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    DENDRITIC CELL TUMOR INJECTION (DCTI) THERAPY
    2.
    发明申请
    DENDRITIC CELL TUMOR INJECTION (DCTI) THERAPY 有权
    DENDRIC细胞肿瘤注射（DCTI）治疗

    公开(公告)号：US20120071860A1

    公开(公告)日：2012-03-22

    申请号：US13303679

    申请日：2011-11-23

    申请人： KENICHIRO HASUMI

    发明人： KENICHIRO HASUMI

    IPC分类号： A61M37/00

    CPC分类号： A61K31/739 ,  A61K35/12 ,  A61K35/15 ,  A61K36/06 ,  A61K36/07 ,  A61K36/074 ,  A61K38/193 ,  A61K38/2026 ,  A61K39/0011 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/5154 ,  A61K2039/55522 ,  A61K2300/00

    摘要： The invention relates to a method of treating tumor cells within a patient wherein immature dendritic cells developed from the patient's monocyte cells and a lymphocyte cultured medium (LCM) adjuvant are introduced into the patient directly into the patient's tumor cells. The immature dendritic cells and LCM adjuvant combine with the antigens in the tumor cells to form a cancer vaccine, thereby immediately treating the tumor cells of the patient. The invention also provides a precursor treatment step of treating the patient with radiation therapy or a chemotherapy regimen.

    摘要翻译： 本发明涉及一种治疗患者肿瘤细胞的方法，其中将从患者的单核细胞发育的未成熟树突状细胞和淋巴细胞培养基（LCM）佐剂直接引入患者的肿瘤细胞。 未成熟树突状细胞和LCM佐剂与肿瘤细胞中的抗原结合形成癌症疫苗，从而立即治疗患者的肿瘤细胞。 本发明还提供了用放射治疗或化学疗法治疗患者的前体治疗步骤。

    Adoptive immune cells for tumor vaccines
    3.
    发明授权
    Adoptive immune cells for tumor vaccines 有权
    免疫细胞用于肿瘤疫苗

    公开(公告)号：US07655393B2

    公开(公告)日：2010-02-02

    申请号：US11579280

    申请日：2004-05-11

    申请人： Kenichiro Hasumi ,  Akira Imaizumi ,  Masamichi Iwama ,  Mitsuaki Goto

    发明人： Kenichiro Hasumi ,  Akira Imaizumi ,  Masamichi Iwama ,  Mitsuaki Goto

    IPC分类号： A01N1/02

    CPC分类号： C12N5/0068 ,  A61K2039/5154 ,  C12N2533/70

    摘要： The present invention provides a method for preparing adoptive immune cells comprising the following steps of a) obtaining mammalian antigen-presenting associated cells; b) culturing the resulting cells in a culture vessel coated with a sugar chain-containing polymer; and c) detaching the cells by shaking the culture vessel without treating the cells with enzyme and without using a cell detaching tool; adoptive immune cells obtained by this preparing method; a culture vessel coated with a sugar chain-containing polymer for use in this preparation method; a kit for preparing an adoptive immune cell vaccine; and a method and a medicine for treating a malignant tumor, type I diabetes, atopic allergic diseases or infections using the adoptive immune cells.

    摘要翻译： 本发明提供一种制备过继免疫细胞的方法，包括以下步骤：a）获得哺乳动物抗原呈递相关细胞; b）将所得细胞培养在涂有含糖链的聚合物的培养容器中; 和c）通过摇动培养容器而不用酶处理细胞并且不使用细胞分离工具来分离细胞; 通过该制备方法获得的过继免疫细胞; 用该制备方法使用的含糖链聚合物的培养容器; 用于制备过继性免疫细胞疫苗的试剂盒; 以及使用过继免疫细胞治疗恶性肿瘤，I型糖尿病，特应性过敏性疾病或感染的方法和药物。

    DENDRITIC CELL TUMOR INJECTION (DCTI) THERAPY
    4.
    发明申请
    DENDRITIC CELL TUMOR INJECTION (DCTI) THERAPY 有权
    DENDRIC细胞肿瘤注射（DCTI）治疗

    公开(公告)号：US20090074713A1

    公开(公告)日：2009-03-19

    申请号：US12100878

    申请日：2008-04-10

    申请人： Kenichiro Hasumi

    发明人： Kenichiro Hasumi

    IPC分类号： A61K38/20 ,  A61K38/21 ,  A61K35/12 ,  A61P35/00

    CPC分类号： A61K31/739 ,  A61K35/12 ,  A61K35/15 ,  A61K36/06 ,  A61K36/07 ,  A61K36/074 ,  A61K38/193 ,  A61K38/2026 ,  A61K39/0011 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/5154 ,  A61K2039/55522 ,  A61K2300/00

    摘要： The invention relates to a method of treating tumor cells within a patient wherein immature dendritic cells developed from the patient's monocyte cells and a lymphocyte cultured medium (LCM) adjuvant are introduced into the patient directly into the patient's tumor cells. The immature dendritic cells and LCM adjuvant combine with the antigens in the tumor cells to form a cancer vaccine, thereby immediately treating the tumor cells of the patient. The invention also provides a precursor treatment step of treating the patient with radiation therapy or a chemotherapy regimen.

    摘要翻译： 本发明涉及一种治疗患者肿瘤细胞的方法，其中从患者的单核细胞发育的未成熟树突状细胞和淋巴细胞培养基（LCM）佐剂直接引入患者的肿瘤细胞。 未成熟树突状细胞和LCM佐剂与肿瘤细胞中的抗原结合形成癌症疫苗，从而立即治疗患者的肿瘤细胞。 本发明还提供了用放射治疗或化学疗法治疗患者的前体治疗步骤。

    Dendritic cell tumor injection (DCTI) therapy
    5.
    发明申请
    Dendritic cell tumor injection (DCTI) therapy 审中-公开
    树突状细胞肿瘤注射（DCTI）治疗

    公开(公告)号：US20060216269A1

    公开(公告)日：2006-09-28

    申请号：US11227374

    申请日：2005-09-15

    申请人： Kenichiro Hasumi

    发明人： Kenichiro Hasumi

    IPC分类号： A61K48/00 ,  A61K38/20 ,  A61K38/19 ,  A61K31/739 ,  A61K36/06

    CPC分类号： A61K45/06 ,  A61K31/739 ,  A61K35/15 ,  A61K36/06 ,  A61K36/07 ,  A61K36/074 ,  A61K38/20 ,  A61K2039/5154 ,  A61K2300/00

    摘要： The invention relates to a method of treating tumor cells within a patient wherein immature dendritic cells developed from the patient's monocyte cells and an adjuvant are introduced into the patient directly into the patient's tumor cells. The immature dendritic cells and adjuvant combine with the antigens in the tumor cells to form a cancer vaccine, thereby immediately treating the tumor cells of the patient. The invention also provides a precursor treatment step of treating the patient with a radiation therapy or chemotherapy regimen.

    摘要翻译： 本发明涉及一种治疗患者肿瘤细胞的方法，其中将从患者的单核细胞发育而来的未成熟树突状细胞和佐剂直接引入患者的肿瘤细胞。 未成熟树突状细胞和佐剂与肿瘤细胞中的抗原结合以形成癌症疫苗，从而立即治疗患者的肿瘤细胞。 本发明还提供了用放射治疗或化学疗法治疗患者的前体治疗步骤。

    THERAPY AND METHODS OF INTRODUCING IMMATURE DENDRITIC CELLS AND/OR CYTOXIC T LYMPHOCYTE AND ANTI PD-1 / PD-L1 ANTIBODY FOR TREATMENT OF TUMORS
    6.
    发明申请
    THERAPY AND METHODS OF INTRODUCING IMMATURE DENDRITIC CELLS AND/OR CYTOXIC T LYMPHOCYTE AND ANTI PD-1 / PD-L1 ANTIBODY FOR TREATMENT OF TUMORS 审中-公开

    公开(公告)号：US20200030375A1

    公开(公告)日：2020-01-30

    申请号：US16404091

    申请日：2019-05-06

    申请人： KENICHIRO HASUMI

    发明人： KENICHIRO HASUMI

    IPC分类号： A61K35/15 ,  A61K39/395 ,  C12N5/0784 ,  C12N5/0783 ,  A61K35/17 ,  C07K16/24 ,  A61K38/19

    摘要： The invention relates to therapy and methods of applying the therapy to a patient. The invention includes the introduction of immature dendritic cells into the patient and the introduction of PD-1 and/or PD-L1 inhibitor into the patient. The immature dendritic cells are introduced intratumorally and/or through vessel and the PD-1 and/or PD-L1 inhibitor is introduced intratumorally and/or through vessel and/or subcutaneously. The immature dendritic cells can be formed by collecting monocyte cells from the patient and culturing the cells in a culture medium. The invention can be effective to regress, reduce or eliminate tumor cells in tumor tissue of the patients, including metastasized tumors. Further, the treatment of the invention is effective in the absence of conventional therapy, such as radiotherapy and chemotherapy.

    Dendritic cell tumor injection (DCTI) therapy
    8.
    发明授权
    Dendritic cell tumor injection (DCTI) therapy 有权
    树突状细胞肿瘤注射（DCTI）治疗

    公开(公告)号：US08076132B2

    公开(公告)日：2011-12-13

    申请号：US12100878

    申请日：2008-04-10

    申请人： Kenichiro Hasumi

    发明人： Kenichiro Hasumi

    IPC分类号： A61K35/12 ,  A61K38/20 ,  A61K38/21 ,  A61P35/00

    CPC分类号： A61K31/739 ,  A61K35/12 ,  A61K35/15 ,  A61K36/06 ,  A61K36/07 ,  A61K36/074 ,  A61K38/193 ,  A61K38/2026 ,  A61K39/0011 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/5154 ,  A61K2039/55522 ,  A61K2300/00

    摘要： The invention relates to a method of treating tumor cells within a patient wherein immature dendritic cells developed from the patient's monocyte cells and a lymphocyte cultured medium (LCM) adjuvant are introduced into the patient directly into the patient's tumor cells. The immature dendritic cells and LCM adjuvant combine with the antigens in the tumor cells to form a cancer vaccine, thereby immediately treating the tumor cells of the patient. The invention also provides a precursor treatment step of treating the patient with radiation therapy or a chemotherapy regimen.

    摘要翻译： 本发明涉及一种治疗患者肿瘤细胞的方法，其中将从患者的单核细胞发育的未成熟树突状细胞和淋巴细胞培养基（LCM）佐剂直接引入患者的肿瘤细胞。 未成熟树突状细胞和LCM佐剂与肿瘤细胞中的抗原结合形成癌症疫苗，从而立即治疗患者的肿瘤细胞。 本发明还提供了用放射治疗或化学疗法治疗患者的前体治疗步骤。

    Adoptive immune cells for tumor vaccines
    9.
    发明授权
    Adoptive immune cells for tumor vaccines 有权
    免疫细胞用于肿瘤疫苗

    公开(公告)号：US08075882B2

    公开(公告)日：2011-12-13

    申请号：US12653090

    申请日：2009-12-08

    申请人： Kenichiro Hasumi ,  Akira Imaizumi ,  Masamichi Iwama ,  Mitsuaki Goto

    发明人： Kenichiro Hasumi ,  Akira Imaizumi ,  Masamichi Iwama ,  Mitsuaki Goto

    IPC分类号： A61K35/12 ,  C12N5/07

    CPC分类号： C12N5/0068 ,  A61K2039/5154 ,  C12N2533/70

    摘要： Adoptive immune cells obtained by a method including (a) obtaining mammalian antigen-presenting associated cells; (b) culturing the resulting cells from step (a) in a culture liquid contained in a culture vessel coated with a sugar chain-containing polymer; and (c) detaching the cells from step (b) by shaking the culture vessel without treating the cells with an enzyme and without using a cell detaching tool. A method for treating a malignant tumor, type I diabetes, an atopic allergic disease or an infection, by administering the adoptive immune cells to a patient. A pharmaceutical composition for treating a malignant tumor, type I diabetes, an atopic allergic disease or an infection, including the adoptive immune cells and a pharmaceutically acceptable carrier.

    摘要翻译： 通过包括（a）获得哺乳动物抗原呈递相关细胞的方法获得的免疫免疫细胞; （b）从包含在含有糖链的聚合物的培养容器中的培养液中培养来自步骤（a）的所得细胞; 和（c）通过摇动培养容器从步骤（b）中分离细胞而不用酶处理细胞，而不使用细胞分离工具。 通过向患者施用过继免疫细胞来治疗恶性肿瘤，I型糖尿病，特应性过敏性疾病或感染的方法。 用于治疗恶性肿瘤，I型糖尿病，特应性过敏性疾病或感染的药物组合物，包括过继免疫细胞和药学上可接受的载体。