利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

9 条记录 (耗时 0.08 秒)

    Phospholipids for the treatment of infection by togaviruses, herpes viruses and coronaviruses
    2.
    发明申请
    Phospholipids for the treatment of infection by togaviruses, herpes viruses and coronaviruses 审中-公开
    用于治疗披膜病毒，疱疹病毒和冠状病毒感染的磷脂

    公开(公告)号：US20050187192A1

    公开(公告)日：2005-08-25

    申请号：US10783927

    申请日：2004-02-20

    申请人： Ronald Fleming ,  Jan Hes ,  Yunsheng Huang ,  Russ Read ,  Susan Morris-Natschke ,  Khalid Ishaq ,  Louis Kucera ,  Phillip Furman

    发明人： Ronald Fleming ,  Jan Hes ,  Yunsheng Huang ,  Russ Read ,  Susan Morris-Natschke ,  Khalid Ishaq ,  Louis Kucera ,  Phillip Furman

    IPC分类号： A61K31/685

    CPC分类号： A61K31/685

    摘要： Provided are compounds, methods and pharmaceutical compositions for treating a host, especially a human, infected with a togavirus, herpes virus and/or coronavirus, and in particular SARS-CoV, cytomegalovirus or varicella-zoster virus. The method in one embodiment comprises administering to that host an effective amount of an anti-togavirus, anti-herpes virus and/or anti-coronavirus phospholipid or a pharmaceutically acceptable salt or prodrug thereof. The phospholipid compound is, e.g., a 3-alkylamido-2-alkoxypropylphosphocholine compound or salt thereof. The compound may be administered alone or in combination and/or alternation with one or more other anti-viral agents.

    摘要翻译： 提供用于治疗感染披膜病毒，疱疹病毒和/或冠状病毒，特别是SARS-CoV，巨细胞病毒或水痘带状疱疹病毒的宿主，特别是人的化合物，方法和药物组合物。 在一个实施方案中的方法包括向该宿主施用有效量的抗披叶病毒，抗疱疹病毒和/或抗冠状病毒磷脂或其药学上可接受的盐或前药。 磷脂化合物是例如3-烷基酰胺基-2-烷氧基丙基磷酰胆碱化合物或其盐。 化合物可以单独施用或与一种或多种其它抗病毒剂组合和/或替代施用。

    Compositions and methods for targeting cancer cells
    3.
    发明申请
    Compositions and methods for targeting cancer cells 有权

    公开(公告)号：US20060264397A1

    公开(公告)日：2006-11-23

    申请号：US11398529

    申请日：2006-04-06

    申请人： Louis Kucera ,  Ronald Fleming ,  Khalid Ishaq ,  Gregory Kucera ,  Susan Morris-Natschke

    发明人： Louis Kucera ,  Ronald Fleming ,  Khalid Ishaq ,  Gregory Kucera ,  Susan Morris-Natschke

    IPC分类号： A61K31/7076 ,  A61K31/7072 ,  C07H19/04

    CPC分类号： C07H19/06 ,  A61K31/66 ,  A61K31/675 ,  C07F9/10 ,  C07H19/10 ,  C07H19/16 ,  Y02A50/463

    摘要： The invention includes compositions and methods useful for treatment of a virus infection in a mammal by double-targeting the virus (i.e. targeting the virus at more than one stage of the virus life cycle) and thereby inhibiting virus replication. The compositions of the invention include compounds which comprise a phosphocholine moiety covalently conjugated with one or more antiviral agents (e.g. nucleoside analogue, protease inhibitor, etc.) to a lipid backbone. The invention also includes pharmaceutical compositions and kits for use in treatment of a virus infection in mammals. The methods of the invention comprise administering a compound of the invention, a pharmaceutically acceptable salt thereof, or a pharmaceutical composition of the invention, in an amount effective to treat the infection, to a mammal infected with a virus. Additionally, the invention includes compositions and methods useful for combating a cancer in a mammal and for facilitating delivery of a therapeutic agent to a mammalian cell. The compositions of the invention include compounds which comprise an alkyl lipid or phospholipid moiety covalently conjugated with an anticancer agent (e.g. a nucleoside analogue). The invention also includes pharmaceutical compositions and kits for combating a cancer and for facilitating delivery of a therapeutic agent to a mammalian cell. The methods of the invention comprise administering a compound of the invention, a pharmaceutically acceptable salt thereof, or a pharmaceutical composition of the invention, in an amount effective to combat a cancer or to facilitate delivery of a therapeutic agent to a mammalian cell.

    FLOW STABILIZER FOR FLOW BENCH
    6.
    发明申请
    FLOW STABILIZER FOR FLOW BENCH 失效
    流量稳定器

    公开(公告)号：US20060021427A1

    公开(公告)日：2006-02-02

    申请号：US10396924

    申请日：2003-03-25

    申请人： Ronald Fleming ,  August Fleming

    发明人： Ronald Fleming ,  August Fleming

    IPC分类号： G01M9/02 ,  G01M9/04

    CPC分类号： G01M9/04

    摘要： Apparatus and methods for airflow testing, especially for air testing of gas turbine components on an airflow test bench. Various embodiments of the present invention include the use of a flow-stabilizing member downstream of the component being tested. Since the flow through or over the component is subsonic, a flow-stabilizing member placed down stream of the component can have an effect on the flow conditions in or around the component being tested. In one embodiment, the flow-stabilizing member provides more consistent results during the testing of the component.

    摘要翻译： 用于气流测试的装置和方法，特别是用于空气测试台上的燃气轮机部件的空气测试。 本发明的各种实施方案包括在待测试组分的下游使用流动稳定构件。 由于通过或超过部件的流量​​是亚音速的，所以放置在部件下游的流动稳定部件可以对被测部件内或周围的流动条件产生影响。 在一个实施例中，流动稳定构件在部件的测试期间提供更一致的结果。

    Large area ionization detector and methods for detecting low level radiation
    7.
    发明申请
    Large area ionization detector and methods for detecting low level radiation 审中-公开
    大面积电离检测器和低水平辐射检测方法

    公开(公告)号：US20050194541A1

    公开(公告)日：2005-09-08

    申请号：US10793319

    申请日：2004-03-03

    申请人： Brett Clark ,  Ronald Fleming

    发明人： Brett Clark ,  Ronald Fleming

    IPC分类号： G01T1/185

    CPC分类号： G01T1/185

    摘要： The invention includes an ionizing radiation detector which includes a chamber within a housing. A receiving member within the chamber has a plurality of spaced holders for receiving samples. The samples are maintained in an array of substantially parallel samples with the samples functioning as electrodes within the chamber. The invention includes a method of counting emissions from samples. An odd number of electrodes are introduced into a detector chamber. Each of the electrodes includes at least one sample to be analyzed. The electrodes are organized into an array of substantially parallel electrodes, each electrode being in electrical communication with a contact surface. The electrode array includes cathodes and anodes where the number of cathodes differs from the number of anodes by one. A voltage is applied across the electrodes and particle emission is detected from the samples based upon ionization of counting gas within the chamber.

    摘要翻译： 本发明包括电离辐射检测器，其包括在壳体内的腔室。 室内的接收构件具有用于接收样品的多个间隔开的保持器。 将样品保持在基本上平行的样品的阵列中，其中样品用作室内的电极。 本发明包括对来自样品的排放物进行计数的方法。 将奇数个电极引入检测器室。 每个电极包括至少一个要分析的样品。 电极被组织成基本平行的电极的阵列，每个电极与接触表面电连通。 电极阵列包括其中阴极数与阳极数不同的阴极和阳极。 在电极之间施加电压，并且基于室内的计数气体的离子化从样品中检测出颗粒发射。