公开(公告)号：US4339500A

公开(公告)日：1982-07-13

申请号：US196238

申请日：1980-10-14

Applicant: Yuzo Yanagihara ,  Kohji Noguchi ,  Hiroshi Suzuki ,  Makoto Honda

Inventor： Yuzo Yanagihara ,  Kohji Noguchi ,  Hiroshi Suzuki ,  Makoto Honda

IPC: B01J20/285 ,  B01D15/34 ,  B01J20/26 ,  B01J20/281 ,  B01J20/291 ,  C08J3/12 ,  C08J9/36 ,  G01N30/88 ,  B32B3/00 ,  C08F226/00

CPC classification number: B01J20/291 ,  B01J20/26 ,  C08J3/12 ,  C08J9/36 ,  B01D15/34 ,  B01J2220/54 ,  C08J2329/04 ,  Y10S521/905 ,  Y10T428/2982

Abstract: Grains of a totally porous, hydroxyl group-containing, nonionic and hydrophilic synthetic cross-linked polymer having alcoholic hydroxyl and ether groups as main hydrophilic groups and having as a main skeleton a chemical structure including carbon atoms, hydrogen atoms and oxygen atoms bonded through single bonds, said synthetic polymer having a hydroxyl group density of 1 to 15 milliequivalents/g, a specific surface area of 5 to 1000 m.sup.2 /g and a water regain of 0.3 to 3.0 g/g. Such grains have been found to be a packing material or gel for high speed, aqueous gel permeation chromatography. The packing material of the present invention which comprises grains of a hydroxyl group-containing nonionic and hydrophilic synthetic cross-linked polymer has a chemical structure obtained by reacting a totally porous, hydroxyl group-containing, nonionic polymer with a polyfunctional substance capable of reacting with the hydroxyl groups of said polymer while forming cross-linking ether groups.

Abstract translation: 具有醇羟基和醚基作为主要亲水基团的全多孔，含羟基，非离子和亲水的合成交联聚合物的颗粒，其主要骨架是包含通过单键键合的碳原子，氢原子和氧原子的化学结构 所述合成聚合物的羟基密度为1〜15毫当量/克，比表面积为5〜1000m 2 / g，水回收率为0.3〜3.0g / g。 已经发现这种颗粒是用于高速，水凝胶渗透色谱的包装材料或凝胶。 包含含羟基的非离子和亲水性合成交联聚合物颗粒的本发明的包装材料具有通过使全部多孔的含羟基的非离子聚合物与能够与 所述聚合物的羟基形成交联醚基团。

公开(公告)号：US4368275A

公开(公告)日：1983-01-11

申请号：US272230

申请日：1981-06-10

Applicant: Yuzo Yanagihara ,  Kohji Noguchi ,  Makoto Honda

Inventor： Yuzo Yanagihara ,  Kohji Noguchi ,  Makoto Honda

IPC: B01J20/291 ,  B01D15/08 ,  B01D15/34 ,  C08F8/12 ,  C08L29/04

CPC classification number: B01J20/285 ,  B01D15/34 ,  B01J20/28047 ,  B01J20/28057 ,  C08F8/12

Abstract: A granular crosslinked copolymer suitable as a high speed liquid chromatographic packing and especially as a gel permeation chromatographic packing is disclosed. In a preferred embodiment of the invention the packing is a copolymer essentially consisting of (I) units of at least one vinyl alcohol, (II) units of at least one vinyl ester of a carboxylic acid and (III) units of at least one crosslinking monomer having an isocyanurate ring, the ratio of the units (I) to the units (II) in the copolymer being within the range satisfying the following equation:about 0.4.ltoreq.a/(a+b).ltoreq.about 0.8whereina and b are molar ratios of the units (I) and (II), respectively, in the total units (I), (II) and (III) of the copolymer,and a process for preparing the same by suspension polymerization is disclosed.

Abstract translation: 公开了一种适合作为高速液相色谱填料，特别是凝胶渗透色谱填料的粒状交联共聚物。 在本发明的优选实施方案中，填料是基本上由以下组成的共聚物：（I）至少一种乙烯醇的单元，（II）至少一种羧酸乙烯基酯的单元和（III）至少一种交联的单元 具有异氰脲酸酯环的单体，共聚物中单元（I）与单元（II）的比例在满足以下等式的范围内：约0.4≤a/（a + b）≤0.8其中 a和b分别是共聚物的总单元（I），（II）和（III）中的单元（I）和（II）的摩尔比，并且公开了通过悬浮聚合制备其的方法 。

公开(公告)号：US4338404A

公开(公告)日：1982-07-06

申请号：US228505

申请日：1981-01-26

Applicant: Yasuyuki Tanaka ,  Junichi Takeda ,  Kohji Noguchi

Inventor： Yasuyuki Tanaka ,  Junichi Takeda ,  Kohji Noguchi

IPC: B01J20/22 ,  C08F212/06 ,  C08J9/16

CPC classification number: B01J20/22 ,  C08F212/06

Abstract: A novel granular crosslinked copolymer suitable as a high speed liquid chromatograph packing and especially as a gel permeation chromatograph packing is disclosed. In a preferred embodiment of the invention the packing is a copolymer of styrene and divinylbenzene having a volume average particle diameter of about 2 to 50 .mu.m, an exclusive molecular weight for a polystyrene being from about 500 to 20,000, and the weight % (X) of divinylbenzene units based on the entire monomeric units of the copolymer and the gradient (.alpha.) of the calibration curve of the polystyrene are defined by the region bounded by and including the following three lines in rectangular coordinates (.alpha., X) ##EQU1##.alpha.=2.5X=35and a process for preparing the same by suspension polymerization in the presence of an initiator having specific half-life properties is disclosed.

Abstract translation: 公开了一种适用于高速液相色谱填料，特别是作为凝胶渗透色谱填料的新型粒状交联共聚物。 在本发明的优选实施方案中，填料是苯乙烯和二乙烯基苯的共聚物，其体积平均粒径为约2-50μm，聚苯乙烯的专用分子量为约500至20,000，重量％（X ）基于共聚物的全部单体单元的二乙烯基苯单元和聚苯乙烯的校准曲线的梯度（α）由由直角坐标（α，X）定义并包括以下三行的区域限定。 α= 2.5X = 35，并公开了在具有特定半衰期特性的引发剂存在下通过悬浮聚合制备该方法。

公开(公告)号：US4288515A

公开(公告)日：1981-09-08

申请号：US919999

申请日：1978-06-28

Applicant: Keitaro Yamashita ,  Kohji Noguchi

Inventor： Keitaro Yamashita ,  Kohji Noguchi

IPC: G03G13/06 ,  G03G13/08 ,  G03G13/09 ,  G03G15/08 ,  G03G13/22

CPC classification number: G03G13/09

Abstract: A reversal developing process carried out preferably with an inductively chargeable magnetic powdery developer. An electrostatic latent image having first charged areas and second lesser charged areas formed on a photoreceptor or a photoconductor is developed negatively by forming a toner brush of single component, i.e., inductively chargeable, magnetic powdery developer on a shell incorporating a permanent magnet to adhere the developer on the first charged areas, charging uniformly the developed photoreceptor with the same polarity as the first charged area and further rubbing the surface of the photoreceptor with a second toner brush to remove the previously adhered developer from the surface and to adhere powdery developer onto the second lesser charged areas. The apparatus includes two applicators for powdery developer positioned along the path of movement of the latent image with a D.C. charger stationed between the applicators. In the preferred embodiment, the two applicators and charger are incorporated in a single device.

Abstract translation: 优选用可感应充电的磁粉显影剂进行反转显影处理。 具有形成在感光体或光电导体上的第一带电区域和第二较小带电区域的静电潜像通过在包含永久磁铁的外壳上形成单一组分即可感应带电的磁性粉末显影剂的调色剂刷而产生负面影响， 显影剂在第一带电区域上，以与第一带电区域相同的极性均匀地装载显影的感光体，并用第二调色剂刷进一步摩擦感光体的表面，以从表面去除先前粘附的显影剂，并将粉状显影剂粘附到 次要收费较低的地区。 该装置包括两个用于粉末状显影剂的涂布器，其沿着潜像的移动路径定位，其中放置有位于施加器之间的直流充电器。 在优选实施例中，两个施加器和充电器结合在单个装置中。

公开(公告)号：US4277552A

公开(公告)日：1981-07-07

申请号：US99853

申请日：1979-12-03

Applicant: Masumi Asanae ,  Kohji Noguchi

Inventor： Masumi Asanae ,  Kohji Noguchi

IPC: G03G9/08 ,  G03G9/083 ,  G03G13/09

CPC classification number: G03G9/0833 ,  G03G9/0835 ,  Y10S430/104

Abstract: Disclosed is an electrostatic image developing process using a magnet roll and a magnetic toner of specified flux density.

Abstract translation: 公开了使用磁辊和规定的磁通密度的磁性调色剂的静电图像显影处理。

公开(公告)号：US4239892A

公开(公告)日：1980-12-16

申请号：US61335

申请日：1979-07-27

Applicant: Tetsuya Miyake ,  Kohji Noguchi ,  Kazuo Imamura

Inventor： Tetsuya Miyake ,  Kohji Noguchi ,  Kazuo Imamura

IPC: C07D213/10 ,  C07D213/16

CPC classification number: C07D213/16 ,  C07D213/10

Abstract: A process for preparing simultaneously pyridine bases including 2-methylpyridine and 4-methylpyridine, occasionally, together with pyridine from acetaldehyde and ammonia by gas phase catalytic reaction, characterized in that the gas phase catalytic reaction is conducted in the presence of a catalyst prepared by (A) incorporating at least one compound containing at least one metal selected from the group consisting of tungsten, manganese, nickel, iron, cobalt, molybdenum, uranium, lead, silver, copper and tin into silica-alumina simultaneously with preparation of the silica-alumina, or (B) subjecting silica-alumina to ion exchange with ions of at least one metal selected from the group consisting of manganese, nickel, iron, cobalt, uranium, lead, silver, copper and tin to adsorb the ions on said silica-alumina. According to the process of the present invention, there can be obtained the desired pyridine bases in high yield, whereas formation of by-products including high boiling point pyridine derivatives is remarkably suppressed. The catalyst employed in the present process has a high resistance to the reaction atmosphere.

Abstract translation: 同时通过气相催化反应同时制备包括2-甲基吡啶和4-甲基吡啶的吡啶碱与乙醛和氨的吡啶一起制备的方法，其特征在于气相催化反应是在催化剂存在下进行的， A）同时制备含有选自钨，锰，镍，铁，钴，钼，铀，铅，银，铜和锡中的至少一种金属的至少一种化合物，同时制备二氧化硅 - 氧化铝，或（B）使二氧化硅 - 氧化铝与选自锰，镍，铁，钴，铀，铅，银，铜和锡中的至少一种金属的离子进行离子交换，以将离子吸附在所述二氧化硅 氧化铝 根据本发明的方法，可以高产率获得所需的吡啶碱，而显着抑制了包括高沸点吡啶衍生物在内的副产物的形成。 本方法中使用的催化剂对反应气氛具有高抗性。

公开(公告)号：US4179576A

公开(公告)日：1979-12-18

申请号：US841083

申请日：1977-10-11

Applicant: Tetsuya Miyake ,  Kohji Noguchi ,  Kazuo Imamura

Inventor： Tetsuya Miyake ,  Kohji Noguchi ,  Kazuo Imamura

IPC: C07D213/10 ,  C07D213/16

CPC classification number: C07D213/16 ,  C07D213/10

Abstract: A process for preparing simultaneously pyridine bases including 2-methylpyridine and 4-methylpyridine, occasionally, together with pyridine from acetaldehyde and ammonia by gas phase catalytic reaction, characterized in that the gas phase catalytic reaction is conducted in the presence of a catalyst prepared by (A) incorporating at least one compound containing at least one metal selected from the group consisting of tungsten, manganese, nickel, iron, cobalt, molybdenum, uranium, lead, silver, copper and tin into silica-alumina simultaneously with preparation of the silica-alumina, or (B) subjecting silica-alumina to ion exchange with ions of at least one metal selected from the group consisting of manganese, nickel, iron, cobalt, uranium, lead, silver, copper and tin to adsorb the ions on said silica-alumina. According to the process of the present invention, there can be obtained the desired pyridine bases in high yield, whereas formation of by-products including high boiling point pyridine derivatives is remarkably suppressed. The catalyst employed in the present process has a high resistance to the reaction atmosphere.

Abstract translation: 同时通过气相催化反应同时制备包括2-甲基吡啶和4-甲基吡啶的吡啶碱与乙醛和氨的吡啶一起制备的方法，其特征在于气相催化反应是在催化剂存在下进行的， A）同时制备含有选自钨，锰，镍，铁，钴，钼，铀，铅，银，铜和锡中的至少一种金属的至少一种化合物，同时制备二氧化硅 - 氧化铝，或（B）使二氧化硅 - 氧化铝与选自锰，镍，铁，钴，铀，铅，银，铜和锡中的至少一种金属的离子进行离子交换，以将离子吸附在所述二氧化硅 氧化铝 根据本发明的方法，可以高产率获得所需的吡啶碱，而显着抑制了包括高沸点吡啶衍生物在内的副产物的形成。 本方法中使用的催化剂对反应气氛具有高抗性。

公开(公告)号：US4416783A

公开(公告)日：1983-11-22

申请号：US341040

申请日：1982-01-20

Applicant: Kohji Noguchi ,  Masao Kasai

Inventor： Kohji Noguchi ,  Masao Kasai

IPC: G01N30/06 ,  B01D15/08 ,  B01D15/20 ,  B01J20/281 ,  B01J20/285 ,  B01J20/291 ,  C08F8/12 ,  G01N30/00 ,  G01N30/56 ,  G01N30/88

CPC classification number: B01J20/291 ,  B01D15/206 ,  B01J20/264 ,  B01J20/267 ,  B01J20/28004 ,  B01J20/285 ,  C08F8/12 ,  B01J2220/54 ,  G01N2030/562

Abstract: A liquid chromatography column comprising a uniform gel bed of a high packing ratio, which is produced by a process in which a column is prepared while avoiding imposing an abrupt change of flow rate or pressure on the gel bed during the column packing operation, thereby making it possible to simultaneously improve the elution speed and the durability of the column. The column comprises gels of small grain diameter, thereby exhibiting an excellent resolution. The column also ensures a direct analysis of blood serum.

Abstract translation: 一种液相色谱柱，其包含高填充率的均匀凝胶床，其通过制备柱的方法制备，同时避免在柱填充操作期间在凝胶床上施加流速或压力的突然变化，从而使 可以同时提高洗脱速度和柱的耐久性。 该柱包括小粒径的凝胶，从而表现出优异的分辨率。 该柱还确保对血清进行直接分析。

公开(公告)号：US4263439A

公开(公告)日：1981-04-21

申请号：US48572

申请日：1979-06-14

Applicant: Tetsuya Miyake ,  Kohji Noguchi ,  Kazuo Imamura

Inventor： Tetsuya Miyake ,  Kohji Noguchi ,  Kazuo Imamura

IPC: C07D213/10 ,  C07D213/16

CPC classification number: C07D213/16 ,  C07D213/10

Abstract: A process for preparing simultaneously pyridine bases including 2-methylpyridine and 4-methylpyridine, occasionally, together with pyridine from acetaldehyde and ammonia by gas phase catalytic reaction, characterized in that the gas phase catalytic reaction is conducted in the presence of a catalyst prepared by (A) incorporating at least one compound containing at least one metal selected from the group consisting of tungsten, manganese, nickel, iron, cobalt, molybdenum, uranium, lead, silver, copper and tin into silica-alumina simultaneously with preparation of the silica-alumina, or (B) subjecting silica-alumina to ion exchange with ions of at least one metal selected from the group consisting of manganese, nickel, iron, cobalt, uranium, lead, silver, copper and tin to adsorb the ions on said silica-alumina. According to the process of the present invention, there can be obtained the desired pyridine bases in high yield, whereas formation of by-products including high boiling point pyridine derivatives is remarkably suppressed. The catalyst employed in the present process has a high resistance to the reaction atmosphere.

Abstract translation: 同时通过气相催化反应同时制备包括2-甲基吡啶和4-甲基吡啶的吡啶碱与乙醛和氨的吡啶一起制备的方法，其特征在于气相催化反应是在催化剂存在下进行的， A）同时制备含有选自钨，锰，镍，铁，钴，钼，铀，铅，银，铜和锡中的至少一种金属的至少一种化合物，同时制备二氧化硅 - 氧化铝，或（B）使二氧化硅 - 氧化铝与选自锰，镍，铁，钴，铀，铅，银，铜和锡中的至少一种金属的离子进行离子交换，以将离子吸附在所述二氧化硅 氧化铝 根据本发明的方法，可以高产率获得所需的吡啶碱，而显着抑制了包括高沸点吡啶衍生物在内的副产物的形成。 本方法中使用的催化剂对反应气氛具有高抗性。

公开(公告)号：US4452918A

公开(公告)日：1984-06-05

申请号：US374369

申请日：1982-05-03

Applicant: Takateru Uchida ,  Kohji Noguchi ,  Takao Kiyota

Inventor： Takateru Uchida ,  Kohji Noguchi ,  Takao Kiyota

IPC: C12N9/00 ,  B01J20/26 ,  B01J20/291 ,  C08F8/00 ,  C08F8/12 ,  C12N11/08 ,  B32B3/00 ,  C08F226/00

CPC classification number: B01J20/291 ,  B01J20/26 ,  C08F8/12 ,  B01J2220/54 ,  C08F2810/20 ,  Y10S521/905 ,  Y10T428/2982

Abstract: A totally porous activated gel which comprises a matrix of a totally porous crosslinked copolymer comprising as main components vinyl alcohol monomer units and crosslinkable monomer units and having a specific surface area of 5 to 1000 m.sup.2 /g and an reactive group linked to said matrix by a covalent bond. The present activated gel is very useful for effectively separating bio-substances due to the peculiar behavior of the reactive group of the activated gel. The activated gel is rigid, and is excellent in mechanical strength, resistance to chemicals, high pH, low pH, high temperature and low temperature, and is very effective in specific adsorption of bio-substances. The activated gel can be subjected to freeze-drying sterilization, heat sterilization and radiation sterilization, so that it can be utilized for the medical treatment by extracorporeal perfusion of, for example, blood.

Abstract translation: 一种全多孔活性凝胶，其包含全部多孔交联共聚物的基质，其包含作为主要组分的乙烯醇单体单元和可交联单体单元，并且具有5至1000m 2 / g的比表面积和与所述基质连接的反应性基团 共价键。 由于活化凝胶的反应性基团的特殊行为，本发明的活化凝胶对于有效分离生物物质非常有用。 活化凝胶是刚性的，机械强度，耐化学品，高pH，低pH，高温和低温都是优异的，对生物物质的特异性吸附是非常有效的。 活化凝胶可以进行冷冻干燥灭菌，加热灭菌和放射线灭菌，从而可以通过例如血液的体外灌注来用于医疗。