公开(公告)号：US06677331B2

公开(公告)日：2004-01-13

申请号：US10217670

申请日：2002-08-14

Applicant: Yuko Kano ,  Toshiro Sasaki ,  Yumiko Sambongi ,  Kiyoshi Tanabe ,  Yoshihisa Akiyama ,  Hideo Kitagawa ,  Takahisa Maruyama ,  Hiromasa Takizawa ,  Takashi Ando ,  Kazuhiro Aihara ,  Kunio Atsumi ,  Katsuyoshi Iwamatsu ,  Takashi Ida

Inventor： Yuko Kano ,  Toshiro Sasaki ,  Yumiko Sambongi ,  Kiyoshi Tanabe ,  Yoshihisa Akiyama ,  Hideo Kitagawa ,  Takahisa Maruyama ,  Hiromasa Takizawa ,  Takashi Ando ,  Kazuhiro Aihara ,  Kunio Atsumi ,  Katsuyoshi Iwamatsu ,  Takashi Ida

IPC: C07D51906

CPC classification number: C07D477/14

Abstract: Disclosed is a novel carbapenem derivative having a substituted imidazo[5,1-b]thiazole group at the 2-position on the carbapenem ring have high anti microbial activities against &bgr;-lactamase producing bacteria, MRSA, resistant-Pseudomonas aeruginosa, PRSP, enterococci, and influenza, and high stabilities to DHP-1. According to the present invention, there is provided a compound represented by the formula (I), or a pharmacologically acceptable salt thereof or an ester at the 3-position on the carbapenem ring thereof:

Abstract translation: 公开了一种在碳青霉烯环上位置具有取代的咪唑并[5,1-b]噻唑基的新型碳青霉烯衍生物对β-内酰胺酶生产细菌，MRSA，耐药铜绿假单胞菌，PRSP，肠球菌具有高抗微生物活性 ，流感，以及DHP-1的高稳定性。 根据本发明，提供由式（I）表示的化合物或其药理学上可接受的盐或其碳青霉烯环的3-位上的酯：

公开(公告)号：US06458780B1

公开(公告)日：2002-10-01

申请号：US09744583

申请日：2001-01-26

Applicant: Yuko Kano ,  Toshiro Sasaki ,  Yumiko Sambongi ,  Kiyoshi Tanabe ,  Yoshihisa Akiyama ,  Hideo Kitagawa ,  Takahisa Maruyama ,  Hiromasa Takizawa ,  Takashi Ando ,  Kazuhiro Aihara ,  Kunio Atsumi ,  Katsuyoshi Iwamatsu ,  Takashi Ida

Inventor： Yuko Kano ,  Toshiro Sasaki ,  Yumiko Sambongi ,  Kiyoshi Tanabe ,  Yoshihisa Akiyama ,  Hideo Kitagawa ,  Takahisa Maruyama ,  Hiromasa Takizawa ,  Takashi Ando ,  Kazuhiro Aihara ,  Kunio Atsumi ,  Katsuyoshi Iwamatsu ,  Takashi Ida

IPC: A61L31429

CPC classification number: C07D477/14

Abstract: Disclosed is a novel carbapenem derivative having a substituted imidazo[5,1-b]thiazole group at the 2-position on the carbapenem ring have high anti-microbial activities against &bgr;-lactamase producing bacteria, MRSA, resistant-Pseudomonas aeruginosa, PRSP, enterococci, and influenza, and high stabilities to DHP-1. According to the present invention, there is provided a compound represented by the formula (I), or a pharmacologically acceptable salt thereof or an ester at the 3-position on the carbapenem ring thereof:

Abstract translation: 公开了一种在碳青霉烯环上2-位具有取代的咪唑并[5,1-b]噻唑基的新型碳青霉烯衍生物对β-内酰胺酶生产细菌，MRSA，耐药铜绿假单胞菌，PRSP， 肠球菌和流感，以及DHP-1的高度稳定性。 根据本发明，提供由式（I）表示的化合物或其药理学上可接受的盐或其碳青霉烯环的3-位上的酯：

公开(公告)号：US5100922A

公开(公告)日：1992-03-31

申请号：US538099

申请日：1990-06-13

Applicant: Hiroshi Wada ,  Kiyoshi Kaiden ,  Tadashi Shimada ,  Kiyoshi Tanabe ,  Shoji Hayashida

Inventor： Hiroshi Wada ,  Kiyoshi Kaiden ,  Tadashi Shimada ,  Kiyoshi Tanabe ,  Shoji Hayashida

IPC: C08G18/48 ,  C08G18/66 ,  C08J9/34

CPC classification number: C08J9/34 ,  C08G18/4837 ,  C08G18/667 ,  C08G2101/0033 ,  C08G2120/00 ,  C08J2375/04

Abstract: A method for producing a molded product of integral-skin polyurethane foam, which comprises reacting and curing (1) a high molecular weight polyol comprising, as the main component, a polyoxyalkylene polyol having, as the main constituent, oxyalkylene groups of at least 3 carbon atoms and oxyethylene groups at its molecular terminals with the overall oxyethylene group content being not higher than 15% by weight and having a hydroxyl value of not higher than 80, (2) a crosslinking agent containing a compound having an aromatic nucleus and at least two active hydrogen-containing groups selected from the group consisting of hydroxyl groups, primary amino groups and secondary amino groups, and (3) a polyisocyanate, in a mold in the presence of a catalyst and a hydrogen atom-containing halogenated hydrocarbon foaming agent.

公开(公告)号：US08261031B2

公开(公告)日：2012-09-04

申请号：US11968253

申请日：2008-01-02

Applicant: Kiyoshi Tanabe ,  Takaki Kuroda

Inventor： Kiyoshi Tanabe ,  Takaki Kuroda

IPC: G06F12/16

CPC classification number: G06F3/0647 ,  G06F3/0605 ,  G06F3/067 ,  G06F2206/1008

Abstract: A management device and management method capable of improving usability of a storage system is proposed. The management device and the management method for managing data migration between volumes in a storage system in which normal volumes to which fixed storage areas are allocated in advance and virtual volumes to which storage areas are dynamically allocated according to use status coexist as types of volumes for reading and writing data is arranged so that information regarding each volume is collected, and based on the collected information, at least a total logical capacity that is a summation of logical capacities determined in advance for the respective volume is separately displayed for normal volumes and virtual volumes.

Abstract translation: 提出了一种能够提高存储系统的可用性的管理装置和管理方法。 用于管理存储系统中的卷之间的数据迁移的管理装置和管理方法，其中预先分配固定存储区域的正常卷和根据使用状态动态分配存储区域的虚拟卷共存为卷的类型 读取和写入数据被布置成使得关于每个卷的信息被收集，并且基于收集的信息，对于正常的卷和虚拟的，分别显示作为对于各个卷预先确定的逻辑容量的总和的总逻辑容量的总和逻辑容量 卷。

公开(公告)号：US20070255922A1

公开(公告)日：2007-11-01

申请号：US11480372

申请日：2006-07-05

Applicant: Naotsugu Toume ,  Nobuo Beniyama ,  Kiyoshi Tanabe

Inventor： Naotsugu Toume ,  Nobuo Beniyama ,  Kiyoshi Tanabe

IPC: G06F12/00

CPC classification number: G06F3/0632 ,  G06F3/0604 ,  G06F3/0605 ,  G06F3/0631 ,  G06F3/067

Abstract: A storage resource management system includes a storage apparatus having one or more pieces of volumes and a management computer. The management computer holds volume characteristic information and use field sort volume information. The management computer executes a single use field portion allocating sequence for allocating the use fields to volumes having volume characteristics suitable for a single use field from volume characteristics described in the use field sort volume information, and also, executes a plural use fields common portion allocating sequence for allocating volumes having volume characteristics suitable for the plural use fields to any use field. Since the sequences are executed by the management computer, such a use field sort volume allocation information is formed which has described that one use field in maximum is allocated to the volume, namely one use field is allocated thereto, or none of these use fields is allocated to the volume.

Abstract translation: 存储资源管理系统包括具有一个或多个卷的存储装置和管理计算机。 管理计算机保存体积特征信息并使用字段排序量信息。 管理计算机执行单个使用场部分分配序列，用于将使用场分配给具有适合于使用场排序卷信息中描述的卷特性的单个使用场的体积特征的体积，并且还执行多个使用场共同部分分配 将具有适于多个使用场的体积特征的体积分配给任何使用场的顺序。 由于这些序列是由管理计算机执行的，因此形成了这样的使用场分类卷分配信息，其描述了将最大的一个使用字段分配给该卷，即分配一个使用字段，或者这些使用字段不是 分配到卷。

公开(公告)号：US06949383B2

公开(公告)日：2005-09-27

申请号：US09600027

申请日：1999-11-11

Applicant: Kiyoshi Tanabe ,  Mitsuru Furusawa

Inventor： Kiyoshi Tanabe ,  Mitsuru Furusawa

IPC: C12N1/21 ,  C12N15/01 ,  C12N15/10 ,  C12N1/20

CPC classification number: C12N15/102 ,  C12N15/01

Abstract: This application provides a method for mutagenesis of a gene, which comprises introducing much more point mutations into one strand of double-stranded genomic DNA of cell or organism individual than into another strand. In accordance with such a method, it is now possible to efficiently and effectively construct various useful mutants of microorganisms, cells or organism individuals. It is also now possible by analyzing the mutating conditions of the gene to clarify the mechanism of drug resistance, to estimate the occurrence of a novel insensible microorganism or to develop a drug therefor, to analyze the mutation of an oncogene and the mechanisms of cancer metastasis and increase in malignancy, to develop a therapeutic method using these mechanisms, etc.

Abstract translation: 该应用提供了一种诱变基因的方法，其包括将多点突变引入单个细胞或生物体的双链基因组DNA的一条链中而不是另一条链。 根据这种方法，现在可以有效地和有效地构建微生物，细胞或生物个体的各种有用的突变体。 现在也可以通过分析基因的突变条件来阐明耐药机制，估计新颖的不敏感微生物的发生或开发药物，分析癌基因的突变和癌转移的机制 并增加恶性肿瘤，开发使用这些机制的治疗方法等。

公开(公告)号：US07447863B2

公开(公告)日：2008-11-04

申请号：US11480372

申请日：2006-07-05

Applicant: Naotsugu Toume ,  Nobuo Beniyama ,  Kiyoshi Tanabe

Inventor： Naotsugu Toume ,  Nobuo Beniyama ,  Kiyoshi Tanabe

IPC: G06F12/00 ,  G06F13/00

CPC classification number: G06F3/0632 ,  G06F3/0604 ,  G06F3/0605 ,  G06F3/0631 ,  G06F3/067

Abstract: A storage resource management system includes a storage apparatus having one or more pieces of volumes and a management computer. The management computer holds volume characteristic information and use field sort volume information. The management computer executes a single use field portion allocating sequence for allocating the use fields to volumes having volume characteristics suitable for a single use field from volume characteristics described in the use field sort volume information, and also, executes a plural use fields common portion allocating sequence for allocating volumes having volume characteristics suitable for the plural use fields to any use field. Since the sequences are executed by the management computer, such a use field sort volume allocation information is formed which has described that one use field in maximum is allocated to the volume, namely one use field is allocated thereto, or none of these use fields is allocated to the volume.

Abstract translation: 存储资源管理系统包括具有一个或多个卷的存储装置和管理计算机。 管理计算机保存体积特征信息并使用字段排序量信息。 管理计算机执行单个使用场部分分配序列，用于将使用场分配给具有适合于使用场排序卷信息中描述的卷特性的单个使用场的体积特征的体积，并且还执行多个使用场共同部分分配 将具有适于多个使用场的体积特征的体积分配给任何使用场的顺序。 由于这些序列是由管理计算机执行的，因此形成了这样的使用场分类卷分配信息，其描述了将最大的一个使用字段分配给该卷，即分配一个使用字段，或者这些使用字段不是 分配到卷。

公开(公告)号：US06255339B1

公开(公告)日：2001-07-03

申请号：US09117070

申请日：1998-07-21

Applicant: Kenichi Kurihara ,  Rie Shinei ,  Kiyoshi Tanabe ,  Yasuo Yamamoto ,  Keiichi Ajito ,  Kaori Miyajima ,  Yuji Tabata ,  Shohei Yasuda ,  Kuniaki Tatsuta ,  Tsuneo Okonogi

Inventor： Kenichi Kurihara ,  Rie Shinei ,  Kiyoshi Tanabe ,  Yasuo Yamamoto ,  Keiichi Ajito ,  Kaori Miyajima ,  Yuji Tabata ,  Shohei Yasuda ,  Kuniaki Tatsuta ,  Tsuneo Okonogi

IPC: A61K3134

CPC classification number: C07D307/92 ,  C07D407/12 ,  C07D407/14 ,  C07D409/12 ,  C07D417/12

Abstract: Compounds represented by the following formula (I) and pharmaceutically acceptable salts thereof are disclosed. The compounds have progesterone receptor binding inhibitory activity and, hence, can be used as therapeutic and prophylactic agents for progesterone-related diseases. Specifically, they are useful as abortifacients, oral contraceptive pills, carcinostatic agents for breast cancer and ovarian cancer, therapeutic agents for endometriosis, meningioma, and myeloma, and therapeutic and prophylactic agents for osteoporosis and climacteric disturbance. wherein R1 and R2 represent a hydroxyl group, alkyloxy, alkenyloxy, alkynyloxy, cycloalkyloxy, alkoxyalkyloxy, cycloalkyloxy containig one oxygen atom, aralkyloxy, alkylcarbonyloxy, alkenylcarbonyloxy, alkynylcarbonyloxy, cycloalkylcarbonyloxy, alkoxycarbonyloxy, aryloxy carbonyloxy, aralkylcarbonyloxy, aromatic acyloxy, heteroaromatic acyloxy, saturated heterocyclic carbonyloxy, alkylsulfonyloxy, aromatic sulfonyloxy, alkylcarbamoyloxy, aromatic carbamoyloxy, alkylcarbonylamino, or aromatic acylamino, provided that R1 may further represent a hydrogen atom, alkyl, alkenyl, or alkynyl; and R3, R4, and R5 each independently represent a hydrogen atom, alkyl or alkenyl.

Abstract translation: 公开了由下式（I）表示的化合物及其药学上可接受的盐。 所述化合物具有孕酮受体结合抑制活性，因此可用作孕酮相关疾病的治疗和预防剂。 具体地说，它们可用作流产者，口服避孕药，乳腺癌和卵巢癌的制癌剂，子宫内膜异位症的治疗剂，脑膜瘤和骨髓瘤，以及骨质疏松症和更年期障碍的治疗和预防剂。其中R1和R2表示羟基， 烷氧基，链烯氧基，炔氧基，环烷氧基，烷氧基烷氧基，含有一个氧原子的环烷氧基，芳烷氧基，烷基羰基氧基，链烯基羰基氧基，炔基羰氧基，环烷基羰基氧基，烷氧基羰基氧基，芳氧基羰基氧基，芳烷基羰基氧基，芳香酰氧基，杂芳基酰氧基，饱和杂环羰氧基，烷基磺酰氧基，芳香磺酰氧基，烷基氨基甲酰氧基， 芳族氨基甲酰氧基，烷基羰基氨基或芳族酰氨基，条件是R 1可以进一步代表氢原子，烷基，烯基或炔基; 并且R 3，R 4和R 5各自独立地表示氢原子，烷基或链烯基。

公开(公告)号：US4808636A

公开(公告)日：1989-02-28

申请号：US184671

申请日：1988-04-22

Applicant: Joichi Saito ,  Hiroshi Wada ,  Shigehito Shibata ,  Takashi Watabe ,  Kiyoshi Tanabe ,  Nobuaki Kunii

Inventor： Joichi Saito ,  Hiroshi Wada ,  Shigehito Shibata ,  Takashi Watabe ,  Kiyoshi Tanabe ,  Nobuaki Kunii

IPC: C08G18/32 ,  C08G18/48 ,  C08G18/50 ,  C08G18/65 ,  C08G18/66 ,  C08G18/14

CPC classification number: C08G18/6685 ,  C08G18/3234 ,  C08G18/324 ,  C08G18/482 ,  C08G18/5024 ,  C08G18/6529 ,  C08G2101/0008 ,  C08G2101/0066 ,  C08G2120/00

Abstract: A process for producing a shaped article of a non-cellular or microcellular polyurethane elastomer by reaction injection molding by using a high molecular weight active hydrogen compound component (A), a chain extender component (B) and a polyisocyanate compound component (C) as starting materials,wherein(I) the high molecular weight active hydrogen compound component (A) comprises(1) at least one polyoxyalkylene polyol (a-1) having an average molecular weight per hydroxyl group of from 800 to 4000 and an average number of hydroxyl groups per molecule of from 2 to 8 and containing at least 5% by weight of oxyethylene groups at the terminal portions of its molecules,(2) a high molecular weight amine (a-2) having from 2 to 8 active hydrogen-containing groups, and optionally(3) a high molecular weight polyol (a-3) other than the polyalkylene polyol (a-1), and(II) the chain extender component (B) comprises(1) a low molecular weight polyol (b-1) having from 2 to 4 hydroxyl groups and a molecular weight of at most 400,(2) at least one diamine (b-2) selected from aromatic and alicyclic compounds and having two primary amino groups and no amino group directly bonded to an aromatic ring, and optionally(3) a chain extender (b-3) other than the constituents (b-1) and (b-2), having from 2 to 4 active hydrogen-containing groups.

公开(公告)号：US08661210B2

公开(公告)日：2014-02-25

申请号：US13589252

申请日：2012-08-20

Applicant: Kiyoshi Tanabe ,  Takaki Kuroda

Inventor： Kiyoshi Tanabe ,  Takaki Kuroda

IPC: G06F12/16

CPC classification number: G06F3/0647 ,  G06F3/0605 ,  G06F3/067 ,  G06F2206/1008

Abstract: A management device and management method capable of improving usability of a storage system is proposed. The management device and the management method for managing data migration between volumes in a storage system in which normal volumes to which fixed storage areas are allocated in advance and virtual volumes to which storage areas are dynamically allocated according to use status coexist as types of volumes for reading and writing data is arranged so that information regarding each volume is collected, and based on the collected information, at least a total logical capacity that is a summation of logical capacities determined in advance for the respective volume is separately displayed for normal volumes and virtual volumes.

Abstract translation: 提出了一种能够提高存储系统的可用性的管理装置和管理方法。 用于管理存储系统中的卷之间的数据迁移的管理装置和管理方法，其中预先分配固定存储区域的正常卷和根据使用状态动态分配存储区域的虚拟卷共存为卷的类型 读取和写入数据被布置成使得关于每个卷的信息被收集，并且基于收集的信息，对于正常的卷和虚拟的，分别显示作为对于各个卷预先确定的逻辑容量的总和的总逻辑容量的总和逻辑容量 卷。