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    Biological diagnostic device and method of use
    2.
    发明授权
    Biological diagnostic device and method of use 失效
    生物诊断装置及使用方法

    公开(公告)号：US4906439A

    公开(公告)日：1990-03-06

    申请号：US133071

    申请日：1987-12-21

    申请人： Gerd Grenner

    发明人： Gerd Grenner

    IPC分类号： G01N33/52 ,  G01N33/53 ,  G01N33/543 ,  G01N33/552

    CPC分类号： B01L3/502707 ,  B01L3/50273 ,  G01N33/525 ,  G01N33/5302 ,  G01N33/54386 ,  G01N33/552 ,  Y10S435/805 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/2575

    摘要： A biological diagnostic device and process for efficiently and accurately analyzing a sample of a biological fluid for in analyte of interest. The device, which is a preferred embodiment utilized for the analysis of whole blood samples, comprises a diagnostic test element and a sample application unit comprising a fluid delivery element and means for providing sample fluid to the fluid delivery element. The fluid delivery element comprises a layer having a plurality of grooves, or channels, in the surface thereof which is adjacent the test element. The fluid which is provided to the grooves is subsequently delivered to the test element.

    摘要翻译： 一种用于有效和准确地分析感兴趣的分析物中生物流体样品的生物诊断装置和方法。 用于分析全血样品的优选实施方案的装置包括诊断测试元件和包括流体输送元件的样品施用单元和用于将样品流体提供给流体输送元件的装置。 流体输送元件包括在其与测试元件相邻的表面中具有多个凹槽或通道的层。 随后将提供给凹槽的流体输送到测试元件。

    Assay element
    3.
    发明授权
    Assay element 失效
    测量元件

    公开(公告)号：US5147609A

    公开(公告)日：1992-09-15

    申请号：US354026

    申请日：1989-05-19

    申请人： Gerd Grenner

    发明人： Gerd Grenner

    IPC分类号： B01L99/00 ,  B01L3/00 ,  G01N33/543 ,  G01N37/00

    CPC分类号： B01L3/5023 ,  G01N33/54366 ,  B01L2200/027 ,  B01L2300/0825 ,  B01L2400/0406 ,  Y10S435/97 ,  Y10S436/808

    摘要： There is described an assay element suitable for use in an automated analytical test instrument for assaying a fluid sample. The element includes a thin porous member possessing a high degree of capillarity such as a fibrous mesh pad supported within a guide defined by surfaces contiguous the porous member. The dimensions of the porous member and its degree of capillarity are such as to provide for capillary transport of fluid through the member. A fluid dispenser and a fluid collecting chamber are disposed contiguous to opposed ends of the porous member. The fluid dispenser is formed as a well with a port at the bottom of the well, the port being contiguous the porous member and having a ridge extending along a perimeter of the port. The ridge protrudes into the porous member a distance sufficient for entraining fluid present in the well to propagate within the member rather than along an interface between a surface of the member and guide surfaces which hold it in place. Reservoirs may also be provided in the housing for storing reagents, mixing fluids and diluting samples so as to provide a self contained assay element. Optionally, and preferably, there may be an opening in the housing to provide fluid access directly to the central area of the porous member.

    摘要翻译： 描述了适合用于测定流体样品的自动分析测试仪器中的测定元件。 元件包括具有高毛细管度的薄多孔构件，例如支撑在由邻近多孔构件的表面限定的引导件内的纤维网垫。 多孔构件的尺寸和毛细管的程度是为了提供流体通过构件的毛细管输送。 流体分配器和流体收集室设置成与多孔构件的相对端邻接。 流体分配器形成为具有在井的底部的端口的井，该端口邻接多孔构件并且具有沿着端口的周边延伸的脊。 脊突出到多孔构件中足以使存在于井中的流体夹带在构件内传播的距离，而不是沿着构件的表面和将其保持在适当位置的引导表面之间的界面。 还可以在壳体中设置储存器以存储试剂，混合流体和稀释样品，以提供自包含的测定元件。 可选地，并且优选地，壳体中可以具有开口以提供流体直接通向多孔构件的中心区域。

    Divalent hapten derivatives
    6.
    发明授权
    Divalent hapten derivatives 失效
    二价半抗原衍生物

    公开(公告)号：US5336621A

    公开(公告)日：1994-08-09

    申请号：US211940

    申请日：1988-06-27

    申请人： Kathleen J. Primes ,  Gerald F. Sigler ,  Gerd Grenner ,  Wolfgang Kapmeyer

    发明人： Kathleen J. Primes ,  Gerald F. Sigler ,  Gerd Grenner ,  Wolfgang Kapmeyer

    IPC分类号： G01N33/531 ,  G01N33/543 ,  G01N33/78 ,  G01N33/94 ,  G01N33/546

    CPC分类号： G01N33/531 ,  G01N33/536 ,  G01N33/543 ,  G01N33/54313 ,  G01N33/78 ,  G01N33/94 ,  Y10S436/815 ,  Y10S436/816 ,  Y10S436/822 ,  Y10S436/823

    摘要： Divalent hapten derivatives wherein two hapten moieties are connected by means of a bifunctional spacer wherein the derivative has the formulaA--X--Awhere A is a bonded hapten moiety and X is a bifunctional spacer having the formula(B).sub.m --Y--(CH.sub.2).sub.n --Z--(CH.sub.2).sub.n --Y--(B).sub.mwhere m is independently 0 or 1, B is (CH.sub.2).sub.n', wherein n' is an integer from 1 to 4, or CO(CH.sub.2).sub.n", wherein n" is an integer from 2 or 4; Y is independently --CONH--, --NHCO--, --OOC, --COO--, --O--, --S--, or --NR--, wherein R is hydrogen or alkyl; n is an integer from 1 to 10; and Z is an organic moiety containing at least one hydrophilic atom, useful for the determination of haptens by immunochemical techniques are disclosed.

    摘要翻译： 二价半抗原衍生物，其中两个半抗原部分通过双官能间隔基连接，其中衍生物具有式AXA，其中A是键合半抗原部分，X是具有式（B）的双官能间隔基mY-（CH2）nZ-（CH2 ）nY-（B）m其中m独立地为0或1，B为（CH 2）n'，其中n'为1至4的整数，或CO（CH 2）n“，其中n”为整数 从2或4; Y独立地为-CONH-，-NHCO-，-OOC，-COO - ， - O - ， - S - 或-NR-，其中R为氢或烷基; n是1至10的整数; 并且Z是含有至少一个亲水性原子的有机部分，其用于通过免疫化学技术测定半抗原。

    Divalent hapten derivatives
    9.
    发明授权
    Divalent hapten derivatives 失效
    二价半抗原衍生物

    公开(公告)号：US4760142A

    公开(公告)日：1988-07-26

    申请号：US69747

    申请日：1987-07-06

    申请人： Kathleen J. Primes ,  Gerald F. Sigler ,  Gerd Grenner ,  Wolfgang Kapmeyer

    发明人： Kathleen J. Primes ,  Gerald F. Sigler ,  Gerd Grenner ,  Wolfgang Kapmeyer

    IPC分类号： G01N33/531 ,  G01N33/543 ,  G01N33/78 ,  G01N33/94 ,  C07D239/72

    CPC分类号： G01N33/531 ,  G01N33/536 ,  G01N33/543 ,  G01N33/54313 ,  G01N33/78 ,  G01N33/94 ,  Y10S436/815 ,  Y10S436/816 ,  Y10S436/822 ,  Y10S436/823

    摘要： Divalent hapten derivatives wherein two hapten moieties are connected by means of a bifunctional spacer wherein the derivative has the formulaA--X--Awhere A is a bonded hapten moiety and X is a bifunctional spacer having the formula(B).sub.m --Y--(CH.sub.2).sub.n --Z--(CH.sub.2).sub.n --Y--(B).sub.mwhere m is independently 0 or 1, B is (CH.sub.2).sub.n', wherein n' is an integer from 1 to 4, or CO(CH.sub.2).sub.n", wherein n" is an integer from 2 to 4; Y is independently --CONH--, NHCO--, OOC--, --COO--, --O--, --S--, or --NR--, wherein R is hydrogen or alkyl; n is an integer from 1 to 10; and Z is an organic moiety containing at least one hydrophilic atom are disclosed.

    摘要翻译： 二价半抗原衍生物，其中两个半抗原部分通过双官能间隔基连接，其中衍生物具有式AXA，其中A是键合半抗原部分，X是具有式（B）的双官能间隔基mY-（CH2）nZ-（CH2 ）nY-（B）m其中m独立地为0或1，B为（CH 2）n'，其中n'为1至4的整数，或CO（CH 2）n“，其中n”为整数 从2到4; Y独立地是-CONH-，NHCO-，OOC-，-COO-，-O - ， - S - 或-NR-，其中R是氢或烷基; n是1至10的整数; 并且Z是含有至少一个亲水性原子的有机部分。