公开(公告)号：US06255339B1

公开(公告)日：2001-07-03

申请号：US09117070

申请日：1998-07-21

申请人： Kenichi Kurihara ,  Rie Shinei ,  Kiyoshi Tanabe ,  Yasuo Yamamoto ,  Keiichi Ajito ,  Kaori Miyajima ,  Yuji Tabata ,  Shohei Yasuda ,  Kuniaki Tatsuta ,  Tsuneo Okonogi

发明人： Kenichi Kurihara ,  Rie Shinei ,  Kiyoshi Tanabe ,  Yasuo Yamamoto ,  Keiichi Ajito ,  Kaori Miyajima ,  Yuji Tabata ,  Shohei Yasuda ,  Kuniaki Tatsuta ,  Tsuneo Okonogi

IPC分类号： A61K3134

CPC分类号： C07D307/92 ,  C07D407/12 ,  C07D407/14 ,  C07D409/12 ,  C07D417/12

摘要： Compounds represented by the following formula (I) and pharmaceutically acceptable salts thereof are disclosed. The compounds have progesterone receptor binding inhibitory activity and, hence, can be used as therapeutic and prophylactic agents for progesterone-related diseases. Specifically, they are useful as abortifacients, oral contraceptive pills, carcinostatic agents for breast cancer and ovarian cancer, therapeutic agents for endometriosis, meningioma, and myeloma, and therapeutic and prophylactic agents for osteoporosis and climacteric disturbance. wherein R1 and R2 represent a hydroxyl group, alkyloxy, alkenyloxy, alkynyloxy, cycloalkyloxy, alkoxyalkyloxy, cycloalkyloxy containig one oxygen atom, aralkyloxy, alkylcarbonyloxy, alkenylcarbonyloxy, alkynylcarbonyloxy, cycloalkylcarbonyloxy, alkoxycarbonyloxy, aryloxy carbonyloxy, aralkylcarbonyloxy, aromatic acyloxy, heteroaromatic acyloxy, saturated heterocyclic carbonyloxy, alkylsulfonyloxy, aromatic sulfonyloxy, alkylcarbamoyloxy, aromatic carbamoyloxy, alkylcarbonylamino, or aromatic acylamino, provided that R1 may further represent a hydrogen atom, alkyl, alkenyl, or alkynyl; and R3, R4, and R5 each independently represent a hydrogen atom, alkyl or alkenyl.

摘要翻译： 公开了由下式（I）表示的化合物及其药学上可接受的盐。 所述化合物具有孕酮受体结合抑制活性，因此可用作孕酮相关疾病的治疗和预防剂。 具体地说，它们可用作流产者，口服避孕药，乳腺癌和卵巢癌的制癌剂，子宫内膜异位症的治疗剂，脑膜瘤和骨髓瘤，以及骨质疏松症和更年期障碍的治疗和预防剂。其中R1和R2表示羟基， 烷氧基，链烯氧基，炔氧基，环烷氧基，烷氧基烷氧基，含有一个氧原子的环烷氧基，芳烷氧基，烷基羰基氧基，链烯基羰基氧基，炔基羰氧基，环烷基羰基氧基，烷氧基羰基氧基，芳氧基羰基氧基，芳烷基羰基氧基，芳香酰氧基，杂芳基酰氧基，饱和杂环羰氧基，烷基磺酰氧基，芳香磺酰氧基，烷基氨基甲酰氧基， 芳族氨基甲酰氧基，烷基羰基氨基或芳族酰氨基，条件是R 1可以进一步代表氢原子，烷基，烯基或炔基; 并且R 3，R 4和R 5各自独立地表示氢原子，烷基或链烯基。

公开(公告)号：US6077840A

公开(公告)日：2000-06-20

申请号：US331294

申请日：1999-06-18

申请人： Kenichi Kurihara ,  Rie Shinei ,  Yasushi Kurata ,  Yuji Tabata ,  Kiyoshi Tanabe ,  Tsuneo Okonogi

发明人： Kenichi Kurihara ,  Rie Shinei ,  Yasushi Kurata ,  Yuji Tabata ,  Kiyoshi Tanabe ,  Tsuneo Okonogi

IPC分类号： C07D209/60 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D521/00 ,  A61K31/535 ,  A61K31/40 ,  A61K31/44 ,  A61K31/50 ,  C07D233/02

CPC分类号： C07D231/12 ,  C07D209/60 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

摘要： Compounds represented by the following formula (I) or pharmaceutically acceptable salts thereof and a process for producing the same are disclosed. The compounds have progesterone receptor binding inhibitory activity and, hence, can be used as therapeutic and prophylactic agents for progesterone-related diseases. Specifically, they are useful as carcinostatic agents for breast cancer and ovarian cancer, therapeutic agents for hysteromyoma, endometriosis, meningioma, and myeloma, abortifacients, oral contraceptive pills, and therapeutic and prophylactic agents for osteoporosis and climacteric disturbance. ##STR1## wherein R.sup.1 represents alkyl or aralkyl; R.sup.2 represents a hydrogen atom, alkylcarbonyl, cycloalkylcarbonyl, aromatic acyl, heteroaromatic acyl, saturated heterocyclic acyl, alkyl, alkenyl, aralkyl, carbamoyl, alkylcarbamoyl, aromatic carbamoyl, aralkylcarbamoyl, alkylaminocarbonyl, cycloalkylcarbamoyl, alkoxycarbonyl, aryloxycarbonyl, heteroaromatic thiocarbonyl, saturated heterocyclic thiocarbonyl, or alkyl-thiocarbamoyl: and R.sup.3 represents a hydrogen atom, a hydroxyl group, alkyloxy, alkylcarbonyloxy, alkylthio, or arylthio.

摘要翻译： PCT No.PCT / JP97 / 04683 Sec。 371日期：1999年6月18日 102（e）1999年6月18日PCT 1997年12月18日PCT公布。 第WO98 / 27059号公报 日期：1998年6月25日公开了由下式（I）表示的化合物或其药学上可接受的盐及其制备方法。 所述化合物具有孕酮受体结合抑制活性，因此可用作孕酮相关疾病的治疗和预防剂。 具体地说，它们可用作乳腺癌和卵巢癌的制癌剂，子宫肌瘤，子宫内膜异位症，脑膜瘤和骨髓瘤的治疗剂，流产者，口服避孕药以及用于骨质疏松和更年期障碍的治疗和预防剂。 其中R1表示烷基或芳烷基; R 2表示氢原子，烷基羰基，环烷基羰基，芳香族酰基，杂芳基酰基，饱和杂环酰基，烷基，烯基，芳烷基，氨基甲酰基，烷基氨基甲酰基，芳香族氨基甲酰基，芳烷基氨基甲酰基，烷基氨基羰基，环烷基氨基甲酰基，烷氧基羰基，芳氧基羰基，杂芳硫基羰基，饱和杂环硫代羰基， 或烷基 - 硫代氨基甲酰基：和R3表示氢原子，羟基，烷氧基，烷基羰氧基，烷硫基或芳硫基。

公开(公告)号：US5444174A

公开(公告)日：1995-08-22

申请号：US22165

申请日：1993-02-25

申请人： Keiichi Ajito ,  Kenichi Kurihara ,  Tsuneo Ishizuka ,  Tetsuro Hara ,  Takayuki Usui ,  Seiji Shibahara

发明人： Keiichi Ajito ,  Kenichi Kurihara ,  Tsuneo Ishizuka ,  Tetsuro Hara ,  Takayuki Usui ,  Seiji Shibahara

IPC分类号： A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07D313/06

CPC分类号： C07H17/08

摘要： 16-membered macrolide compounds wherein both of hydroxyl groups at the 3"- and 4"-positions form ether bonds together with two alkyl groups which are either the same or different from each other is useful as an antibacterial agent. The macrolide compounds represented by formula (I) are prepared by chemically modifying midecamycin A.sub.3 to obtain a synthesis intermediate of the formula (II), which is further chemically modified. ##STR1##

摘要翻译： 3“和4”位上的两个羟基与其彼此相同或不同的两个烷基形成醚键的16元大环内酯化合物可用作抗菌剂。 由式（I）表示的大环内酯化合物通过化学修饰麦地卡霉素A3制备得到式（II）的合成中间体，其进一步化学修饰。 （一）

公开(公告)号：US20140011757A1

公开(公告)日：2014-01-09

申请号：US13982397

申请日：2012-01-31

申请人： Kenichi Kurihara ,  Masaaki Mitomi

发明人： Kenichi Kurihara ,  Masaaki Mitomi

IPC分类号： C07H17/08

CPC分类号： C07H17/08 ,  A61K31/7048

摘要： The inventors of the present invention have succeeded in acquiring a compound having excellent antibacterial activities against pathogens of respiratory tract infections in animals through the use of josamycin as a lead scaffold.

摘要翻译： 本发明的发明人通过使用约沙霉素作为引脚支架，成功地获得了对动物呼吸道感染病原体具有优异抗菌活性的化合物。

公开(公告)号：US08394728B2

公开(公告)日：2013-03-12

申请号：US12694342

申请日：2010-01-27

申请人： Hirotaka Akao ,  Yuriko Kaino ,  Takahiro Kamei ,  Masaki Hara ,  Kenichi Kurihara

发明人： Hirotaka Akao ,  Yuriko Kaino ,  Takahiro Kamei ,  Masaki Hara ,  Kenichi Kurihara

IPC分类号： H01L21/469 ,  H01L21/31

CPC分类号： H01L21/28229 ,  C23C18/1212 ,  C23C18/122 ,  C23C18/1225 ,  C23C18/1295 ,  H01L21/02164 ,  H01L21/02255 ,  H01L21/02532 ,  H01L21/02628 ,  H01L21/02664 ,  H01L21/28211 ,  H01L27/1285 ,  H01L27/1292 ,  H01L29/6675

摘要： A film deposition method includes the steps of: coating a solution containing a polysilane compound on a substrate to form a coating film and then carrying out a first thermal treatment in an inert atmosphere, thereby forming the coating film into a silicon film; forming a coating film containing a polysilane compound on the silicon film and then carrying out a second thermal treatment in an inert atmosphere or a reducing atmosphere, thereby forming the coating film into a silicon oxide precursor film; and carrying out a third thermal treatment in an oxidizing atmosphere, thereby forming the silicon oxide precursor film into a silicon oxide film and simultaneously densifying the silicon film.

摘要翻译： 膜沉积方法包括以下步骤：在基板上涂布含有聚硅烷化合物的溶液，形成涂膜，然后在惰性气氛中进行第一热处理，从而将涂膜形成硅膜; 在硅膜上形成含有聚硅烷化合物的涂膜，然后在惰性气氛或还原气氛中进行第二次热处理，从而将涂膜形成氧化硅前体膜; 并在氧化气氛中进行第三次热处理，从而将氧化硅前体膜形成为氧化硅膜，同时使硅膜致密化。

公开(公告)号：US20120322334A1

公开(公告)日：2012-12-20

申请号：US13487731

申请日：2012-06-04

申请人： Kenichi Kurihara ,  Takako Sekiyama ,  Masanobu Tanaka

发明人： Kenichi Kurihara ,  Takako Sekiyama ,  Masanobu Tanaka

IPC分类号： H01J9/20 ,  B41M1/10

CPC分类号： H01L21/76802 ,  G02F1/1303 ,  G02F1/133345 ,  G02F1/136227 ,  H01L51/0023 ,  H01L51/0081 ,  H01L51/56

摘要： There are provided a method of manufacturing a film, suitable for forming a film having a plurality of minute through holes, and a method of manufacturing a display using the method of manufacturing a film. The method of manufacturing a film, includes: transferring a film of a first pattern onto a base material with use of an intaglio plate including the first pattern and a second pattern; and forming a film including through holes on the base material by transferring a film of the second pattern of the intaglio plate onto the film of the first pattern.

摘要翻译： 提供一种适于形成具有多个微通孔的膜的膜的制造方法以及使用该膜的制造方法制造显示器的方法。 制造薄膜的方法包括：使用包括第一图案和第二图案的凹版印刷将第一图案的薄膜转印到基材上; 以及通过将所述凹版的所述第二图案的膜转印到所述第一图案的膜上，在所述基材上形成包括通孔的膜。

公开(公告)号：US20120046470A1

公开(公告)日：2012-02-23

申请号：US13266671

申请日：2010-05-12

申请人： Yoshimasa Fukuda ,  Takashi Ando ,  Kimihiko Goto ,  Nozomu Nakanishi ,  Takashi Watanabe ,  Kenichi Kurihara ,  Nobuto Minowa ,  Masaaki Mitomi

发明人： Yoshimasa Fukuda ,  Takashi Ando ,  Kimihiko Goto ,  Nozomu Nakanishi ,  Takashi Watanabe ,  Kenichi Kurihara ,  Nobuto Minowa ,  Masaaki Mitomi

IPC分类号： C07D493/04

CPC分类号： C07D493/04

摘要： Disclosed is a process for efficiently producing pyripyropene derivatives having acyloxy at the 1-position and 11-position and hydroxyl at the 7-position. The process comprises selectively acylating hydroxyl at the 1-position and 11-position of a compound represented by formula B1 through one to three steps with an acylating agent in the presence or absence of a base.

摘要翻译： 公开了一种有效生产在1-位和11位上具有酰氧基并在7-位具有羟基的吡啶并苯衍生物的方法。 该方法包括在存在或不存在碱的情况下用酰化剂选择性地将式B1化合物的1位和11位羟基选择性酰化1-3步。

公开(公告)号：US5048179A

公开(公告)日：1991-09-17

申请号：US480013

申请日：1990-02-14

申请人： Masahiro Shindo ,  Toshikazu Yoshimizu ,  Kenichi Kurihara ,  Shunpei Tamaki ,  Toshio Kawakami ,  Yukio Kadowaki ,  Shoji Matsumoto

发明人： Masahiro Shindo ,  Toshikazu Yoshimizu ,  Kenichi Kurihara ,  Shunpei Tamaki ,  Toshio Kawakami ,  Yukio Kadowaki ,  Shoji Matsumoto

IPC分类号： G06K19/077 ,  H01L23/14 ,  H01L23/538

CPC分类号： H01L24/25 ,  G06K19/07745 ,  H01L23/142 ,  H01L23/5388 ,  H01L23/5389 ,  H01L24/24 ,  H01L24/82 ,  H01L24/96 ,  H01L2224/04105 ,  H01L2224/2413 ,  H01L2224/24137 ,  H01L2224/24227 ,  H01L2224/2518 ,  H01L2224/92144 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01011 ,  H01L2924/01013 ,  H01L2924/01015 ,  H01L2924/01019 ,  H01L2924/01024 ,  H01L2924/01027 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01055 ,  H01L2924/01057 ,  H01L2924/01058 ,  H01L2924/01075 ,  H01L2924/01079 ,  H01L2924/01093 ,  H01L2924/1305 ,  H01L2924/14 ,  H01L2924/18162 ,  H01L2924/19041 ,  H01L2924/19043 ,  Y10T29/4913 ,  Y10T29/49144

摘要： An IC mounting method and its resulting structure, such as an IC card is provided. An IC card includes a metal plate formed with at least one hole, and an IC chip is located fixed in position in the hole with a filler material filling the gap between the hole and the IC chip. An interconnect pattern is provided on the plate with an electrically insulating film sandwiched therebetween, and the interconnect pattern is in electrical contact with a contact pad of the IC chip. Preferably, the surface of the IC chip on which the contact pad is provided is substantially flush with one surface of the plate. When an electrically insulating film is fixedly attached to a substrate having a hole, in which an IC chip is fixedly provided, by an adhesive agent, the material of the film is selected to be similar to the material of the adhesive agent. In this manner, a contact hole may be formed in registry with a contact pad of the IC chip in the insulating film by one etching step without formation of a stepped portion in the resulting contact hole. Moreover, a film to be later removed is first formed on a substrate, and after providing elements on the film and its supporting structure, a predetermined processing, such as exposure to light, is applied to the film to change its property, thereby causing the elements to be separated away from the film.

摘要翻译： 提供IC安装方法及其结果，如IC卡。 IC卡包括形成有至少一个孔的金属板，并且IC芯片被固定在孔中的适当位置，填充填充孔和IC芯片之间的间隙的填充材料。 在该板上设置有夹在其间的电绝缘膜的互连图案，并且布线图案与IC芯片的接触焊盘电接触。 优选地，设置接触垫的IC芯片的表面与板的一个表面基本齐平。 当通过粘合剂将电绝缘膜固定地附接到具有固定设置有IC芯片的孔的基板上时，选择膜的材料与粘合剂的材料相似。 以这种方式，可以通过一个蚀刻步骤在绝缘膜中与IC芯片的接触焊盘对准形成接触孔，而不会在所形成的接触孔中形成阶梯部分。 此外，首先在基板上形成要去除的膜，并且在膜上提供元件及其支撑结构之后，对膜进行预定处理，例如曝光以改变其性能，从而使 要从电影中分离的元素。

公开(公告)号：US4938923A

公开(公告)日：1990-07-03

申请号：US429485

申请日：1989-10-31

申请人： Takeshi Kujiraoka ,  Koichiro Mukoyama ,  Hiromi Yamamoto ,  Kenichi Kurihara

发明人： Takeshi Kujiraoka ,  Koichiro Mukoyama ,  Hiromi Yamamoto ,  Kenichi Kurihara

IPC分类号： C22C5/02 ,  H01L23/49

CPC分类号： H01L24/45 ,  C22C5/02 ,  H01L2224/45015 ,  H01L2224/45144 ,  H01L2924/00011 ,  H01L2924/00014 ,  H01L2924/01004 ,  H01L2924/01005 ,  H01L2924/01011 ,  H01L2924/01012 ,  H01L2924/01015 ,  H01L2924/0102 ,  H01L2924/01023 ,  H01L2924/01027 ,  H01L2924/01033 ,  H01L2924/01039 ,  H01L2924/01042 ,  H01L2924/01045 ,  H01L2924/01046 ,  H01L2924/01047 ,  H01L2924/01055 ,  H01L2924/01057 ,  H01L2924/01058 ,  H01L2924/01059 ,  H01L2924/0106 ,  H01L2924/01068 ,  H01L2924/01074 ,  H01L2924/01075 ,  H01L2924/01076 ,  H01L2924/01077 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/01105 ,  H01L2924/01205 ,  H01L2924/20752 ,  Y10T428/12431

摘要： The gold wire used for the wire bonding of a semiconductor device comprises at least three kinds of elements selected from rare earth elements such as La, Ce and Pr: Be, Ca, Mg, Ag, Fe: and platinum group elements; and the balance of Au at high purity.

摘要翻译： 用于半导体器件的引线接合的金线包括从稀土元素如La，Ce和Pr：Be，Ca，Mg，Ag，Fe和铂族元素中选出的至少三种元素; 余量为Au，纯度高。

公开(公告)号：US07560415B2

公开(公告)日：2009-07-14

申请号：US10531339

申请日：2003-10-07

申请人： Hisanori Tsuboi ,  Noriyuki Kishii ,  Kenichi Kurihara

发明人： Hisanori Tsuboi ,  Noriyuki Kishii ,  Kenichi Kurihara

IPC分类号： G11B15/18

CPC分类号： B41M5/465 ,  B41M5/305 ,  B41M5/34

摘要： A reversible multicolor thermal recording medium which is free from fogging and has sharp contrast even after recording and erasing are performed repeatedly, and a recording method using the same are provided.A reversible multicolor recording medium is provided, which includes recording layers each containing a plurality of reversible thermal coloring compositions having different coloring tones, formed to be separated from and stacked on a surface direction of a supporting substrate; and the plurality of reversible thermal coloring compositions containing light-to-heat transforming materials which absorb infrared rays having different wavelength ranges to generate heat, respectively; wherein an absorption peak wavelength of the light-to-heat transforming material contained in the recording layers becomes the longest wavelength at the layer formed nearest the supporting substrate, and becomes a shorter wavelength as the layer is closer to the surface layer in the stacked order.

摘要翻译： 重复执行即使在记录和擦除之后也不起雾并具有尖锐对比度的可逆多色热记录介质，并且提供使用该多色热记录介质的记录方法。 提供了一种可逆的多色记录介质，其包括各自包含多个具有不同着色色调的可逆热着色组合物的记录层，其形成为在支撑基板的表面方向上分离并层叠; 以及含有吸收具有不同波长范围的红外线以分别发热的光 - 热转换材料的多个可逆热着色组合物; 其中包含在记录层中的光 - 热转换材料的吸收峰波长在最靠近支撑衬底的层处成为最长波长，并且随着层以堆叠顺序更靠近表面层而变成较短的波长 。