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公开(公告)号：US06509369B2
公开(公告)日：2003-01-21
申请号：US10041423
申请日：2002-01-08
申请人： Malcolm K. Scott , Pauline J. Sanfilippo , Louis J. Fitzpatrick, III , Richard Cordova , Kevin Pan , Joseph Meschino
发明人： Malcolm K. Scott , Pauline J. Sanfilippo , Louis J. Fitzpatrick, III , Richard Cordova , Kevin Pan , Joseph Meschino
IPC分类号： A61K31381
CPC分类号： C07C311/13 , C07C233/05 , C07C233/11 , C07C233/13 , C07C271/44 , C07C311/16 , C07C317/44 , C07C323/62 , C07C2601/02 , C07C2603/18 , C07C2603/32 , C07D209/18 , C07D209/42 , C07D213/56 , C07D333/24 , C07D333/38 , C07D333/60 , C07D333/70
摘要： This invention relates to anti-inflammatory compounds, methods of making such compounds and methods of using such compounds having the following structure:
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公开(公告)号：US07141674B2
公开(公告)日：2006-11-28
申请号：US10690341
申请日：2003-10-21
申请人： Malcolm K. Scott , Pauline J. Sanfilippo , Louis J. Fitzpatrick, III , Richard Cordova , Kevin Pan , Joseph Meschino
发明人： Malcolm K. Scott , Pauline J. Sanfilippo , Louis J. Fitzpatrick, III , Richard Cordova , Kevin Pan , Joseph Meschino
IPC分类号： C07D211/72 , C07D209/02 , C07D333/56
CPC分类号： C07C311/13 , C07C233/05 , C07C233/11 , C07C233/13 , C07C271/44 , C07C311/16 , C07C317/44 , C07C323/62 , C07C2601/02 , C07C2603/18 , C07C2603/32 , C07D209/18 , C07D209/42 , C07D213/56 , C07D333/24 , C07D333/38 , C07D333/60 , C07D333/70
摘要： This invention relates to anti-inflammatory compounds, methods of making such compounds and methods of using such compounds having the following structure:
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公开(公告)号：US06372779B1
公开(公告)日：2002-04-16
申请号：US09221254
申请日：1998-12-28
申请人： Malcolm K. Scott , Pauline J. Sanfilippo , Louis J. Fitzpatrick, III , Richard Cordova , Kevin Pan , Joseph Meschino
发明人： Malcolm K. Scott , Pauline J. Sanfilippo , Louis J. Fitzpatrick, III , Richard Cordova , Kevin Pan , Joseph Meschino
IPC分类号： A61K31381
CPC分类号： C07C311/13 , C07C233/05 , C07C233/11 , C07C233/13 , C07C271/44 , C07C311/16 , C07C317/44 , C07C323/62 , C07C2601/02 , C07C2603/18 , C07C2603/32 , C07D209/18 , C07D209/42 , C07D213/56 , C07D333/24 , C07D333/38 , C07D333/60 , C07D333/70
摘要： This invention relates to anti-inflammatory compounds, methods of making such compounds and methods of using such compounds having the following structure:
摘要翻译： 本发明涉及抗炎化合物，制备这些化合物的方法和使用具有以下结构的这些化合物的方法：
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4.发明授权S-heteroatom containing alkyl substituted-3-oxo-pyrido�1,2-A!benzimidozole-4-carboxamide derivatives useful in treating central nervous system disorders 失效含有可用于治疗中枢神经系统疾病的烷基取代-3-氧代 - 吡啶并[1,2-A]苯甲亚氨基-4-甲酰胺衍生物的S-杂原子
公开(公告)号：US5817668A
公开(公告)日：1998-10-06
申请号：US943578
申请日：1997-10-03
申请人： Allen B. Reitz , Alfonzo D. Jordan , Pauline J. Sanfilippo , Malcolm K. Scott , Anna Vavouyios-Smith
发明人： Allen B. Reitz , Alfonzo D. Jordan , Pauline J. Sanfilippo , Malcolm K. Scott , Anna Vavouyios-Smith
IPC分类号： A61K31/437 , A61K31/496 , A61K31/5377 , A61P25/00 , A61P25/02 , A61P25/22 , A61P25/30 , C07D471/04 , A61K31/435 , A61K31/535
CPC分类号： C07D471/04 , A61K31/437
摘要： A compound of the general formula 1; ##STR1## is disclosed as useful in treating disorders of the central nervous system. Pharmaceutical compositions and methods of treatment are also disclosed.
摘要翻译： 通式1的化合物; 公开了一种治疗中枢神经系统疾病的方法。 还公开了药物组合物和治疗方法。
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5.发明授权
公开(公告)号：US5457212A
公开(公告)日：1995-10-10
申请号：US315668
申请日：1994-09-30
IPC分类号： A61K31/38 , A61P9/00 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P17/00 , A61P25/02 , C07B57/00 , C07D495/04 , C07D495/02 , C07D401/02 , C07D409/04 , C07D411/04
CPC分类号： C07D495/04
摘要： A process for the preparation of enantiomerically pure thienopyran derivatives of the formula ##STR1## is described. The thienopyran derivatives are relaxants of smooth muscle tone and as such are useful in vascular tissue for the treatment of hypertension disease, angina and other vascular disorders characterized by poor regional perfusion.
摘要翻译： 描述了制备具有式
的对映体纯的噻吩并吡喃衍生物的方法。 噻吩衍生物是平滑肌张力的松弛剂，因此在血管组织中可用于治疗以区域性灌注不良为特征的高血压疾病，心绞痛和其他血管疾病。 -
6.发明授权Substituted pyrimidinylaminothiazole derivatives useful as platelet aggreggation inhibitors 失效可用作血小板聚集抑制剂的取代的嘧啶基氨基噻唑衍生物
公开(公告)号：US5530000A
公开(公告)日：1996-06-25
申请号：US171804
申请日：1993-12-22
IPC分类号： C07D417/12 , C07D521/00 , C07D277/28 , A61K31/425
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D417/12
摘要： This invention relates to substituted thiazole derivatives of the following general formula, the substituent groups of which are as defined in the specification herein: ##STR1## These compounds are useful as inhibitors of platelet aggregation and inhibitors of adhesion molecules and may be provided in pharmaceutical compositions and in methods of treating reperfusion thrombosis injury in patients. Also included are novel intermediates for preparing the compounds of the invention.
摘要翻译： 本发明涉及以下通式的取代噻唑衍生物，其取代基如本说明书中所定义：这些化合物可用作血小板聚集抑制剂和粘附分子抑制剂，并可提供于药物组合物 以及治疗患者再灌注血栓形成的方法。 还包括用于制备本发明化合物的新型中间体。
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7.发明授权
公开(公告)号：US5342851A
公开(公告)日：1994-08-30
申请号：US958193
申请日：1992-10-07
IPC分类号： C07D417/04 , A61K31/425
CPC分类号： C07D417/04
摘要： This invention relates to substituted thiazole derivatives of the following general formula, the substituent groups of which are as defined herein: ##STR1## These compounds are useful as inhibitors of platelet aggregation and inhibitors of adhesion molecules and may be provided in pharmaceutical compositions and in methods of treating reperfusion thrombosis injury in patients.
摘要翻译： 本发明涉及以下通式的取代噻唑衍生物，其取代基如本文所定义：mpounds可用作血小板聚集抑制剂和粘附分子抑制剂，可用于药物组合物和治疗再灌注血栓形成的方法 患者受伤。
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8.发明授权Substituted thiazolylaminotetrahydropyridopyrimidines derivatives useful as platelet aggregation inhibitors 失效用作血小板聚集抑制剂的取代的噻唑基氨基四氢吡啶并嘧啶衍生物
公开(公告)号：US5405848A
公开(公告)日：1995-04-11
申请号：US171581
申请日：1993-12-22
IPC分类号： C07D471/04 , A61K31/425 , C07D413/00 , C07D471/00
CPC分类号： C07D471/04
摘要： This invention relates to substituted thiazolylaminotetrahydropyridopyrimidines derivatives of the following general formula, the substituent groups of which are as defined in the specification herein: ##STR1## These compounds are useful as inhibitors of platelet aggregation and inhibitors of adhesion molecules and may be provided in pharmaceutical compositions and in methods of treating reperfusion thrombosis injury in patients.
摘要翻译： 本发明涉及以下通式的取代的噻唑基氨基四氢吡啶并嘧啶衍生物，其取代基如本说明书中所定义：这些化合物可用作血小板聚集抑制剂和粘附分子抑制剂，并且可以在药物组合物中提供 以及治疗患者再灌注血栓形成的方法。
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9.发明授权5-�(heteroaryl)alkyl!-3-oxo-pyrido�1,2-a!benzimidazole-4-carboxamide derivatives useful in treating central nervous system disorders 失效5 - [（杂芳基）烷基] -3-氧代 - 吡啶并[1,2-a]苯并咪唑-4-甲酰胺衍生物，用于治疗中枢神经系统疾病
公开(公告)号：US5922731A
公开(公告)日：1999-07-13
申请号：US884804
申请日：1997-06-30
IPC分类号： A61K31/435 , A61P25/00 , C07D471/04 , A61K31/44 , C07D471/00 , C07D498/00 , C07D513/00
CPC分类号： C07D471/04
摘要： A compound of the general formula 1; ##STR1## is disclosed as useful in treating disorders of the central nervous system. Pharmaceutical compositions and methods of treatment are also disclosed.
摘要翻译： 通式1的化合物; 被公开用于治疗中枢神经系统疾病。 还公开了药物组合物和治疗方法。
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10.发明授权Substituted pyrimidinylaminothiazole derivatives useful as platelet aggregation inhibitors 失效可用作血小板聚集抑制剂的取代的嘧啶基氨基噻唑衍生物
公开(公告)号：US5665724A
公开(公告)日：1997-09-09
申请号：US446267
申请日：1995-05-22
IPC分类号： C07D417/12 , C07D521/00 , A61K31/33 , A61K31/425 , C07D239/02 , C07D411/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D417/12
摘要： This invention relates to substituted thiazole derivatives of the following general formula, the substituent groups of which are as defined in the specification herein: ##STR1## These compounds are useful as inhibitors of platelet aggregation and inhibitors of adhesion molecules and may be provided in pharmaceutical compositions and in methods of treating reperfusion thrombosis injury in patients. Also included are novel intermediates for preparing the compounds of the invention.
摘要翻译： 本发明涉及以下通式的取代噻唑衍生物，其取代基如本说明书中所定义：这些化合物可用作血小板聚集抑制剂和粘附分子抑制剂，并可提供于药物组合物中 以及治疗患者再灌注血栓形成的方法。 还包括用于制备本发明化合物的新型中间体。
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