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16 条记录 (耗时 0.012 秒)

    Method for determining the presence of endohydrolase in a liquid and composition therefor
    5.
    发明授权
    Method for determining the presence of endohydrolase in a liquid and composition therefor 失效
    用于测定液体中水解产物的存在的方法及其组合物

    公开(公告)号：US4563421A

    公开(公告)日：1986-01-07

    申请号：US555435

    申请日：1983-11-25

    申请人： Klaus Habenstein ,  Helmut Kohl

    发明人： Klaus Habenstein ,  Helmut Kohl

    IPC分类号： C08B11/04 ,  C08B31/12 ,  C08B37/02 ,  C12Q1/34 ,  C12Q1/40 ,  G01N31/22 ,  G01N33/52 ,  A61K31/715

    CPC分类号： G01N33/52 ,  C08B31/12 ,  C08B37/0021 ,  C12Q1/34 ,  G01N31/221

    摘要： What are disclosed are polysaccharide derivatives of the formula ##STR1## in which n denotes a number from 100 to 12,500 and R denotes hydrogen, a carboxyalkyl or hydroxyalkyl group with 1 to 5 carbon atoms in the alkyl radical or a detectable molecular group, any combination of the (3n+2) R radicals being possible, but at least one R being a carboxyalkyl or hydroxyalkyl group and at least one R being a detectable molecular group, and a process for their preparation and their use for the determination of endohydrolases, in indicator paper and for the detection of metabolites in biological liquids, are described.

    摘要翻译： 所公开的是式“IMAGE”的多糖衍生物，其中n表示100至12,500的数，R表示氢，在烷基或可检测分子基团中具有1至5个碳原子的羧基烷基或羟烷基，任何组合 的（3n + 2）R基团是可能的，但至少一个R是羧基烷基或羟烷基，并且至少一个R是可检测分子基团，以及它们的制备方法及其用于测定水解产物的用途 指示纸和生物液体中代谢物的检测。

    Azo dye chromogenic substrates
    8.
    发明授权
    Azo dye chromogenic substrates 失效
    AZO染料染色底物

    公开(公告)号：US5077200A

    公开(公告)日：1991-12-31

    申请号：US251166

    申请日：1988-09-28

    申请人： Klaus Habenstein

    发明人： Klaus Habenstein

    IPC分类号： G01N33/50 ,  C09B29/42 ,  C09B43/18 ,  C12Q1/34 ,  C12Q1/42 ,  C12Q1/44 ,  C12Q1/46

    CPC分类号： C12Q1/34 ,  C12Q1/42 ,  C12Q1/44 ,  C12Q1/46 ,  C12Q2334/00 ,  Y10S530/802

    摘要： Chromogenic substrates for the detection of hydrolyzing enzymes, processes for the preparation of these chromogenic substrates and the use of the chromogenic substrates.The quantification of hydrolyzing enzymes for diagnostic purposes has to date been carried out by determination of the amounts of a fluorescent or highly absorbent chromogenic dyestuff liberated in the hydrolytic reaction, detection of which has in part been possible exlusively by instruments or in the neutral to alkaline pH range. After enzymatic hydrolysis, the chromogenic substrates according to the invention lead to highly sensitive and specifically measurable signals regardless of the pH range.Azo dyestuff compounds with the general formulaA--N.dbd.N--B (OR)in which A) and B) have the meanings given in claim 1 andR) is a radical which can be liberated by enzymatic hydrolysis, excluding a carbonyl radical,are provided.After enzymatic hydrolysis, highly sensitively and specifically measurable signals are obtained regardless of the pH range.The azo dystuff compounds mentioned are used for the detection of hydrolyzing enzymes, in particular glycosidases, phosphatases and sulfatases.

    摘要翻译： 用于检测水解酶的显色底物，用于制备这些显色底物的方法和使用显色底物。 迄今为止，用于诊断目的的水解酶的定量是通过测定在水解反应中释放的荧光或高吸收性显色染料的量进行的，其检测部分可能通过仪器或中性至碱性 pH范围。 在酶水解之后，根据本发明的显色底物导致高度灵敏且具体可测量的信号，而与pH范围无关。 具有通式A-N = N-B（OR）的偶氮染料化合物，其中A）和B）具有权利要求1中给出的含义，R）是可通过酶水解除去羰基而释放的基团。 酶水解后，无论pH范围如何，均可获得高灵敏度和特异性可测量的信号。 所提及的偶氮胶囊化合物用于检测水解酶，特别是糖苷酶，磷酸酶和硫酸酯酶。

    Agent for detecting peroxidatively active substances and the use of a polyvinylmethylacylamide in such an agent
    10.
    发明授权
    Agent for detecting peroxidatively active substances and the use of a polyvinylmethylacylamide in such an agent 失效
    用于检测过氧化活性物质的试剂和在这种试剂中使用聚乙烯基甲酰胺

    公开(公告)号：US4372746A

    公开(公告)日：1983-02-08

    申请号：US279731

    申请日：1981-07-02

    申请人： Klaus Habenstein

    发明人： Klaus Habenstein

    IPC分类号： G01N33/50 ,  C12Q1/28 ,  G01N33/72 ,  G01N33/52

    CPC分类号： G01N33/725 ,  C12Q1/28 ,  C12Q2326/14

    摘要： Rapid diagnostic agent comprising an absorbent carrier matrix, a chromogen, a hydroperoxide, a detergent, an activator and a compound of the formula I ##STR1## or a copolymer containing such a compound, and, if appropriate, another protective colloid. A diagnostic agent of this type can be used in a method for detecting, in body fluids and excreta, peroxidatively active substances.

    摘要翻译： 快速诊断剂包括吸收性载体基质，色原体，氢过氧化物，洗涤剂，活化剂和式I化合物或含有这种化合物的共聚物，以及如果合适的话，其它保护胶体。 这种诊断剂可用于检测体液和排泄物中过氧化物质活性物质的方法。