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公开(公告)号：US6150363A
公开(公告)日：2000-11-21
申请号：US319285
申请日：1999-06-02
申请人： Toshihiro Takahashi , Yutaka Nomura , Haruo Seto , Kazuo Shin-ya
发明人： Toshihiro Takahashi , Yutaka Nomura , Haruo Seto , Kazuo Shin-ya
IPC分类号： C07D241/48 , A61K31/495 , C07D241/46
CPC分类号： C07D241/48
摘要： Dihydrophenazinecarboxylic acid derivatives of the formula (I) wherein R.sup.1 represents hydrogen, linear or branched alkyl, etc., each of R.sup.2 and R.sup.3 represents hydrogen, 3-methyl-2-butenyl, etc., and each of R.sup.4 and R.sup.5 represents hydrogen, alkyl, alkenyl, aralkyl, aryl, hydroxyl, alkoxy, aryloxy, aralkyloxy, halogen, nitro, cyano, alkylsulfonyl, arylsulfonyl, alkylcarbonyl, arylcarbonyl, etc., provided that there is no case that both of R.sup.4 and R.sup.5 are hydrogen. The dihydrophenazinecarboxylic acid derivatives are excellent in the inhibition of glutamic acid toxicity. ##STR1##
摘要翻译： PCT No.PCT / JP97 / 03674。 371日期1999年6月2日 102（e）1999年6月2日PCT 1997年10月14日提交PCT公布。 出版物WO98 / 24772 日期：1998年6月11日其中R 1表示氢，直链或支链烷基等的式（I）的二氢吩嗪嗪羧酸衍生物，R 2和R 3各自表示氢，3-甲基-2-丁烯基等，R 4 并且R 5表示氢，烷基，烯基，芳烷基，芳基，羟基，烷氧基，芳氧基，芳烷氧基，卤素，硝基，氰基，烷基磺酰基，芳基磺酰基，烷基羰基，芳基羰基等。 是氢。 二氢吩嗪酮羧酸衍生物对谷氨酸毒性的抑制是优异的。
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公开(公告)号：US06706705B1
公开(公告)日：2004-03-16
申请号：US08809770
申请日：1997-03-28
IPC分类号： C07D23995
CPC分类号： C07D239/95
摘要： The present invention provides a new compound which shows slow and continuous blood pressure reducing action and is useful as an antihypertensive agent. The invention resides in a quinazoline derivative of the following formula (I) and its pharmaceutically acceptable salt: in which, each of R1 and R2 is H or an alkyl group of 1 to 6 carbon atoms, or R1 and R2 are combined to form an ethylene group; each of R3 and R4 is an alkyl group of 1 to 6 carbon atoms; R5 is a hydrogen atom, a hydroxyl group, an alkyl group of 1 to 6 carbon atoms, or an alkoxy group of 1 to 6 carbon atoms; each of R6 and R7 is a hydrogen atom or an alkyl group of 1 to 6 carbon atoms; and n is 2 or 3. The invention further resides in an antihypertensive agent containing the above compound.
摘要翻译： 本发明提供了一种新的化合物，其显示缓慢且持续的减压作用，并且可用作抗高血压药。本发明涉及下式（I）的喹唑啉衍生物及其药学上可接受的盐：其中R 1和R 2是H或1至6个碳原子的烷基，或R 1和R 2结合形成亚乙基; R 3和R 4各自为1至6个碳原子的烷基; R 5为氢原子，羟基，碳原子数为1〜6的烷基或碳原子数1〜6的烷氧基， R 6和R 7各自为氢原子或1〜6个碳原子的烷基; 并且n为2或3.本发明还涉及含有上述化合物的抗高血压药。
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公开(公告)号：US06387908B1
公开(公告)日：2002-05-14
申请号：US09508026
申请日：2000-05-05
IPC分类号： A61K31336
CPC分类号： C07D405/12 , C07D303/48
摘要： Epoxysuccinamide derivatives of the formula (1): wherein R1 is hydrogen, alkyl, alkenyl, alkynyl, aryl, or aralkyl; R2 is alkyl, alkenyl, alkynyl, aryl, or aralkyl; R3 is hydrogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, heterocyclic, or heterocyclic-alkyl; X is —O— or —NR4— (R4 is hydrogen, alkyl, aryl, aralkyl, heterocyclic, or heterocyclic-alkyl); Y1 is OR5, SR6, or NR7R8; and Y2 is hydrogen or alkyl. The compounds are useful as remedies for bone diseases and arthritis.
摘要翻译： 式（1）的环氧琥珀酰胺衍生物：其中R1是氢，烷基，烯基，炔基，芳基或芳烷基; R2是烷基，烯基，炔基，芳基或芳烷基; R3是氢，烷基，烯基，炔基，芳基，芳烷基，杂环或杂环烷基; X是-O-或-NR 4 - （R 4是氢，烷基，芳基，芳烷基，杂环或杂环烷基）。 Y1是OR5，SR6或NR7R8; 而Y2是氢或烷基。 该化合物可用作骨疾病和关节炎的补救措施。
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公开(公告)号：US06689785B2
公开(公告)日：2004-02-10
申请号：US10042994
申请日：2002-01-08
IPC分类号： A61K31497
CPC分类号： C07D405/12 , C07D303/48
摘要： Novel epoxysuccinamide derivatives represented by the general formula (1) or physiologically acceptable salts thereof, which are useful particularly as remedies for bone diseases and arthritis, wherein R1 and R3 are each hydrogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, a heterocyclic group, or a heterocyclic-alkyl group; R2 is alkyl, alkenyl, alkynyl, aryl, aralkyl, a heterocyclic group, or a hetericyclic-alkyl group; X is —O— or —NR4— (wherein R4 is hydrogen, alkyl, aryl, aralkyl, a heterocyclic group, or a heterocyclic-alkyl group; Y1 is OR5, SR6, or NR7R8 (wherein each of R5, R6 and R7 is hydrogen, alkyl, aryl, aralkyl, acyl, a heterocyclic group, or a heterocyclic-alkyl group, and R8 is the same as defined for R4); and Y2 is hydrogen or alkyl, or alternatively Y1 and Y2 can be combined to form ═O, ═S, ═N—R9, or ═N—OR10 (wherein each of R9 and R10 is the same as defined for R4), provided that each of the alkyl, aryl and heterocyclic groups defined for R5 to R10 can have one or more specific substituents and that each of the group defined for R1 to R10 and Y2 is specificed in the number of carbon atoms.
摘要翻译： 由通式（1）表示的新型环氧琥珀酰胺衍生物或其生理学上可接受的盐，其特别适用于骨疾病和关节炎的治疗，其中R 1和R 3各自为氢，烷基，烯基，炔基，芳基 ，芳烷基，杂环基或杂环烷基; R 2是烷基，烯基，炔基，芳基，芳烷基，杂环基或杂环烷基; X是-O-或-NR 4 - （其中R 4是氢，烷基，芳基，芳烷基，杂环基或杂环烷基; Y 1是OR 5， 或其中R 5，R 6和R 7各自为氢，烷基，芳基，芳烷基，酰基，杂环基或杂环烷基 基团和R 8与R 4中定义的相同）; Y 2是氢或烷基，或者Y 1和Y 2可以组合形成= O，= S ，= NR 9或= N-OR 10（其中R 9和R 10各自与R 4中定义的相同），条件是烷基，芳基和杂环基 对R 5至R 10定义的基团可以具有一个或多个特定取代基，并且对于R 1至R 10和Y 2定义的基团中的每一个以碳原子数为特定。
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公开(公告)号：US5843992A
公开(公告)日：1998-12-01
申请号：US930509
申请日：1997-09-29
IPC分类号： C07D303/48 , A61K31/335
CPC分类号： C07D303/48
摘要： An epoxysuccinic acid derivative having the following formula: ##STR1## �wherein R.sup.1 is hydrogen, alkyl, aryl, or aralkyl; each of R.sup.2 and R.sup.3 independently is aryl, aralkyl or alkyl; X is --O-- or --NR.sup.4 --; and R.sup.4 is hydrogen, alkyl, or aralkyl! is useful for prevention and treatment of bone diseases such as osteoporosis, malignant hypercalcemia and Paget's syndrome, and further useful for treatment of osteoarthritis and rheumatoid arthritis which are accompanied by abnormal enhancement of cathepsin L activity, and furthermore useful as a medicine for treating diseases in which cathepsin B and L participate, such as muscular dystrophy and muscular atrophy.
摘要翻译： PCT No.PCT / JP96 / 00889 Sec。 371日期：1997年9月29日 102（e）日期1997年9月29日PCT提交1996年4月1日PCT公布。 出版物WO96 / 30354 日期：1996年10月3日具有下式的环氧琥珀酸衍生物：其中R 1是氢，烷基，芳基或芳烷基; R2和R3各自独立地为芳基，芳烷基或烷基; X是-O-或-NR4-; 和R4是氢，烷基或芳烷基]可用于预防和治疗骨质疏松症，恶性高钙血症和佩吉特综合征等骨疾病，并且还可用于治疗组织蛋白酶L活性异常增强的骨关节炎和类风湿性关节炎， 并且还可用作治疗组织蛋白酶B和L参与的疾病的药物，例如肌营养不良和肌肉萎缩。
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公开(公告)号：US09045848B2
公开(公告)日：2015-06-02
申请号：US14223031
申请日：2014-03-24
申请人： Masaru Jimbo , Yutaka Nomura , Kentaro Torii , Kazuki Kojima , Daisuke Honda
发明人： Masaru Jimbo , Yutaka Nomura , Kentaro Torii , Kazuki Kojima , Daisuke Honda
摘要： A coordinate computation device includes a position indication portion, a detection portion, a processor, and a memory. The position indication portion includes an indicating portion, a switch, and a transmitter. The detection portion is configured to detect ultrasonic waves transmitted by the transmitter. The memory is configured to store computer-readable instructions. The computer-readable instructions cause the processor to perform processes that include computing sets of first coordinates, based on times when the detection portion detects the ultrasonic waves, computing a movement direction of the position indication portion on a plane, computing an angle formed between the plane and a direction in which the position indication portion is long, and computing a set of second coordinates, based on the computed movement direction, the computed angle, and a set of third coordinates among the sets of the computed first coordinates.
摘要翻译： 坐标计算装置包括位置指示部分，检测部分，处理器和存储器。 位置指示部分包括指示部分，开关和发射器。 检测部被配置为检测由发送器发送的超声波。 存储器被配置为存储计算机可读指令。 计算机可读指令使得处理器基于检测部分检测超声波的时间，执行包括第一坐标的计算集的处理，计算平面上的位置指示部分的移动方向，计算在 平面以及位置指示部分长的方向，并且基于所计算的运动方向，所计算的角度和所计算的第一坐标的组中的一组第三坐标来计算一组第二坐标。
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公开(公告)号：US08607443B2
公开(公告)日：2013-12-17
申请号：US12827755
申请日：2010-06-30
申请人： Shinji Okamoto , Katsumi Takeuchi , Yutaka Nomura
发明人： Shinji Okamoto , Katsumi Takeuchi , Yutaka Nomura
IPC分类号： H05K3/36
CPC分类号： H05K3/368 , H01R12/52 , H05K3/3442 , H05K2201/10378 , Y10T29/49126
摘要： A method of manufacturing a connector chip includes preparing a plate-like insulating substrate material with a plurality of through hole rows arranged therein; forming a plurality of first and second base layers on opposite surfaces of the insulating substrate material; forming insulating layers between each two adjoining first base layers and between each two adjoining second base layers; forming third base layers on the one side over edge portions of the first base layers, internal surfaces of the through holes, and edge portions of the second base layers; forming fourth base layers on the other side over edge portions of the first base layers, the internal surfaces of the through holes, and edge portions of the second base layers; cutting the insulating substrate material along a middle of each of the through hole rows; and forming one or more plated layers over the first to fourth base layers.
摘要翻译： 一种制造连接器芯片的方法包括制备其中布置有多个通孔列的板状绝缘基板材料; 在所述绝缘基板材料的相对表面上形成多个第一和第二基底层; 在每个两个邻接的第一基底层之间和每个两个相邻的第二基底层之间形成绝缘层; 在所述第一基底层的边缘部分，所述通孔的内表面和所述第二基底层的边缘部分的一侧上形成第三基底层; 在所述第一基底层的边缘部分的另一侧上形成第四基底层，所述通孔的内表面和所述第二基底层的边缘部分; 沿着每个通孔列的中间切割绝缘基板材料; 以及在所述第一至第四基底层上形成一个或多个镀层。
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公开(公告)号：US08288282B2
公开(公告)日：2012-10-16
申请号：US12670292
申请日：2008-07-28
申请人： Yutaka Nomura , Masato Fukasawa , Hiroshi Nakagawa
发明人： Yutaka Nomura , Masato Fukasawa , Hiroshi Nakagawa
IPC分类号： C09K13/00
CPC分类号： H01L21/3212 , C09G1/02 , C09K3/1463
摘要： Disclosed is a metal-polishing liquid comprising: a metal-oxide-dissolving agent; a metal-oxidizing agent; a metal anticorrosive; a water-soluble polymer having a weight-average molecular weight of 8,000 or higher and having an anionic functional group and a nonionic functional group; and water, and having a pH within the range of 2.5 or higher but 5.0 or less. The metal-polishing liquid is effective in reducing the frictional force in polishing which generates during CMP. And is highly effective in flattening the surface of a work to be polished.
摘要翻译： 公开了一种金属抛光液，其包含：金属氧化物溶解剂; 金属氧化剂; 金属防腐; 重均分子量为8000以上且具有阴离子官能团和非离子官能团的水溶性聚合物; 和水，并且pH在2.5以上至5.0以下的范围内。 金属抛光液有效减少在CMP期间产生的抛光摩擦力。 并且对于要抛光的工件的表面变平，是非常有效的。
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公开(公告)号：US20110080251A1
公开(公告)日：2011-04-07
申请号：US12995867
申请日：2009-06-01
CPC分类号： H01C7/003 , H01C1/06 , H01C17/006 , H01C17/06506 , Y10T29/49155
摘要： A chip-like electric component such as a chip resistor is provided, which is easy to manufacture and in which cracks or fractures of an insulating substrate are unlikely to occur. A pair of surface electrodes 21, 23 are formed so that thicknesses of the pair of surface electrodes increase from a resistor layer 13 toward end portions 30 of an insulating substrate 29 in a direction in which the pair of surface electrodes 21, 23 are arranged. A plating reservoir S is formed between one of the surface electrodes 21, 23 and an insulating protective layer 15. When forming at least one plated layer 33, a plated metal pools in the plating reservoir S. The at least one plated layer 33 may work to reduce to some extent a height difference between a soldering electrode portion 21, 23, 27, 33 and the insulating protective layer 15.
摘要翻译： 提供了诸如片状电阻器的芯片状电气部件，其易于制造，并且其中不可能发生绝缘基板的裂纹或断裂。 形成一对表面电极21,23，使得一对表面电极的厚度从电阻层13朝向绝缘基板29的端部配置在一对表面电极21,23的方向上增加。 在一个表面电极21,23和绝缘保护层15之间形成电镀槽S.当形成至少一个镀层33时，电镀金属池在电镀槽S中。至少一个镀层33可以工作 以在一定程度上减少焊接电极部分21,23,27,33与绝缘保护层15之间的高度差。
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公开(公告)号：US20070072454A1
公开(公告)日：2007-03-29
申请号：US10595809
申请日：2004-11-12
申请人： Shinji Okamoto , Katsumi Takeuchi , Yutaka Nomura
发明人： Shinji Okamoto , Katsumi Takeuchi , Yutaka Nomura
IPC分类号： H01R4/58
CPC分类号： H05K3/368 , H01R12/52 , H05K3/3442 , H05K2201/10378 , Y10T29/49126
摘要： The present invention provides a connector chip capable of preventing electrical shorting between adjoining electrodes and also capable of readily connecting a plurality of electrodes on a first circuit substrate and a plurality of electrodes on a second circuit substrate without using a dedicated mounting device or the like. A plurality of conductive paths 5 are formed on an outer periphery surface constituted by continuous four surfaces 9A to 9D of an insulating substrate 3 including six surfaces of the surfaces 9A to 9D and surfaces 9E and 9F. Each of the conductive paths 5 goes round on the outer periphery surface. The conductive paths 5 are formed on the outer periphery surface at a predetermined interval in an opposing direction in which the remaining two surfaces 9E and 9F are opposing to each other. Each of insulating layers 7 having a property of repelling molten solder is formed between portions of each two adjoining conductive paths located on a pair of the surfaces 9A and 9B. The width of a conductive-path-formed portion 3A with a conductive path 5 formed thereon, orthogonal to a center line C is formed to be smaller than the width of a conductive-path-unformed portion 3B with no conductive path 5 formed thereon, orthogonal to the center line C.
摘要翻译： 本发明提供一种连接器芯片，其能够防止相邻电极之间的电短路，并且还能够容易地连接第一电路基板上的多个电极和第二电路基板上的多个电极，而不使用专用的安装装置等。 在由包括表面9A至9D的六个表面和表面9E和9F的绝缘基板3的连续的四个表面9A至9D构成的外周面上形成多个导电路径5。 导电路径5在外周表面上圆周。 导电路径5以与剩下的两个表面9E和9F相对的相反方向以预定的间隔形成在外周表面上。 具有排斥熔融焊料性质的绝缘层7中的每一个形成在位于一对表面9A和9B上的每个两个邻接导电路径的部分之间。具有导电性的导电路径形成部分3A的宽度 形成在其上的与中心线C正交的路径5形成为小于没有形成在其上的导电路径5的与中心线C正交的导电路径未成形部分3B的宽度。
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