公开(公告)号：US5176909A

公开(公告)日：1993-01-05

申请号：US590230

申请日：1990-09-28

申请人： Kuniaki Nerome ,  Kuniharu Seki ,  Katsuhiko Ohyama

发明人： Kuniaki Nerome ,  Kuniharu Seki ,  Katsuhiko Ohyama

IPC分类号： A61K9/20 ,  A61K9/16 ,  A61K9/50 ,  A61K9/52 ,  A61K39/00 ,  A61K39/10 ,  A61K39/12 ,  A61K39/145 ,  A61K39/29 ,  A61K47/42

CPC分类号： A61K9/5026 ,  A61K9/1658 ,  A61K9/5042 ,  Y10S530/806

摘要： A stable immunogen composition for oral administration which includes a dried spherical form comprised of an immunogen capable of immunizing human or animals and a gelatin having an average molecular weight of 80,000-120,000 and jelly strength of more than 150 (Bloom, g, 6.2/3%), and is enteric.

摘要翻译： 用于口服给药的稳定的免疫原组合物，其包括由能够免疫人或动物的免疫原组成的干燥球形形式和平均分子量为80,000-120,000和凝胶强度大于150的明胶（Bloom，g，6.2 / 3 ％），是肠溶性的。

公开(公告)号：US20110111064A1

公开(公告)日：2011-05-12

申请号：US13003353

申请日：2009-07-08

申请人： Kuniaki Nerome

发明人： Kuniaki Nerome

IPC分类号： A61K36/58 ,  A61K36/185 ,  A61P31/16

CPC分类号： A61K36/58 ,  A61K36/185 ,  A61K36/49

摘要： The present invention herein provides an anti-influenza virus agent, an anti-RS virus agent or an anti-immunodeficiency virus agent, which comprises components originated from plants and which has excellent infectivity-inhibitory effect and proliferation-inhibitory effect against influenza viruses, RS viruses and immunodeficiency viruses. The anti-influenza virus agent, anti-RS virus agent or anti-immunodeficiency virus agent of the present invention comprises an extract derived from, or dry powder of the leaves of a plant belonging to the family Betulaceae and/or a plant belonging to the family Meliaceae.

摘要翻译： 本发明提供了抗流感病毒剂，抗RS病毒剂或抗免疫缺陷病毒剂，其包含起源于植物的组分，其具有优异的感染抑制作用和对流感病毒的增殖抑制作用，RS 病毒和免疫缺陷病毒。 本发明的抗流感病毒剂，抗-RS病毒剂或抗免疫缺陷病毒剂包括来自属于桦木科的植物的叶子的提取物或干粉，和/或属于 家蚕科

公开(公告)号：US4826687A

公开(公告)日：1989-05-02

申请号：US867539

申请日：1986-05-28

申请人： Kuniaki Nerome ,  Akira Oya ,  Kunio Ohkuma ,  Atsuo Inoue

发明人： Kuniaki Nerome ,  Akira Oya ,  Kunio Ohkuma ,  Atsuo Inoue

IPC分类号： A61K39/102 ,  A61K9/127 ,  A61K9/50 ,  A61K39/145 ,  A61K39/39 ,  A61P31/12 ,  A61P31/16 ,  A61K39/22 ,  A61K39/12 ,  B01J13/02

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K9/1271 ,  A61K9/1272 ,  A61K9/1277 ,  A61K9/5068 ,  A61K2039/5555 ,  A61K2039/55555 ,  C12N2760/16134 ,  Y10S436/829 ,  Y10S514/885 ,  Y10T428/2984

摘要： This invention relates to a novel influenza vaccine comprising a complex of HANA antigen and an MDP derivative.The novel vaccine is prepared by mixing an influenza HANA antigen and at least one MDP derivative in a suitable medium; solubilizing the resulting mixture with a surface active agent capable of being removed by dialysis, the solubilization being conducted in the presence or absence of cholesterol, lecithin and dicetyl phosphate or a mixture thereof; and then removing the surface active agent therefrom by dialysis to obtain an influenza vaccine comprising artificial vesicle-like particles of a complex of HANA antigen and MDP derivative, where the MDP derivative forms a membrane of the particle (corresponding to the lipid membrane of natural influenza virus particle) on the surface of which there exists the HANA antigen being bonded to the MDP derivative so as to form the complex. Thus, said artificial vesicle-like particle of the HANA antigen-MDP derivative complex has nearly the same particle size and shape as the natural influenza virus particle.The novel vaccine has an improved immunogenicity compared with the conventional vaccine.

摘要翻译： 本发明涉及包含HANA抗原和MDP衍生物的复合物的新型流感疫苗。 通过将流感HANA抗原和至少一种MDP衍生物混合在合适的培养基中来制备新型疫苗; 将所得混合物与能够通过透析除去的表面活性剂溶解，所述溶解在胆固醇，卵磷脂和磷酸二鲸蜡酯或其混合物存在或不存在下进行; 然后通过透析除去表面活性剂，得到包含HANA抗原和MDP衍生物的复合物的人造囊泡状颗粒的流感疫苗，其中MDP衍生物形成颗粒膜（对应于天然流感的脂质膜 病毒颗粒），其表面上存在与MDP衍生物键合的HANA抗原，以形成复合物。 因此，HANA抗原-MDP衍生物复合物的所述人造囊泡状颗粒具有与天然流感病毒颗粒几乎相同的粒度和形状。 与常规疫苗相比，新型疫苗具有改善的免疫原性。

公开(公告)号：US20130236580A1

公开(公告)日：2013-09-12

申请号：US13872304

申请日：2013-04-29

申请人： Kuniaki Nerome

发明人： Kuniaki Nerome

IPC分类号： A61K36/58 ,  A61K36/49 ,  A61K36/185

CPC分类号： A61K36/58 ,  A61K36/185 ,  A61K36/49

摘要： An anti-influenza virus agent, an anti-RS virus agent, or an anti-immunodeficiency virus agent, which comprises components originated from plants and which has excellent infectivity-inhibitory effect and proliferation-inhibitory effect against influenza viruses, RS viruses and immunodeficiency viruses. The anti-influenza virus agent, anti-RS virus agent or anti-immunodeficiency virus agent of the present invention comprises an extract derived from, or dry powder of the leaves of a plant belonging to the family Betulaceae and/or a plant belonging to the family Meliaceae.

摘要翻译： 抗流感病毒剂，抗RS病毒剂或抗免疫缺陷病毒剂，其包含起源于植物的组分，其具有优异的感染抑制作用和对流感病毒，RS病毒和免疫缺陷病毒的增殖抑制作用 。 本发明的抗流感病毒剂，抗-RS病毒剂或抗免疫缺陷病毒剂包括来自属于桦木科的植物的叶子的提取物或干粉，和/或属于 家蚕科