
发明人: Kazuma Kamigiri , Masato Watanabe , Koji Nagai , Nakako Arao , Kenichi Suzumura , Ken-ichi Suzuki , Ryuichiro Kurane , Masakazu Yamaoka , Yasuhiro Kawano
CPC分类号: C07K5/06139 , A61K38/00 , C12P17/185 , C12R1/07
摘要: A microorganism belonging to the genus Bacillus is cultured and thiopeptide compounds QN3323 and thiocillin I/II compounds are collected from the culture medium. The compounds are useful as drugs to treat infections caused by multidrug-resistant bacteria.
摘要翻译: 培养属于芽孢杆菌属的微生物,并从培养基中收集硫肽化合物QN3323和硫辛西林I / II化合物。 该化合物可用作治疗由多重耐药细菌引起的感染的药物。
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公开(公告)号:US06670326B1
公开(公告)日:2003-12-30
申请号:US09889303
申请日:2001-07-13
申请人: Koji Nagai , Nakako Arao , Kinya Souda , Kazuma Kamigiri , Masamichi Mori , Nobuaki Shindo , Haruo Seto , Kazuo Shin-Ya
发明人: Koji Nagai , Nakako Arao , Kinya Souda , Kazuma Kamigiri , Masamichi Mori , Nobuaki Shindo , Haruo Seto , Kazuo Shin-Ya
IPC分类号: C07K512
CPC分类号: C07K5/0205 , A61K35/00 , A61K38/00
摘要: This invention relates to a novel compound which has a cytotoxic activity and TGF-&bgr; like activity for human cancer cells and is useful as an antitumor agent and to a pharmaceutical composition which contains the same.
摘要翻译: 本发明涉及对人癌细胞具有细胞毒活性和TGF-β样活性并可用作抗肿瘤剂的新型化合物和含有该化合物的药物组合物。
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