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11 条记录 (耗时 0.012 秒)

    AUTOMATED SYSTEM FOR MEASUREMENT OF ZONE 1 IN ASSESSMENT OF SEVERITY OF RETINOPATHY OF PREMATURITY
    2.
    发明申请
    AUTOMATED SYSTEM FOR MEASUREMENT OF ZONE 1 IN ASSESSMENT OF SEVERITY OF RETINOPATHY OF PREMATURITY 审中-公开
    用于测量区域1的自动化系统评估临床前期严重程度

    公开(公告)号：US20160213242A1

    公开(公告)日：2016-07-28

    申请号：US14968622

    申请日：2015-12-14

    申请人： Michael T. Trese ,  Antonio Capone, JR. ,  Kimberly Drenser ,  Carl Park

    发明人： Michael T. Trese ,  Antonio Capone, JR. ,  Kimberly Drenser ,  Carl Park

    IPC分类号： A61B3/00 ,  A61B5/00 ,  A61B3/12

    CPC分类号： A61B3/0025 ,  A61B3/0033 ,  A61B3/1241 ,  A61B5/0022

    摘要： An automated method for diagnosing and evaluating severity of retinopathy of prematurity in a retina of a patient is provided that is superior to conventional techniques. A graphical user interface (GUI) is provided for receiving biographical information for the patient creating a patient record in a database via the GUI. A photograph of the retina of the patient is collected and placed in the patient record via the GUI. The photograph is then analyzed to determine vascular distributions within the retina. A zone 1 boundary is assigned to the retina based on a set of threshold levels with respect to the determined vascular distributions. A system for performing the automated method is also provided.

    摘要翻译： 提供了一种诊断和评估患者视网膜视网膜病变严重程度的自动化方法，其优于常规技术。 提供图形用户界面（GUI），用于接收通过GUI在数据库中创建患者记录的患者的传记信息。 收集患者视网膜的照片，并通过GUI放置在患者记录中。 然后分析照片以确定视网膜内的血管分布。 基于关于所确定的血管分布的一组阈值水平将区域1边界分配给视网膜。 还提供了一种用于执行自动化方法的系统。

    Methods and compositions for genetic and retinal disease
    3.
    发明申请
    Methods and compositions for genetic and retinal disease 有权
    遗传和视网膜疾病的方法和组成

    公开(公告)号：US20100239499A1

    公开(公告)日：2010-09-23

    申请号：US12381777

    申请日：2009-03-17

    申请人： Kimberly Drenser

    发明人： Kimberly Drenser

    IPC分类号： A61B10/00 ,  A61K48/00 ,  A61P27/02

    CPC分类号： A61K9/08 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/0051 ,  A61K9/1647 ,  A61K9/50 ,  A61K38/1709

    摘要： An inventive method for treatment or prevention of vascular diseases of the retina is provided. A Norrin compound is optionally administered to a subject either directly and/or as expressed by a cell. The presence of the compound is either protective of or therapeutic for a pathological condition of the retina. Preferred pathological conditions are those linked to the absence of or mutation of norrin protein and are preferably Norrie disease, FEVR, or macular degeneration.

    摘要翻译： 提供了用于治疗或预防视网膜血管疾病的创新方法。 Norrin化合物任选地直接和/或由细胞表达给受试者。 化合物的存在是对视网膜的病理状况的保护或治疗。 优选的病理条件是与诺瑞林蛋白质不存在或突变相关的病理条件，优选为诺里病，FEVR或黄斑变性。

    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF GENETIC AND RETINAL DISEASE
    6.
    发明申请
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF GENETIC AND RETINAL DISEASE 审中-公开
    用于诊断和治疗遗传性和退行性疾病的方法和组合物

    公开(公告)号：US20120282230A1

    公开(公告)日：2012-11-08

    申请号：US13503444

    申请日：2010-10-20

    申请人： Kimberly Drenser

    发明人： Kimberly Drenser

    IPC分类号： A61K48/00 ,  A61K35/12 ,  A61P35/00 ,  A61P27/02 ,  A61P9/10 ,  A61P15/08 ,  C12Q1/68 ,  A61K38/17

    CPC分类号： G01N33/564 ,  A61K35/12 ,  A61K38/1774 ,  A61K38/179 ,  G01N2800/164 ,  G01N2800/50

    摘要： A process of detecting the presence of or susceptibility to a disease involving the Frizzled-4 receptor is provided. The inventive method determines the presence or absence of one or more mutations in Frizzled-4 alone or in conjunction with other proteins such as Norrin and LRP5. The presence of a mutation predicts the presence of a disease or susceptibility to a disease. The inventive process further provides correction or prevention of a disease by administration of frizzled-4 to a subject to alter or maintain a physiological function.

    摘要翻译： 提供了检测涉及卷曲4受体的疾病的存在或易感性的过程。 本发明的方法确定了卷曲-4-单独存在或与其它蛋白如Norrin和LRP5结合的一个或多个突变的存在或不存在。 突变的存在预测疾病的存在或对疾病的易感性。 本发明的方法进一步通过向受试者施用卷曲状-4来改变或预防疾病以改变或维持生理功能。

    Methods and compositions for genetic and retinal disease
    8.
    发明授权
    Methods and compositions for genetic and retinal disease 有权
    遗传和视网膜疾病的方法和组成

    公开(公告)号：US09114078B2

    公开(公告)日：2015-08-25

    申请号：US12381777

    申请日：2009-03-17

    申请人： Kimberly Drenser

    发明人： Kimberly Drenser

    IPC分类号： A61K9/00 ,  A61K9/08 ,  A61K9/16 ,  A61K9/50 ,  A61K38/17

    CPC分类号： A61K9/08 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/0051 ,  A61K9/1647 ,  A61K9/50 ,  A61K38/1709

    摘要： An inventive method for treatment or prevention of vascular diseases of the retina is provided. A Norrin compound is optionally administered to a subject either directly and/or as expressed by a cell. The presence of the compound is either protective of or therapeutic for a pathological condition of the retina. Preferred pathological conditions are those linked to the absence of or mutation of norrin protein and are preferably Norrie disease, FEVR, or macular degeneration.

    摘要翻译： 提供了用于治疗或预防视网膜血管疾病的创新方法。 Norrin化合物任选地直接和/或由细胞表达给受试者。 化合物的存在是对视网膜的病理状况的保护或治疗。 优选的病理条件是与诺瑞林蛋白质不存在或突变相关的病理条件，优选为诺里病，FEVR或黄斑变性。

    METHOD AND COMPOSITIONS FOR GENETIC AND RETINAL DISEASE
    10.
    发明申请
    METHOD AND COMPOSITIONS FOR GENETIC AND RETINAL DISEASE 有权
    遗传与反应性疾病的方法和组合

    公开(公告)号：US20150352184A1

    公开(公告)日：2015-12-10

    申请号：US14834967

    申请日：2015-08-25

    申请人： Kimberly Drenser

    发明人： Kimberly Drenser

    IPC分类号： A61K38/17 ,  A61K9/00 ,  A61K9/50

    CPC分类号： A61K9/08 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/0051 ,  A61K9/1647 ,  A61K9/50 ,  A61K38/1709

    摘要： An inventive method for treatment or prevention of vascular diseases of the retina is provided. A Norrin compound is optionally administered to a subject either directly and/or as expressed by a cell. The presence of the compound is either protective of or therapeutic for a pathological condition of the retina. Preferred pathological conditions are those linked to the absence of or mutation of norrin protein and are preferably Norrie disease, FEVR, or macular degeneration.

    摘要翻译： 提供了用于治疗或预防视网膜血管疾病的创新方法。 Norrin化合物任选地直接和/或由细胞表达给受试者。 化合物的存在是对视网膜的病理状况的保护或治疗。 优选的病理条件是与诺瑞林蛋白质不存在或突变相关的病理条件，优选为诺里病，FEVR或黄斑变性。