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    Lipid peptide and hydrogel
    2.
    发明授权
    Lipid peptide and hydrogel 有权
    脂质肽和水凝胶

    公开(公告)号：US08916682B2

    公开(公告)日：2014-12-23

    申请号：US12452473

    申请日：2008-07-04

    Applicant: Nobuhide Miyachi ,  Takehisa Iwama ,  Masahiro Gotoh ,  Tatsuo Maruyama ,  Daisuke Koda

    Inventor： Nobuhide Miyachi ,  Takehisa Iwama ,  Masahiro Gotoh ,  Tatsuo Maruyama ,  Daisuke Koda

    IPC: A61K38/04 ,  C07K14/50 ,  C07K5/107 ,  C07K7/06 ,  C07K5/103 ,  C07K5/11 ,  C07K5/117

    CPC classification number: C07K7/06 ,  C07K5/1008 ,  C07K5/101 ,  C07K5/1016 ,  C07K5/1019 ,  C07K5/1024

    Abstract: There is provided a lipid peptide that is capable of forming a hydrogel with an extremely small amount thereof over a liquid property range from acidic to alkaline, and a hydrogel having high environmental suitability, biocompatibility and biodegradability. A lipid peptide represented by Formula (1): (where R1 represents an aliphatic group having 9 to 23 carbon atoms; R2, R3, R4 and R5 independently represent a hydrogen atom, an alkyl group having 1 to 7 carbon atom(s) which optionally has a branched chain having 1 to 3 carbon atom(s), a phenylmethyl group, a phenylethyl group or a —(CH2)n—X group, and at least one of R2, R3, R4 and R5 represents a —(CH2)n—X group; n represents the number of 1 to 4; X represents an amino group, a guanidine group, a —CONH2 group or a 5-membered ring, a 6-membered ring or a fused heterocyclic ring composed of a 5-membered ring and a 6-membered ring which optionally have 1 to 3 nitrogen atom(s); and in represents 1 or 2), and a hydrogel comprising the lipid peptide.

    Abstract translation: 提供了能够在从酸性到碱性的液体性质范围内形成极少量的水凝胶的脂质肽，以及具有高环境适应性，生物相容性和生物降解性的水凝胶。 由式（1）表示的脂质肽：其中，R1表示碳原子数9〜23的脂肪族基; R2，R3，R4，R5分别表示氢原子，碳原子数1〜7的烷基， 任选具有1至3个碳原子的支链，苯基甲基，苯基乙基或 - （CH 2）n -X基团，并且R 2，R 3，R 4和R 5中的至少一个表示 - （CH 2 ）n-X基; n表示1〜4的数; X表示氨基，胍基，-CONH 2基或5元环，6元环或稠合杂环，由5 含有1〜3个氮原子的6元环，代表1或2）和包含脂质肽的水凝胶。

    Lipid tripeptide-based hydrogelator and hydrogel
    3.
    发明授权
    Lipid tripeptide-based hydrogelator and hydrogel 有权
    脂质三肽基水凝胶和水凝胶

    公开(公告)号：US08486896B2

    公开(公告)日：2013-07-16

    申请号：US12452472

    申请日：2008-07-04

    Applicant: Nobuhide Miyachi ,  Takehisa Iwama ,  Masahiro Gotoh ,  Tatsuo Maruyama ,  Daisuke Koda

    Inventor： Nobuhide Miyachi ,  Takehisa Iwama ,  Masahiro Gotoh ,  Tatsuo Maruyama ,  Daisuke Koda

    IPC: C11D3/32 ,  D06P1/00 ,  C12N1/04 ,  C12N9/00 ,  C05F11/00 ,  C09K3/00

    CPC classification number: B01F17/005 ,  A23L29/20 ,  A61K8/042 ,  A61K8/64 ,  A61Q19/00 ,  C07K5/0806 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/0821

    Abstract: There is provided a hydrogelator that is capable of forming a hydrogel with an extremely small amount thereof over a liquid property range from acidic to alkaline, and a hydrogel having high environmental suitability, biocompatibility and biodegradability. A hydrogelator comprising a lipid peptide represented by Formula (1): (where R1 represents an aliphatic group having 9 to 21 carbon atoms; R2, R3 and R4 independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atom(s) which may have a branched chain having 1 or 2 carbon atom(s), a phenylmethyl group or a —(CH2)n—X group, and at least one of R2, R3 and R4 represents a —(CH2)n—X group; n represents the number of 1 to 4; X represents an amino group, a guanidino group, a —CONH2 group or a 5-membered ring, a 6-membered ring or a fused heterocyclic ring composed of a 5-membered ring and a 6-membered ring which may have 1 to 3 nitrogen atom(s)) or a salt thereof, and a hydrogel comprising the hydrogelator.

    Abstract translation: 提供一种水凝胶化剂，其能够在从酸性到碱性的液体性质范围内形成极少量的水凝胶，以及具有高环境适应性，生物相容性和生物降解性的水凝胶。 包含由式（1）表示的脂质肽的水凝胶体：（其中，R1表示碳原子数为9〜21的脂肪族基; R2，R3，R4分别独立地表示氢原子，碳原子数为1〜4的烷基， 其可以具有1或2个碳原子的支链，苯甲基或 - （CH 2）n X基团，并且R 2，R 3和R 4中的至少一个表示 - （CH 2）n X基团; n表示 数1至4; X表示氨基，胍基，-CONH 2基或5元环，6元环或由5元环和6元环组成的稠合杂环 其可以具有1至3个氮原子）或其盐，以及包含水凝胶体的水凝胶。

    SPRAY BASE MATERIAL INCLUDING LOW-MOLECULAR GELATOR
    9.
    发明申请
    SPRAY BASE MATERIAL INCLUDING LOW-MOLECULAR GELATOR 有权
    喷雾基材料包括低分子凝胶

    公开(公告)号：US20120035108A1

    公开(公告)日：2012-02-09

    申请号：US13256765

    申请日：2010-03-12

    Applicant: Misao Miyamoto ,  Takehisa Iwama ,  Nobuhide Miyachi ,  Masahiro Gotoh

    Inventor： Misao Miyamoto ,  Takehisa Iwama ,  Nobuhide Miyachi ,  Masahiro Gotoh

    IPC: A01N33/00 ,  C07K5/103 ,  A61K31/405 ,  A61K38/18 ,  A61K38/39 ,  A61K31/728 ,  A61K31/14 ,  A01N33/12 ,  A01N43/04 ,  A61K8/64 ,  A61K8/65 ,  A61K8/60 ,  A61K8/49 ,  A61K8/40 ,  A01P15/00 ,  A61P43/00 ,  A61Q5/00 ,  A61Q19/00 ,  C11D3/60 ,  C09K15/00 ,  C08K5/09 ,  C09K3/00 ,  C07D233/64

    CPC classification number: A61K8/64 ,  A61K8/046 ,  A61K9/7015 ,  A61K38/05 ,  A61K2800/48 ,  A61Q19/00

    Abstract: There is provided a spray base material that can be safely used with a sense of security, that prevents leakage of liquid from a spray container, that is sprayable under any condition (when inverted, for example), that is sprayable to achieve uniform coating of the surface of an object (surface to be sprayed) without scattering, that causes no dripping from a sprayed surface, and that is safe when sprayed on a skin surface and the like; and a spray base material with an excellent sprayability that can include both hydrophilic and hydrophobic low-molecular compounds such as physiologically active compounds and perfume components to be used in pharmaceuticals, agrochemicals, and cosmetics, and that has a sustained release property. A spray base material comprising an aqueous medium that is gelled by a low-molecular gelator in the medium, wherein the low-molecular gelator includes one, two, or more compounds selected from a group consisting of low-molecular compounds capable of gelling the aqueous medium via self-assembly.

    Abstract translation: 提供了一种可以安全使用的喷雾基材，其防止液体从喷雾容器泄漏，该喷雾容器可在任何条件（例如倒置时）下喷雾，其可喷雾以实现均匀涂布 物体的表面（待喷射的表面）不会飞散，不会从喷射表面滴落，并且当喷涂在皮肤表面等时是安全的; 以及具有优异的喷雾性的喷雾基材，其可以包括用于药物，农业化学品和化妆品中的亲水性和疏水性低分子化合物如生理活性化合物和香料组分，并具有持续释放性质。 一种喷雾基材，其包含在介质中被低分子胶凝剂凝胶化的水性介质，其中所述低分子胶凝剂包括一种，两种或更多种选自以下的化合物：低分子化合物，其能够胶凝所述水性 介质通过自组装。

    NOVEL LIPID DIPEPTIDE AND GEL
    10.
    发明申请
    NOVEL LIPID DIPEPTIDE AND GEL 有权
    新型脂蛋白和凝胶

    公开(公告)号：US20110183913A1

    公开(公告)日：2011-07-28

    申请号：US13056517

    申请日：2009-06-19

    Applicant: Misao Miyamoto ,  Nobuhide Miyachi ,  Takehisa Iwama

    Inventor： Misao Miyamoto ,  Nobuhide Miyachi ,  Takehisa Iwama

    IPC: A61K8/64 ,  C07K5/062 ,  A61Q19/00 ,  A61K47/42 ,  C08K5/3445 ,  C11D3/43 ,  A23L1/05

    CPC classification number: A61K47/22 ,  A61K9/0014 ,  A61K9/7007 ,  A61K47/10 ,  A61K47/183 ,  C07K5/06026 ,  C07K5/06052 ,  C07K5/06139 ,  C07K5/06147 ,  C07K5/1008

    Abstract: There is provided a gelator that is capable of forming a gel by an extremely small amount of addition in a wide pH range from acidic to alkaline regions, and a gel having high environmental compatibility, biocompatibility, and biodegradability. A gelator comprising: a lipid peptide of Formula (1) wherein R1 is a C9-23 aliphatic group, R2 is a hydrogen atom or a C1-4 alkyl group optionally having a C1-2 branched chain, R3 is a —(CH2)n-X group, n is a number from 1 to 4, and X is an amino group, a guanidino group, a —CONH2 group, or a 5-membered ring optionally having 1 to 3 nitrogen atoms, a 6-membered ring optionally having 1 to 3 nitrogen atoms, or a fused heterocycle including a 5-membered ring and a 6-membered ring that optionally has 1 to 3 nitrogen atoms); or a pharmaceutically usable salt of the lipid peptide.

    Abstract translation: 提供了一种胶凝剂，其能够在从酸性到碱性区域的宽pH范围内通过极少量的添加形成凝胶，以及具有高环境相容性，生物相容性和生物降解性的凝胶。 一种凝胶剂，其包含：式（1）的脂质肽，其中R 1是C 9-23脂族基团，R 2是氢原子或任选具有C 1-2支链的C 1-4烷基，R 3是 - （CH 2） nX基团，n为1至4的数，X为氨基，胍基，-CONH 2基或任选具有1至3个氮原子的5元环，任选具有1至6个氮原子的6元环 或3个氮原子的稠合杂环，或包含任选具有1至3个氮原子的5元环和6元环的稠合杂环）; 或脂质肽的药学上可用的盐。

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