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公开(公告)号：US20160095910A1
公开(公告)日：2016-04-07
申请号：US14854224
申请日：2015-09-15
IPC分类号： A61K39/00 , C07K14/50 , C07K14/495
摘要： The present disclosure provides for a synthetic immunogenic protein for use as an immuno-modulatory agent to enhance mammalian immune reactions towards conjugated protein or peptide containing antigens that are otherwise poorly immunogenic, including but not limited to self-antigens. The chimeric immunogenic proteins of the present disclosure can be used in the treatment of many illnesses, including but not limited to cancers, infectious disease, autoimmune disease, allergies and any clinical indication involving or affected by the immune response of a mammalian host.
摘要翻译： 本公开内容提供了用作免疫调节剂的合成免疫原性蛋白，以增强对包含但不限于自身抗原的共轭蛋白或含有抗原的哺乳动物免疫反应，否则其抗原性差。 本公开的嵌合免疫原性蛋白质可用于治疗许多疾病，包括但不限于癌症，感染性疾病，自身免疫疾病，过敏症以及涉及或受哺乳动物宿主的免疫应答影响的任何临床适应症。
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公开(公告)号：US20110027280A1
公开(公告)日：2011-02-03
申请号：US12837588
申请日：2010-07-16
CPC分类号： C07K16/44 , A61K2039/505 , C07K16/1203 , C07K16/1214 , C07K2317/21 , C07K2317/622 , C07K2317/73
摘要： The present invention relates to methods for the killing of infectious bacteria by modulating the extra-cellular concentration of bacterial cell signalling molecules. This has the effect of inducing rapid cell death (autolysis) in the majority of bacterial cells, and preventing virulence or restoring a benign state in surviving cells. These receptors have applications for the treatment of individuals with susceptibility to infection, the treatment of patients with existing infections, in disease management, and in related applications where the host for infection is an animal or plant. The compositions described herein are particularly relevant to Pseudomonas aeruginosa infection, for example in the treatment of pulmonary infection in cystic fibrosis patients, and represent a unique bactericidal medication that does not directly target the bacteria.
摘要翻译： 本发明涉及通过调节细菌细胞信号分子的细胞外浓度来杀死感染性细菌的方法。 这具有在大多数细菌细胞中诱导快速细胞死亡（自溶）的作用，并且防止存活细胞中的毒力或恢复良性状态。 这些受体具有用于治疗感染易感性，治疗现有感染患者，疾病管理以及感染宿主是动物或植物的相关应用的个体的应用。 本文描述的组合物与铜绿假单胞菌感染特别相关，例如在囊性纤维化患者中治疗肺部感染，并且代表不直接靶向细菌的独特的杀菌药物。
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公开(公告)号：US20200297827A1
公开(公告)日：2020-09-24
申请号：US16843118
申请日：2020-04-08
IPC分类号： A61K39/00 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/50
摘要： The present disclosure provides for a synthetic immunogenic protein for use as an immuno-modulatory agent to enhance mammalian immune reactions towards conjugated protein or peptide containing antigens that are otherwise poorly immunogenic, including but not limited to self-antigens. The chimeric immunogenic proteins of the present disclosure can be used in the treatment of many illnesses, including but not limited to cancers, infectious disease, autoimmune disease, allergies and any clinical indication involving or affected by the immune response of a mammalian host.
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公开(公告)号：US10736948B2
公开(公告)日：2020-08-11
申请号：US14854224
申请日：2015-09-15
IPC分类号： A61K39/00 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/50
摘要： The present disclosure provides for a synthetic immunogenic protein for use as an immuno-modulatory agent to enhance mammalian immune reactions towards conjugated protein or peptide containing antigens that are otherwise poorly immunogenic, including but not limited to self-antigens. The chimeric immunogenic proteins of the present disclosure can be used in the treatment of many illnesses, including but not limited to cancers, infectious disease, autoimmune disease, allergies and any clinical indication involving or affected by the immune response of a mammalian host.
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公开(公告)号：US20130011400A1
公开(公告)日：2013-01-10
申请号：US13412218
申请日：2012-03-05
CPC分类号： C07K16/44 , A61K2039/505 , C07K16/1203 , C07K16/1214 , C07K2317/21 , C07K2317/622 , C07K2317/73
摘要： The present invention relates to methods for the killing of infectious bacteria by modulating the extra-cellular concentration of bacterial cell signalling molecules. This has the effect of inducing rapid cell death (autolysis) in the majority of bacterial cells, and preventing virulence or restoring a benign state in surviving cells. These receptors have applications for the treatment of individuals with susceptibility to infection, the treatment of patients with existing infections, in disease management, and in related applications where the host for infection is an animal or plant. The compositions described herein are particularly relevant to Pseudomonas aeruginosa infection, for example in the treatment of pulmonary infection in cystic fibrosis patients, and represent a unique bactericidal medication that does not directly target the bacteria.
摘要翻译： 本发明涉及通过调节细菌细胞信号分子的细胞外浓度来杀死感染性细菌的方法。 这具有在大多数细菌细胞中诱导快速细胞死亡（自溶）的作用，并且防止存活细胞中的毒力或恢复良性状态。 这些受体具有用于治疗感染易感性，治疗现有感染患者，疾病管理以及感染宿主是动物或植物的相关应用的个体的应用。 本文描述的组合物与铜绿假单胞菌感染特别相关，例如在囊性纤维化患者中治疗肺部感染，并且代表不直接靶向细菌的独特的杀菌药物。
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6.发明授权Methods for the treatment of an infectious bacterial disease with an anti-lactone or lactone derived signal molecules antibody 失效用抗内酯或内酯衍生的信号分子抗体治疗感染性细菌性疾病的方法公开(公告)号：US08168397B2
公开(公告)日：2012-05-01
申请号：US12791927
申请日：2010-06-02
IPC分类号： G01N33/53 , G01N33/554
CPC分类号： G01N33/9446 , A61K2039/505 , C07K16/1214 , C07K16/44 , C07K2317/21 , C07K2317/622 , C07K2317/73 , G01N33/6854
摘要： The present invention relates to methods for the control of virulence of infectious bacteria by modulating the extra-cellular concentration of bacterial cell signalling molecules. Derivatives of cell signalling molecules are conjugated to suitable carrier proteins and used to isolate high affinity receptors recognizing the native signal molecule(s). By binding to signalling molecules, the receptors reduce and maintain extra-cellular concentrations of signal molecules below the threshold level that would otherwise result in certain opportunistic pathogens adopting a virulent form, and can transform virulent organisms to non-virulent states. These receptors have applications for the treatment of individuals with susceptibility to infection, the treatment of patients with existing infections, in disease monitoring and management, and in related applications where the host for infection is an animal or plant.
摘要翻译： 本发明涉及通过调节细菌细胞信号分子的细胞外浓度来控制感染性细菌的毒力的方法。 细胞信号分子的衍生物与合适的载体蛋白缀合并用于分离识别天然信号分子的高亲和力受体。 通过结合信号分子，受体减少并维持低于阈值水平的信号分子的细胞外浓度，否则会导致某些机会性病原体采用有毒的形式，并且可以将有毒生物转化为非毒性状态。 这些受体可用于治疗感染易感性，治疗现有感染患者，疾病监测和管理以及感染宿主是动物或植物的相关应用中的个体。
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7.发明授权Methods for the treatment of an infectious bacterial disease with an anti-lactone or lactone derived signal molecules antibody 有权用抗内酯或内酯衍生的信号分子抗体治疗感染性细菌性疾病的方法公开(公告)号：US07812134B2
公开(公告)日：2010-10-12
申请号：US10524082
申请日：2003-08-13
CPC分类号： G01N33/9446 , A61K2039/505 , C07K16/1214 , C07K16/44 , C07K2317/21 , C07K2317/622 , C07K2317/73 , G01N33/6854
摘要： The present invention relates to methods for the control of virulence of infectious bacteria by modulating the extra-cellular concentration of bacterial cell signalling molecules. Derivatives of cell signalling molecules are conjugated to suitable carrier proteins and used to isolate high affinity receptors recognising the native signal molecule(s). By binding to signalling molecules, the receptors reduce and maintain extra-cellular concentrations of signal molecules below the threshold level that would otherwise result in certain opportunistic pathogens adopting a virulent form, and can transform virulent organisms to non-virulent states. These receptors have applications for the treatment of individuals with susceptibility to infection, the treatment of patients with existing infections, in disease monitoring and management, and in related applications where the host for infection is an animal or plant.
摘要翻译： 本发明涉及通过调节细菌细胞信号分子的细胞外浓度来控制感染性细菌的毒力的方法。 细胞信号分子的衍生物与合适的载体蛋白缀合并用于分离识别天然信号分子的高亲和力受体。 通过结合信号分子，受体减少并维持低于阈值水平的信号分子的细胞外浓度，否则会导致某些机会性病原体采用有毒的形式，并且可以将有毒生物转化为非毒性状态。 这些受体可用于治疗感染易感性，治疗现有感染患者，疾病监测和管理以及感染宿主是动物或植物的相关应用中的个体。
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8.发明申请Methods for the Treatment of an Infectious Bacterial Disease with an Anti-Lactone or Lactone Derived Signal Molecules Antibody 审中-公开用抗内酯或内酯衍生的信号分子治疗感染性细菌病的方法抗体公开(公告)号：US20130045208A1
公开(公告)日：2013-02-21
申请号：US13438303
申请日：2012-04-03
CPC分类号： G01N33/9446 , A61K2039/505 , C07K16/1214 , C07K16/44 , C07K2317/21 , C07K2317/622 , C07K2317/73 , G01N33/6854
摘要： The present invention relates to methods for the control of virulence of infectious bacteria by modulating the extra-cellular concentration of bacterial cell signalling molecules. Derivatives of cell signalling molecules are conjugated to suitable carrier proteins and used to isolate high affinity receptors recognising the native signal molecule(s). By binding to signalling molecules, the receptors reduce and maintain extra-cellular concentrations of signal molecules below the threshold level that would otherwise result in certain opportunistic pathogens adopting a virulent form, and can transform virulent organisms to non-virulent states. These receptors have applications for the treatment of individuals with susceptibility to infection, the treatment of patients with existing infections, in disease monitoring and management, and in related applications where the host for infection is an animal or plant.
摘要翻译： 本发明涉及通过调节细菌细胞信号分子的细胞外浓度来控制感染性细菌的毒力的方法。 细胞信号分子的衍生物与合适的载体蛋白缀合并用于分离识别天然信号分子的高亲和力受体。 通过结合信号分子，受体减少并维持低于阈值水平的信号分子的细胞外浓度，否则会导致某些机会性病原体采用有毒的形式，并且可以将有毒生物转化为非毒性状态。 这些受体可用于治疗感染易感性，治疗现有感染患者，疾病监测和管理以及感染宿主是动物或植物的相关应用中的个体。
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9.发明申请公开(公告)号：US20100303831A1
公开(公告)日：2010-12-02
申请号：US12791927
申请日：2010-06-02
CPC分类号： G01N33/9446 , A61K2039/505 , C07K16/1214 , C07K16/44 , C07K2317/21 , C07K2317/622 , C07K2317/73 , G01N33/6854
摘要： The present invention relates to methods for the control of virulence of infectious bacteria by modulating the extra-cellular concentration of bacterial cell signalling molecules. Derivatives of cell signalling molecules are conjugated to suitable carrier proteins and used to isolate high affinity receptors recognising the native signal molecule(s). By binding to signalling molecules, the receptors reduce and maintain extra-cellular concentrations of signal molecules below the threshold level that would otherwise result in certain opportunistic pathogens adopting a virulent form, and can transform virulent organisms to non-virulent states. These receptors have applications for the treatment of individuals with susceptibility to infection, the treatment of patients with existing infections, in disease monitoring and management, and in related applications where the host for infection is an animal or plant.
摘要翻译： 本发明涉及通过调节细菌细胞信号分子的细胞外浓度来控制感染性细菌的毒力的方法。 细胞信号分子的衍生物与合适的载体蛋白缀合并用于分离识别天然信号分子的高亲和力受体。 通过结合信号分子，受体减少并维持低于阈值水平的信号分子的细胞外浓度，否则会导致某些机会性病原体采用有毒的形式，并且可以将有毒生物转化为非毒性状态。 这些受体可用于治疗感染易感性，治疗现有感染患者，疾病监测和管理以及感染宿主是动物或植物的相关应用中的个体。
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