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公开(公告)号：US09776029B2
公开(公告)日：2017-10-03
申请号：US14234303
申请日：2012-07-23
IPC分类号： A62D1/00 , C07K14/785 , A62D1/02
CPC分类号： A62D1/0042 , A62D1/00 , A62D1/0014 , A62D1/0071 , C07K14/785
摘要： The objective of the present invention is to provide an extinguishing agent which has excellent fire-extinguishing property and which exhibits high safety to the environment and human body. The fire extinguishing agent of the present invention is characterized in comprising a biosurfactant.
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公开(公告)号：US20140290970A1
公开(公告)日：2014-10-02
申请号：US14234303
申请日：2012-07-23
IPC分类号： A62D1/00
CPC分类号： A62D1/0042 , A62D1/00 , A62D1/0014 , A62D1/0071 , C07K14/785
摘要： The objective of the present invention is to provide an extinguishing agent which has excellent fire-extinguishing property and which exhibits high safety to the environment and human body. The fire extinguishing agent of the present invention is characterized in comprising a biosurfactant.
摘要翻译： 本发明的目的是提供一种具有优异的灭火性能，对环境和人体的安全性高的灭火剂。 本发明的灭火剂的特征在于包含生物表面活性剂。
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公开(公告)号：US07655450B2
公开(公告)日：2010-02-02
申请号：US10587085
申请日：2005-01-26
申请人： Satohiro Yanagisawa , Makoto Ueda , Hirokazu Nanba
发明人： Satohiro Yanagisawa , Makoto Ueda , Hirokazu Nanba
CPC分类号： C12R1/06 , C12N9/80 , C12P13/04 , C12P13/22 , C12P41/006 , C12Y305/01004
摘要： It is an object of the present invention to provide a novel amidase that is useful for production of an optically active amino acid, and in particular, a D-amino acid, and a production method thereof.The present invention relates to a novel D-amidase isolated and purified from the Arthrobacter sp. KNK1101J, a gene encoding the above amidase, a recombinant plasmid comprising the above gene, and a transformant into which the above amidase gene has been introduced. In addition, the present invention also relates to a method for producing the amidase, comprising culturing the Arthrobacter sp. KNK1101J or the above transformant, and collecting the above amidase.
摘要翻译： 本发明的目的是提供一种可用于制备光学活性氨基酸，特别是D-氨基酸的新型酰胺酶及其制备方法。 本发明涉及从节杆菌属分离和纯化的新型D-酰胺酶。 KNK1101J，编码上述酰胺酶的基因，包含上述基因的重组质粒，以及引入了上述酰胺酶基因的转化体。 此外，本发明还涉及一种生产酰胺酶的方法，包括培养节杆菌属（Arthrobacter sp。 KNK1101J或上述转化体，并收集上述酰胺酶。
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4.发明申请公开(公告)号：US20100197934A1
公开(公告)日：2010-08-05
申请号：US12757947
申请日：2010-04-09
申请人： Takahiro Ohishi , Hirokazu Nanba , Masanobu Sugawara , Masashi Izumida , Tatsuya Honda , Kohei Mori , Satohiro Yanagisawa , Nobuo Nagashima , Kenji Inoue
发明人： Takahiro Ohishi , Hirokazu Nanba , Masanobu Sugawara , Masashi Izumida , Tatsuya Honda , Kohei Mori , Satohiro Yanagisawa , Nobuo Nagashima , Kenji Inoue
IPC分类号： C12P17/10 , C12P13/12 , C07C321/00 , C07D233/02
CPC分类号： C12P13/12 , C07C319/06 , C07D233/76 , C12P17/04 , C12P17/10 , C12P41/009 , C07C323/58
摘要： The present invention provides a simple industrial process for producing an L- or D-optically active α-methylcysteine derivative or its salt, which is a useful pharmaceutical intermediate, from readily available, inexpensive raw materials. In a process for producing an L- or D-optically active α-methylcysteine derivative or its salt, a racemic N-carbamoyl-α-methylcysteine derivative or its salt is D-selectively cyclized with hydantoinase to produce a D-5-methyl-5-thiomethylhydantoin derivative or its salt and an N-carbamoyl-α-methyl-L-cysteine derivative or its salt, which are then subjected to deprotection of the amino group and the sulfur atom, and hydrolysis.
摘要翻译： 本发明提供了一种简单的工业方法，用于从容易获得的便宜的原料制备作为有用的药物中间体的L-或D-光学活性的α-甲基半胱氨酸衍生物或其盐。 在制备L-或D-光学活性α-甲基半胱氨酸衍生物或其盐的方法中，外消旋的N-氨基甲酰基-α-甲基半胱氨酸衍生物或其盐与乙内酰脲酶D选择性环化以产生D-5-甲基 - 5-硫代甲基乙内酰脲衍生物或其盐和N-氨基甲酰基-α-甲基-L-半胱氨酸衍生物或其盐，然后进行氨基和硫原子的脱保护和水解。
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5.发明授权5-Substituted hydantoin racemase, DNA encoding the same, recombinant DNA, transformed cell, and process for production of optically active N-carbamylamino acid or optically active amino acid 有权5-取代的乙内酰脲消旋酶，编码它们的DNA，重组DNA，转化细胞和用于制备光学活性N-氨基甲酰基氨基酸或光学活性氨基酸的方法公开(公告)号：US07709235B2
公开(公告)日：2010-05-04
申请号：US11883306
申请日：2006-01-26
申请人： Kenichi Nishi , Satohiro Yanagisawa , Hirokazu Nanba , Makoto Ueda , Naoto Noro
发明人： Kenichi Nishi , Satohiro Yanagisawa , Hirokazu Nanba , Makoto Ueda , Naoto Noro
CPC分类号： C12P13/04 , C12N9/90 , C12P41/009
摘要： Disclosed are a novel hydantoin racemase and a process for producing an optically active N-carbamylamino acid or an optically active amino acid using the hydantoin racemase. A novel hydantoin racemase isolated and purified from Bacillus sp. Strain KNK519HR; a gene encoding the hydantoin racemase; a recombinant plasmid having the gene introduced therein; a transformant having the hydantoin racemase gene introduced therein; and a process for producing an optically active N-carbamylamino acid or an optically active amino acid characterized in that a 5-substituted hydantoin compound is treated in the presence of hydantoinase and N-carbamylamino acid amidohydrolase as well as the hydantoin racemase.
摘要翻译： 公开了一种新型乙内酰脲消旋酶和使用乙内酰脲消旋酶制备光学活性N-氨基甲酰基氨基酸或光学活性氨基酸的方法。 从芽孢杆菌分离和纯化的新型乙内酰脲消化酶 菌株KNK519HR; 编码乙内酰脲消化酶的基因; 具有引入其中的基因的重组质粒; 其中引入了乙内酰脲消化酶基因的转化体; 以及用于制备光学活性N-氨基甲酰基氨基酸或光学活性氨基酸的方法，其特征在于在乙内酰脲酶和N-氨基甲酰基氨基酸酰胺水解酶以及乙内酰脲消旋酶的存在下处理5-取代的乙内酰脲化合物。
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公开(公告)号：US20060051846A1
公开(公告)日：2006-03-09
申请号：US10526888
申请日：2003-08-27
申请人： Takahiro Ohishi , Hirokazu Nanba , Masanobu Sugawara , Masashi Izumida , Tatsuya Honda , Kouhei Mori , Satohiro Yanagisawa , Kenji Inoue
发明人： Takahiro Ohishi , Hirokazu Nanba , Masanobu Sugawara , Masashi Izumida , Tatsuya Honda , Kouhei Mori , Satohiro Yanagisawa , Kenji Inoue
IPC分类号： C12P17/16
CPC分类号： C12P17/10 , C07B2200/07 , C07C319/06 , C07C319/14 , C07C323/58 , C07C327/34 , C07D233/76 , C12P41/009
摘要： A process for easily producing an L-α-methylcysteine derivative or its salt, which is useful as a drug intermediate, from a cheap easily procurable raw material through an enzymatic D-stereoselective hydrolysis of racemic 5-halomethyl-5-methyl-hydantoin. L-α-methylcysteine derivative or its salt is produced by converting racemic 5-halomethyl-5-methylhydantoin to L-5-halomethyl-5-methylhydantoin through an enzymatic D-stereoselective hydrolysis, reacting the L-5-halomethyl-5-methylhydantoin with a sulfurizing agent into L-5-methyl-5-thiomethylhydantoin and hydrolyzing the L-5-methyl-5-thiomethylhydantoin.
摘要翻译： 通过外消旋5-卤代甲基-5-甲基乙内酰脲的酶促D-立体选择性水解，从便宜的可原始的原料容易地制备可用作药物中间体的L-α-甲基半胱氨酸衍生物或其盐的方法。 通过酶促D-立体选择性水解将外消旋5-卤代甲基-5-甲基乙内酰脲转化为L-5-卤代甲基-5-甲基乙内酰脲来制备L-α-甲基半胱氨酸衍生物或其盐，使L-5-卤代甲基-5-甲基乙内酰脲 用硫化剂加入到L-5-甲基-5-硫代甲基乙内酰脲中并水解L-5-甲基-5-硫代甲基乙内酰脲。
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公开(公告)号：US08664373B2
公开(公告)日：2014-03-04
申请号：US13126532
申请日：2009-10-23
CPC分类号： C07H15/10 , A61K8/60 , A61K31/7016 , A61Q19/00 , C07H15/04 , C11C3/04 , C12P19/44 , C12R1/72
摘要： The present invention provides a low-cost, efficient method for producing a glycolipid biosurfactant, in particular, lactonic sophorose lipids. This method is characterized by culturing a microorganism capable of producing the biosurfactant under limited oxygen supply. The present invention enables preferential production of lactonic sophorose lipids and facilitates recovery of the lactonic sophorose lipids in a solid form. Further, the present invention enables production of high purity acidic sophorose lipids by hydrolyzing high purity lactonic sophorose lipids produced by the above method. The present invention also provides lactonic sophorose lipids that possess strong antibacterial and antifungal activities, and an antibacterial and/or antifungal agent containing the sophorose lipids.
摘要翻译： 本发明提供了制备糖脂生物表面活性剂，特别是内酯槐糖脂的低成本，有效的方法。 该方法的特征在于培养能够在有限供氧下产生生物表面活性剂的微生物。 本发明能够优先生产内酯槐糖脂，并有利于以固体形式回收内酯槐糖脂。 此外，本发明能够通过水解由上述方法生产的高纯度内酯槐糖脂来生产高纯度酸性槐糖脂。 本发明还提供具有强抗菌和抗真菌活性的内酯槐糖脂，以及含有槐糖脂的抗菌和/或抗真菌剂。
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8.发明申请5-Substituted Hydantoin Racemase, Dna Encoding the Same, Recombinant Dna, Transformed Cell, and Process for Production of Optically Active N-Carbamylamino Acid or Optically Active Amino Acid 有权5-取代的乙内酰脲消旋酶，编码其的Dna，重组Dna，转化细胞和用于制备光学活性N-氨基甲酰氨基酸或光活性氨基酸的方法公开(公告)号：US20080261268A1
公开(公告)日：2008-10-23
申请号：US11883306
申请日：2006-01-26
申请人： Kenichi Nishi , Satohiro Yanagisawa , Hirokazu Nanba , Makoto Ueda , Naoto Noro
发明人： Kenichi Nishi , Satohiro Yanagisawa , Hirokazu Nanba , Makoto Ueda , Naoto Noro
CPC分类号： C12P13/04 , C12N9/90 , C12P41/009
摘要： Disclosed are a novel hydantoin racemase and a process for producing an optically active N-carbamylamino acid or an optically active amino acid using the hydantoin racemase. A novel hydantoin racemase isolated and purified from Bacillus sp. Strain KNK519HR; a gene encoding the hydantoin racemase; a recombinant plasmid having the gene introduced therein; a transformant having the hydantoin racemase gene introduced therein; and a process for producing an optically active N-carbamylamino acid or an optically active amino acid characterized in that a 5-substituted hydantoin compound is treated in the presence of hydantoinase and N-carbamylamino acid amidohydrolase as well as the hydantoin racemase.
摘要翻译： 公开了一种新型乙内酰脲消旋酶和使用乙内酰脲消旋酶制备光学活性N-氨基甲酰基氨基酸或光学活性氨基酸的方法。 从芽孢杆菌分离和纯化的新型乙内酰脲消化酶 菌株KNK519HR; 编码乙内酰脲消化酶的基因; 具有引入其中的基因的重组质粒; 其中引入了乙内酰脲消化酶基因的转化体; 以及用于制备光学活性N-氨基甲酰基氨基酸或光学活性氨基酸的方法，其特征在于在乙内酰脲酶和N-氨基甲酰基氨基酸酰胺水解酶以及乙内酰脲消旋酶的存在下处理5-取代的乙内酰脲化合物。
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9.发明申请公开(公告)号：US20060105435A1
公开(公告)日：2006-05-18
申请号：US10515658
申请日：2003-06-05
申请人： Takahiro Ohishi , Hirokazu Nanba , Masanobu Sugawara , Masashi Izumida , Tatsuya Honda , Kohei Mori , Satohiro Yanagisawa , Nobuo Nagashima , Kenji Inoue
发明人： Takahiro Ohishi , Hirokazu Nanba , Masanobu Sugawara , Masashi Izumida , Tatsuya Honda , Kohei Mori , Satohiro Yanagisawa , Nobuo Nagashima , Kenji Inoue
CPC分类号： C12P13/12 , C07C319/06 , C07D233/76 , C12P17/04 , C12P17/10 , C12P41/009 , C07C323/58
摘要： The present invention provides a simple industrial process for producing an L- or D-optically active α-methylcysteine derivative or its salt, which is a useful pharmaceutical intermediate, from readily available, inexpensive raw materials. In a process for producing an L- or D-optically active α-methylcysteine derivative or its salt, a racemic N-carbamoyl-α-methylcysteine derivative or its salt is D-selectively cyclized with hydantoinase to produce a D-5-methyl-5-thiomethylhydantoin derivative or its salt and an N-carbamoyl-α-methyl-L-cysteine derivative or its salt, which are then subjected to deprotection of the amino group and the sulfur atom, and hydrolysis.
摘要翻译： 本发明提供了一种用于从容易得到的廉价原料生产L-或D-光学活性α-甲基半胱氨酸衍生物或其盐的简单工业方法，其是有用的药物中间体。 在制备L-或D-光学活性α-甲基半胱氨酸衍生物或其盐的方法中，外消旋的N-氨基甲酰基-α-甲基半胱氨酸衍生物或其盐与乙内酰脲酶D选择性环化以产生D-5-甲基 - 5-硫代甲基乙内酰脲衍生物或其盐和N-氨基甲酰基-α-甲基-L-半胱氨酸衍生物或其盐，然后对氨基和硫原子进行脱保护和水解。
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公开(公告)号：US06972289B1
公开(公告)日：2005-12-06
申请号：US10181786
申请日：2000-09-29
IPC分类号： A61K31/496 , A61P35/00 , A61K31/495 , C07D241/02 , C07D241/04 , C07D403/02
CPC分类号： A61K31/496
摘要： The present invention relates to a cell division inhibitor comprising various dehydrodiketopiperazines such as dehydrophenylahistin, or analogs thereof as an active ingredient, and a dehydrogenase and a method for producing the same inhibitor.
摘要翻译： 本发明涉及包含各种脱氢二酮哌嗪的脱细胞抑制剂，例如脱氢二硬脂酰胆碱，或其类似物作为活性成分，以及脱氢酶及其制备方法。
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